This document discusses several key marketing issues that brands should pay attention to in 2022, including increased use of NFTs, ensuring influencer endorsements comply with regulations, reviewing advertising practices for children to ensure compliance with CARU guidelines, navigating state-level NIL laws for college athletes, adapting sponsorships amid ongoing pandemic disruption, addressing heightened scrutiny of environmental marketing claims, complying with automatic renewal laws, and handling supply chain issues and related advertising disclosures.