The 2nd Annual Medical Informatics World Conference, held on April 28-29, 2014, at the Seaport World Trade Center in Boston, focused on healthcare IT innovations, data collaboration across providers, payers, and pharmaceutical companies, and the integration of electronic health records in clinical research. The event featured keynotes from leaders in the field discussing reform in health delivery, population health management, and quality improvement, while fostering connections between over 300 executives in the industry. In conjunction with the Bio-IT World Expo, the conference provided networking opportunities and insights into the evolving healthcare landscape fueled by technology.