This document summarizes a study on the first pass effects of Oltipraz, a drug, in rats. The study measured the disappearance of Oltipraz in tissue homogenates, its biliary excretion after intravenous administration, and its hepatic and gastrointestinal first pass effects after intravenous, intraportal, intragastric, and intraduodenal administration. The results showed significant first pass effects of Oltipraz through the liver and gastrointestinal tract in rats, with an oral bioavailability of 41.2% after accounting for these first pass effects.

1. HEPATIC AND INTESTINAL FIRST PASS EFFECTS OF OLTIPRAZ IN RATS BY SANTHOSH MENNANI

4. Biliary excretion after i.v. Administration

5. Measurement of hepatic first pass effect

8. Measurement of hepatic first pass effect

9. Measurement of gastric and intestinal first pass effectscntd...

10. Discussion Figure 1. Arterial plasma concentration–time profiles of oltiprazafter 15 min intravenous (*; n = 5) and intraportal (*; n = 5) infusion (A), and after 15 min intraportalinfusion (&; n = 4) (B) of the drug at a dose of 20 mg/kg to male rats. The inset in Figure 1(B) shows the profiles after intragastric (*; n = 4) and intraduodenal (*; n = 3) administration of the drug at a dose of 20 mg/kg to rats. Each point represents the mean standard deviation. * represents significant difference (p 5 0.001) compared with intravenous data

11. Conclusion The oral bioavailability of Oltipraz at a dose of 20mg/kg was found to be 41.2%

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