This document provides an appraisal report for a project to support agricultural research and development of strategic crops in Africa through partnerships with CGIAR centers. The project aims to enhance food and nutrition security and reduce poverty. It will pursue this by increasing productivity, income, and market access around four key crops: cassava, maize, rice, and wheat. The project will be implemented over 5 years with $39.9 million from the African Development Fund and $13.9 million of in-kind contributions from participating countries. It is expected to achieve high economic and financial returns while minimizing social and environmental risks.