This document provides an overview of mixed-use development and discusses some of the challenges involved. It notes that while mixed-use developments can make a positive contribution to town centre regeneration, they are not a complete solution on their own. Key challenges discussed include negotiating the complex planning process, optimizing the configuration and phasing of developments, maximizing financial value, and establishing the proper long-term management strategy. The article also provides a case study examining the factors that contributed to the success of the mixed-use Quays development in Chatham, UK.