This chapter discusses midlife and menopause in women. It defines midlife as ages 45-65, a time of emotional, social, and physical changes for women, including menopause. Menopause is defined as the end of monthly menstrual periods, and is usually around age 51 but can vary. During midlife, women experience hormonal changes, social role changes as children leave home, and increased health risks. The chapter provides information on managing symptoms and health risks at this stage of life.