Kawasaki Disease (KD) is an acute inflammatory syndrome that predominantly affects children. It is characterized by fever and changes in the mouth, hands, and feet. Important complications include coronary artery dilation and aneurysm formation if left untreated. While the cause is unknown, it is suspected to be infectious in nature and to involve an immunological component. Treatment aims to reduce the risk of heart complications and involves high doses of intravenous immunoglobulin and aspirin.
3. clinical features of Kawasaki disease Peeling and erythema of the fingertips. Strawberry tongue. http://emedicine.medscape.com/article/804960-overview
10. Pathogenesis Proposed role of S100 proteins (myeloid-related protein [MRP]-8, MRP-14, and S100A12) in the genesis and maintenance of the vasculitis in Kawasaki disease.
11. Pathogenesis The net result of S100 protein binding is platelet aggregation and adherence to endothelium.