The Madrid Protocol allows trademark owners to protect their marks across multiple countries by filing one international application instead of separate applications in each country. It is administered by the World Intellectual Property Organization and became effective in the US in 2003. Under the Madrid Protocol, applicants can file for an international registration of their trademark with WIPO to automatically extend protection to the other 79 member countries if no refusals are issued within 18 months. This provides a more cost-effective way for individuals, businesses, and other entities to protect their trademarks internationally.