This review analyzed 7 randomized controlled trials that evaluated the use of intravenous magnesium sulfate for treating acute asthma exacerbations in the emergency department. The studies involved a total of 665 patients. The review found that magnesium sulfate appears to be safe and may provide additional bronchodilation benefits for patients presenting with severe acute asthma, as shown by improved pulmonary function testing results. However, for all patients with acute asthma, the review did not find clear evidence that magnesium sulfate routinely reduces admission to the hospital or significantly improves outcomes beyond standard treatments.
This Cochrane review examines 8 randomized controlled trials comparing continuous versus intermittent beta-agonists for acute asthma. The review found that continuous beta-agonist treatment was associated with a 32% reduction in hospital admissions compared to intermittent treatment. Patients receiving continuous treatment also demonstrated small but statistically significant improvements in lung function tests. Continuous treatment was generally well-tolerated with no significant differences in side effects compared to intermittent treatment. The review concludes that current evidence supports the use of continuous beta-agonists in the emergency department for patients with severe acute asthma.
This thesis examines the effects of varying loads and repetitions on caloric expenditure during back squats. Fifteen subjects performed four different 4-minute squat protocols using loads of 5kg, 10kg, 15kg, or 20kg at contraction speeds of 1, 2, 3, or 4 seconds respectively, to maintain the same total work. Heart rate and physical activity energy expenditure were measured. Results showed that mean heart rate and caloric expenditure decreased as load increased from 5kg to 20kg. The 5kg protocol elicited the highest caloric expenditure, suggesting that a high-repetition, low-load protocol maximizes energy use during back squats in a short time period.
This document provides guidance for military medical personnel on preventing and treating heat stress and heat casualties. It discusses the physiological responses to heat, risk factors for heat illness, management of heat stress through acclimatization and fluid replacement, and treatment of heat illnesses ranging from heat exhaustion to heat stroke. The roles of unit commanders, medical officers, and medics are outlined for developing prevention programs, monitoring soldiers, and providing medical support during training and operations.
Efectos del calentamiento corto o largo en el rendimiento de carrera intermediaCristian Salazar
This study compared the effects of a long warm-up (10 minutes of jogging at 80% max heart rate plus 8 sprints of increasing intensity) versus a short warm-up (just the 8 sprints) on a 3-minute intermediate running performance. Thirteen endurance athletes completed both warm-ups in a counterbalanced crossover design with one week between. Physiological measures (oxygen uptake, heart rate, blood lactate) and perceptual measures (RPE) were taken during the warm-ups and running test. No significant differences were found between the warm-ups for any running performance or physiological measures during the 3-minute run, except RPE and heart rate were higher after the long warm-up.
A evidência apresentada sugere que a variação é um componente necessário do planejamento efetivo do treinamento. Apoiando essa perspectiva, outras pesquisas sugerem que a monotonia de treinamento elevado - que pode ser amplamente percebida como uma falta de variação20 - leva a uma maior incidência de síndromes de overtraining21, um mau desempenho e freqüência de infecções banais.22 Inversamente, as reduções na monotonia têm Tem sido associada a uma maior incidência de melhor desempenho pessoal 22, e os índices de monotonia têm sido defendidos como ferramentas benéficas de treinamento-regulação na elite rowing23 e no sprint24.
Smoking cessation for chronic obstructive pulmonary diseaGeorgi Daskalov
This review examines the effectiveness of smoking cessation interventions for patients with chronic obstructive pulmonary disease (COPD). The review found evidence that a combination of psychosocial interventions (such as counseling and behavioral therapy) and pharmacological interventions (such as nicotine replacement therapy) is more effective for smoking cessation than no treatment or psychosocial interventions alone. However, the review concludes that there is insufficient evidence to determine the effectiveness of psychosocial interventions alone due to a lack of high-quality studies directly comparing psychosocial interventions to no treatment.
Smoking cessation for chronic obstructive pulmonary diseaGeorgi Daskalov
This review examines the effectiveness of smoking cessation interventions for patients with chronic obstructive pulmonary disease (COPD). The review found evidence that a combination of psychosocial interventions (such as counseling and behavioral therapy) and pharmacological interventions (such as nicotine replacement therapy) is more effective for smoking cessation than no treatment or psychosocial interventions alone. However, the review concludes that there is insufficient evidence to determine the effectiveness of psychosocial interventions alone due to a lack of high-quality studies directly comparing psychosocial interventions to no treatment.
Fisioterapia respiratoria toracica en neuminias en adultos.pdfJavierManriqueSoto1
This review analyzed 6 randomized controlled trials with 434 participants to evaluate the effectiveness of chest physiotherapy for pneumonia in adults. The review found that chest physiotherapy did not improve mortality or cure rates compared to no treatment or placebo. However, osteopathic manipulative treatment and positive expiratory pressure reduced the duration of hospital stay compared to no treatment. Additionally, positive expiratory pressure reduced fever duration and osteopathic manipulative treatment reduced intravenous and total antibiotic treatment duration compared to placebo or no treatment. The review was limited by the small number and size of included studies.
This Cochrane review examines 8 randomized controlled trials comparing continuous versus intermittent beta-agonists for acute asthma. The review found that continuous beta-agonist treatment was associated with a 32% reduction in hospital admissions compared to intermittent treatment. Patients receiving continuous treatment also demonstrated small but statistically significant improvements in lung function tests. Continuous treatment was generally well-tolerated with no significant differences in side effects compared to intermittent treatment. The review concludes that current evidence supports the use of continuous beta-agonists in the emergency department for patients with severe acute asthma.
This thesis examines the effects of varying loads and repetitions on caloric expenditure during back squats. Fifteen subjects performed four different 4-minute squat protocols using loads of 5kg, 10kg, 15kg, or 20kg at contraction speeds of 1, 2, 3, or 4 seconds respectively, to maintain the same total work. Heart rate and physical activity energy expenditure were measured. Results showed that mean heart rate and caloric expenditure decreased as load increased from 5kg to 20kg. The 5kg protocol elicited the highest caloric expenditure, suggesting that a high-repetition, low-load protocol maximizes energy use during back squats in a short time period.
This document provides guidance for military medical personnel on preventing and treating heat stress and heat casualties. It discusses the physiological responses to heat, risk factors for heat illness, management of heat stress through acclimatization and fluid replacement, and treatment of heat illnesses ranging from heat exhaustion to heat stroke. The roles of unit commanders, medical officers, and medics are outlined for developing prevention programs, monitoring soldiers, and providing medical support during training and operations.
Efectos del calentamiento corto o largo en el rendimiento de carrera intermediaCristian Salazar
This study compared the effects of a long warm-up (10 minutes of jogging at 80% max heart rate plus 8 sprints of increasing intensity) versus a short warm-up (just the 8 sprints) on a 3-minute intermediate running performance. Thirteen endurance athletes completed both warm-ups in a counterbalanced crossover design with one week between. Physiological measures (oxygen uptake, heart rate, blood lactate) and perceptual measures (RPE) were taken during the warm-ups and running test. No significant differences were found between the warm-ups for any running performance or physiological measures during the 3-minute run, except RPE and heart rate were higher after the long warm-up.
A evidência apresentada sugere que a variação é um componente necessário do planejamento efetivo do treinamento. Apoiando essa perspectiva, outras pesquisas sugerem que a monotonia de treinamento elevado - que pode ser amplamente percebida como uma falta de variação20 - leva a uma maior incidência de síndromes de overtraining21, um mau desempenho e freqüência de infecções banais.22 Inversamente, as reduções na monotonia têm Tem sido associada a uma maior incidência de melhor desempenho pessoal 22, e os índices de monotonia têm sido defendidos como ferramentas benéficas de treinamento-regulação na elite rowing23 e no sprint24.
Smoking cessation for chronic obstructive pulmonary diseaGeorgi Daskalov
This review examines the effectiveness of smoking cessation interventions for patients with chronic obstructive pulmonary disease (COPD). The review found evidence that a combination of psychosocial interventions (such as counseling and behavioral therapy) and pharmacological interventions (such as nicotine replacement therapy) is more effective for smoking cessation than no treatment or psychosocial interventions alone. However, the review concludes that there is insufficient evidence to determine the effectiveness of psychosocial interventions alone due to a lack of high-quality studies directly comparing psychosocial interventions to no treatment.
Smoking cessation for chronic obstructive pulmonary diseaGeorgi Daskalov
This review examines the effectiveness of smoking cessation interventions for patients with chronic obstructive pulmonary disease (COPD). The review found evidence that a combination of psychosocial interventions (such as counseling and behavioral therapy) and pharmacological interventions (such as nicotine replacement therapy) is more effective for smoking cessation than no treatment or psychosocial interventions alone. However, the review concludes that there is insufficient evidence to determine the effectiveness of psychosocial interventions alone due to a lack of high-quality studies directly comparing psychosocial interventions to no treatment.
Fisioterapia respiratoria toracica en neuminias en adultos.pdfJavierManriqueSoto1
This review analyzed 6 randomized controlled trials with 434 participants to evaluate the effectiveness of chest physiotherapy for pneumonia in adults. The review found that chest physiotherapy did not improve mortality or cure rates compared to no treatment or placebo. However, osteopathic manipulative treatment and positive expiratory pressure reduced the duration of hospital stay compared to no treatment. Additionally, positive expiratory pressure reduced fever duration and osteopathic manipulative treatment reduced intravenous and total antibiotic treatment duration compared to placebo or no treatment. The review was limited by the small number and size of included studies.
This Cochrane review analyzed 13 randomized controlled trials involving 5,686 intensive care patients to compare outcomes for patients managed with or without a pulmonary artery catheter (PAC). The review found no significant differences in mortality, length of stay in the intensive care unit or hospital, or hospital costs between patients managed with or without a PAC. While PACs provide diagnostic information, the review concluded they did not significantly impact these important patient outcomes when used in general intensive care patients or high-risk surgery patients.
This document is a reference guide for cardiopulmonary care published by Edwards Lifesciences. It provides concise summaries of anatomy, physiology, monitoring techniques, and central venous access. The guide is intended as an educational reference for medical personnel and disclaims any liability. It has been compiled from available literature and the editors cannot guarantee the correctness of the information.
This systematic review evaluated the effects of glucocorticoid with cyclophosphamide treatment for paraquat-induced lung fibrosis based on three randomized controlled trials with a total of 164 participants. The review found that patients receiving glucocorticoid with cyclophosphamide in addition to standard care had a lower risk of death at final follow-up compared to those receiving standard care alone, with a risk ratio of 0.72 (95% CI 0.59 to 0.89). Based on these findings, the authors concluded that glucocorticoid with cyclophosphamide may provide a beneficial treatment for patients with paraquat-induced lung fibrosis. However, they noted that the studies were small and one was of low quality, so the benefits need
Second or third additional chemotherapy drug for non-small cell lung cancer i...James Hilbert
This Cochrane review evaluated 65 randomized controlled trials with over 13,000 patients to determine the clinical benefit of adding additional chemotherapy drugs to treatment regimens for advanced non-small cell lung cancer. The review found that adding a second drug to a single-agent chemotherapy regimen improved tumor response rates and one-year survival rates. Adding a third drug to a two-drug chemotherapy regimen increased tumor response rates but did not improve one-year survival rates and was associated with higher toxicity.
The document describes a review that aimed to determine if advising patients to increase fluid intake provides benefits or causes harm for treating acute respiratory infections. No randomized controlled trials on this topic were found. While increased fluids may help replace losses and thin mucus, it could also potentially cause hyponatremia. More research is needed to understand the effects of advising extra fluid intake for acute respiratory infections.
Aversive smoking for smoking cessation (review)Georgi Daskalov
This review evaluated the effectiveness of aversive smoking techniques for smoking cessation. Aversive smoking pairs smoking with unpleasant stimuli to reduce cravings. The review found that rapid smoking, which requires taking a puff every 6-10 seconds, may help smokers quit compared to a control, but the evidence is inconclusive due to methodological issues in studies. Other aversive methods did not show effectiveness. There was borderline evidence that more aversive methods may help quitting more than less aversive methods, but the evidence is uncertain. Further research is needed to determine if rapid smoking or varying levels of aversiveness can effectively help smokers quit smoking.
This document provides recommendations from the AAPM Radiation Therapy Committee Task Group 43 on a new dosimetry protocol for interstitial brachytherapy sources. The protocol defines a dose calculation formalism and recommends dosimetry parameters for Iridium-192, Iodine-125 and Palladium-103 sources. It introduces new quantities such as air kerma strength, dose rate constant, radial dose function and anisotropy function to replace older quantities like exposure rate constant. The formalism allows for direct calculation of dose from a single source based on these new quantities designed to standardize brachytherapy dosimetry calculations.
This Cochrane review evaluated the effectiveness and safety of 5-FU topical treatment for genital warts in non-immunocompromised individuals. The review included 6 trials with 988 patients comparing 5-FU to placebo, meta-cresol-sulfonic acid, podophylin, CO2 laser, 5-FU + INFα-2a, and combination treatments. The review found that 5-FU showed better cure rates than placebo, meta-cresol-sulfonic acid, and podophylin. There were no differences in treatment failure between 5-FU and CO2 laser. Poorer results were seen for 5-FU compared to 5-FU + INFα-2a (high
American Thoracic Society American College Of Chest Physicians ATS ACCP Stat...Justin Knight
This document provides guidelines for cardiopulmonary exercise testing (CPET) based on expert consensus. CPET provides a global assessment of how the body functions during exercise by evaluating multiple organ systems together. It is increasingly being used clinically to evaluate unexplained exercise intolerance, functional capacity, and impairment. The document covers indications for CPET, methodology, measurements and interpretations, reference values, and patterns of abnormal exercise responses in various diseases. The intended audience is those performing and using CPET to assist clinical decision making.
This Cochrane review assessed the benefits and harms of non-surgical (chemoradiotherapy or radiotherapy) versus surgical (oesophagectomy) treatment for people with esophageal cancer. The review included eight randomized controlled trials with a total of 1114 participants. The review found no difference in long-term mortality between chemoradiotherapy and surgery, but found higher long-term mortality with radiotherapy compared to surgery. The review also found no difference in long-term recurrence rates between non-surgical and surgical treatments. However, the evidence was of low to very low quality.
This review analyzed 7 randomized controlled trials involving 581 infants with mild to moderate acute viral bronchiolitis. The review found that nebulized 3% saline solution was associated with a shorter hospital stay compared to 0.9% saline. 3% saline also improved clinical severity scores over the first 3 days of treatment compared to 0.9% saline. No significant adverse events were reported with 3% saline.
The document reviews the association between COVID-19 and diabetes. It summarizes the general characteristics of COVID-19, including its incubation period, modes of transmission, clinical presentation, and diagnosis. It then discusses the relationship between diabetes and viral infections in general, and explores some potential pathophysiological mechanisms linking COVID-19 and diabetes. The review suggests chronic inflammation, immune dysfunction, and direct pancreatic damage as possible underlying factors. It notes that more research is needed to fully understand this relationship and its clinical implications.
This document discusses pneumonia in elderly patients, with a focus on aspiration pneumonia. It makes three key points:
1) Pneumonia in the elderly is primarily caused by aspiration pneumonia, which involves inhaling oropharyngeal contents due to dysphagia or swallowing problems. Aspiration pneumonia accounts for around 70% of pneumonia cases in elderly patients.
2) Common pathogens in elderly pneumonia are similar to those that cause pneumonia in adults, with Streptococcus pneumoniae being the most frequent. However, anaerobic bacteria and oral microbes also play an important role in aspiration pneumonia cases.
3) Effective management of pneumonia in the elderly requires both antibiotic treatment and measures to address dys
The review evaluated the effectiveness of ACE inhibitors (ACEi) and angiotensin receptor blockers (ARB) for adults with early stage chronic kidney disease without diabetes. Four randomized controlled trials with 2,177 participants were included. Low to moderate quality evidence from two studies found that ACEi had no impact on mortality or cardiovascular events compared to placebo in people with stage 3 kidney disease. One study found no difference in risk of end-stage kidney disease between ACEi and placebo in people with eGFR >45 mL/min/1.74 m2. No published studies directly compared ARB to placebo. In summary, there is currently insufficient evidence to determine the effectiveness of ACEi or ARB for patients
Cochrane Review on local vs general anesthesia for carotid endarterectomysamirsharshar
This Cochrane review analyzes 14 randomized controlled trials involving over 4,500 carotid endarterectomy operations to compare outcomes of the procedures when performed under local versus general anesthesia. The review found no significant difference in the percentage of patients experiencing a stroke or death within 30 days between the two anesthesia types. Specifically, around 3% of patients experienced a stroke and 1% died within 30 days under both local and general anesthesia. The review concludes that either anesthesia technique is acceptable for carotid endarterectomy based on safety and that patient and surgeon preferences can guide the decision.
This systematic review and meta-analysis examined the effects of intravenous and nebulised magnesium sulfate for acute asthma. It included 24 studies with 1669 patients. The analysis found:
- Intravenous magnesium sulfate was associated with improved pulmonary function in children but not adults, and reduced hospital admissions in children.
- Nebulised magnesium sulfate showed weak evidence of improved pulmonary function in adults but no significant effects in children. It was also associated with weak evidence of reduced admissions in adults.
- Further trials are needed of intravenous magnesium sulfate in adults and nebulised magnesium sulfate in both adults and children to better establish their roles in acute asthma treatment.
Analgesia in patients with acute abdominal pain. the chochrane libery 2010Cirugias
This review evaluates evidence on the use of opioid analgesics for patients with acute abdominal pain (AAP) during the diagnostic process. The review identified 8 randomized controlled trials comparing opioid analgesia regimens to no analgesia in adults with AAP. The studies found that using opioid analgesics for AAP reduced pain intensity and improved patient comfort without increasing risks of diagnostic errors or inaccurate treatment decisions. The evidence therefore supports the use of opioid analgesics for AAP during diagnosis to improve patient outcomes without negatively impacting diagnostic accuracy.
This Cochrane review analyzed randomized controlled trials that assessed the effect of long-term modest reductions in salt intake on blood pressure. It found that in trials with individuals with elevated blood pressure (n=802), a median reduction in salt intake of 4.6 g/day resulted in a mean reduction in systolic blood pressure of 5.06 mmHg and diastolic blood pressure of 2.70 mmHg. In individuals with normal blood pressure (n=2220), a median salt reduction of 4.4 g/day reduced systolic blood pressure by 2.03 mmHg and diastolic blood pressure by 0.99 mmHg. The review also found a significant dose-response relationship between the magnitude of salt reduction
This Cochrane review analyzed 13 randomized controlled trials involving 5,686 intensive care patients to compare outcomes for patients managed with or without a pulmonary artery catheter (PAC). The review found no significant differences in mortality, length of stay in the intensive care unit or hospital, or hospital costs between patients managed with or without a PAC. While PACs provide diagnostic information, the review concluded they did not significantly impact these important patient outcomes when used in general intensive care patients or high-risk surgery patients.
This document is a reference guide for cardiopulmonary care published by Edwards Lifesciences. It provides concise summaries of anatomy, physiology, monitoring techniques, and central venous access. The guide is intended as an educational reference for medical personnel and disclaims any liability. It has been compiled from available literature and the editors cannot guarantee the correctness of the information.
This systematic review evaluated the effects of glucocorticoid with cyclophosphamide treatment for paraquat-induced lung fibrosis based on three randomized controlled trials with a total of 164 participants. The review found that patients receiving glucocorticoid with cyclophosphamide in addition to standard care had a lower risk of death at final follow-up compared to those receiving standard care alone, with a risk ratio of 0.72 (95% CI 0.59 to 0.89). Based on these findings, the authors concluded that glucocorticoid with cyclophosphamide may provide a beneficial treatment for patients with paraquat-induced lung fibrosis. However, they noted that the studies were small and one was of low quality, so the benefits need
Second or third additional chemotherapy drug for non-small cell lung cancer i...James Hilbert
This Cochrane review evaluated 65 randomized controlled trials with over 13,000 patients to determine the clinical benefit of adding additional chemotherapy drugs to treatment regimens for advanced non-small cell lung cancer. The review found that adding a second drug to a single-agent chemotherapy regimen improved tumor response rates and one-year survival rates. Adding a third drug to a two-drug chemotherapy regimen increased tumor response rates but did not improve one-year survival rates and was associated with higher toxicity.
The document describes a review that aimed to determine if advising patients to increase fluid intake provides benefits or causes harm for treating acute respiratory infections. No randomized controlled trials on this topic were found. While increased fluids may help replace losses and thin mucus, it could also potentially cause hyponatremia. More research is needed to understand the effects of advising extra fluid intake for acute respiratory infections.
Aversive smoking for smoking cessation (review)Georgi Daskalov
This review evaluated the effectiveness of aversive smoking techniques for smoking cessation. Aversive smoking pairs smoking with unpleasant stimuli to reduce cravings. The review found that rapid smoking, which requires taking a puff every 6-10 seconds, may help smokers quit compared to a control, but the evidence is inconclusive due to methodological issues in studies. Other aversive methods did not show effectiveness. There was borderline evidence that more aversive methods may help quitting more than less aversive methods, but the evidence is uncertain. Further research is needed to determine if rapid smoking or varying levels of aversiveness can effectively help smokers quit smoking.
This document provides recommendations from the AAPM Radiation Therapy Committee Task Group 43 on a new dosimetry protocol for interstitial brachytherapy sources. The protocol defines a dose calculation formalism and recommends dosimetry parameters for Iridium-192, Iodine-125 and Palladium-103 sources. It introduces new quantities such as air kerma strength, dose rate constant, radial dose function and anisotropy function to replace older quantities like exposure rate constant. The formalism allows for direct calculation of dose from a single source based on these new quantities designed to standardize brachytherapy dosimetry calculations.
This Cochrane review evaluated the effectiveness and safety of 5-FU topical treatment for genital warts in non-immunocompromised individuals. The review included 6 trials with 988 patients comparing 5-FU to placebo, meta-cresol-sulfonic acid, podophylin, CO2 laser, 5-FU + INFα-2a, and combination treatments. The review found that 5-FU showed better cure rates than placebo, meta-cresol-sulfonic acid, and podophylin. There were no differences in treatment failure between 5-FU and CO2 laser. Poorer results were seen for 5-FU compared to 5-FU + INFα-2a (high
American Thoracic Society American College Of Chest Physicians ATS ACCP Stat...Justin Knight
This document provides guidelines for cardiopulmonary exercise testing (CPET) based on expert consensus. CPET provides a global assessment of how the body functions during exercise by evaluating multiple organ systems together. It is increasingly being used clinically to evaluate unexplained exercise intolerance, functional capacity, and impairment. The document covers indications for CPET, methodology, measurements and interpretations, reference values, and patterns of abnormal exercise responses in various diseases. The intended audience is those performing and using CPET to assist clinical decision making.
This Cochrane review assessed the benefits and harms of non-surgical (chemoradiotherapy or radiotherapy) versus surgical (oesophagectomy) treatment for people with esophageal cancer. The review included eight randomized controlled trials with a total of 1114 participants. The review found no difference in long-term mortality between chemoradiotherapy and surgery, but found higher long-term mortality with radiotherapy compared to surgery. The review also found no difference in long-term recurrence rates between non-surgical and surgical treatments. However, the evidence was of low to very low quality.
This review analyzed 7 randomized controlled trials involving 581 infants with mild to moderate acute viral bronchiolitis. The review found that nebulized 3% saline solution was associated with a shorter hospital stay compared to 0.9% saline. 3% saline also improved clinical severity scores over the first 3 days of treatment compared to 0.9% saline. No significant adverse events were reported with 3% saline.
The document reviews the association between COVID-19 and diabetes. It summarizes the general characteristics of COVID-19, including its incubation period, modes of transmission, clinical presentation, and diagnosis. It then discusses the relationship between diabetes and viral infections in general, and explores some potential pathophysiological mechanisms linking COVID-19 and diabetes. The review suggests chronic inflammation, immune dysfunction, and direct pancreatic damage as possible underlying factors. It notes that more research is needed to fully understand this relationship and its clinical implications.
This document discusses pneumonia in elderly patients, with a focus on aspiration pneumonia. It makes three key points:
1) Pneumonia in the elderly is primarily caused by aspiration pneumonia, which involves inhaling oropharyngeal contents due to dysphagia or swallowing problems. Aspiration pneumonia accounts for around 70% of pneumonia cases in elderly patients.
2) Common pathogens in elderly pneumonia are similar to those that cause pneumonia in adults, with Streptococcus pneumoniae being the most frequent. However, anaerobic bacteria and oral microbes also play an important role in aspiration pneumonia cases.
3) Effective management of pneumonia in the elderly requires both antibiotic treatment and measures to address dys
The review evaluated the effectiveness of ACE inhibitors (ACEi) and angiotensin receptor blockers (ARB) for adults with early stage chronic kidney disease without diabetes. Four randomized controlled trials with 2,177 participants were included. Low to moderate quality evidence from two studies found that ACEi had no impact on mortality or cardiovascular events compared to placebo in people with stage 3 kidney disease. One study found no difference in risk of end-stage kidney disease between ACEi and placebo in people with eGFR >45 mL/min/1.74 m2. No published studies directly compared ARB to placebo. In summary, there is currently insufficient evidence to determine the effectiveness of ACEi or ARB for patients
Cochrane Review on local vs general anesthesia for carotid endarterectomysamirsharshar
This Cochrane review analyzes 14 randomized controlled trials involving over 4,500 carotid endarterectomy operations to compare outcomes of the procedures when performed under local versus general anesthesia. The review found no significant difference in the percentage of patients experiencing a stroke or death within 30 days between the two anesthesia types. Specifically, around 3% of patients experienced a stroke and 1% died within 30 days under both local and general anesthesia. The review concludes that either anesthesia technique is acceptable for carotid endarterectomy based on safety and that patient and surgeon preferences can guide the decision.
This systematic review and meta-analysis examined the effects of intravenous and nebulised magnesium sulfate for acute asthma. It included 24 studies with 1669 patients. The analysis found:
- Intravenous magnesium sulfate was associated with improved pulmonary function in children but not adults, and reduced hospital admissions in children.
- Nebulised magnesium sulfate showed weak evidence of improved pulmonary function in adults but no significant effects in children. It was also associated with weak evidence of reduced admissions in adults.
- Further trials are needed of intravenous magnesium sulfate in adults and nebulised magnesium sulfate in both adults and children to better establish their roles in acute asthma treatment.
Analgesia in patients with acute abdominal pain. the chochrane libery 2010Cirugias
This review evaluates evidence on the use of opioid analgesics for patients with acute abdominal pain (AAP) during the diagnostic process. The review identified 8 randomized controlled trials comparing opioid analgesia regimens to no analgesia in adults with AAP. The studies found that using opioid analgesics for AAP reduced pain intensity and improved patient comfort without increasing risks of diagnostic errors or inaccurate treatment decisions. The evidence therefore supports the use of opioid analgesics for AAP during diagnosis to improve patient outcomes without negatively impacting diagnostic accuracy.
This Cochrane review analyzed randomized controlled trials that assessed the effect of long-term modest reductions in salt intake on blood pressure. It found that in trials with individuals with elevated blood pressure (n=802), a median reduction in salt intake of 4.6 g/day resulted in a mean reduction in systolic blood pressure of 5.06 mmHg and diastolic blood pressure of 2.70 mmHg. In individuals with normal blood pressure (n=2220), a median salt reduction of 4.4 g/day reduced systolic blood pressure by 2.03 mmHg and diastolic blood pressure by 0.99 mmHg. The review also found a significant dose-response relationship between the magnitude of salt reduction
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis