Some of the most expensive bags in the world include the Himalayan Birkin bag made from exotic crocodile skin that can sell for over $200,000. Another is the Diamond encrusted bag by Stuart Weitzman that has over 500 diamonds and sells for around $375,000. The most expensive bag ever sold was a custom made bag by designer Stuart Hughes that had diamonds, sapphires, and rubies totaling over $3.8 million.