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Memory Science in
Medical Education
                        Frank Lau, MD
     Co-Founder & Chief Medical Officer
                  GunnerTraining.com
The Challenge for Medical Students


   “I feel like every   time I
      review something or learn something new, I
  forget something else.”
                                 – C.C., 2nd year medical student,
                            University of Michigan Medical School
The Challenge Persists for Residents
    Resuscitation, July 2009
         70 Johns Hopkins pediatrics residents
         66% failed to start timely CPR (basic life support)
              95% of the residents had received this level of training
         83% made errors during defibrillation (shocking the patient)
              80% of the residents had been trained in defibrillation
         More years of training did not improve physician performance



                     Medical knowledge is routinely forgotten,
                       even by the best and the brightest.
The Challenge Persists for Attending
Physicians
    Journal of Trauma, June 1996
         60 practicing trauma physicians took the standard Advanced
          Trauma Life Support course, followed by an examination
              National course for managing traumas (car accidents, gunshots, stab
               wounds, etc)
         Immediate testing: 86% average score
         6 months later, 50% failed
         13 years after this study, no novel approaches to learning and
          retaining medical knowledge


                 Basic, critical knowledge is routinely forgotten,
                         even by experienced specialists.
Who Should Care?
    Medical Students
    Physicians-in-training (residents)
    Educators
    Foreign medical graduates
    Practicing physicians

    Patients
    Healthcare policy makers
    Patient safety advocates
The 2 Phases of Knowledge Acquisition


           Mastering the
             material

           Maintaining that
             knowledge
Mastering the Material
    We think we’re good at this
         We did well on the MCAT, we pass our exams
    But these are graded on a curve!
         Patient outcomes don’t work on a curve
    In reality, we do poorly at judging how well we’ve
     mastered specific topics
Mastery: The Problem




                            32%
                           of the
                         reviewed
                        material is
                       immediately
                        forgotten.
Mastery: The Problem
Maintaining Your Knowledge
    We rarely focus on knowledge maintenance
         Johns Hopkins study, the ATLS study
         Affects patient outcomes
    For Step 1, the review process involves re-learning a lot of
     material that you once knew but have since forgotten
Intro to Gunner Training
    The first Knowledge Management platform
         Created to help students master and maintain their Step 1
          knowledge base
    Personalized: users choose which subjects to study  can
     correlate with school's curriculum
    Dynamic: custom review schedule changes according to
     student's forward learning
    Mobile:
         iPhone/mobile browser compatible
         No software installation required
Intro to Gunner Training
    Launched April 2009:
         Hundreds of users
         Thousands of data points
    We use this data and user feedback to continually validate
     and improve Gunner Training
The GT Way
1.         Learn the material from flashcards
      •      High-yield, interactive
2.         Immediate testing on that material
      •      Open-ended study questions
3.         Spaced Learning algorithms create a personalized review
           schedule for that material
      •      Incorporates Step 1 style multiple choice questions
      •      Short intervals help you master that material
      •      Longer intervals maintain your knowledge


4.         Exam simulation
      •      Eases anxiety
      •      Increases test-taking stamina
The GT Way
1.         Learn the material from flashcards
      •      High-yield, interactive
2.         Immediate testing on that material
      •      Open-ended study questions              Apply 19
3.         Spaced Learning algorithms create a      principles of
           personalized review schedule for that
           material                                   efficient,
      •      Incorporates Step 1 style multiple
             choice questions                         effective
      •      Short intervals help you master that
             material                                 learning
      •      Longer intervals maintain your
             knowledge

4.         Exam simulation
      •      Eases anxiety
      •      Increases test-taking stamina
GT: Flashcard Learning Principles
1.         Contiguity Effects. Ideas that are associated should be
           presented contiguously in space and time
          One flashcard per topic, rather than one-fact-per-flashcard
2.         Dual Code and Multimedia Effects. Visual + multimedia
           form richer representations vs. a single medium
          Hundreds of relevant images: gram stains, CT scans, X-rays,
           clinical photos
3.         Coherence Effect. Materials should explicitly link related
           ideas
GT: Flashcard Learning Principles
4.         Segmentation Principle. A complex lesson should be broken
           down into manageable subparts
          Two levels of bulletpoints
5.         Manageable Cognitive Load. The information presented to
           the learner should not overload working memory
          Second bulletpoints are initially hidden
6.         Cognitive Flexibility. This improves w/ multiple viewpoints
           linking facts and deep conceptual principles
          Material presented in several locations
          Ex: TB is covered under Microbiology, Pulmonology, Immunology
7.         Anchored Learning. Materials are anchored in real world
           problems that you care about
          Clinical correlation
Contiguity, Dual code/Multimedia, &
Coherence Effects
Segmentation & Manageable Cognitive Load
Cognitive Flexibility
Anchored Learning
GT: Study Question Principles
8.         Imperfect Metacognition. We rarely have an accurate
           knowledge of our cognition  need assistance with
           calibrating comprehension, learning, and memory
          Immediate testing solves this
9.         Generation Effect. Learning is enhanced when learners
           produce answers (vs. recognizing answers)
          This is why GT employs open-ended study questions
10.        Testing Effect. Testing enhances learning, especially when
           the tests are aligned with important content
GT: Study Question Principles
11.    Feedback Effects. Students benefit from immediate
       feedback on their performance
12.    Negative Suggestion Effects. Learning wrong information
       can be reduced when feedback is immediate
13.    Deep questions. More benefit from answering questions
       that elicit explanations (e.g., why, why not, how, what-if)
Imperfect Metacognition, Generation Effect
& Testing Effect
Feedback Effects & Negative Suggestion
Effects
GT: Review Schedule Principles
14.    Goldilocks Principle. Assignments should be at the right
       difficulty level
15.    Self-regulated Learning. Most students need to self-
       regulate their learning
16.    Exam Expectations. Students benefit more from
       repeated testing
17.    Spaced Learning.
Goldilocks, Self-regulated Learning, and
Exam Expectations
GT: MCQ Principles
18.     Desirable difficulties. Challenges make learning and
        retrieval effortful  improve retention
       Multi-part questions, on par with Step 1 question difficulty
20.     Cognitive Disequilibrium. Deep reasoning and learning is
        stimulated by problems that create cognitive
        disequilibrium, such as obstacles to goals, contradictions,
        conflict, and anomalies
       “2-jump” & “3-jump” questions
MCQs in Review Schedule
MCQs in Review Schedule
Spaced Learning
in Gunner Training
Personalized Review Schedule Generation
Spaced Learning
    In 1913, Ebbinghaus discovered that the best time to
     review something was just before it was forgotten

    Minimizes the amount of time spent learning
    Minimizes the number of times the same material must be
     relearned
Spaced Learning: Example
    Let’s say it takes 2 minutes to memorize the 15 bones of
     the wrist
    Reviewing this material if it’s not forgotten takes 30
     seconds
    Re-learning this material if it’s forgotten takes another 2
     minutes
    Without review, this information is forgotten in 4 days
    There is a test at the end of Day 6
Spaced Learning: Example
    Option 1: Review it every day
         Day 0: 2 minutes learning
         Day 1: 30 second review
         Day 2: 30 second review
         Day 3: 30 second review
         Day 4: 30 second review
         Day 5: 30 second review
         Day 6: 30 second review  Take the test
    Total time: 5 minutes
    Pros: In this approach, the knowledge is never forgotten
    Cons: Large burden of review  few people will adhere to this
     review schedule
Spaced Learning: Example
    Option 2: Cram for the exam
         Day 0: 2 minutes learning
         Day 1: no time spent
         Day 2: no time spent
         Day 3: no time spent
         Day 4: no time spent (knowledge forgotten)
         Day 5: no time spent
         Day 6: 2 minutes re-learning  Take the test
    Total time: 4 minutes
    Pros: It’s “easy” – learn it once and re-learn it just before the
     test
    Cons: The knowledge is forgotten
         Cramming produces high stress
         Doesn’t work in clinical settings (no predetermined “test” date)
         Less effective as the volume of information goes up
Spaced Learning: Example
    Option 3: Spaced Learning
         Day 0: 2 minutes learning
         Day 1: no time spent
         Day 2: no time spent
         Day 3: no time spent
         Day 4: 30 second review
         Day 5: no time spent
         Day 6: Take the test
    Total time: 2 minutes, 30 seconds
         Compared to daily review (5 mins): 50% less time spent
         Compared to cramming (4 mins): 38.5% less time spent
    Pros: In this approach, information is never forgotten and
     time spent studying is minimized
Spaced Learning Works in Medicine
    3 randomized, controlled trials at Harvard Medical School
     demonstrate that Spaced Learning improves retention of
     medical knowledge
         RCTs are the gold standard experimental methodology
         Published in:
              American Journal of Surgery, January 2009
              Journal of General Internal Medicine, January 2008
              Medical Education, January 2007
Basic Research on Spaced Learning
    The molecular mechanism behind Spaced Learning is an
     active area of research
         Cell, October 2009. Cold Spring Harbor & Mount Sinai School
          of Medicine
              The Phosphatase SHP2 Regulates the Spacing Effect for Long-Term Memory Induction
         Journal of Neuroscience, August 2009. McGill University
              PKC Differentially Translocates during Spaced and Massed Training in Alypsia

         Neuron, December 2006. Baylor College of Medicine
              Drosophila Mushroom Body Neurons Form a Branch-Specific, Long-Term Cellular
               Memory Trace after Spaced Olfactory Conditioning



                There is rock-solid science behind Spaced Learning.
Gunner Training Works!
Gunner Training’s Effectiveness
                                                                                    *




                                                                                        19.3%
                                                                                        (p<0.000001)**




* All data where user completed 4 reviews within the maximum time (115 days)
** Heteroscedastic, one-tailed t-test. Same results with paired, 2-tailed t-test.
Gunner Training’s Effectiveness

                                                         Avg time to 4th
                                                         review: 26.4 days

                                                         Max time to 4th
                                                         review: 115 days




     Two major successes:
          1) Knowledge isn’t lost during >100 days since initial review
          2) 19.3% gain in retained knowledge
Summary
    GT is the first Knowledge Management specifically
     platform for medical students
    The application of 19 Learning Principles yields a highly
     efficient and effective program
    Users who follow our algorithms gain an average of 19.3%
     in ability to recall knowledge after 4 reviews
    Users don’t forget what they have already learned
Priced for Students
User Comments
    “I absolutely loved this site. I          “I'll definitely let the 2nd years
     didn't get far into the program            in my school know about
     because of time constraints, but           your program. I've already
     I really wish I knew about it              recommended the program to
     before starting 2nd year. It               the Dean of Student Affairs at
     would've been amazing to use               my school.”
     it while studying for the                                        – J.W., 2nd year
     course. I used to study with
                                                                    medical student
     RecallPlus and Anki during the
     course but found it so time
     consuming to make the cards,
     so you can say Gunner Training
     is just perfect.”
                        – H.A., 2nd year
                       medical student
Anonymous Comments
    It's surprising how much I've learned            “On my exam, there were questions
     in such a short time span with what               that I actually thought, ‘I know that
     feels like not a lot of effort. I've maybe        flashcard exactly.’ This is, however,
     spent 30 minutes to an hour every                 after I had continuously gotten the nit
     other day (sometimes every 2nd or                 picky factoid wrong on several
     3rd day) on it and it's gone quickly.             occasions at Gunner Training. ”
     I've been tracking my progress with                                         Caboose, on
     the analytics it provides. After 2
     weeks of studying and a few                                    Student Doctor Network
     repetitions my recall has gone up
     significantly (the amount of 5's has
     increased by almost 20% - this
     meaning that when I do my scheduled
     review questions, the number of
     answers that I get right without having
     to think about the question is
     increasing). ”
                                AggieSean, on
                   Student Doctor Network
http://www.gunnertraining.com

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Memory Science & Medical Education

  • 1. Memory Science in Medical Education Frank Lau, MD Co-Founder & Chief Medical Officer GunnerTraining.com
  • 2. The Challenge for Medical Students “I feel like every time I review something or learn something new, I forget something else.” – C.C., 2nd year medical student, University of Michigan Medical School
  • 3. The Challenge Persists for Residents   Resuscitation, July 2009   70 Johns Hopkins pediatrics residents   66% failed to start timely CPR (basic life support)   95% of the residents had received this level of training   83% made errors during defibrillation (shocking the patient)   80% of the residents had been trained in defibrillation   More years of training did not improve physician performance Medical knowledge is routinely forgotten, even by the best and the brightest.
  • 4. The Challenge Persists for Attending Physicians   Journal of Trauma, June 1996   60 practicing trauma physicians took the standard Advanced Trauma Life Support course, followed by an examination   National course for managing traumas (car accidents, gunshots, stab wounds, etc)   Immediate testing: 86% average score   6 months later, 50% failed   13 years after this study, no novel approaches to learning and retaining medical knowledge Basic, critical knowledge is routinely forgotten, even by experienced specialists.
  • 5. Who Should Care?   Medical Students   Physicians-in-training (residents)   Educators   Foreign medical graduates   Practicing physicians   Patients   Healthcare policy makers   Patient safety advocates
  • 6. The 2 Phases of Knowledge Acquisition Mastering the material Maintaining that knowledge
  • 7. Mastering the Material   We think we’re good at this   We did well on the MCAT, we pass our exams   But these are graded on a curve!   Patient outcomes don’t work on a curve   In reality, we do poorly at judging how well we’ve mastered specific topics
  • 8. Mastery: The Problem 32% of the reviewed material is immediately forgotten.
  • 10. Maintaining Your Knowledge   We rarely focus on knowledge maintenance   Johns Hopkins study, the ATLS study   Affects patient outcomes   For Step 1, the review process involves re-learning a lot of material that you once knew but have since forgotten
  • 11. Intro to Gunner Training   The first Knowledge Management platform   Created to help students master and maintain their Step 1 knowledge base   Personalized: users choose which subjects to study  can correlate with school's curriculum   Dynamic: custom review schedule changes according to student's forward learning   Mobile:   iPhone/mobile browser compatible   No software installation required
  • 12. Intro to Gunner Training   Launched April 2009:   Hundreds of users   Thousands of data points   We use this data and user feedback to continually validate and improve Gunner Training
  • 13. The GT Way 1.  Learn the material from flashcards •  High-yield, interactive 2.  Immediate testing on that material •  Open-ended study questions 3.  Spaced Learning algorithms create a personalized review schedule for that material •  Incorporates Step 1 style multiple choice questions •  Short intervals help you master that material •  Longer intervals maintain your knowledge 4.  Exam simulation •  Eases anxiety •  Increases test-taking stamina
  • 14. The GT Way 1.  Learn the material from flashcards •  High-yield, interactive 2.  Immediate testing on that material •  Open-ended study questions Apply 19 3.  Spaced Learning algorithms create a principles of personalized review schedule for that material efficient, •  Incorporates Step 1 style multiple choice questions effective •  Short intervals help you master that material learning •  Longer intervals maintain your knowledge 4.  Exam simulation •  Eases anxiety •  Increases test-taking stamina
  • 15. GT: Flashcard Learning Principles 1.  Contiguity Effects. Ideas that are associated should be presented contiguously in space and time   One flashcard per topic, rather than one-fact-per-flashcard 2.  Dual Code and Multimedia Effects. Visual + multimedia form richer representations vs. a single medium   Hundreds of relevant images: gram stains, CT scans, X-rays, clinical photos 3.  Coherence Effect. Materials should explicitly link related ideas
  • 16. GT: Flashcard Learning Principles 4.  Segmentation Principle. A complex lesson should be broken down into manageable subparts   Two levels of bulletpoints 5.  Manageable Cognitive Load. The information presented to the learner should not overload working memory   Second bulletpoints are initially hidden 6.  Cognitive Flexibility. This improves w/ multiple viewpoints linking facts and deep conceptual principles   Material presented in several locations   Ex: TB is covered under Microbiology, Pulmonology, Immunology 7.  Anchored Learning. Materials are anchored in real world problems that you care about   Clinical correlation
  • 17. Contiguity, Dual code/Multimedia, & Coherence Effects
  • 18. Segmentation & Manageable Cognitive Load
  • 21. GT: Study Question Principles 8.  Imperfect Metacognition. We rarely have an accurate knowledge of our cognition  need assistance with calibrating comprehension, learning, and memory   Immediate testing solves this 9.  Generation Effect. Learning is enhanced when learners produce answers (vs. recognizing answers)   This is why GT employs open-ended study questions 10.  Testing Effect. Testing enhances learning, especially when the tests are aligned with important content
  • 22. GT: Study Question Principles 11.  Feedback Effects. Students benefit from immediate feedback on their performance 12.  Negative Suggestion Effects. Learning wrong information can be reduced when feedback is immediate 13.  Deep questions. More benefit from answering questions that elicit explanations (e.g., why, why not, how, what-if)
  • 23. Imperfect Metacognition, Generation Effect & Testing Effect
  • 24. Feedback Effects & Negative Suggestion Effects
  • 25. GT: Review Schedule Principles 14.  Goldilocks Principle. Assignments should be at the right difficulty level 15.  Self-regulated Learning. Most students need to self- regulate their learning 16.  Exam Expectations. Students benefit more from repeated testing 17.  Spaced Learning.
  • 26. Goldilocks, Self-regulated Learning, and Exam Expectations
  • 27. GT: MCQ Principles 18.  Desirable difficulties. Challenges make learning and retrieval effortful  improve retention   Multi-part questions, on par with Step 1 question difficulty 20.  Cognitive Disequilibrium. Deep reasoning and learning is stimulated by problems that create cognitive disequilibrium, such as obstacles to goals, contradictions, conflict, and anomalies   “2-jump” & “3-jump” questions
  • 28. MCQs in Review Schedule
  • 29. MCQs in Review Schedule
  • 30. Spaced Learning in Gunner Training Personalized Review Schedule Generation
  • 31. Spaced Learning   In 1913, Ebbinghaus discovered that the best time to review something was just before it was forgotten   Minimizes the amount of time spent learning   Minimizes the number of times the same material must be relearned
  • 32. Spaced Learning: Example   Let’s say it takes 2 minutes to memorize the 15 bones of the wrist   Reviewing this material if it’s not forgotten takes 30 seconds   Re-learning this material if it’s forgotten takes another 2 minutes   Without review, this information is forgotten in 4 days   There is a test at the end of Day 6
  • 33. Spaced Learning: Example   Option 1: Review it every day   Day 0: 2 minutes learning   Day 1: 30 second review   Day 2: 30 second review   Day 3: 30 second review   Day 4: 30 second review   Day 5: 30 second review   Day 6: 30 second review  Take the test   Total time: 5 minutes   Pros: In this approach, the knowledge is never forgotten   Cons: Large burden of review  few people will adhere to this review schedule
  • 34. Spaced Learning: Example   Option 2: Cram for the exam   Day 0: 2 minutes learning   Day 1: no time spent   Day 2: no time spent   Day 3: no time spent   Day 4: no time spent (knowledge forgotten)   Day 5: no time spent   Day 6: 2 minutes re-learning  Take the test   Total time: 4 minutes   Pros: It’s “easy” – learn it once and re-learn it just before the test   Cons: The knowledge is forgotten   Cramming produces high stress   Doesn’t work in clinical settings (no predetermined “test” date)   Less effective as the volume of information goes up
  • 35. Spaced Learning: Example   Option 3: Spaced Learning   Day 0: 2 minutes learning   Day 1: no time spent   Day 2: no time spent   Day 3: no time spent   Day 4: 30 second review   Day 5: no time spent   Day 6: Take the test   Total time: 2 minutes, 30 seconds   Compared to daily review (5 mins): 50% less time spent   Compared to cramming (4 mins): 38.5% less time spent   Pros: In this approach, information is never forgotten and time spent studying is minimized
  • 36. Spaced Learning Works in Medicine   3 randomized, controlled trials at Harvard Medical School demonstrate that Spaced Learning improves retention of medical knowledge   RCTs are the gold standard experimental methodology   Published in:   American Journal of Surgery, January 2009   Journal of General Internal Medicine, January 2008   Medical Education, January 2007
  • 37. Basic Research on Spaced Learning   The molecular mechanism behind Spaced Learning is an active area of research   Cell, October 2009. Cold Spring Harbor & Mount Sinai School of Medicine   The Phosphatase SHP2 Regulates the Spacing Effect for Long-Term Memory Induction   Journal of Neuroscience, August 2009. McGill University   PKC Differentially Translocates during Spaced and Massed Training in Alypsia   Neuron, December 2006. Baylor College of Medicine   Drosophila Mushroom Body Neurons Form a Branch-Specific, Long-Term Cellular Memory Trace after Spaced Olfactory Conditioning There is rock-solid science behind Spaced Learning.
  • 39. Gunner Training’s Effectiveness * 19.3% (p<0.000001)** * All data where user completed 4 reviews within the maximum time (115 days) ** Heteroscedastic, one-tailed t-test. Same results with paired, 2-tailed t-test.
  • 40. Gunner Training’s Effectiveness Avg time to 4th review: 26.4 days Max time to 4th review: 115 days   Two major successes:   1) Knowledge isn’t lost during >100 days since initial review   2) 19.3% gain in retained knowledge
  • 41. Summary   GT is the first Knowledge Management specifically platform for medical students   The application of 19 Learning Principles yields a highly efficient and effective program   Users who follow our algorithms gain an average of 19.3% in ability to recall knowledge after 4 reviews   Users don’t forget what they have already learned
  • 43. User Comments   “I absolutely loved this site. I   “I'll definitely let the 2nd years didn't get far into the program in my school know about because of time constraints, but your program. I've already I really wish I knew about it recommended the program to before starting 2nd year. It the Dean of Student Affairs at would've been amazing to use my school.” it while studying for the – J.W., 2nd year course. I used to study with medical student RecallPlus and Anki during the course but found it so time consuming to make the cards, so you can say Gunner Training is just perfect.” – H.A., 2nd year medical student
  • 44. Anonymous Comments   It's surprising how much I've learned   “On my exam, there were questions in such a short time span with what that I actually thought, ‘I know that feels like not a lot of effort. I've maybe flashcard exactly.’ This is, however, spent 30 minutes to an hour every after I had continuously gotten the nit other day (sometimes every 2nd or picky factoid wrong on several 3rd day) on it and it's gone quickly. occasions at Gunner Training. ” I've been tracking my progress with Caboose, on the analytics it provides. After 2 weeks of studying and a few Student Doctor Network repetitions my recall has gone up significantly (the amount of 5's has increased by almost 20% - this meaning that when I do my scheduled review questions, the number of answers that I get right without having to think about the question is increasing). ” AggieSean, on Student Doctor Network