The document discusses the process of critically appraising a journal article by asking six key questions: 1) what is the clinical question? 2) why was the question asked? 3) what methods were used? 4) what were the results? 5) what conclusions were drawn? 6) how should the information be applied? It emphasizes evaluating validity, bias, and significance to determine if the study changes clinical practice. The anatomy of a scientific article and tips for organizing a review are also reviewed.