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Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 1
Malabsorption of Major Micronutrients after Bariatric Procedures, Physical Effects of
Deficiency, and Preventive Measures
Kyle Valeski
University of Delaware
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 2
Abstract
The purpose of this paper is to examine the link between weight loss surgeries, otherwise
known as Bariatric surgeries, and the increased risk of nutrient deficiencies after surgery. These
types of surgical procedures severely limit the amount of calories and nutrients absorbed into the
body. Steps are generally taken to prevent these patients from experiencing any form of nutrient
deficiency in the form of vitamin supplementation, which is sometimes not enough nutritional
value, Patients are on a high protein diet, up to 100 grams per day (depending on their height),
which can make it difficult to consume foods high in micronutrients. This paper explores
research done on micronutrient malabsorption and deficiencies for post-operative patients, as
well as preventative measures that can be taken to avoid said deficiencies. Information sheets
have been created to aid those who may think they are at risk for micronutrient deficiencies, and
are based on previous research. These sheets contain information on common deficiencies and
preventative measures, vitamin supplementation information, and tips for proper hydration after
surgery. This information is meant to present vital information in a simple manner to individuals
who may not have a proper nutritional background.
Keywords: Bariatric surgery, malabsorption, micronutrients
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 3
Within the past three decades, bariatric weight loss procedures have become a safe and
effective method of modern day obesity prevention. Surgical procedures such as the gastric
bypass and stomach banding have helped a magnitude of people lose most of their excess fat and
return to a healthier lifestyle within a matter of months or years. While the results of a weight
loss surgery usually take place quickly, this weight loss only comes if the patient alters their
lifestyle choices, such as their diet and physical activity output. The diet of a bariatric patient is
somewhat of a drastic change, as the stomach is physically altered to retain much less food.
With less food comes less nutrients, which can cause an array of long lasting health issues. Steps
are taken to help the individual avoid suffering a deficiency through nutritional supplementation,
yet this option is not always enough for some individuals. The patient’s diet is very limited, and
due to such a high need for protein and very little room in the stomach, most of their food intake
does not include vital vitamins and minerals. Based on previous research, bariatric patients are
at a higher risk of developing vitamin and mineral deficiencies due to nutrient malabsorption,
and must use alternate diet strategies combined with supplements to ensure they are achieving
proper daily micronutrient intake.
Much of the basis for nutrient deficiency after weight loss surgery does not lie in the
patient’s inability to follow instructions as far as dieting goes, but insufficient changes in the diet
itself. Many patients are driven to meet their protein goals, and can cause patients to have a diet
of strictly focused on protein. Protein is an essential part of weight loss surgery, as protein
satisfies hunger quickly and promotes weight loss and maintenance. (Faria) Protein can be
consumed in either its natural form, which would be from food sources, or synthetic protein,
which is in the form of protein supplements such as protein bars and drinks. Both forms of
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 4
protein are acceptable, yet can be difficult to achieve when put on a low calorie diet following
surgery. Based on previous research, “Dietary Protein Intake and Bariatric Surgery Patients: A
Review”, it is stated that “an individual consuming a 478-kcal/day very-low-calorie diet would
need to consume 47% of their calories as proteins to obtain a minimally acceptable protein intake
of 52 g/day”. (Faria) This is still a minimal amount of protein for bariatric patients, as most
bariatric patients require 60-120 grams of protein, depending on height, body weight and the
level of weight loss. (Faria) Protein deficiencies are very rare among bariatric patients, yet can
occur, usually within the first 12 months following surgery. This is due to intolerance to protein
rich foods combined with a calorie restrictive diet for a long period of time (Moize). The main
deficiency issue after surgery is not protein, but micronutrients, which is something that patients
will usually focus less on compared to their protein intake.
With a low calorie diet and a focus on protein, patients may have difficulty finding ways
to create a diet that has adequate protein, low calories, and correct amounts of supplementation
throughout the day. While patients do have the option to supplement vitamins and minerals, this
is not always a reliable option as patients may have difficulties with ingesting their pills or
simply forget to take their supplements on a daily basis. Previous research has shown that due to
the malabsorptive nature of most weight loss surgeries partnered with the patients altered diet
containing low fat causes a higher chance of developing a deficiency in fat soluble vitamins.
(Xanthakos)
Vitamin D deficiency is prevalent in the United States; it is thought that up to fifty eight
percent (58%) of Americans suffer from some form of vitamin D deficiency. (Flancbaum)
Vitamin D is easily accessible, and can be obtained from sunlight, natural sources and
supplementation. After surgery most patients are prescribed a multi-vitamin, which must be
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 5
taken throughout the day to have any form of proper health benefit. Many studies have been
done on the recommended amount of vitamin D needed post bariatric surgery, as a deficiency in
vitamin B can have long lasting health issues. One study, titled “Serum fat-soluble vitamin
deficiency and abnormal calcium metabolism after malabsorptive bariatric surgery “, suggests
that patients should intake a multivitamin containing 1200 IU (International Unit) of vitamin D
(Slater), while another study, “Preoperative nutritional status of patients undergoing Roux-en-Y
gastric bypass for morbid obesity’, suggests that 1200 is not a high enough dosage for post
bariatric patients, and that over time research will show a need for a higher doses of vitamin D.
(Flancbaum) While the exact dose is still unclear, it seems that the current vitamin dosages are
not offering a correct amount of vitamin D to post bariatric patients. One example is a
commonly used bariatric vitamin by the name of Bariatric Fusion. According to their nutritional
information published on their website, one vitamin contains 500 IU of vitamin D. (Nutritional
Information, Bariatric Fusion) Low dosages of vitamin D means that either the patients must rely
on taking multiple pills throughout the day, or find other sources of vitamin D. This company
also does not clarify if this pill contains vitamin D2 or D3, as vitamin D3 is a more efficient
storage form of vitamin D, yet usually D2 is found in most supplements. (Xanthakos) Taking
pills post-operation can be difficult for bariatric patients, as the stomach opening is smaller in
size. One study has shown that following a one year check-up of 46 post bariatric patients, all of
which received malabsorptive surgeries, stated that upwards of 57 percent (26 patients) were
considered vitamin D deficient. (Slater) Vitamin D deficiency can negatively affect the innate
immune system, which can lead to health problems such as “increasing risk of cancers, diabetes
mellitus, autoimmune diseases and cardiovascular disease”. (Xanthakos) Calcium absorption is
also greatly affected by a lack of vitamin D, which can lead to a variety of health problems
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 6
connected to a loss of bone tissue. (Xanthakos) Avoiding vitamin D deficiency can be difficult,
but one method is to inplement supplementation alongside natural sources like fortified foods,
milks that are low in fat and calories, eggs and fish (NIH, Vitamin D), and exposure to sunlight.
A sedentary period after surgery can lead to reduced sunlight, so it is vital that patients make an
effort to avoid sitting too long and try to walk outside in direct sunlight to increase vitamin D
levels. (Xanthakos)
Vitamin D may be the most prominent vitamin deficiency after Bariatric surgery, yet
vitamins A, K, and E are also an issue for bariatric patients, both pre-operative and post-
operative. According to the FDA daily reference values, a person on a 2000 calorie diet should
have an average intake of 5000 IU of vitamin A, 80 micrograms of vitamin K, and 30 IU of
vitamin E. (FDA) Supplementation for these vitamins is usually prescribed through a
multivitamin, yet comparing Bariatric Fusion multivitamins to FDA guidelines shows that none
of these vitamin needs are met through one Bariatric Fusion pill, and must be taken multiple
times throughout the day to ensure proper nutritional supplementation. One pill contains 1875
IU of vitamin A, 7.5 IU of vitamin E, and contains no vitamin K. (Nutritional Information)
Patients who suffer from a lack of micronutrients can experience an array of of health issues if
the patient is left deficient in vitamins A, E, and K.
Vitamin A plays a vital role in protecting the body from free radicals, as vitamins A is an
antioxidant. Antioxidants protect the body from oxidative stress, which can lead to chronic
illness and cancers. (Pereira) Based on information from the research article “Class III Obesity
and its Relationship with the Nutritional Status of Vitamin A in Pre- and Postoperative Gastric
Bypass,” 28.1% of their 114 participants showed signs of light vitamin A deficiency (0.7-1.5
mmol/L) after 180 days post-op, while 10.5% suffered from moderate vitamin A deficiency
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 7
(0.35-0.69 mmol/L)after 180 days post-op. (Pereira) Serum retinol and B-carotene were also
tested against participants BMI pre-op, 30 days post-op, and 180 days post-op. These results
showed little negative correlation, yet do not dismiss that even minimal vitamin A deficiencies
can pose an issue. (Pereira) Deficiencies in Vitamin A primarily affect eyesight, causing
conditions such as xerophthalmia, which is irritation of the corneas, and nyctalopia, which is a
condition causing night blindness. (Xanthakos) Vitamin A is easy to finds in many foods, many
of which are nutrient dense and low in calories. Spinach is an excellent source of vitamin A,
containing 229% of the daily value intake, and is extremely low is calories. Carrots are another
vital source of vitamin A, containing 184% of the daily value intake per half cup serving. (NIH,
Vitamin A) Combining low calorie, highly nutrient dense foods such as spinach and carrots with
vitamin A supplementation can aid bariatric patients in avoiding vitamin A deficiency.
Vitamin E and Vitamin K, the two remaining fat soluble vitamins, are rarely a health
issue for bariatric patients, yet can create health complications if there is an occurrence of
deficiency. According to the research article “Serum fat-soluble vitamin deficiency and
abnormal calcium metabolism after malabsorptive bariatric surgery,” Vitamin E deficiency is
quite rare, showing that the greatest incidence of vitamin E deficiency in their study (Less than
7mmol/L) was at two years post op, with six patients experiencing deficiencies out of 42 total
participants. (Slater) A deficiency in vitamin E, while being rare, can create issues regarding
malabsorption of Alpha-tocopherol, the form of vitamin E that is absorbed into the body.
Inability to absorb this form of vitamin E may have links with diseases such as Cystic fibrosis
and pancreatogenic steatorrhea. (Farrell) In the same research article, Vitamin K deficiencies
were found to be quite drastic; according to the researchers, by the end of the fourth year follow
up, “42% of patients had serum vitamin K levels below the measurable range of 0.1 nmol/L
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 8
compared with 14% at the end of the first year.” (Slater) Another study states that up to 68% of
post-op Biliopancreatic diversion patients experience some form of vitamin K deficiency.
(Xanthakos) While there are various research studies done to prove that bariatric patients suffer
from some form of vitamin K deficiency, there has been little evidence of major health effects
after surgery. Deficiency in vitamin K can lead to issues with blood clotting and gastrointestinal
bleeding, there is documented cases linked between vitamin K and severe bleeding of the
intestines after malabsorptive surgeries (Slater). Vitamin E is mainly found in seeds and nuts,
such as almonds (6.8 mg per ounce, 34% DV) and sunflower seeds (7.4 mg per ounce, 37% DV),
yet both type of nuts are usually avoided after bariatric surgery due to their higher fat content.
Oils, such as vegetable oil and wheat germ oil, are also higher sources of vitamin E, with wheat
germ oil contains nearly 100% daily value of vitamin E. (NIH, Vitamin E) Vitamin K can be
found in leafy greens, which are nutrient dense. Greens such as Kale, spinach, and turnip greens
contain 113 micrograms (141% DV), 145 micrograms (181%) and 426 micrograms (532% DV),
respectively. (NIH, Vitamin K)
Vitamin B12, while not a fat soluble vitamin, can pose a risk for bariatric patients if
absent from their diets post-operation. According to the FDA daily intake values, a standard diet
should consist of 6 micrograms of Vitamin B12 daily. (FDA) Vitamin B12, otherwise known as
Cobalamin, is a water soluble vitamin, which means that these vitamins are not stored in the
body’s fat, and access of these the vitamins not used by the body will be lost through sweat and
urine. Water soluble vitamins are needed throughout the day, which can be difficult for bariatric
patients who already have difficulty retaining nutrients. Vitamin B12, like other protein bound
nutrients, are greatly limited after malabsorptive procedures due to much of the intestinal tract
being passed over and reduced secretion of stomach acid. (Xanthakos) A 2008 study,
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 9
“Prevalence of Iron, Folate, and Vitamin B12 Deficiency Anemia after Laparoscopic Roux-en-Y
Gastric Bypass”, analyzed the data of 74 post bariatric patients up to three years post-operation.
The studies found that out of 30 patients in a six month follow up, two tested for vitamin B12
deficiency (less than 150 pg/ml), three out of 30 in the one year follow up, five out of 30 in the
two year follow up, and two out of 11 in the three year follow up. (Vargas-Ruiz) Based on this
evidence, patients gradually developed vitamin B12 deficiencies up until two years post
operation. Time seems to play a slight role in deficiency, as each data set showed a slight
increase of deficient patients over time. A similar study, “Vitamin B12 Deficiency After Gastric
Bypass Surgery for Obesity”, came to a similar conclusion regarding B12 deficiency after
bariatric surgery. This research tested 50 patients, 21 having normal B12 levels and 29 having a
below average B12 serum level, and gave all participants vitamin B12 supplementation daily for
a three month time span. 47 of the 50 had an increase in their B12 levels, yet the mean of all the
participants serum B12 levels still fell below average. (Shilling) Multiple articles of research
show that even with proper supplementation, post bariatric patients still suffer from low levels of
B12, which can lead to anemia if left unchecked for a substantial period of time. (Vargas-Ruiz)
Many food sources that are high in protein also contain high amounts of B12. Seafood is an
excellent source of B12, such as tuna, trout and salmon. These fish are all low calorie, high
protein foods, and contain anywhere from two to four micrograms of B12 per 3 ounce serving.
Bariatric patients may not be able to handle large portion right after surgery, yet smaller portions
still contain adequate amounts of B12. Yogurts containing fruits, which are usually implemented
into bariatric diets, contain 1.1, or 18% daily value of B12. (NIH, Vitamin B12). While some
patients might finds it difficult to reach their B12 threshold every day, the body can store around
2000 micrograms, as long as B12 intake is spread out in a timely manner throughout the day.
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 10
(Vargas-Ruiz) Vitamin B12 should not be overshadowed by fat soluble vitamins, as each
vitamin is essential for bariatric patients to fulfill their goal of a healthier lifestyle.
Among all micronutrients deficiencies, minerals are the most common and recognizable
deficiencies in post bariatric patients. Trace minerals, which are needed in very small amounts
in the body, often do not make their way into the diets of post bariatric diets. Iron, a trace
mineral, is an extremely common deficiency, occurring in up to an estimated 47% of post
bariatric patients at some point in time, (Xanthakos) while other studies have found even higher
levels of iron deficiency in their testing groups, such as 54% in three year range post-operative
patients. (Vargas) The daily intake value for iron falls at 18 mg. (FDA) Due to iron being
absorbed mainly in the duodenum and jejunum, both of which are bypassed after malabsorptive
surgery, many patients suffer any inability to properly absorb most of the iron they take in.
(Vargas-Ruiz) A 1999 study titled “Iron Absorption and Therapy after Gastric Bypass” explores
iron absorption in bariatric patients both with and without an iron supplement in the form of
ferrous gluconate. Their findings showed that out of the 55 patients who took the 50 mg iron
supplement, 19 of the patients experienced a below average iron absorption rate. (Rhode) 29 of
the same participants also underwent a second clinical trial, this time taking an iron supplement
for one month, followed by an iron supplement combined with a vitamin C supplement. While
the iron supplement alone increased ferritin levels, the groups noticed a larger ferritin increase
when paired with vitamin C. (Rhode) With iron having such a large impact in red blood cells, it
is common for iron deficient patients to develop anemia. (Vargas-Ruiz) To prevent iron loss and
potentially anemia, patients need to find a balance between artificially made iron supplements,
and naturally occurring ferritin in foods. This can be a difficult task, as many foods do not
contain a high serving of iron. Many breakfast cereals are fortified with iron; it is important to
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 11
find a cereal that is low in calories and does not contain artificial sugars, as artificial sugars turn
to fat and can lead to Dumping Syndrome. Beans are source of iron that is also abundant in
protein and various other micronutrients, containing up to 44% daily intake for a cup of beans.
(NIH, Iron)
With such a large focus on fat soluble vitamins and retaining iron and calcium after
surgery, some micronutrients are looked over in regards to their deficiencies post operation.
Zinc has become one of the larger researched trace minerals after malabsorptive surgeries, as
many studies provide evidence of excessive loss of zinc, even with supplements. In the research
article “Vitamin and Trace Mineral Levels after Laparoscopic Gastric Bypass”, 36% of their 33
one year checkup patients suffered from abnormal zinc levels. (Madan) This data is somewhat
concerning, as zinc is already a common deficiency in pre-operative patients who are obese.
(Salle) Patients that have a difficult time absorbing zinc, while post-bariatric patients experience
continued absorption difficulties with malabsorption procedures. A similar study, “Zinc
Deficiency: A Frequent and Underestimated Complication After Bariatric Surgery”, conducted a
similar study, yet with a larger patient group and a larger breakdown of data. 266 pre-surgical
patients were selected, and 8.1% of the patients suffered from zinc deficiency pre-surgery. All
266 patients underwent Roux-en-Y gastric bypass surgery, and no patients took zinc
supplementation before their surgical procedure. Post-surgical data showed that out of the 146
patients that were consulted in the follow up blood plasma testing, 40.7 of these patients suffered
from zinc deficiency, while 17 of these patients were taking some form of zinc supplementation.
There is a positive correlation between successful malabsorptive surgical procedures, yet zinc
deficiency levels seem to level off after one year, as opposed to iron levels constantly decreasing
over time. (Salle) At 12 months, 146 patients experienced a mean total mass weight loss of
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 12
32.4% of their total weight, showing that their procedure triggered a substantial amount of
weight loss. These studies show that zinc deficiency is common in both obese and bariatric
malabsorptive patients, yet the latter suffer from a sharp increase and need increased
supplementation to avoid the negative health risks associated with a loss in zinc. The main issue
is that zinc deficiency can be overlooked, yet is a commonly occurring deficiency coupled with
protein deficiency. (Salle) One case of an acrodermatitis enteropathica based rash occurred in a
gastric bypass patient. While she suffered from multiple nutrient deficiencies due to avoiding her
multivitamin supplements, acrodermatitis enteropathica based rashes have been found to have a
link to zinc deficiencies. (Helen) To avoid a zinc deficiency, patients should aim for 11 mg of
zinc a day, and always choose a multivitamin that also has a focus on trace minerals, and not just
the major fat soluble vitamins. Proper nutrition after surgery is also an essential step, yet can be
challenging as very little foods naturally contain large amounts of zinc. Oysters, at three ounces,
contain 74 mg of zinc, which is 493% the daily intake recommendation. This number may seem
impressive, but the body has little ability to store zinc, as zinc storage in the body is limited to
around 3 mg. (Salle) Crab meat (3 ounces) contains 43% daily value intake (6.5 mg), and is a
food that is high in protein. Many other sources of zinc are various meats, such as beef, (5.3mg
at 3 ounces) pork (2.9 mg at 3 ounces), and lobster (3.4 mg at 3 ounces). Various nuts contain
small traces of zinc, yet contain phytates which limit the bioavailability of zinc. (NIH, Zinc)
After a patient undergoes any form of bariatric surgery, a major concern is proper
consumption of fluids post-operatively. Post-op patients should avoid liquids with artificial
sugars and beverages that contain carbonation. Alcohol should be avoided for the first year after
surgery; it is recommended that the patient stop drinking alcohol for the rest of their life.
Recommended liquid intake is a minimum of 64 ounces daily. (Elkins) In the study
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 13
“Noncompliance with Behavioral Recommendations Following Bariatric Surgery”, 100 post-
surgical bariatric patients were tested on various noncompliant factors, such as continued soda
use, and limited attempts to increase proper liquid consumption. At a six month follow up, 4%
were still drinking soda, and 14% were not meeting recommended liquid intake. At 12 months,
2% were still drinking sodas, while 7% were not drinking enough water. (Elkin) Most patients
understand the importance of hydration, and understand that dehydration is a major health issue
after surgery. This data shows that many bariatric patients understand how to properly hydrate
themselves after a surgical procedure with the correct amount of liquids.
Based on previous research done on malabsorptive practices and its effect on
micronutrient absorption, three fact sheets have been created to properly educate pre-bariatric
patients on their nutrient status after surgery. A large focus before surgery is about obtaining the
proper amount of protein needs. Protein is the key component in regards to nutrients after
surgery, yet this extreme focus makes it seems as though other nutrients do not matter as much as
protein. Patients are also taught about proper vitamin supplementation, yet many believe that
this supplement is all they need for micronutrients. Micronutrients from natural sources carry a
higher amount of bioavailability, and are needed in case patients either forget to take their
supplemental pill on a daily basis or have difficulty ingesting pills. Each fact sheet covers a
specific subject, such as nutrient comparisons for supplemental vitamins, proper hydration, and
vitamin/mineral nutrient information from natural sources. These fact sheets contain information
that is simple to understand, as patients come from all educational backgrounds. Assuring that
every patient can comprehend the information presented in essential to properly assisting patients
in their post-operational healthy lifestyle.
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 14
The first information sheet titled “Is My Multivitamin Enough?” (Pages 18-19), which
explains the concept of malabsorption in a simple manner, so that the rest of the information
sheets are easier to comprehend. The definition of micronutrients is also explained in case the
patient viewing the information sheet does not have a strong nutritional background. The data
presented compares a standard Bariatric vitamin that is taken by post-operative patients to up to
date RDA guidelines. This data is comparing the serving for one bariatric multivitamin, which
does not supply a full dose of dietary intake values for most micronutrients available in the pill.
The patient can use this information to either realize that many doses of multivitamins are
needed throughout the day, or to supplement micronutrients while obtaining micronutrients from
natural food sources. Five healthy food choices are also presented on this information sheet,
containing information regarding protein, fat, micronutrients, and calories.
The second collection of information sheet, “Vitamins and Minerals after Surgery” (Page
20), educates the patients on the different types of bariatric procedures. These forms are aimed
more towards those patients who will undergo a form of malabsorptive procedure. Patients
should understand the difference between a restrictive surgery and a malabsorptive surgery, as
each function differently and have a different effect on nutrient absorption. Once the patients
understand the difference between the two major forms of bariatric surgery, they can read about
major vitamin and mineral deficiencies commonly found post-operatively. The sheet focusing
on vitamin deficiency, “Adding Vitamins to your Diet” (Page 21) explains which deficient
vitamins are fat soluble, and which water soluble are. Due to bariatric surgery patients having
limited fat intake after surgery, fat soluble vitamins are harder to retain in the body. Vitamin
deficiencies in vitamins A, K, D, and B12 and presented for the patients so that can have a basic
understanding of some of the warning signs of a deficiency issue. Examples are then listed for
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 15
foods that provide a sufficient amount of vitamins, while also provided some form of protein
(disregarding vitamin K dense foods). Patients can use this information to find ways to add
natural sources of vitamins to their daily diet routine. “Adding Minerals to your Diet” (Page 22)
expands on the concept of major minerals and trace minerals. The information focuses on the
two larger minerals deficiencies, calcium and iron. Deficiency signs are presented for both
minerals, so that the patients has a clear understanding of what signs to look for if the patient
suspected they suffer from a deficiency. Calcium deficiency is largely associated with loss of
vitamin D. The information sheet explains that calcium and vitamin D both play a large impact
on bone density, and that a deficiency in vitamin D means there is a chance that there is a
deficiency in calcium. Iron is largely associated with anemia. This information sheet explains
the signs of loss of oxygenated blood cells so that the patient can identify if they may be
suffering from anemia. As many deficiencies share common signs, patients should be aware that
only a blood test can truly identify which deficiencies are present. These sheets are for
informational use and to aid in micronutrient consumption before a deficiency occurs.
The final information sheet presented, “Hydration and You” (Pages 23-24) focuses on
creative ways to incorporate water around the patient’s diet. Bariatric patients are advised to not
drink water while eating and to drink water in small sips throughout the day, which in some
cases can cause patients to forget to properly hydrate. Each of the four categories mentioned in
this information sheet gives suggestions to ensure the patients remembers to drink acceptable
liquids. The first category informs the patient on acceptable liquids after surgery. Decaffeinated
coffees and teas are liquids with additional health benefits and are considered acceptable liquids
after bariatric surgery. Flavored waters are another method to create a more diverse variety of
liquids for the patient. Many bottled water companies sell flavored waters based on fruit flavors.
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 16
Patients can create their own flavored water by adding fruits and vegetables to water. These
mixtures can be used to hydrate and to receive the health benefits from the fruits and vegetables
being used. The final category informs patients on larger water containers that can contain a
days’ worth of liquid. Seeing the amount of liquids consumed for that day can help a client
realize how much more they need to drink, or if they are not drinking at an adequate pace for that
day.
Weight loss surgeries have become a revolutionary method in a world where obesity has
become an epidemic. Every year more individuals are diagnosed as obese, and more people turn
to bariatric surgeries to create a better life for themselves. Weight loss surgeries are a gateway
for individuals who want to live a healthy lifestyle, and keep the excess weight off for life.
These weight loss procedures are very beneficial and have a high success rate, yet come with
additional health risks. One of these higher risks is developing a micronutrient deficiency. With
the proper preventative information and dietary supplementation, weight loss patients will be
able to fulfill their goal of weight loss without suffering from the negative health issues
surrounding deficiencies from micronutrients.
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 17
Is my Multivitamin Enough?
After bariatric surgery, your body may lose some of its ability to absorb nutrients from food and
limits the amount of food you can take in at once. The body doesn’t always get the proper
amounts of micronutrients after surgery. Micronutrients are vitamins (vitamin A, vitamin D,
etc.), minerals (iron, potassium, iodine, etc.). Multivitamins are a great way to add needed
vitamins and minerals to your diet. These vitamin supplements are essential in almost any post-
operative diet, but are they giving you all the nutrients your body needs? Let’s compare
Bariatric Fusion Vitamin nutritional info with RDA daily guidelines:
Vitamin
A
Vitamin
D
Vitamin
E
Vitamin
B6
Vitamin
B12
Calcium Iron Iodine Zinc
Bariatric
Fusion
(One
pill=one
serving
size)
1875 IU 500 IU 7.5 IU 0.5 mg 140
mcg
300 mg 7.5
mg
37.5
mcg
7.5 mg
RDA
Guidelines
(as of July
2016)
3000 IU
(Men)
2300 IU
(Woman)
600 IU 22 IU 1.3 mg 2.4 mcg 1000
mg
18
mg
150
mcg
11 mg
(Men)
8 mg
(Women)
Many of these single serving Multivitamins do not meet the RDA doses!!!
Not only that, but this is considering that all of the nutrients are being absorbed, while some of
these vitamins and minerals will not be fully absorbed. An example is Vitamin A; this
multivitamin contains 65% the daily dose for men, and around 82% for woman, but what if only
900 IU gets absorbed? That would drop these percentages by over half! One solution is to take
more than one multivitamin throughout the day. Ask your doctor how many multivitamins you
will need in a day. Make sure to take these at different times of the day, as the body can only
absorb so much at once! To get the right amount of vitamins and minerals into your daily diet,
try some of these super foods that contain not only contain lots of vitamins and minerals, but are
low in calories as well!
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 18
Salmon: This fish is high in oily fats, high in protein, and contains good
amounts of vitamin A and potassium. Salmon is a lean meat with little calories making it very
nutritious!
Kale: This leafy green is extremely low in calories and fat, yet very high in
essential vitamins like vitamin A and C!
Sardines: Like most fish, sardines are high in protein and fats, and
contain great amounts of potassium and calcium.
Eggs (with yolk): Eggs are a good source of protein, vitamin A, vitamin C,
calcium, and Iron. Try cooking eggs in a variety of ways to mix up your diet!
Quinoa: Adding quinoa throughout your diet can be a high source of fiber and
protein, while getting much needed amounts of minerals such as copper and iron.
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 19
Vitamins and Minerals after Surgery
While much of the emphasis post-surgery is all about protein, remembering to take vitamins and
minerals is very important. After surgery, it is very difficult to eat enough foods to meet vitamin
and mineral needs. To prevent malnutrition, you must take the vitamins your doctor advises you
to take, as well as eat foods high in vitamins and minerals.
Did you have…
A restrictive surgery? Ie. Gastric Band or Sleeve
Restrictive surgeries limit the amount of food that can enter the stomach at once. These
procedures allow for more nutrients to be absorbed than other weight loss surgeries.
A malabsorptive surgery? Ie. GBP or BPD
This type of surgery involves removing or bypassing most of the stomach and alters the path in
which food takes in the intestinal track to limit caloric absorption. The diversion can also be
combined with the duodenal switch. This type of surgery allows fewer nutrients to be absorbed
than a restrictive surgery.
Below are the vitamins and minerals that are at a high risk of deficiency after surgery.
Vitamins Minerals
Vitamin A Vitamin D Calcium Iron
Vitamin K Vitamin B12
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 20
Adding Vitamins to your Diet
Vitamins A, D, and K are fat soluble vitamins. The post bariatric diet is low in fat, making it
difficult to absorb enough vitamins. It is important to know the warnings of low vitamin intake,
specifically the fat soluble vitamins. B12 is also a common vitamin deficiency, but is water
soluble and easier to obtain in a diet.
Vitamin A: Inability to see well in the dark, inability to produce tears (xerophthalmia) prone to
infections
Vitamin D: Weak bone density, bones softening (osteomalacia)
Vitamin K: Excessive bleeding from wounds, bruising, blood in urine and/or stool
Vitamin B12: Fatigue, anemia, neurological damage, numbness, depression, memory loss
Try adding these foods to your to reduce your risk of vitamin deficiency and mix up your diet.
Most of these foods are also high in protein!
Vitamin A: Eggs with yolk, cheese, milk, oatmeal
Vitamin D: Milks, cheeses, sardines, cod, egg yolks, tofu, pork
Vitamin K: Kale, spinach
Vitamin B12: Fish (cod, sardines), eggs with yolk, red meats (steak, beef, etc.), milk and yogurt
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 21
Adding Minerals to your Diet
There are many minerals that the body needs to stay healthy before and after surgery. Bariatric
patients display lower levels of calcium and iron, which can have lasting health effects. These
deficiencies can be hard to treat, so make sure to know the signs!
Calcium Iron
-Numbness in various aspects of -Headaches and dizziness
the extremities, such as hands and feet -Fatigue and overall weakness
-Muscle spasms -Chest pains/irregular heartbeat
-Depression -Cravings for non-nutritious substances
-Brittle nails that break off easily
Calcium and iron deficiencies can lead to very serious health issues long term. Calcium and
vitamin D deficiencies, can lead to serious bone problems like osteopetrosis. Iron deficiency
leads to iron-deficiency anemia. The main concern with iron deficiency anemia is long term
issues with the heart if not treated. Make sure to take the recommended dosage of minerals
through supplements combined with these foods to ensure adequate intake.
Calcium: Egg yolks, milk, cheeses, spinach, chickpeas, almonds, soybeans
Iron: Tofu products, potatoes, soybeans, peanuts and peanut butter, wheat products, chickpeas,
spinach
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 22
Hydration and You
After your bariatric surgery, it is important that you drink a good amount of liquid on a day to
day basis. Since eating and drinking have to take place at different times after surgery, it may
be difficult to remember to drink throughout the day. Planning your diet is important, and so is
planning your drinking! Try to drink at least 64 ounces of liquid a day! Here are fun ways to
make hydration more interesting.
Mix it up! All 64 ounces don’t have to be water. Try drinking decaf
coffees or decaf teas (With no sugars) to take a break from plain water. Coffees and teas also
have their own health benefits, such as antioxidants and reduced risk of diabetes!
Try flavored waters! Many companies make waters that are
flavored after fruits like blackberry or strawberry. These waters usually do not have any added
calories or sugars, but always be sure to check before you buy!
DIY Flavored water! Adding fruits and veggies to your water can be
a fun way to stay hydrated. Try out different varieties to find which combo is your favorite!
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 23
Keep your liquids in one place! Instead of drinking many
small portions throughout the day, keep a large container of water with you. 64 ounces of
water is the same as a half-gallon, so filling up a half gallon of water will give you that days’
hydration requirements! This way, you can see how much you have drunk for already, and how
much more you need to drink. Try adding labels to the side of the container that will give you a
time frame of how much has been drunk already.
Look out for the signs of Dehydration!!!
Fatigue Whitened tongue Excessive thirst
Dried Skin Headaches
Light-headed Cloudy/yellow urine Infrequent urination
Make sure to drink more if you experience one or more of these
symptoms!
If symptoms persist, talk to your doctor, or go to the nearest ER Facility!
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 24
Bibliography
1. Elkins, G., Whitfield, P., Marcus, J. et al. OBES SURG (2005) 15: 546.
doi:10.1381/0960892053723385
2. Faria, S.L., Faria, O.P., Buffington, C. et al. OBES SURG (2011)
21: 1798. doi:10.1007/s11695- 011-0441-y
http://link.springer.com/article/10.1007/s11695-011-0441-y
3. Farrell, P. M., Bieri, J. G., Fratantoni, J. F., Wood, R. E., & di Sant’Agnese, P. A. (1977).
The Occurrence and Effects of Human Vitamin E Deficiency: A STUDY IN PATIENTS
WITH CYSTIC FIBROSIS. Journal of Clinical Investigation, 60(1), 233–241.
4. Flancbaum, L., Belsley, S., Drake, V. et al. J Gastrointest Surg (2006)
10: 1033. doi:10.1016/j.gassur.2006.03.004
5. Guidance for Industry: A Food Labeling Guide (14. Appendix F: Calculate the Percent
Daily Value for the Appropriate Nutrients). (n.d.). Retrieved October 11, 2016, from
http://www.fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformati
on/LabelingNutrition/ucm064928.htm
6. Helen Lewandowski, Tracy Breen, and Eric Huang (2007) Kwashiorkor and an
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 25
Acrodermatitis Enteropathica-Like Eruption After a Distal Gastric Bypass Surgical
Procedure. Endocrine Practice: May 2007, Vol. 13, No. 3, pp. 277-282.
7. Iron — Health Professional Fact Sheet. (n.d.). Retrieved October 11, 2016,
from https://ods.od.nih.gov/factsheets/Iron-HealthProfessional/
8. Madan, A.K., Orth, W.S., Tichansky, D.S. et al. OBES SURG (2006)
16: 603. doi:10.1381/096089206776945057
http://link.springer.com/article/10.1381%2F096089206776945057
9. Moize, V., Geliebter, A., Gluck, M.E. et al. OBES SURG (2003)
13: 23.doi:10.1381/096089203321136548
http://link.springer.com/article/10.1381/096089203321136548
10. Nutritional Information. (n.d.). Retrieved October 11, 2016,
From http://bariatricfusion.com/supplementnutrition.php
11. Pereira, S., Saboya, C., Chaves, G. et al. OBES SURG (2009) 19: 738.
doi:10.1007/s11695-008-9478-y
12. Rhode, B.M., Shustik, C., Christou, N.V. et al. OBES SURG (1999)
9: 17. doi:10.1381/096089299765553656
13. Sallé, A., Demarsy, D., Poirier, A.L. et al. OBES SURG (2010)
20: 1660. doi:10.1007/s11695-010-0237-5
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 26
http://link.springer.com/article/10.1007/s11695-010-0237-5
14. SCHILLING RF, GOHDES PN, HARDIE GH. Vitamin B12 Deficiency After
Gastric Bypass Surgery for Obesity. Ann Intern Med. 1984;101:501-502.
doi:10.7326/0003-4819-101-4-501
15. Slater, G.H., Ren, C.J., Siegel, N. et al. J Gastrointest Surg (2004)
8: 48. doi:10.1016/j.gassur.2003.09.020
http://link.springer.com/article/10.1016/j.gassur.2003.09.020
16. Vargas-Ruiz, A.G., Hernández-Rivera, G. & Herrera, M.F. OBES SURG (2008)
18: 288. doi:10.1007/s11695-007-9310-0
http://link.springer.com/article/10.1007/s11695-007-9310-0
17. Vitamin A — Health Professional Fact Sheet. (n.d.). Retrieved October 11, 2016,
from https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/
18. Vitamin B12 — Health Professional Fact Sheet.(n.d.). Retrieved October 11, 2016,
from https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
19. Vitamin D — Health Professional Fact Sheet. (n.d.). Retrieved October 11, 2016,
from https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/
20. Vitamin E — Health Professional Fact Sheet. (n.d.). Retrieved October 11, 2016, from
https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/
Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 27
21. Vitamin K — Health Professional Fact Sheet. (n.d.). Retrieved October 11, 2016,
from https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/
22. Xanthakos, S. A. (2009). Nutritional Deficiencies in Obesity and After Bariatric
Surgery. Pediatric Clinics of North America, 56(5), 1105–1121.
http://doi.org/10.1016/j.pcl.2009.07.002
23. Zinc — Health Professional Fact Sheet. (n.d.). Retrieved October 12, 2016,
from https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/

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Malabsorption of Major Micronutrients after Bariatric Procedures

  • 1. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 1 Malabsorption of Major Micronutrients after Bariatric Procedures, Physical Effects of Deficiency, and Preventive Measures Kyle Valeski University of Delaware
  • 2. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 2 Abstract The purpose of this paper is to examine the link between weight loss surgeries, otherwise known as Bariatric surgeries, and the increased risk of nutrient deficiencies after surgery. These types of surgical procedures severely limit the amount of calories and nutrients absorbed into the body. Steps are generally taken to prevent these patients from experiencing any form of nutrient deficiency in the form of vitamin supplementation, which is sometimes not enough nutritional value, Patients are on a high protein diet, up to 100 grams per day (depending on their height), which can make it difficult to consume foods high in micronutrients. This paper explores research done on micronutrient malabsorption and deficiencies for post-operative patients, as well as preventative measures that can be taken to avoid said deficiencies. Information sheets have been created to aid those who may think they are at risk for micronutrient deficiencies, and are based on previous research. These sheets contain information on common deficiencies and preventative measures, vitamin supplementation information, and tips for proper hydration after surgery. This information is meant to present vital information in a simple manner to individuals who may not have a proper nutritional background. Keywords: Bariatric surgery, malabsorption, micronutrients
  • 3. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 3 Within the past three decades, bariatric weight loss procedures have become a safe and effective method of modern day obesity prevention. Surgical procedures such as the gastric bypass and stomach banding have helped a magnitude of people lose most of their excess fat and return to a healthier lifestyle within a matter of months or years. While the results of a weight loss surgery usually take place quickly, this weight loss only comes if the patient alters their lifestyle choices, such as their diet and physical activity output. The diet of a bariatric patient is somewhat of a drastic change, as the stomach is physically altered to retain much less food. With less food comes less nutrients, which can cause an array of long lasting health issues. Steps are taken to help the individual avoid suffering a deficiency through nutritional supplementation, yet this option is not always enough for some individuals. The patient’s diet is very limited, and due to such a high need for protein and very little room in the stomach, most of their food intake does not include vital vitamins and minerals. Based on previous research, bariatric patients are at a higher risk of developing vitamin and mineral deficiencies due to nutrient malabsorption, and must use alternate diet strategies combined with supplements to ensure they are achieving proper daily micronutrient intake. Much of the basis for nutrient deficiency after weight loss surgery does not lie in the patient’s inability to follow instructions as far as dieting goes, but insufficient changes in the diet itself. Many patients are driven to meet their protein goals, and can cause patients to have a diet of strictly focused on protein. Protein is an essential part of weight loss surgery, as protein satisfies hunger quickly and promotes weight loss and maintenance. (Faria) Protein can be consumed in either its natural form, which would be from food sources, or synthetic protein, which is in the form of protein supplements such as protein bars and drinks. Both forms of
  • 4. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 4 protein are acceptable, yet can be difficult to achieve when put on a low calorie diet following surgery. Based on previous research, “Dietary Protein Intake and Bariatric Surgery Patients: A Review”, it is stated that “an individual consuming a 478-kcal/day very-low-calorie diet would need to consume 47% of their calories as proteins to obtain a minimally acceptable protein intake of 52 g/day”. (Faria) This is still a minimal amount of protein for bariatric patients, as most bariatric patients require 60-120 grams of protein, depending on height, body weight and the level of weight loss. (Faria) Protein deficiencies are very rare among bariatric patients, yet can occur, usually within the first 12 months following surgery. This is due to intolerance to protein rich foods combined with a calorie restrictive diet for a long period of time (Moize). The main deficiency issue after surgery is not protein, but micronutrients, which is something that patients will usually focus less on compared to their protein intake. With a low calorie diet and a focus on protein, patients may have difficulty finding ways to create a diet that has adequate protein, low calories, and correct amounts of supplementation throughout the day. While patients do have the option to supplement vitamins and minerals, this is not always a reliable option as patients may have difficulties with ingesting their pills or simply forget to take their supplements on a daily basis. Previous research has shown that due to the malabsorptive nature of most weight loss surgeries partnered with the patients altered diet containing low fat causes a higher chance of developing a deficiency in fat soluble vitamins. (Xanthakos) Vitamin D deficiency is prevalent in the United States; it is thought that up to fifty eight percent (58%) of Americans suffer from some form of vitamin D deficiency. (Flancbaum) Vitamin D is easily accessible, and can be obtained from sunlight, natural sources and supplementation. After surgery most patients are prescribed a multi-vitamin, which must be
  • 5. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 5 taken throughout the day to have any form of proper health benefit. Many studies have been done on the recommended amount of vitamin D needed post bariatric surgery, as a deficiency in vitamin B can have long lasting health issues. One study, titled “Serum fat-soluble vitamin deficiency and abnormal calcium metabolism after malabsorptive bariatric surgery “, suggests that patients should intake a multivitamin containing 1200 IU (International Unit) of vitamin D (Slater), while another study, “Preoperative nutritional status of patients undergoing Roux-en-Y gastric bypass for morbid obesity’, suggests that 1200 is not a high enough dosage for post bariatric patients, and that over time research will show a need for a higher doses of vitamin D. (Flancbaum) While the exact dose is still unclear, it seems that the current vitamin dosages are not offering a correct amount of vitamin D to post bariatric patients. One example is a commonly used bariatric vitamin by the name of Bariatric Fusion. According to their nutritional information published on their website, one vitamin contains 500 IU of vitamin D. (Nutritional Information, Bariatric Fusion) Low dosages of vitamin D means that either the patients must rely on taking multiple pills throughout the day, or find other sources of vitamin D. This company also does not clarify if this pill contains vitamin D2 or D3, as vitamin D3 is a more efficient storage form of vitamin D, yet usually D2 is found in most supplements. (Xanthakos) Taking pills post-operation can be difficult for bariatric patients, as the stomach opening is smaller in size. One study has shown that following a one year check-up of 46 post bariatric patients, all of which received malabsorptive surgeries, stated that upwards of 57 percent (26 patients) were considered vitamin D deficient. (Slater) Vitamin D deficiency can negatively affect the innate immune system, which can lead to health problems such as “increasing risk of cancers, diabetes mellitus, autoimmune diseases and cardiovascular disease”. (Xanthakos) Calcium absorption is also greatly affected by a lack of vitamin D, which can lead to a variety of health problems
  • 6. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 6 connected to a loss of bone tissue. (Xanthakos) Avoiding vitamin D deficiency can be difficult, but one method is to inplement supplementation alongside natural sources like fortified foods, milks that are low in fat and calories, eggs and fish (NIH, Vitamin D), and exposure to sunlight. A sedentary period after surgery can lead to reduced sunlight, so it is vital that patients make an effort to avoid sitting too long and try to walk outside in direct sunlight to increase vitamin D levels. (Xanthakos) Vitamin D may be the most prominent vitamin deficiency after Bariatric surgery, yet vitamins A, K, and E are also an issue for bariatric patients, both pre-operative and post- operative. According to the FDA daily reference values, a person on a 2000 calorie diet should have an average intake of 5000 IU of vitamin A, 80 micrograms of vitamin K, and 30 IU of vitamin E. (FDA) Supplementation for these vitamins is usually prescribed through a multivitamin, yet comparing Bariatric Fusion multivitamins to FDA guidelines shows that none of these vitamin needs are met through one Bariatric Fusion pill, and must be taken multiple times throughout the day to ensure proper nutritional supplementation. One pill contains 1875 IU of vitamin A, 7.5 IU of vitamin E, and contains no vitamin K. (Nutritional Information) Patients who suffer from a lack of micronutrients can experience an array of of health issues if the patient is left deficient in vitamins A, E, and K. Vitamin A plays a vital role in protecting the body from free radicals, as vitamins A is an antioxidant. Antioxidants protect the body from oxidative stress, which can lead to chronic illness and cancers. (Pereira) Based on information from the research article “Class III Obesity and its Relationship with the Nutritional Status of Vitamin A in Pre- and Postoperative Gastric Bypass,” 28.1% of their 114 participants showed signs of light vitamin A deficiency (0.7-1.5 mmol/L) after 180 days post-op, while 10.5% suffered from moderate vitamin A deficiency
  • 7. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 7 (0.35-0.69 mmol/L)after 180 days post-op. (Pereira) Serum retinol and B-carotene were also tested against participants BMI pre-op, 30 days post-op, and 180 days post-op. These results showed little negative correlation, yet do not dismiss that even minimal vitamin A deficiencies can pose an issue. (Pereira) Deficiencies in Vitamin A primarily affect eyesight, causing conditions such as xerophthalmia, which is irritation of the corneas, and nyctalopia, which is a condition causing night blindness. (Xanthakos) Vitamin A is easy to finds in many foods, many of which are nutrient dense and low in calories. Spinach is an excellent source of vitamin A, containing 229% of the daily value intake, and is extremely low is calories. Carrots are another vital source of vitamin A, containing 184% of the daily value intake per half cup serving. (NIH, Vitamin A) Combining low calorie, highly nutrient dense foods such as spinach and carrots with vitamin A supplementation can aid bariatric patients in avoiding vitamin A deficiency. Vitamin E and Vitamin K, the two remaining fat soluble vitamins, are rarely a health issue for bariatric patients, yet can create health complications if there is an occurrence of deficiency. According to the research article “Serum fat-soluble vitamin deficiency and abnormal calcium metabolism after malabsorptive bariatric surgery,” Vitamin E deficiency is quite rare, showing that the greatest incidence of vitamin E deficiency in their study (Less than 7mmol/L) was at two years post op, with six patients experiencing deficiencies out of 42 total participants. (Slater) A deficiency in vitamin E, while being rare, can create issues regarding malabsorption of Alpha-tocopherol, the form of vitamin E that is absorbed into the body. Inability to absorb this form of vitamin E may have links with diseases such as Cystic fibrosis and pancreatogenic steatorrhea. (Farrell) In the same research article, Vitamin K deficiencies were found to be quite drastic; according to the researchers, by the end of the fourth year follow up, “42% of patients had serum vitamin K levels below the measurable range of 0.1 nmol/L
  • 8. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 8 compared with 14% at the end of the first year.” (Slater) Another study states that up to 68% of post-op Biliopancreatic diversion patients experience some form of vitamin K deficiency. (Xanthakos) While there are various research studies done to prove that bariatric patients suffer from some form of vitamin K deficiency, there has been little evidence of major health effects after surgery. Deficiency in vitamin K can lead to issues with blood clotting and gastrointestinal bleeding, there is documented cases linked between vitamin K and severe bleeding of the intestines after malabsorptive surgeries (Slater). Vitamin E is mainly found in seeds and nuts, such as almonds (6.8 mg per ounce, 34% DV) and sunflower seeds (7.4 mg per ounce, 37% DV), yet both type of nuts are usually avoided after bariatric surgery due to their higher fat content. Oils, such as vegetable oil and wheat germ oil, are also higher sources of vitamin E, with wheat germ oil contains nearly 100% daily value of vitamin E. (NIH, Vitamin E) Vitamin K can be found in leafy greens, which are nutrient dense. Greens such as Kale, spinach, and turnip greens contain 113 micrograms (141% DV), 145 micrograms (181%) and 426 micrograms (532% DV), respectively. (NIH, Vitamin K) Vitamin B12, while not a fat soluble vitamin, can pose a risk for bariatric patients if absent from their diets post-operation. According to the FDA daily intake values, a standard diet should consist of 6 micrograms of Vitamin B12 daily. (FDA) Vitamin B12, otherwise known as Cobalamin, is a water soluble vitamin, which means that these vitamins are not stored in the body’s fat, and access of these the vitamins not used by the body will be lost through sweat and urine. Water soluble vitamins are needed throughout the day, which can be difficult for bariatric patients who already have difficulty retaining nutrients. Vitamin B12, like other protein bound nutrients, are greatly limited after malabsorptive procedures due to much of the intestinal tract being passed over and reduced secretion of stomach acid. (Xanthakos) A 2008 study,
  • 9. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 9 “Prevalence of Iron, Folate, and Vitamin B12 Deficiency Anemia after Laparoscopic Roux-en-Y Gastric Bypass”, analyzed the data of 74 post bariatric patients up to three years post-operation. The studies found that out of 30 patients in a six month follow up, two tested for vitamin B12 deficiency (less than 150 pg/ml), three out of 30 in the one year follow up, five out of 30 in the two year follow up, and two out of 11 in the three year follow up. (Vargas-Ruiz) Based on this evidence, patients gradually developed vitamin B12 deficiencies up until two years post operation. Time seems to play a slight role in deficiency, as each data set showed a slight increase of deficient patients over time. A similar study, “Vitamin B12 Deficiency After Gastric Bypass Surgery for Obesity”, came to a similar conclusion regarding B12 deficiency after bariatric surgery. This research tested 50 patients, 21 having normal B12 levels and 29 having a below average B12 serum level, and gave all participants vitamin B12 supplementation daily for a three month time span. 47 of the 50 had an increase in their B12 levels, yet the mean of all the participants serum B12 levels still fell below average. (Shilling) Multiple articles of research show that even with proper supplementation, post bariatric patients still suffer from low levels of B12, which can lead to anemia if left unchecked for a substantial period of time. (Vargas-Ruiz) Many food sources that are high in protein also contain high amounts of B12. Seafood is an excellent source of B12, such as tuna, trout and salmon. These fish are all low calorie, high protein foods, and contain anywhere from two to four micrograms of B12 per 3 ounce serving. Bariatric patients may not be able to handle large portion right after surgery, yet smaller portions still contain adequate amounts of B12. Yogurts containing fruits, which are usually implemented into bariatric diets, contain 1.1, or 18% daily value of B12. (NIH, Vitamin B12). While some patients might finds it difficult to reach their B12 threshold every day, the body can store around 2000 micrograms, as long as B12 intake is spread out in a timely manner throughout the day.
  • 10. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 10 (Vargas-Ruiz) Vitamin B12 should not be overshadowed by fat soluble vitamins, as each vitamin is essential for bariatric patients to fulfill their goal of a healthier lifestyle. Among all micronutrients deficiencies, minerals are the most common and recognizable deficiencies in post bariatric patients. Trace minerals, which are needed in very small amounts in the body, often do not make their way into the diets of post bariatric diets. Iron, a trace mineral, is an extremely common deficiency, occurring in up to an estimated 47% of post bariatric patients at some point in time, (Xanthakos) while other studies have found even higher levels of iron deficiency in their testing groups, such as 54% in three year range post-operative patients. (Vargas) The daily intake value for iron falls at 18 mg. (FDA) Due to iron being absorbed mainly in the duodenum and jejunum, both of which are bypassed after malabsorptive surgery, many patients suffer any inability to properly absorb most of the iron they take in. (Vargas-Ruiz) A 1999 study titled “Iron Absorption and Therapy after Gastric Bypass” explores iron absorption in bariatric patients both with and without an iron supplement in the form of ferrous gluconate. Their findings showed that out of the 55 patients who took the 50 mg iron supplement, 19 of the patients experienced a below average iron absorption rate. (Rhode) 29 of the same participants also underwent a second clinical trial, this time taking an iron supplement for one month, followed by an iron supplement combined with a vitamin C supplement. While the iron supplement alone increased ferritin levels, the groups noticed a larger ferritin increase when paired with vitamin C. (Rhode) With iron having such a large impact in red blood cells, it is common for iron deficient patients to develop anemia. (Vargas-Ruiz) To prevent iron loss and potentially anemia, patients need to find a balance between artificially made iron supplements, and naturally occurring ferritin in foods. This can be a difficult task, as many foods do not contain a high serving of iron. Many breakfast cereals are fortified with iron; it is important to
  • 11. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 11 find a cereal that is low in calories and does not contain artificial sugars, as artificial sugars turn to fat and can lead to Dumping Syndrome. Beans are source of iron that is also abundant in protein and various other micronutrients, containing up to 44% daily intake for a cup of beans. (NIH, Iron) With such a large focus on fat soluble vitamins and retaining iron and calcium after surgery, some micronutrients are looked over in regards to their deficiencies post operation. Zinc has become one of the larger researched trace minerals after malabsorptive surgeries, as many studies provide evidence of excessive loss of zinc, even with supplements. In the research article “Vitamin and Trace Mineral Levels after Laparoscopic Gastric Bypass”, 36% of their 33 one year checkup patients suffered from abnormal zinc levels. (Madan) This data is somewhat concerning, as zinc is already a common deficiency in pre-operative patients who are obese. (Salle) Patients that have a difficult time absorbing zinc, while post-bariatric patients experience continued absorption difficulties with malabsorption procedures. A similar study, “Zinc Deficiency: A Frequent and Underestimated Complication After Bariatric Surgery”, conducted a similar study, yet with a larger patient group and a larger breakdown of data. 266 pre-surgical patients were selected, and 8.1% of the patients suffered from zinc deficiency pre-surgery. All 266 patients underwent Roux-en-Y gastric bypass surgery, and no patients took zinc supplementation before their surgical procedure. Post-surgical data showed that out of the 146 patients that were consulted in the follow up blood plasma testing, 40.7 of these patients suffered from zinc deficiency, while 17 of these patients were taking some form of zinc supplementation. There is a positive correlation between successful malabsorptive surgical procedures, yet zinc deficiency levels seem to level off after one year, as opposed to iron levels constantly decreasing over time. (Salle) At 12 months, 146 patients experienced a mean total mass weight loss of
  • 12. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 12 32.4% of their total weight, showing that their procedure triggered a substantial amount of weight loss. These studies show that zinc deficiency is common in both obese and bariatric malabsorptive patients, yet the latter suffer from a sharp increase and need increased supplementation to avoid the negative health risks associated with a loss in zinc. The main issue is that zinc deficiency can be overlooked, yet is a commonly occurring deficiency coupled with protein deficiency. (Salle) One case of an acrodermatitis enteropathica based rash occurred in a gastric bypass patient. While she suffered from multiple nutrient deficiencies due to avoiding her multivitamin supplements, acrodermatitis enteropathica based rashes have been found to have a link to zinc deficiencies. (Helen) To avoid a zinc deficiency, patients should aim for 11 mg of zinc a day, and always choose a multivitamin that also has a focus on trace minerals, and not just the major fat soluble vitamins. Proper nutrition after surgery is also an essential step, yet can be challenging as very little foods naturally contain large amounts of zinc. Oysters, at three ounces, contain 74 mg of zinc, which is 493% the daily intake recommendation. This number may seem impressive, but the body has little ability to store zinc, as zinc storage in the body is limited to around 3 mg. (Salle) Crab meat (3 ounces) contains 43% daily value intake (6.5 mg), and is a food that is high in protein. Many other sources of zinc are various meats, such as beef, (5.3mg at 3 ounces) pork (2.9 mg at 3 ounces), and lobster (3.4 mg at 3 ounces). Various nuts contain small traces of zinc, yet contain phytates which limit the bioavailability of zinc. (NIH, Zinc) After a patient undergoes any form of bariatric surgery, a major concern is proper consumption of fluids post-operatively. Post-op patients should avoid liquids with artificial sugars and beverages that contain carbonation. Alcohol should be avoided for the first year after surgery; it is recommended that the patient stop drinking alcohol for the rest of their life. Recommended liquid intake is a minimum of 64 ounces daily. (Elkins) In the study
  • 13. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 13 “Noncompliance with Behavioral Recommendations Following Bariatric Surgery”, 100 post- surgical bariatric patients were tested on various noncompliant factors, such as continued soda use, and limited attempts to increase proper liquid consumption. At a six month follow up, 4% were still drinking soda, and 14% were not meeting recommended liquid intake. At 12 months, 2% were still drinking sodas, while 7% were not drinking enough water. (Elkin) Most patients understand the importance of hydration, and understand that dehydration is a major health issue after surgery. This data shows that many bariatric patients understand how to properly hydrate themselves after a surgical procedure with the correct amount of liquids. Based on previous research done on malabsorptive practices and its effect on micronutrient absorption, three fact sheets have been created to properly educate pre-bariatric patients on their nutrient status after surgery. A large focus before surgery is about obtaining the proper amount of protein needs. Protein is the key component in regards to nutrients after surgery, yet this extreme focus makes it seems as though other nutrients do not matter as much as protein. Patients are also taught about proper vitamin supplementation, yet many believe that this supplement is all they need for micronutrients. Micronutrients from natural sources carry a higher amount of bioavailability, and are needed in case patients either forget to take their supplemental pill on a daily basis or have difficulty ingesting pills. Each fact sheet covers a specific subject, such as nutrient comparisons for supplemental vitamins, proper hydration, and vitamin/mineral nutrient information from natural sources. These fact sheets contain information that is simple to understand, as patients come from all educational backgrounds. Assuring that every patient can comprehend the information presented in essential to properly assisting patients in their post-operational healthy lifestyle.
  • 14. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 14 The first information sheet titled “Is My Multivitamin Enough?” (Pages 18-19), which explains the concept of malabsorption in a simple manner, so that the rest of the information sheets are easier to comprehend. The definition of micronutrients is also explained in case the patient viewing the information sheet does not have a strong nutritional background. The data presented compares a standard Bariatric vitamin that is taken by post-operative patients to up to date RDA guidelines. This data is comparing the serving for one bariatric multivitamin, which does not supply a full dose of dietary intake values for most micronutrients available in the pill. The patient can use this information to either realize that many doses of multivitamins are needed throughout the day, or to supplement micronutrients while obtaining micronutrients from natural food sources. Five healthy food choices are also presented on this information sheet, containing information regarding protein, fat, micronutrients, and calories. The second collection of information sheet, “Vitamins and Minerals after Surgery” (Page 20), educates the patients on the different types of bariatric procedures. These forms are aimed more towards those patients who will undergo a form of malabsorptive procedure. Patients should understand the difference between a restrictive surgery and a malabsorptive surgery, as each function differently and have a different effect on nutrient absorption. Once the patients understand the difference between the two major forms of bariatric surgery, they can read about major vitamin and mineral deficiencies commonly found post-operatively. The sheet focusing on vitamin deficiency, “Adding Vitamins to your Diet” (Page 21) explains which deficient vitamins are fat soluble, and which water soluble are. Due to bariatric surgery patients having limited fat intake after surgery, fat soluble vitamins are harder to retain in the body. Vitamin deficiencies in vitamins A, K, D, and B12 and presented for the patients so that can have a basic understanding of some of the warning signs of a deficiency issue. Examples are then listed for
  • 15. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 15 foods that provide a sufficient amount of vitamins, while also provided some form of protein (disregarding vitamin K dense foods). Patients can use this information to find ways to add natural sources of vitamins to their daily diet routine. “Adding Minerals to your Diet” (Page 22) expands on the concept of major minerals and trace minerals. The information focuses on the two larger minerals deficiencies, calcium and iron. Deficiency signs are presented for both minerals, so that the patients has a clear understanding of what signs to look for if the patient suspected they suffer from a deficiency. Calcium deficiency is largely associated with loss of vitamin D. The information sheet explains that calcium and vitamin D both play a large impact on bone density, and that a deficiency in vitamin D means there is a chance that there is a deficiency in calcium. Iron is largely associated with anemia. This information sheet explains the signs of loss of oxygenated blood cells so that the patient can identify if they may be suffering from anemia. As many deficiencies share common signs, patients should be aware that only a blood test can truly identify which deficiencies are present. These sheets are for informational use and to aid in micronutrient consumption before a deficiency occurs. The final information sheet presented, “Hydration and You” (Pages 23-24) focuses on creative ways to incorporate water around the patient’s diet. Bariatric patients are advised to not drink water while eating and to drink water in small sips throughout the day, which in some cases can cause patients to forget to properly hydrate. Each of the four categories mentioned in this information sheet gives suggestions to ensure the patients remembers to drink acceptable liquids. The first category informs the patient on acceptable liquids after surgery. Decaffeinated coffees and teas are liquids with additional health benefits and are considered acceptable liquids after bariatric surgery. Flavored waters are another method to create a more diverse variety of liquids for the patient. Many bottled water companies sell flavored waters based on fruit flavors.
  • 16. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 16 Patients can create their own flavored water by adding fruits and vegetables to water. These mixtures can be used to hydrate and to receive the health benefits from the fruits and vegetables being used. The final category informs patients on larger water containers that can contain a days’ worth of liquid. Seeing the amount of liquids consumed for that day can help a client realize how much more they need to drink, or if they are not drinking at an adequate pace for that day. Weight loss surgeries have become a revolutionary method in a world where obesity has become an epidemic. Every year more individuals are diagnosed as obese, and more people turn to bariatric surgeries to create a better life for themselves. Weight loss surgeries are a gateway for individuals who want to live a healthy lifestyle, and keep the excess weight off for life. These weight loss procedures are very beneficial and have a high success rate, yet come with additional health risks. One of these higher risks is developing a micronutrient deficiency. With the proper preventative information and dietary supplementation, weight loss patients will be able to fulfill their goal of weight loss without suffering from the negative health issues surrounding deficiencies from micronutrients.
  • 17. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 17 Is my Multivitamin Enough? After bariatric surgery, your body may lose some of its ability to absorb nutrients from food and limits the amount of food you can take in at once. The body doesn’t always get the proper amounts of micronutrients after surgery. Micronutrients are vitamins (vitamin A, vitamin D, etc.), minerals (iron, potassium, iodine, etc.). Multivitamins are a great way to add needed vitamins and minerals to your diet. These vitamin supplements are essential in almost any post- operative diet, but are they giving you all the nutrients your body needs? Let’s compare Bariatric Fusion Vitamin nutritional info with RDA daily guidelines: Vitamin A Vitamin D Vitamin E Vitamin B6 Vitamin B12 Calcium Iron Iodine Zinc Bariatric Fusion (One pill=one serving size) 1875 IU 500 IU 7.5 IU 0.5 mg 140 mcg 300 mg 7.5 mg 37.5 mcg 7.5 mg RDA Guidelines (as of July 2016) 3000 IU (Men) 2300 IU (Woman) 600 IU 22 IU 1.3 mg 2.4 mcg 1000 mg 18 mg 150 mcg 11 mg (Men) 8 mg (Women) Many of these single serving Multivitamins do not meet the RDA doses!!! Not only that, but this is considering that all of the nutrients are being absorbed, while some of these vitamins and minerals will not be fully absorbed. An example is Vitamin A; this multivitamin contains 65% the daily dose for men, and around 82% for woman, but what if only 900 IU gets absorbed? That would drop these percentages by over half! One solution is to take more than one multivitamin throughout the day. Ask your doctor how many multivitamins you will need in a day. Make sure to take these at different times of the day, as the body can only absorb so much at once! To get the right amount of vitamins and minerals into your daily diet, try some of these super foods that contain not only contain lots of vitamins and minerals, but are low in calories as well!
  • 18. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 18 Salmon: This fish is high in oily fats, high in protein, and contains good amounts of vitamin A and potassium. Salmon is a lean meat with little calories making it very nutritious! Kale: This leafy green is extremely low in calories and fat, yet very high in essential vitamins like vitamin A and C! Sardines: Like most fish, sardines are high in protein and fats, and contain great amounts of potassium and calcium. Eggs (with yolk): Eggs are a good source of protein, vitamin A, vitamin C, calcium, and Iron. Try cooking eggs in a variety of ways to mix up your diet! Quinoa: Adding quinoa throughout your diet can be a high source of fiber and protein, while getting much needed amounts of minerals such as copper and iron.
  • 19. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 19 Vitamins and Minerals after Surgery While much of the emphasis post-surgery is all about protein, remembering to take vitamins and minerals is very important. After surgery, it is very difficult to eat enough foods to meet vitamin and mineral needs. To prevent malnutrition, you must take the vitamins your doctor advises you to take, as well as eat foods high in vitamins and minerals. Did you have… A restrictive surgery? Ie. Gastric Band or Sleeve Restrictive surgeries limit the amount of food that can enter the stomach at once. These procedures allow for more nutrients to be absorbed than other weight loss surgeries. A malabsorptive surgery? Ie. GBP or BPD This type of surgery involves removing or bypassing most of the stomach and alters the path in which food takes in the intestinal track to limit caloric absorption. The diversion can also be combined with the duodenal switch. This type of surgery allows fewer nutrients to be absorbed than a restrictive surgery. Below are the vitamins and minerals that are at a high risk of deficiency after surgery. Vitamins Minerals Vitamin A Vitamin D Calcium Iron Vitamin K Vitamin B12
  • 20. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 20 Adding Vitamins to your Diet Vitamins A, D, and K are fat soluble vitamins. The post bariatric diet is low in fat, making it difficult to absorb enough vitamins. It is important to know the warnings of low vitamin intake, specifically the fat soluble vitamins. B12 is also a common vitamin deficiency, but is water soluble and easier to obtain in a diet. Vitamin A: Inability to see well in the dark, inability to produce tears (xerophthalmia) prone to infections Vitamin D: Weak bone density, bones softening (osteomalacia) Vitamin K: Excessive bleeding from wounds, bruising, blood in urine and/or stool Vitamin B12: Fatigue, anemia, neurological damage, numbness, depression, memory loss Try adding these foods to your to reduce your risk of vitamin deficiency and mix up your diet. Most of these foods are also high in protein! Vitamin A: Eggs with yolk, cheese, milk, oatmeal Vitamin D: Milks, cheeses, sardines, cod, egg yolks, tofu, pork Vitamin K: Kale, spinach Vitamin B12: Fish (cod, sardines), eggs with yolk, red meats (steak, beef, etc.), milk and yogurt
  • 21. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 21 Adding Minerals to your Diet There are many minerals that the body needs to stay healthy before and after surgery. Bariatric patients display lower levels of calcium and iron, which can have lasting health effects. These deficiencies can be hard to treat, so make sure to know the signs! Calcium Iron -Numbness in various aspects of -Headaches and dizziness the extremities, such as hands and feet -Fatigue and overall weakness -Muscle spasms -Chest pains/irregular heartbeat -Depression -Cravings for non-nutritious substances -Brittle nails that break off easily Calcium and iron deficiencies can lead to very serious health issues long term. Calcium and vitamin D deficiencies, can lead to serious bone problems like osteopetrosis. Iron deficiency leads to iron-deficiency anemia. The main concern with iron deficiency anemia is long term issues with the heart if not treated. Make sure to take the recommended dosage of minerals through supplements combined with these foods to ensure adequate intake. Calcium: Egg yolks, milk, cheeses, spinach, chickpeas, almonds, soybeans Iron: Tofu products, potatoes, soybeans, peanuts and peanut butter, wheat products, chickpeas, spinach
  • 22. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 22 Hydration and You After your bariatric surgery, it is important that you drink a good amount of liquid on a day to day basis. Since eating and drinking have to take place at different times after surgery, it may be difficult to remember to drink throughout the day. Planning your diet is important, and so is planning your drinking! Try to drink at least 64 ounces of liquid a day! Here are fun ways to make hydration more interesting. Mix it up! All 64 ounces don’t have to be water. Try drinking decaf coffees or decaf teas (With no sugars) to take a break from plain water. Coffees and teas also have their own health benefits, such as antioxidants and reduced risk of diabetes! Try flavored waters! Many companies make waters that are flavored after fruits like blackberry or strawberry. These waters usually do not have any added calories or sugars, but always be sure to check before you buy! DIY Flavored water! Adding fruits and veggies to your water can be a fun way to stay hydrated. Try out different varieties to find which combo is your favorite!
  • 23. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 23 Keep your liquids in one place! Instead of drinking many small portions throughout the day, keep a large container of water with you. 64 ounces of water is the same as a half-gallon, so filling up a half gallon of water will give you that days’ hydration requirements! This way, you can see how much you have drunk for already, and how much more you need to drink. Try adding labels to the side of the container that will give you a time frame of how much has been drunk already. Look out for the signs of Dehydration!!! Fatigue Whitened tongue Excessive thirst Dried Skin Headaches Light-headed Cloudy/yellow urine Infrequent urination Make sure to drink more if you experience one or more of these symptoms! If symptoms persist, talk to your doctor, or go to the nearest ER Facility!
  • 24. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 24 Bibliography 1. Elkins, G., Whitfield, P., Marcus, J. et al. OBES SURG (2005) 15: 546. doi:10.1381/0960892053723385 2. Faria, S.L., Faria, O.P., Buffington, C. et al. OBES SURG (2011) 21: 1798. doi:10.1007/s11695- 011-0441-y http://link.springer.com/article/10.1007/s11695-011-0441-y 3. Farrell, P. M., Bieri, J. G., Fratantoni, J. F., Wood, R. E., & di Sant’Agnese, P. A. (1977). The Occurrence and Effects of Human Vitamin E Deficiency: A STUDY IN PATIENTS WITH CYSTIC FIBROSIS. Journal of Clinical Investigation, 60(1), 233–241. 4. Flancbaum, L., Belsley, S., Drake, V. et al. J Gastrointest Surg (2006) 10: 1033. doi:10.1016/j.gassur.2006.03.004 5. Guidance for Industry: A Food Labeling Guide (14. Appendix F: Calculate the Percent Daily Value for the Appropriate Nutrients). (n.d.). Retrieved October 11, 2016, from http://www.fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformati on/LabelingNutrition/ucm064928.htm 6. Helen Lewandowski, Tracy Breen, and Eric Huang (2007) Kwashiorkor and an
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  • 26. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 26 http://link.springer.com/article/10.1007/s11695-010-0237-5 14. SCHILLING RF, GOHDES PN, HARDIE GH. Vitamin B12 Deficiency After Gastric Bypass Surgery for Obesity. Ann Intern Med. 1984;101:501-502. doi:10.7326/0003-4819-101-4-501 15. Slater, G.H., Ren, C.J., Siegel, N. et al. J Gastrointest Surg (2004) 8: 48. doi:10.1016/j.gassur.2003.09.020 http://link.springer.com/article/10.1016/j.gassur.2003.09.020 16. Vargas-Ruiz, A.G., Hernández-Rivera, G. & Herrera, M.F. OBES SURG (2008) 18: 288. doi:10.1007/s11695-007-9310-0 http://link.springer.com/article/10.1007/s11695-007-9310-0 17. Vitamin A — Health Professional Fact Sheet. (n.d.). Retrieved October 11, 2016, from https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/ 18. Vitamin B12 — Health Professional Fact Sheet.(n.d.). Retrieved October 11, 2016, from https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/ 19. Vitamin D — Health Professional Fact Sheet. (n.d.). Retrieved October 11, 2016, from https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/ 20. Vitamin E — Health Professional Fact Sheet. (n.d.). Retrieved October 11, 2016, from https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/
  • 27. Malabsorptionof Major MicronutrientsafterBariatricProcedures P a g e | 27 21. Vitamin K — Health Professional Fact Sheet. (n.d.). Retrieved October 11, 2016, from https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/ 22. Xanthakos, S. A. (2009). Nutritional Deficiencies in Obesity and After Bariatric Surgery. Pediatric Clinics of North America, 56(5), 1105–1121. http://doi.org/10.1016/j.pcl.2009.07.002 23. Zinc — Health Professional Fact Sheet. (n.d.). Retrieved October 12, 2016, from https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/