No Free Lunch, Indeed: Three Years of Microservices at SoundCloud - Phil Calcadodistributed matters
SoundCloud is the largest repository of audio on the web, used by more than 200 million people every month, who upload more than 11 hours of audio every minute. Like so many others, we have migrated from a typical monolithic architecture to microservices. While the benefits brought by this style of SOA to our productivity and reliability are clear, the architecture required some non-obvious changes in the way we operate systems, and a way to tackle the overhead associated with having hundreds of small moving parts to serve every request. In this talk we’ll share the toolkit and strategy SoundCloud uses to keep its microservices explosion manageable. What do we do about the operations overhead? How to spread devops skills across teams to support the “you build it, you run it” vision? How to deal with breaking changes and asynchronous behaviours? How to deal with chatty interactions? Which protocol? How do I even get a diagram telling me how all this stuff is put together?
The video for this presentation is available on our Youtube channel:
https://youtube.com/allceuseducation A continuing education course for this presentation can be found at https://www.allceus.com/member/cart/index/index?c=
Using aromatherapy, meditation and guided imagery in the treatment of addiction, anxiety, depression
OSCON: Advanced Docker developer workflows on Mac OS and WindowsDocker, Inc.
with Anil Madhavapeddy and Richard Mortier
Most developers use a Mac or Windows host to develop Docker Linux containers. This normally requires the installation of a Linux virtual machine as well as a complicated setup that includes a local networked filesystem for sharing data between the host and the Linux container, including UID mapping and case sensitivity, with inotify often being unreliable into the container; replicating Linux networking configuration locally to reflect the structure of the deployed microservices on the local laptop; and maintaining a separate Linux virtual machine and hypervisor such as VirtualBox, leading to heavyweight resource usage on a developer laptop.
Anil Madhavapeddy and Richard Mortier outline various methods to make using Docker on a Mac OS or Windows laptop as transparent as possible to the developer, including build scenarios from the conventional (Compose-based web stacks) to the deep end of systems (unikernel compilation) to the multi-CPU architecture (cross-compiling ARM containers on a normal Mac or Windows host).
No nosso negócio, informação é ouro! Leia nosso FAQ e tire todas as suas dúvidas sobre este grande negócio que está se iniciando no Brasil, mas que conquistará o mundo todo em pouco tempo.
Para maiores informações, acesse:
www.minerglobal.wordpress.com
Welcome
http://www.winwithmdc.com/strawberrydaily
Welcome http://www.HempWorxBizOp.com/strawberrydaily
Gift Save more,share and win more Hotels,Flights,Cruise,Car Rentals,Vacation Packages
Welcome http://www.TravelWithCashBack.com/strawberrydaily
Welcome
http://www.winwithmdc.com/strawberrydaily
Welcome http://www.HempWorxBizOp.com/strawberrydaily
Gift Save more,share and win more Hotels,Flights,Cruise,Car Rentals,Vacation Packages
Welcome http://www.TravelWithCashBack.com/strawberrydaily
Revolutionary Online Marketing
a global debt-free company founded in 2006 desiring to see the world a happier, healthier, more financially secure and free place – was built on two ideals… Freedom and Sharing. Our products and business opportunity are easy to use and have great potential to improve lives around the world.
Join Jeunesse http://joinjeunesseglobal.com
Like my Facebook page https://www.facebook.com/building4success
Friend me in Facebook http://alexfbwall.com
Jeunesse Global Reviews
Jeunesse Global Products
Jeunesse Product Review
Jeunesse Global International
Jeunesse Global
Jeunesse Global Business Opportunity
What is Jeunesse
Jeunesse Global Compensation Plan
Jeunesse Global Distributor
Jeunesse Global Team
Jeunesse Global Scam
Jeunesse Skin Care Products
Jeunesse Skin Care
Jeunesse Nutrition
Best 10 Skin Care Products
Anti Aging Skin Care Products
Dermatologist Skin Care Products
Best 10 Skin Care Companies
Top 10 Face Care Products
Best Skin Care Line
MyBoomDirect - Our concept is simple, 20% of investments are offered to our members BoomDirect partner companies in web advertising. We create professional marketing campaigns, Google Adwords, YouTube Ads, Facebook Ads, Adsense etc ... in exchange for advertising our partner companies share their profits with BoomDirect and we redistribute more than 80% of those profits to our members in the form of virtual shares.
No Free Lunch, Indeed: Three Years of Microservices at SoundCloud - Phil Calcadodistributed matters
SoundCloud is the largest repository of audio on the web, used by more than 200 million people every month, who upload more than 11 hours of audio every minute. Like so many others, we have migrated from a typical monolithic architecture to microservices. While the benefits brought by this style of SOA to our productivity and reliability are clear, the architecture required some non-obvious changes in the way we operate systems, and a way to tackle the overhead associated with having hundreds of small moving parts to serve every request. In this talk we’ll share the toolkit and strategy SoundCloud uses to keep its microservices explosion manageable. What do we do about the operations overhead? How to spread devops skills across teams to support the “you build it, you run it” vision? How to deal with breaking changes and asynchronous behaviours? How to deal with chatty interactions? Which protocol? How do I even get a diagram telling me how all this stuff is put together?
The video for this presentation is available on our Youtube channel:
https://youtube.com/allceuseducation A continuing education course for this presentation can be found at https://www.allceus.com/member/cart/index/index?c=
Using aromatherapy, meditation and guided imagery in the treatment of addiction, anxiety, depression
OSCON: Advanced Docker developer workflows on Mac OS and WindowsDocker, Inc.
with Anil Madhavapeddy and Richard Mortier
Most developers use a Mac or Windows host to develop Docker Linux containers. This normally requires the installation of a Linux virtual machine as well as a complicated setup that includes a local networked filesystem for sharing data between the host and the Linux container, including UID mapping and case sensitivity, with inotify often being unreliable into the container; replicating Linux networking configuration locally to reflect the structure of the deployed microservices on the local laptop; and maintaining a separate Linux virtual machine and hypervisor such as VirtualBox, leading to heavyweight resource usage on a developer laptop.
Anil Madhavapeddy and Richard Mortier outline various methods to make using Docker on a Mac OS or Windows laptop as transparent as possible to the developer, including build scenarios from the conventional (Compose-based web stacks) to the deep end of systems (unikernel compilation) to the multi-CPU architecture (cross-compiling ARM containers on a normal Mac or Windows host).
No nosso negócio, informação é ouro! Leia nosso FAQ e tire todas as suas dúvidas sobre este grande negócio que está se iniciando no Brasil, mas que conquistará o mundo todo em pouco tempo.
Para maiores informações, acesse:
www.minerglobal.wordpress.com
Welcome
http://www.winwithmdc.com/strawberrydaily
Welcome http://www.HempWorxBizOp.com/strawberrydaily
Gift Save more,share and win more Hotels,Flights,Cruise,Car Rentals,Vacation Packages
Welcome http://www.TravelWithCashBack.com/strawberrydaily
Welcome
http://www.winwithmdc.com/strawberrydaily
Welcome http://www.HempWorxBizOp.com/strawberrydaily
Gift Save more,share and win more Hotels,Flights,Cruise,Car Rentals,Vacation Packages
Welcome http://www.TravelWithCashBack.com/strawberrydaily
Revolutionary Online Marketing
a global debt-free company founded in 2006 desiring to see the world a happier, healthier, more financially secure and free place – was built on two ideals… Freedom and Sharing. Our products and business opportunity are easy to use and have great potential to improve lives around the world.
Join Jeunesse http://joinjeunesseglobal.com
Like my Facebook page https://www.facebook.com/building4success
Friend me in Facebook http://alexfbwall.com
Jeunesse Global Reviews
Jeunesse Global Products
Jeunesse Product Review
Jeunesse Global International
Jeunesse Global
Jeunesse Global Business Opportunity
What is Jeunesse
Jeunesse Global Compensation Plan
Jeunesse Global Distributor
Jeunesse Global Team
Jeunesse Global Scam
Jeunesse Skin Care Products
Jeunesse Skin Care
Jeunesse Nutrition
Best 10 Skin Care Products
Anti Aging Skin Care Products
Dermatologist Skin Care Products
Best 10 Skin Care Companies
Top 10 Face Care Products
Best Skin Care Line
MyBoomDirect - Our concept is simple, 20% of investments are offered to our members BoomDirect partner companies in web advertising. We create professional marketing campaigns, Google Adwords, YouTube Ads, Facebook Ads, Adsense etc ... in exchange for advertising our partner companies share their profits with BoomDirect and we redistribute more than 80% of those profits to our members in the form of virtual shares.
DIGITAL INDIA REVOLUTION –NEXMONEY-angel09SNEH LATA
https://play.google.com/store/apps/details?id=com.nexgen.nexmoney&referrer=angel09
refer id:angel09
1) Save upto 10% (Guaranteed) of Your Living Expenses from the Usage of Utility Services like Jio, Airtel, Tata sky, Hotels, Bus, Flight.... Bookings + Amazon, Flipkart, Myntra, Tatacliq, Big Basket.....Lots of Brands.
2) Earn as much as you can just Referring NEXMONEY® App to Your Nears & Dears.
Approved Startup by Govt. of India
Life Time Membership Fee - ₹1500+270 (GST) = ₹1,770/- (No Renewal)
for more details:https://onlinenexmoney.blogspot.com
contact at:only whatsapp no:9643087409,call at:9560460531
Visit http://MyQnanza.com/offlineedge for all the details on how to earn while others save and business owners in your local area profit by getting new customers without any upfront cost or risk.
Profit sharing company where you can get profit share in company by clicking 10 ads in 24 hours join free for one month only you have to purchase one CP in the first month
#revenueshare
#advertisingpays
#profitshare
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
3. www.magic10marketing.com 3
STEP 1: BUY AT LEAST 1 PRODUCT
$
PRODUCT COST
$15 USD for product
$5 for shipping and
handling ($10 INTL)
$15.00
BUY 1 PRODUCT
This will be the only out-
of-pocket expense
necessary to participate
in Part 1 of the
Marketing Opportunity.
HASSLE-FREE
ENROLLMENT
No one is required to enroll
others into our program to
receive $0.60 USD on each
product purchased in your
personal 5x5 Forced Matrix.
$0.60
4. www.magic10marketing.com 4
5 X 5 FORCED MATRIX
Compensation Plan
If and when your personal 5x5 Forced Matrix is full, you could have a
whole team of distributors creating commissions for you every month.
Up to
3,905
Independent
Distributors
Level 5
Up to 3,125 people x
$0.60
qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq
*$5 USA, $10 INTL
Level 1
Up to 5 people x
$0.60 per product
purchased
Level 2
Up to 25 people x
$0.60
qqqqq qqqqq qqqqq qqqqq qqqqq
per product
purchased
qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq
Level 3
Up to 125 people x
$0.60 per product
purchased
You buy at least one
product each month
$15 + Shipping and
Handling*
qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq
Level 4
Up to 625 people x
$0.60per product
purchased
per product
purchased
5. www.magic10marketing.com 5
Earn money the easy way
RECEIVE MONEY
Every time a product
is purchased in your
5x5 Forced Matrix,
you will automatically
receive $0.60 in your
E-Wallet.
$0.60
for every
product
purchased
in your
5x5
Forced Matrix
E-WALLET RESERVE
From the money received, $2
will be held in your E-Wallet
Reserve to pay for your monthly
website marketing and
maintenance fee. There will also
be a $20 USA/$25 INTL product
fee deducted from your E-Wallet
Reserve each month the Reserve
is met.*
$22
Monthly
GET PAID
All commissions that are
received above and beyond the
E-Wallet Reserve can be
requested at any time after your
Reserve requirements have
been met in a month.
Commissions can be paid
weekly by check or PayPal
($2.95 processing fee).
$
Above
Reserve
E-WALLET FOR COMMISSIONS
*If for any reason you do not receive $20 in commissions within a month, your E-Wallet Reserve will simply accumulate until the
necessary funds are earned. Once this happens, it will trigger your website fee and next product purchase. You will not be penalized or
lose your spot in the 5x5 Forced Matrix if this happens. Fees do not accumulate and your account will not go into the negative.
6. www.magic10marketing.com 6
PART 1 RECAP
1. You will receive $0.60 USD per every product purchased within your
personal 5x5 Forced Matrix
2. All money received will go directly into your E-Wallet
3. You agree to allow the company to withhold $2 USD each month from your
E-Wallet as a website marketing and maintenance fee
4. You agree to allow the company to reserve $20 USD (USA)/$25 USD (INTL)
from your E-Wallet for your monthly product purchase
5. All compensation accumulated in your E-Wallet in excess of the monthly
Reserve requirements is available for withdrawal by check or PayPal
transfer ($2.95 processing fee).
6. It’s understood that you will not be penalized in any way if you do not have
enough money in your E-Wallet Reserve to cover your monthly website fee
or product purchase. The company will wait until you have received the
necessary funds and start the process over again.
DISCLAIMER
Earning and Income statements made by Magic 10 Marketing, Inc. and its customers are estimates of what we think you can
possibly earn. There is no guarantee that you will make these levels of income and you accept the risk that the earnings and income
statements differ by individual. As with any business, your results may vary, and will be based on your individual capacity, business
experience, expertise, and level of desire. There are no guarantees concerning the level of success you may experience.
7. www.magic10marketing.com 7
PART 1 REVIEW
It is understood by the company and the individual that by purchasing
at least one product, the individual has no more out-of-pocket
expense to participate in Part 1 of our company. Each individual can
receive what has been explained in Part 1, so long as they agree to the
Terms and Conditions and all E-Wallet Reserve requirements have
been met.
Most of you are probably wondering how people will fall into your 5x5
Forced Matrix without anyone being required to purchase more than
one product out of pocket.
Part 2 is our Leadership Opportunity
Magic 10 Marketing has created a Leadership Program for people who
are passionate about the Marketing Opportunity and want substantial
earning potential. If you want to participate in Part 2 of our program
and enroll additional Independent Distributors into the Forced Matrix,
then continue with the presentation.
.
9. www.magic10marketing.com 9
BONUS LEVEL 1
A qualified position
ENROLL 2
Qualify by personally enrolling 2
new people into the company who
purchase at least one product each
PURCHASE 2
Qualify by personally purchasing 2 products
each month for retail sale. Products can be
drafted from your E-Wallet instead of being
paid for out of pocket if you wish.
EARN 20% BONUS COMMISSION
qqqqq
Pays 20% bonus override on commissions received by Level 1 people in
your 5x5 Forced Matrix as illustrated in Part 1 (up to 5 people)
10. www.magic10marketing.com 10
BONUS LEVEL 2
A qualified position
ENROLL 4
Qualify by personally enrolling 4 total
new people into the company who
purchase at least one product each
PURCHASE 4
Qualify by personally purchasing 4
products each month for retail sale.
Products can be drafted from your E-
Wallet instead of being paid for out
of pocket if you wish.
EARN 20% BONUS COMMISSION
qqqqq qqqqq qqqqq qqqqq qqqqq
Pays 20% bonus override on commissions received by Level 2 people in
your 5x5 Forced Matrix as illustrated in Part 1 (up to 25 people)
11. www.magic10marketing.com 11
BONUS LEVEL 3
A qualified position
ENROLL 6
Qualify by personally enrolling 6 total
new people into the company who
purchase at least one product each
PURCHASE 6
Qualify by personally purchasing 6
products each month for retail sale.
Products can be drafted from your E-
Wallet instead of being paid for out of
pocket if you wish.
EARN 20% BONUS COMMISSION
qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq
Pays 20% bonus override on commissions received by Level 3 people in
your 5x5 Forced Matrix as illustrated in Part 1 (up to 125 people)
12. www.magic10marketing.com 12
BONUS LEVEL 4
A qualified position
ENROLL 8
Qualify by personally enrolling 8
total new people into the company
who purchase at least one product
each
PURCHASE 8
Qualify by personally purchasing 8
products each month for retail sale.
Products can be drafted from your E-
Wallet instead of being paid for out of
pocket if you wish.
EARN 20% BONUS COMMISSION
qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq
qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq
qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq
qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq
qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq qqqqq
Pays 20% bonus override on commissions received by Level 4 people in
your 5x5 Forced Matrix as illustrated in Part 1 (up to 625 people)
14. www.magic10marketing.com 14
PART 2 RECAP
1. You can potentially earn 20% commission on all the people
within your 5x5 Forced Matrix so long as you meet the
minimum requirements for each Bonus Level.
2. You agree to pay the $2 monthly website fee and all costs
of purchasing product for retail sale as required by each
Bonus Level.
3. It is understood that after a person sponsors enough
people to participate in our Bonus Levels, he or she can
purchase the desired amount of products to qualify
immediately or they can wait to earn the money to
purchase the products to qualify at a later date through
their E-Wallet. The E-Wallet Reserve can be set to reflect
the required amount
DISCLAIMER
Earning and Income statements made by Magic 10 Marketing, Inc. and its customers are estimates of what we think you can
possibly earn. There is no guarantee that you will make these levels of income and you accept the risk that the earnings and income
statements differ by individual. As with any business, your results may vary, and will be based on your individual capacity, business
experience, expertise, and level of desire. There are no guarantees concerning the level of success you may experience.
16. www.magic10marketing.com 16
GLOBAL BONUS POOLS
We have 4 Global Bonus Pools
GLOBAL BONUS POOL 1
You share $0.20 from each
sale worldwide daily. You
must personally enroll 25
people to qualify and meet
minimum monthly
requirements.
25 50
GLOBAL BONUS POOL 2
You share $0.20 from each
sale worldwide daily. You
must personally enroll 50
people to qualify and meet
minimum monthly
requirements.
100
GLOBAL BONUS POOL 3
You share $0.20 from each
sale worldwide daily. You
must personally enroll 100
people to qualify and meet
minimum monthly
requirements.
200
GLOBAL BONUS POOL 4
You share $0.20 from each
sale worldwide daily. You
must personally enroll 200
people to qualify and meet
minimum monthly
requirements.
100,000 members in the company
who purchase at least one product
each would generate $20,000 in each
Global Bonus Pool. This would be split
evenly between every Global Leader
who qualifies. Global Bonus Pools are
computed daily.
Example:
18. www.magic10marketing.com 18
5 X 5 FORCED MATRIX
How does it work?
It all starts with
YOU
$15
Make money
from above with
SPILLOVER
New Distributors
Placed from Left to Right
5 per line
Your 5x5 Forced Matrix
will begin to
GROW
Organization Grows
When others recruit you make
Commission
.60 .60 .60 .60 .60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
q.60
Your Recruits
Shown in
RED
Spillover is a
benefit of
enrollment from
upline
qqqqq qqqqq qqqqqqqqqq qqqqq
qqqqq qqqqq qqqqq qqqqq qqqqq
After First Line is Full
A new referral will go to first
available spot under the first
available person from
left to right
If you recruit again
This spot will round robin to
the next person in your first
line (for their first line) until
your second line is full
If Second Line is Full
This spot goes to the next
available spot in your next
person’s first row.
*$5 USA, $10 INTL
+ Shipping and
Handling*
If and when your personal 5x5 Forced Matrix is full, you could have a
whole team of distributors creating commissions for you every month.
Up to
3,905
Independent
Distributors
19. www.magic10marketing.com 19
BONUS LEVEL 1 MATCHING BONUSES
Explained
A
A
Matching Bonuses
Receive a 20% matching
bonus for upto 5 people
on Level 1
1
2
3
4
5
6
B
C
D
E
F
A 0.60 = $0.60
B A
B 0.60 + 0.12 = $0.72
C A
C 0.60 + 0.12 = $0.72
D A
D 0.60 + 0.12 = $0.72
E A
E 0.60 + 0.12 = $0.72
A
F 0.12 = $0.12
20. www.magic10marketing.com 20
BONUS LEVEL 2 MATCHING BONUSES
Explained
A
1
2
3
4
5
6
7
B
C
D
E
F
G
A
A 0.60 = $0.60
B A
B 0.60 + 0.12 = $0.72
C B A
C 0.60 + 0.12 + 0.12 = $0.84
D B A
D 0.60 + 0.12 + 0.12 = $0.84
E B A
E 0.60 + 0.12 + 0.12 = $0.84
B A
F 0.12 + 0.12 = $0.24
Matching Bonuses
Receive a 20% matching
bonus for upto 25 people
on Level 2
A
G 0.12 = $0.12
21. www.magic10marketing.com 21
BONUS LEVEL 3 MATCHING BONUSES
Explained
A
1
2
3
4
5
6
7
8
B
C
D
E
F
G
A
A 0.60 = $0.60
B A
B 0.60 + 0.12 = $0.72
C B A
C 0.60 + 0.12 + 0.12 = $0.84
D C B A
D 0.60 + 0.12 + 0.12 + 0.12 = $0.96
E C B A
E 0.60 + 0.12 + 0.12 + 0.12 = $0.96
C B A
F 0.12 + 0.12 + 0.12 = $0.36
Matching Bonuses
Receive a 20% matching
bonus for upto 125 people
on Level 3
C B
G 0.12 + 0.12 = $0.24
H
C
H 0.12 = $0.12
22. www.magic10marketing.com 22
BONUS LEVEL 4 MATCHING BONUSES
Explained
A
1
2
3
4
5
B
C
D
A
A 0.60 = $0.60
B A
B 0.60 + 0.12 = $0.72
C B A
C 0.60 + 0.12 + 0.12 = $0.84
D C B A
D 0.60 + 0.12 + 0.12 + 0.12 = $0.96
E D C B A
E 0.60 + 0.12 + 0.12 + 0.12 + 0.12 = $1.08
D C B A
F 0.12 + 0.12 + 0.12 + 0.12 = $0.48
Matching Bonuses
Receive a 20% matching
bonus for upto 625 people
on Level 4
D C B
G 0.12 + 0.12 + 0.12 = $0.36
D C
H 0.12 + 0.12 = $0.24
6
7
8
9
E
F
G
D
I 0.12 = $0.12
H
I
23. www.magic10marketing.com 23
BONUS LEVEL 5 MATCHING BONUSES
Explained
A
1
2
3
4
5
B
C
D
A
A 0.60 = $0.60
B A
B 0.60 + 0.12 = $0.72
C B A
C 0.60 + 0.12 + 0.12 = $0.84
D C B A
D 0.60 + 0.12 + 0.12 + 0.12 = $0.96
E D C B A
E 0.60 + 0.12 + 0.12 + 0.12 + 0.12 = $1.08
E D C B A
F 0.12 + 0.12 + 0.12 + 0.12 + 0.12 = $0.60
Matching Bonuses
Receive a 20% matching
bonus for upto 3,125 people
on Level 5
E D C B
G 0.12 + 0.12 + 0.12 + 0.12 = $0.48
E D C
H 0.12 + 0.12 + 0.12 = $0.36
6
7
8
9
10
F
E
G
H
E D
I 0.12 + 0.12 = $0.24I
E
J 0.12 = $0.12J
24. www.magic10marketing.com 24
DISCLOSURE
We make every effort to ensure that we accurately represent these products and
services and their potential for income. Earning and Income statements made by
Magic 10 Marketing, Inc. and its customers are estimates of what we think you can
possibly earn. There is no guarantee that you will make these levels of income and
you accept the risk that the earnings and income statements differ by individual. As
with any business, your results may vary, and will be based on your individual
capacity, business experience, expertise, and level of desire. There are no
guarantees concerning the level of success you may experience. The testimonials
and examples used are exceptional results, which do not apply to the average
purchaser, and are not intended to represent or guarantee that anyone will achieve
the same or similar results. Each individual’s success depends on his or her
background, dedication, desire and motivation. There is no assurance that
examples of past earnings can be duplicated in the future. We cannot guarantee
your future results and/or success. There are some unknown risks in business and
on the internet that we cannot foresee which can reduce results. We are not
responsible for your actions.
The use of our information, products and services should be based on your own due
diligence and you agree that our company is not liable for any success or failure of
your business that is directly or indirectly related to the purchase and use of our
information, products and services.