This document summarizes information about the drug "Krokodile" or desomorphine. It is a synthetic opioid that first emerged in Russia in 2002. It is made from a combination of codeine, gasoline, paint thinner, iodine, and red phosphorus. It is much cheaper to produce than heroin but highly toxic and addictive. Use of krokodile typically results in death within 1-3 years due to issues such as infections, gangrene, and organ damage. It has spread among impoverished drug users in Russia and nearby regions due to low costs but comes with severe health risks.
La desomorfina (conocida también como dihidrodesoximorfina o por su antiguo nombre comercial, Permonid) es un análogo de opiáceo inventado en 1932 en la Unión Soviética. Es un derivado de la morfina, en el cual se ha eliminado el grupo 6-hidroxilo y se ha reducido el doble enlace.
Hendricks, la velle a new synthetic drug ije v2 n1 2014William Kritsonis
William Allan Kritsonis, Editor-in-Chief, NATIONAL FORUM JOURNALS (Founded 1982). Dr. LaVelle Henricks, Texas A&M University-Commerce and colleagues published in national refereed journal.
Dr. William Allan Kritsonis, Distinguished Alumnus, Central Washington University, College of Education and Professional Studies, Ellensburg, Washington; Invited Guest Lecturer, Oxford Round Table, University of Oxford, United Kingdom; Hall of Honor, Prairie View A&M University/Member of the Texas A&M University System.
La desomorfina (conocida también como dihidrodesoximorfina o por su antiguo nombre comercial, Permonid) es un análogo de opiáceo inventado en 1932 en la Unión Soviética. Es un derivado de la morfina, en el cual se ha eliminado el grupo 6-hidroxilo y se ha reducido el doble enlace.
Hendricks, la velle a new synthetic drug ije v2 n1 2014William Kritsonis
William Allan Kritsonis, Editor-in-Chief, NATIONAL FORUM JOURNALS (Founded 1982). Dr. LaVelle Henricks, Texas A&M University-Commerce and colleagues published in national refereed journal.
Dr. William Allan Kritsonis, Distinguished Alumnus, Central Washington University, College of Education and Professional Studies, Ellensburg, Washington; Invited Guest Lecturer, Oxford Round Table, University of Oxford, United Kingdom; Hall of Honor, Prairie View A&M University/Member of the Texas A&M University System.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
2. 'Krokodile' apareció en
Rusia en 2002 y se fue
instalando entre los
consumidores de drogas
de menos poder
adquisitivo.
Era barata y parecía
heroína, aunque sus
efectos psicotrópicos
duran apenas dos horas.
3.
4. La esperanza de vida es
menos de tres años.
Muerte por envenenamiento
de la
sangre, meningitis, neumonía
o, literalmente, podridos.
Las autoridades
alemanas, después de
descubrir los primeros
casos, advirtieron que una
simple dosis es suficiente
para matar.
5. Alemania
Según los datos del Observatorio Europeo de
Drogas y Toxicomanías, los casos descubiertos
en Europa occidental, por su escaso número, son
anecdóticos, pero las autoridades de la ciudad
alemana de Bochum tienen censados al menos a
cuatro personas afectadas. Y Axel
Pütter, portavoz de la policía de Bochum, dijo a
la agencia AFP que tienen conocimiento de
casos "por toda Alemania".
6.
7. Rusia
Según estimaciones de la prensa rusa, habría
más de un millón de adictos -entre ellos más de
100.000 menores de 18 años, todos con una tasa
de mortalidad mucho mayor que otros
consumidores de drogas.
Adicción a heroina mata 30, 000 personas al
año.
8. krokodile
En Rusia su expansión parece incontenible.
People literally rot to death.
Mr Ivanov recalled a recent visit to a drug-
treatment centre in Western Siberia. "They
told me that two years ago almost all their
drug users used heroin," said the drugs tsar.
"Now, more than half of them are on
desomorphine."
9. Mezcla de
heroína, gasolina, codeína, disolvente para
pintura, yodo y fósforo rojo. Según los
países, cuesta de tres a diez veces menos que la
heroína y todos sus componentes son fáciles de
comprar en el mercado legal.
10. "Over the past five years, sales of codeine-based
tablets have grown by dozens of times," says
Viktor Ivanov, the head of Russia's Drug Control
Agency. "It's pretty obvious that it's not because
everyone has suddenly developed headaches."
11. La Heroina cuesta 20-50 euros por dosis, al
sintetizarla se puede obtener por 2 euros.
"If you miss the vein, that's an abscess straight
away," says Sasha.
"She won't go to hospital, she just keeps
injecting. Her flesh is falling off and she can
hardly move anymore," says Sasha.
12. Russia tiene dos millones de usuarios de
heroina, el mayor número en el mundo.
"With heroin withdrawal, the main symptoms
last for five to 10 days. After that there is still a
big danger of relapse but the physical pain will
be gone. With krokodil, the pain can last up to a
month, and it's unbearable. They have to be
injected with extremely strong tranquilisers just
to keep them from passing out from the pain."
13. 5% de consumidores de droga rusos aprox.
10 000 adictos consumen krokodile.
No se necesita receta para comprar codeina.
14. Dr Yegorov says krokodil users are instantly
identifiable because of their smell. "It's that
smell of iodine that infuses all their clothes," he
says. "There's no way to wash it out, all you can
do is burn the clothes. Any flat that has been
used as a krokodil cooking house is best
forgotten about as a place to live. You'll never
get that smell out of the flat.”
15. Most krokodil users inject the
drug only when they run out of
money for heroin. As soon as
they earn or steal enough, they
go back to heroin. In other
more isolated regions of
Russia, where heroin is more
expensive and people are
poorer, the problem is worse.
People become full-time
krokodil addicts, giving them a
life expectancy of less than a
year.
16. "You can feel how disgusting it
is when you're doing it," he
recalls. "You're dreaming of
heroin, of something that feels
clean and not like poison. But
you can't afford it, so you keep
doing the krokodil. Until you
die."
17.
18. Krokodil":revival of an old
drug with new problems.
Autor: Gahr, Maximilian; Freudenmann, Roland W;
Hiemke, Christoph; Gunst, Ingo M; Connemann, Bernhard J;
Información de publicación: Substance use & misuse 47. 7 (June
2012): 861-863.
Resumen: In order to summarize current knowledge about the drug
"Krokodil" a systematic review including a iterature search of the
databases PubMed, Embase, Scopus, and Google was conducted in
December 2011.
According to information acquired, "Krokodil" is a mixture of several
substances and was first reported to have been used in Russia in
2003.
The core agent of "Krokodil" is desomorphine, an opioid-analogue
that can be easily and cheaply manufactured by oneself. Self-
production results in a contaminated suspension that is injected
intravenously. Due to its pharmacologic features, desomorphine
shows a high potential to cause dependence.
19. Emerging drug in Ukraine:
“Crocodile” desomorphine
Category: Epidemiology
Year: 2012
P. Smyrnov, S. Tatyana. International HIV/AIDS Alliance, Ukraine
Background: During a series of interviews with drug users conducted
in July 2011 in Kyiv, Ukraine, many respondents mentioned
desomorphine as a new popular street drug.
Street desomorphine (named “crocodile”) is prepared by users from
codeine-containing pills, red phosphorus, and iodine. This drug is very
popular in neighboring Russia, but fewer reports on its use were
received from Ukraine.
Conclusion: Analysis of data from the BSS conducted in Ukraine in
2011 suggests that in the drug scene in Ukraine, crocodile has
become a popular drug of choice; especially in some cities, it is
important to monitor its use and adjust harm reduction interventions
accordingly.