Neonatal deaths in Odisha remain a significant public health problem, accounting for over half of infant and under-5 mortality. The neonatal mortality rate in Odisha is 42 per 1000 live births, with 33 occurring in the early neonatal period. Prematurity, low birth weight, birth asphyxia, and infections are the leading causes. Coverage of antenatal care, institutional deliveries, and postnatal practices like early and exclusive breastfeeding remain areas for improvement. Expanding programs like the Janani Surakshya Yojana and improving access to skilled birth attendance and emergency obstetric and newborn care can help reduce neonatal mortality in Odisha.