Jesse Xiao at the Data Publishing session at CODATA2017: Updates to the GigaDB open access data publishing platform. Wednesday 11th October in St Petersburg, Russia
Tutorial: Describing Datasets with the Health Care and Life Sciences Communit...Alasdair Gray
Access to consistent, high-quality metadata is critical to finding, understanding, and reusing scientific data. However, while there are many relevant vocabularies for the annotation of a dataset, none sufficiently captures all the necessary metadata. This prevents uniform indexing and querying of dataset repositories. Towards providing a practical guide for producing a high quality description of biomedical datasets, the W3C Semantic Web for Health Care and the Life Sciences Interest Group (HCLSIG) identified Resource Description Framework (RDF) vocabularies that could be used to specify common metadata elements and their value sets. The resulting HCLS community profile covers elements of description, identification, attribution, versioning, provenance, and content summarization. The HCLS community profile reuses existing vocabularies, and is intended to meet key functional requirements including indexing, discovery, exchange, query, and retrieval of datasets, thereby enabling the publication of FAIR data. The resulting metadata profile is generic and could be used by other domains with an interest in providing machine readable descriptions of versioned datasets. The goal of this tutorial is to explain elements of the HCLS community profile and to enable users to craft and validate descriptions for datasets of interest.
Supporting Dataset Descriptions in the Life SciencesAlasdair Gray
Machine processable descriptions of datasets can help make data more FAIR; that is Findable, Accessible, Interoperable, and Reusable. However, there are a variety of metadata profiles for describing datasets, some specific to the life sciences and others more generic in their focus. Each profile has its own set of properties and requirements as to which must be provided and which are more optional. Developing a dataset description for a given dataset to conform to a specific metadata profile is a challenging process.
In this talk, I will give an overview of some of the dataset description specifications that are available. I will discuss the difficulties in writing a dataset description that conforms to a profile and the tooling that I've developed to support dataset publishers in creating metadata description and validating them against a chosen specification.
Seminar talk given at the EBI on 5 April 2017
The HCLS Community Profile: Describing Datasets, Versions, and DistributionsAlasdair Gray
Access to consistent, high-quality metadata is critical to finding, understanding, and reusing scientific data. However, while there are many relevant vocabularies for the annotation of a dataset, none sufficiently captures all the necessary metadata. This prevents uniform indexing and querying of dataset repositories. Towards providing a practical guide for producing a high quality description of biomedical datasets, the W3C Semantic Web for Health Care and the Life Sciences Interest Group (HCLSIG) identified Resource Description Framework (RDF) vocabularies that could be used to specify common metadata elements and their value sets. The resulting HCLS community profile covers elements of description, identification, attribution, versioning, provenance, and content summarization. The HCLS community profile reuses existing vocabularies, and is intended to meet key functional requirements including indexing, discovery, exchange, query, and retrieval of datasets, thereby enabling the publication of FAIR data. The resulting metadata profile is generic and could be used by other domains with an interest in providing machine readable descriptions of versioned datasets.
The goal of this presentation is to give an overview of the HCLS Community Profile and explain how it extends and builds upon other approaches.
Presentation given at SDSVoc (https://www.w3.org/2016/11/sdsvoc/)
FAIR Computational Workflows
Computational workflows capture precise descriptions of the steps and data dependencies needed to carry out computational data pipelines, analysis and simulations in many areas of Science, including the Life Sciences. The use of computational workflows to manage these multi-step computational processes has accelerated in the past few years driven by the need for scalable data processing, the exchange of processing know-how, and the desire for more reproducible (or at least transparent) and quality assured processing methods. The SARS-CoV-2 pandemic has significantly highlighted the value of workflows.
This increased interest in workflows has been matched by the number of workflow management systems available to scientists (Galaxy, Snakemake, Nextflow and 270+ more) and the number of workflow services like registries and monitors. There is also recognition that workflows are first class, publishable Research Objects just as data are. They deserve their own FAIR (Findable, Accessible, Interoperable, Reusable) principles and services that cater for their dual roles as explicit method description and software method execution [1]. To promote long-term usability and uptake by the scientific community, workflows (as well as the tools that integrate them) should become FAIR+R(eproducible), and citable so that author’s credit is attributed fairly and accurately.
The work on improving the FAIRness of workflows has already started and a whole ecosystem of tools, guidelines and best practices has been under development to reduce the time needed to adapt, reuse and extend existing scientific workflows. An example is the EOSC-Life Cluster of 13 European Biomedical Research Infrastructures which is developing a FAIR Workflow Collaboratory based on the ELIXIR Research Infrastructure for Life Science Data Tools ecosystem. While there are many tools for addressing different aspects of FAIR workflows, many challenges remain for describing, annotating, and exposing scientific workflows so that they can be found, understood and reused by other scientists.
This keynote will explore the FAIR principles for computational workflows in the Life Science using the EOSC-Life Workflow Collaboratory as an example.
[1] Carole Goble, Sarah Cohen-Boulakia, Stian Soiland-Reyes,Daniel Garijo, Yolanda Gil, Michael R. Crusoe, Kristian Peters, and Daniel Schober FAIR Computational Workflows Data Intelligence 2020 2:1-2, 108-121 https://doi.org/10.1162/dint_a_00033.
An Identifier Scheme for the Digitising Scotland ProjectAlasdair Gray
The Digitising Scotland project is having the vital records of Scotland transcribed from images of the original handwritten civil registers . Linking the resulting dataset of 24 million vital records covering the lives of 18 million people is a major challenge requiring improved record linkage techniques. Discussions within the multidisciplinary, widely distributed Digitising Scotland project team have been hampered by the teams in each of the institutions using their own identification scheme. To enable fruitful discussions within the Digitising Scotland team, we required a mechanism for uniquely identifying each individual represented on the certificates. From the identifier it should be possible to determine the type of certificate and the role each person played. We have devised a protocol to generate for any individual on the certificate a unique identifier, without using a computer, by exploiting the National Records of Scotland•À_s registration districts. Importantly, the approach does not rely on the handwritten content of the certificates which reduces the risk of the content being misread resulting in an incorrect identifier. The resulting identifier scheme has improved the internal discussions within the project. This paper discusses the rationale behind the chosen identifier scheme, and presents the format of the different identifiers. The work reported in the paper was supported by the British ESRC under grants ES/K00574X/1(Digitising Scotland) and ES/L007487/1 (Administrative Data Research Center - Scotland).
Tutorial: Describing Datasets with the Health Care and Life Sciences Communit...Alasdair Gray
Access to consistent, high-quality metadata is critical to finding, understanding, and reusing scientific data. However, while there are many relevant vocabularies for the annotation of a dataset, none sufficiently captures all the necessary metadata. This prevents uniform indexing and querying of dataset repositories. Towards providing a practical guide for producing a high quality description of biomedical datasets, the W3C Semantic Web for Health Care and the Life Sciences Interest Group (HCLSIG) identified Resource Description Framework (RDF) vocabularies that could be used to specify common metadata elements and their value sets. The resulting HCLS community profile covers elements of description, identification, attribution, versioning, provenance, and content summarization. The HCLS community profile reuses existing vocabularies, and is intended to meet key functional requirements including indexing, discovery, exchange, query, and retrieval of datasets, thereby enabling the publication of FAIR data. The resulting metadata profile is generic and could be used by other domains with an interest in providing machine readable descriptions of versioned datasets. The goal of this tutorial is to explain elements of the HCLS community profile and to enable users to craft and validate descriptions for datasets of interest.
Supporting Dataset Descriptions in the Life SciencesAlasdair Gray
Machine processable descriptions of datasets can help make data more FAIR; that is Findable, Accessible, Interoperable, and Reusable. However, there are a variety of metadata profiles for describing datasets, some specific to the life sciences and others more generic in their focus. Each profile has its own set of properties and requirements as to which must be provided and which are more optional. Developing a dataset description for a given dataset to conform to a specific metadata profile is a challenging process.
In this talk, I will give an overview of some of the dataset description specifications that are available. I will discuss the difficulties in writing a dataset description that conforms to a profile and the tooling that I've developed to support dataset publishers in creating metadata description and validating them against a chosen specification.
Seminar talk given at the EBI on 5 April 2017
The HCLS Community Profile: Describing Datasets, Versions, and DistributionsAlasdair Gray
Access to consistent, high-quality metadata is critical to finding, understanding, and reusing scientific data. However, while there are many relevant vocabularies for the annotation of a dataset, none sufficiently captures all the necessary metadata. This prevents uniform indexing and querying of dataset repositories. Towards providing a practical guide for producing a high quality description of biomedical datasets, the W3C Semantic Web for Health Care and the Life Sciences Interest Group (HCLSIG) identified Resource Description Framework (RDF) vocabularies that could be used to specify common metadata elements and their value sets. The resulting HCLS community profile covers elements of description, identification, attribution, versioning, provenance, and content summarization. The HCLS community profile reuses existing vocabularies, and is intended to meet key functional requirements including indexing, discovery, exchange, query, and retrieval of datasets, thereby enabling the publication of FAIR data. The resulting metadata profile is generic and could be used by other domains with an interest in providing machine readable descriptions of versioned datasets.
The goal of this presentation is to give an overview of the HCLS Community Profile and explain how it extends and builds upon other approaches.
Presentation given at SDSVoc (https://www.w3.org/2016/11/sdsvoc/)
FAIR Computational Workflows
Computational workflows capture precise descriptions of the steps and data dependencies needed to carry out computational data pipelines, analysis and simulations in many areas of Science, including the Life Sciences. The use of computational workflows to manage these multi-step computational processes has accelerated in the past few years driven by the need for scalable data processing, the exchange of processing know-how, and the desire for more reproducible (or at least transparent) and quality assured processing methods. The SARS-CoV-2 pandemic has significantly highlighted the value of workflows.
This increased interest in workflows has been matched by the number of workflow management systems available to scientists (Galaxy, Snakemake, Nextflow and 270+ more) and the number of workflow services like registries and monitors. There is also recognition that workflows are first class, publishable Research Objects just as data are. They deserve their own FAIR (Findable, Accessible, Interoperable, Reusable) principles and services that cater for their dual roles as explicit method description and software method execution [1]. To promote long-term usability and uptake by the scientific community, workflows (as well as the tools that integrate them) should become FAIR+R(eproducible), and citable so that author’s credit is attributed fairly and accurately.
The work on improving the FAIRness of workflows has already started and a whole ecosystem of tools, guidelines and best practices has been under development to reduce the time needed to adapt, reuse and extend existing scientific workflows. An example is the EOSC-Life Cluster of 13 European Biomedical Research Infrastructures which is developing a FAIR Workflow Collaboratory based on the ELIXIR Research Infrastructure for Life Science Data Tools ecosystem. While there are many tools for addressing different aspects of FAIR workflows, many challenges remain for describing, annotating, and exposing scientific workflows so that they can be found, understood and reused by other scientists.
This keynote will explore the FAIR principles for computational workflows in the Life Science using the EOSC-Life Workflow Collaboratory as an example.
[1] Carole Goble, Sarah Cohen-Boulakia, Stian Soiland-Reyes,Daniel Garijo, Yolanda Gil, Michael R. Crusoe, Kristian Peters, and Daniel Schober FAIR Computational Workflows Data Intelligence 2020 2:1-2, 108-121 https://doi.org/10.1162/dint_a_00033.
An Identifier Scheme for the Digitising Scotland ProjectAlasdair Gray
The Digitising Scotland project is having the vital records of Scotland transcribed from images of the original handwritten civil registers . Linking the resulting dataset of 24 million vital records covering the lives of 18 million people is a major challenge requiring improved record linkage techniques. Discussions within the multidisciplinary, widely distributed Digitising Scotland project team have been hampered by the teams in each of the institutions using their own identification scheme. To enable fruitful discussions within the Digitising Scotland team, we required a mechanism for uniquely identifying each individual represented on the certificates. From the identifier it should be possible to determine the type of certificate and the role each person played. We have devised a protocol to generate for any individual on the certificate a unique identifier, without using a computer, by exploiting the National Records of Scotland•À_s registration districts. Importantly, the approach does not rely on the handwritten content of the certificates which reduces the risk of the content being misread resulting in an incorrect identifier. The resulting identifier scheme has improved the internal discussions within the project. This paper discusses the rationale behind the chosen identifier scheme, and presents the format of the different identifiers. The work reported in the paper was supported by the British ESRC under grants ES/K00574X/1(Digitising Scotland) and ES/L007487/1 (Administrative Data Research Center - Scotland).
The swings and roundabouts of a decade of fun and games with Research Objects Carole Goble
Research Objects and their instantiation as RO-Crate: motivation, explanation, examples, history and lessons, and opportunities for scholarly communications, delivered virtually to 17th Italian Research Conference on Digital Libraries
presented at WORKS 2021
https://works-workshop.org/
16th Workshop on Workflows in Support of Large-Scale Science
November 15, 2021
Held in conjunction with SC21: The International Conference for High Performance Computing, Networking, Storage and Analysis
This a talk that I gave at BioIT World West on March 12, 2019. The talk was called: A Gen3 Perspective of Disparate Data:From Pipelines in Data Commons to AI in Data Ecosystems.
RO-Crate: A framework for packaging research products into FAIR Research ObjectsCarole Goble
RO-Crate: A framework for packaging research products into FAIR Research Objects presented to Research Data Alliance RDA Data Fabric/GEDE FAIR Digital Object meeting. 2021-02-25
This is an overview of the Data Biosphere Project, its goals, its architecture, and the three core projects that form its foundation. We also discuss data commons.
What is Data Commons and How Can Your Organization Build One?Robert Grossman
This is a talk that I gave at the Molecular Medicine Tri Conference on data commons and data sharing to accelerate research discoveries and improve patient outcomes. It also covers how your organization can build a data commons using the Open Commons Consortium's Data Commons Framework and the University of Chicago's Gen3 data commons platform.
Crossing the Analytics Chasm and Getting the Models You Developed DeployedRobert Grossman
There are two cultures in data science and analytics - those that develop analytic models and those that deploy analytic models into operational systems. In this talk, we review the life cycle of analytic models and provide an overview of some of the approaches that have been developed for managing analytic models and workflows and for deploying them, including using analytic engines and analytic containers . We give a quick overview of languages for analytic models (PMML) and analytic workflows (PFA). We also describe the emerging discipline of AnalyticOps that has borrowed some of the techniques of DevOps.
FAIR Workflows and Research Objects get a Workout Carole Goble
So, you want to build a pan-national digital space for bioscience data and methods? That works with a bunch of pre-existing data repositories and processing platforms? So you can share FAIR workflows and move them between services? Package them up with data and other stuff (or just package up data for that matter)? How? WorkflowHub (https://workflowhub.eu) and RO-Crate Research Objects (https://www.researchobject.org/ro-crate) that’s how! A step towards FAIR Digital Objects gets a workout.
Presented at DataVerse Community Meeting 2021
Written and presented by Tom Ingraham (F1000), at the Reproducible and Citable Data and Model Workshop, in Warnemünde, Germany. September 14th -16th 2015.
Publishing your research: Research Data Management (Introduction) Jamie Bisset
Publishing your research: Research Data Management (Introduction) (November 2013) slides. Delivered as part of the Durham University Researcher Development Programme. Further Training available at https://www.dur.ac.uk/library/research/training/
CEDAR is a metadata management tool that lets user define metadata templates using a well described yet flexible metdata format. CEDAR then presents the forms represented by those templates to other users to fill out. CEDAR offers semantic precision (with support from the BioPortal ontology repository), metadata completion assistance, intelligent recommendations, support for JSON-LD and RDF metadata export, and an easy-to-use user interface.
Better software, better service, better research: The Software Sustainabilit...Carole Goble
Ever spotted some great looking software only to discover you can’t get it, it doesn’t work, there is no documentation to help fix it and the developers don’t have the time or incentive to help? Ever produced some software that you want to be widely used or have folks contribute? What’s the sustainability of that key platform/library/tool /database your lab uses day in and day out? Are you helping the providers? The same issues stand for Data (or as we now say “FAIR” Findable, Accessible, Interoperable, Reusable Data) and its metadata. Is anyone looking out for Europe’s data services– the datasets and analysis systems you use and you make – the standards they use and the curators and developers who make them? Or is FAIR just a FAIRy story? I’ll tell how two organisations with quite different structures and approaches - the UK’s Software Sustainability Institute and the ELIXIR European Research Infrastructure for Life Science Data – are working for the common goal of better software, better service, and better research.
https://www.rothamsted.ac.uk/events/14th-international-symposium-integrative-bioinformatics
A Big Picture in Research Data ManagementCarole Goble
A personal view of the big picture in Research Data Management, given at GFBio - de.NBI Summer School 2018 Riding the Data Life Cycle! Braunschweig Integrated Centre of Systems Biology (BRICS), 03 - 07 September 2018
Scott Edmunds: A new publishing workflow for rapid dissemination of genomes u...GigaScience, BGI Hong Kong
Scott Edmunds on a new publishing workflow for rapid dissemination of genomes using GigaByte & GigaDB. Presented at Biodiversity 2020 in the Annotation & Databases track, 9th October 2020.
GUODA: A Unified Platform for Large-Scale Computational Research on Open-Acce...Matthew J Collins
Part of the Global Unified Open Data Architecture (GUODA) infrastructure hosted at iDigBio is providing Jupyter Notebooks to biodiversity researchers to facilitate analyzing large datasets with Apache Spark. This talk was delivered at the TDWG 2016 Annual Conference in Santa Clara de San Carlos, Costa Rica.
Scott Edmunds flashtalk on "Rewarding Reproducibility and Method Publishing the GigaScience Way" from Beyond the PDF 2 "Making it Happen" session. 20/3/13
The swings and roundabouts of a decade of fun and games with Research Objects Carole Goble
Research Objects and their instantiation as RO-Crate: motivation, explanation, examples, history and lessons, and opportunities for scholarly communications, delivered virtually to 17th Italian Research Conference on Digital Libraries
presented at WORKS 2021
https://works-workshop.org/
16th Workshop on Workflows in Support of Large-Scale Science
November 15, 2021
Held in conjunction with SC21: The International Conference for High Performance Computing, Networking, Storage and Analysis
This a talk that I gave at BioIT World West on March 12, 2019. The talk was called: A Gen3 Perspective of Disparate Data:From Pipelines in Data Commons to AI in Data Ecosystems.
RO-Crate: A framework for packaging research products into FAIR Research ObjectsCarole Goble
RO-Crate: A framework for packaging research products into FAIR Research Objects presented to Research Data Alliance RDA Data Fabric/GEDE FAIR Digital Object meeting. 2021-02-25
This is an overview of the Data Biosphere Project, its goals, its architecture, and the three core projects that form its foundation. We also discuss data commons.
What is Data Commons and How Can Your Organization Build One?Robert Grossman
This is a talk that I gave at the Molecular Medicine Tri Conference on data commons and data sharing to accelerate research discoveries and improve patient outcomes. It also covers how your organization can build a data commons using the Open Commons Consortium's Data Commons Framework and the University of Chicago's Gen3 data commons platform.
Crossing the Analytics Chasm and Getting the Models You Developed DeployedRobert Grossman
There are two cultures in data science and analytics - those that develop analytic models and those that deploy analytic models into operational systems. In this talk, we review the life cycle of analytic models and provide an overview of some of the approaches that have been developed for managing analytic models and workflows and for deploying them, including using analytic engines and analytic containers . We give a quick overview of languages for analytic models (PMML) and analytic workflows (PFA). We also describe the emerging discipline of AnalyticOps that has borrowed some of the techniques of DevOps.
FAIR Workflows and Research Objects get a Workout Carole Goble
So, you want to build a pan-national digital space for bioscience data and methods? That works with a bunch of pre-existing data repositories and processing platforms? So you can share FAIR workflows and move them between services? Package them up with data and other stuff (or just package up data for that matter)? How? WorkflowHub (https://workflowhub.eu) and RO-Crate Research Objects (https://www.researchobject.org/ro-crate) that’s how! A step towards FAIR Digital Objects gets a workout.
Presented at DataVerse Community Meeting 2021
Written and presented by Tom Ingraham (F1000), at the Reproducible and Citable Data and Model Workshop, in Warnemünde, Germany. September 14th -16th 2015.
Publishing your research: Research Data Management (Introduction) Jamie Bisset
Publishing your research: Research Data Management (Introduction) (November 2013) slides. Delivered as part of the Durham University Researcher Development Programme. Further Training available at https://www.dur.ac.uk/library/research/training/
CEDAR is a metadata management tool that lets user define metadata templates using a well described yet flexible metdata format. CEDAR then presents the forms represented by those templates to other users to fill out. CEDAR offers semantic precision (with support from the BioPortal ontology repository), metadata completion assistance, intelligent recommendations, support for JSON-LD and RDF metadata export, and an easy-to-use user interface.
Better software, better service, better research: The Software Sustainabilit...Carole Goble
Ever spotted some great looking software only to discover you can’t get it, it doesn’t work, there is no documentation to help fix it and the developers don’t have the time or incentive to help? Ever produced some software that you want to be widely used or have folks contribute? What’s the sustainability of that key platform/library/tool /database your lab uses day in and day out? Are you helping the providers? The same issues stand for Data (or as we now say “FAIR” Findable, Accessible, Interoperable, Reusable Data) and its metadata. Is anyone looking out for Europe’s data services– the datasets and analysis systems you use and you make – the standards they use and the curators and developers who make them? Or is FAIR just a FAIRy story? I’ll tell how two organisations with quite different structures and approaches - the UK’s Software Sustainability Institute and the ELIXIR European Research Infrastructure for Life Science Data – are working for the common goal of better software, better service, and better research.
https://www.rothamsted.ac.uk/events/14th-international-symposium-integrative-bioinformatics
A Big Picture in Research Data ManagementCarole Goble
A personal view of the big picture in Research Data Management, given at GFBio - de.NBI Summer School 2018 Riding the Data Life Cycle! Braunschweig Integrated Centre of Systems Biology (BRICS), 03 - 07 September 2018
Scott Edmunds: A new publishing workflow for rapid dissemination of genomes u...GigaScience, BGI Hong Kong
Scott Edmunds on a new publishing workflow for rapid dissemination of genomes using GigaByte & GigaDB. Presented at Biodiversity 2020 in the Annotation & Databases track, 9th October 2020.
GUODA: A Unified Platform for Large-Scale Computational Research on Open-Acce...Matthew J Collins
Part of the Global Unified Open Data Architecture (GUODA) infrastructure hosted at iDigBio is providing Jupyter Notebooks to biodiversity researchers to facilitate analyzing large datasets with Apache Spark. This talk was delivered at the TDWG 2016 Annual Conference in Santa Clara de San Carlos, Costa Rica.
Scott Edmunds flashtalk on "Rewarding Reproducibility and Method Publishing the GigaScience Way" from Beyond the PDF 2 "Making it Happen" session. 20/3/13
IDW2022: A decades experiences in transparent and interactive publication of ...GigaScience, BGI Hong Kong
Scott Edmunds at International Data Week 2022: A decades experiences in transparent and interactive publication of FAIR data and software via an end-to-end XML publishing platform. 21st June 2022
The global need to securely derive (instant) insights, have motivated data architectures from distributed storage, to data lakes, data warehouses and lake-houses. In this talk we describe Tag.bio, a next generation data mesh platform that embeds vital elements such as domain centricity/ownership, Data as Products, Self-serve architecture, with a federated computational layer. Tag.bio data products combine data sets, smart APIs, statistical and machine learning algorithms into decentralized data products for users to discover insights using FAIR Principles. Researchers can use its point and click (no-code) system to instantly perform analysis and share versioned, reproducible results. The platform combines a dynamic cohort builder with analysis protocols and applications (low-code) to drive complex analysis workflows. Applications within data products are fully customizable via R and Python plugins (pro-code), and the platform supports notebook based developer environments with individual workspaces.
Join us for a talk/demo session on Tag.bio data mesh platform and learn how major pharma industries and university health systems are using this technology to promote value based healthcare, precision healthcare, find cures for disease, and promote collaboration (without explicitly moving data around). The talk also outlines Tag.bio secure data exchange features for real world evidence datasets, privacy centric data products (confidential computing) as well as integration with cloud services
German Conference on Bioinformatics 2021
https://gcb2021.de/
FAIR Computational Workflows
Computational workflows capture precise descriptions of the steps and data dependencies needed to carry out computational data pipelines, analysis and simulations in many areas of Science, including the Life Sciences. The use of computational workflows to manage these multi-step computational processes has accelerated in the past few years driven by the need for scalable data processing, the exchange of processing know-how, and the desire for more reproducible (or at least transparent) and quality assured processing methods. The SARS-CoV-2 pandemic has significantly highlighted the value of workflows.
This increased interest in workflows has been matched by the number of workflow management systems available to scientists (Galaxy, Snakemake, Nextflow and 270+ more) and the number of workflow services like registries and monitors. There is also recognition that workflows are first class, publishable Research Objects just as data are. They deserve their own FAIR (Findable, Accessible, Interoperable, Reusable) principles and services that cater for their dual roles as explicit method description and software method execution [1]. To promote long-term usability and uptake by the scientific community, workflows (as well as the tools that integrate them) should become FAIR+R(eproducible), and citable so that author’s credit is attributed fairly and accurately.
The work on improving the FAIRness of workflows has already started and a whole ecosystem of tools, guidelines and best practices has been under development to reduce the time needed to adapt, reuse and extend existing scientific workflows. An example is the EOSC-Life Cluster of 13 European Biomedical Research Infrastructures which is developing a FAIR Workflow Collaboratory based on the ELIXIR Research Infrastructure for Life Science Data Tools ecosystem. While there are many tools for addressing different aspects of FAIR workflows, many challenges remain for describing, annotating, and exposing scientific workflows so that they can be found, understood and reused by other scientists.
This keynote will explore the FAIR principles for computational workflows in the Life Science using the EOSC-Life Workflow Collaboratory as an example.
[1] Carole Goble, Sarah Cohen-Boulakia, Stian Soiland-Reyes,Daniel Garijo, Yolanda Gil, Michael R. Crusoe, Kristian Peters, and Daniel Schober FAIR Computational Workflows Data Intelligence 2020 2:1-2, 108-121 https://doi.org/10.1162/dint_a_00033.
Science Services and Science Platforms: Using the Cloud to Accelerate and Dem...Ian Foster
Ever more data- and compute-intensive science makes computing increasingly important for research. But for advanced computing infrastructure to benefit more than the scientific 1%, we need new delivery methods that slash access costs, new sustainability models beyond direct research funding, and new platform capabilities to accelerate the development of new, interoperable tools and services.
The Globus team has been working towards these goals since 2010. We have developed software-as-a-service methods that move complex and time-consuming research IT tasks out of the lab and into the cloud, thus greatly reducing the expertise and resources required to use them. We have demonstrated a subscription-based funding model that engages research institutions in supporting service operations. And we are now also showing how the platform services that underpin Globus applications can accelerate the development and use of an integrated ecosystem of advanced science applications, such as NCAR’s Research Data Archive and OSG Connect, thus enabling access to powerful data and compute resources by many more people than is possible today.
In this talk, I introduce Globus services and the underlying Globus platform. I present representative applications and discuss opportunities that this platform presents for both small science and large facilities.
BioThings API: Promoting Best-practices via a Biomedical API Development Ecos...Chunlei Wu
Overview of BioThings project (https://biothings.io) with the highlight of BioThings Studio tool, a web development environment for building Biomedical APIs
GBIF in one slide
Where is the infrastructure in GBIF?
Physical infrastructure
Information infrastructure
Capability infrastructure
Infrastructure usage
In this session we will explore how Google's Cloud services (CloudML, Vision, Genomics API) can be used to process genomic and phenotypic data and solve problems in healthcare and agriculture.
STM Week: Demonstrating bringing publications to life via an End-to-end XML p...GigaScience, BGI Hong Kong
Scott Edmunds at the STM Week 2020 Digital Publishing seminar on Demonstrating bringing publications to life via an End-to-end XML publishing platform. 2nd December 2020
This is a talk I gave at a Northwestern University - Complete Genomics Workshop on April 21, 2011 about using clouds to support research in genomics and related areas.
ImageJ2 is a new version of ImageJ for the next generation of multidimensional image data, with a focus on scientific imaging. Its central goal is to broaden the paradigm of ImageJ beyond the limitations of ImageJ 1.x, to support the next generation of multidimensional scientific imaging.
ImageJ2 is more than just an application: it is also a collection of reusable software libraries built on the SciJava software stack, using a powerful plugin framework to facilitate rapid development and painless user customization.
This talk provides an overview of the motivation behind the ImageJ2 project and related SciJava software projects, and quickly covers some of ImageJ2's current features.
GBIF web services for biodiversity data, for USDA GRIN, Washington DC, USA (2...Dag Endresen
Presentation of GBIF and the sharing of biodiversity data with web services. USDA GRIN Beltsville Washington DC, 13th December 2005. GBIF is the Global Biodiversity Information Facility for free and open access to biodiversity data.
Similar to Jesse Xiao at CODATA2017: Updates to the GigaDB open access data publishing platform (20)
GigaByte Chief Editor Scott Edmunds presents on how to prepare a data paper for the TDR and WHO sponsored call for data papers describing datasets on vectors of human diseases launched in Nov 2021. Presented at the GBIF webinar on 25th January 2022 and aimed at authors interested in submitting a manuscript submitted to the series.
Scott Edmunds: Quantifying how FAIR is Hong Kong: The Hong Kong Shareability ...GigaScience, BGI Hong Kong
Scot Edmunds talk at CODATA2019 on Quantifying how FAIR is Hong Kong: The Hong Kong Shareability of Hong Kong University Research Experiment. 19th September 2019 in Beijing
Scott Edmunds talk at IARC: How can we make science more trustworthy and FAIR...GigaScience, BGI Hong Kong
Scott Edmunds talk at IARC, Lyon. How can we make science more trustworthy and FAIR? Principled publishing for more evidence based research. 8th July 2019
PAGAsia19 - The Digitalization of Ruili Botanical Garden Project: Production...GigaScience, BGI Hong Kong
A 3 part talk presented at PAG Asia 2019 in Shenzhen- The Digitalization of Ruili Botanical Garden Project: Production, Curation and Re-Use. Presented by Huan Liu (CNGB), Scott Edmunds (GigaScience) & Stephen Tsui (CUHK). 8th June 2019
Democratising biodiversity and genomics research: open and citizen science to...GigaScience, BGI Hong Kong
Scott Edmunds at the China National GeneBank Youth Biodiversity MegaData Forum: Democratising biodiversity and genomics research: open and citizen science to build trust and fill the data gaps. 18th December 2018
Ricardo Wurmus at #ICG13: Reproducible genomics analysis pipelines with GNU Guix. Presented at the GigaScience Prize Track at the International Conference on Genomics, Shezhen 26th October 2018
Paul Pavlidis at #ICG13: Monitoring changes in the Gene Ontology and their im...GigaScience, BGI Hong Kong
Paul Pavlidis talk at the #ICG13 GigaScience Prize Track: Monitoring changes in the Gene Ontology and their impact on genomic data analysis (GOtrack). Shenzhen, 26th October 2018
Stefan Prost at #ICG13: Genome analyses show strong selection on coloration, ...GigaScience, BGI Hong Kong
Stefan Prost presentation for the #ICG13 GigaScience Prize Track: Genome analyses show strong selection on coloration, morphological and behavioral phenotypes in birds-of-paradise. Shenzhen, 26th October, 2018
Lisa Johnson at #ICG13: Re-assembly, quality evaluation, and annotation of 67...GigaScience, BGI Hong Kong
Lisa Johnson's talk at the #ICG13 GigaScience Prize Track: Re-assembly, quality evaluation, and annotation of 678 microbial eukaryotic reference transcriptomes. Shenzhen, 26th October 2018
Reproducible method and benchmarking publishing for the data (and evidence) d...GigaScience, BGI Hong Kong
Scott Edmunds presentation on: Reproducible method and benchmarking publishing for the data (and evidence) driven era. The Silk Road Forensics Conference, Yantai, 18th September 2018
Mary Ann Tuli: What MODs can learn from Journals – a GigaDB curator’s perspec...GigaScience, BGI Hong Kong
Mary Ann Tuli's talk at the International Society of Biocuration meeting : What MODs can learn from Journals – a GigaDB curator’s perspective. Shanghai 9th April 2018
Laurie Goodman: Sharing and Reusing Cell Image Data, ASCB/EMBO 2017 Subgroup ...GigaScience, BGI Hong Kong
Laurie Goodman's pre-prepared slides for the Subgroup S Sharing and Reusing Cell Image Data session at the 2017 ASCB│EMBO meeting in Philadelphia. December 2017
Susanna Sansone's talk at the "Beyond Open" Knowledge Dialogues/Open Data Hong Kong event on research data, hosted at the Hong Kong Innocentre on Monday 20 November 2017.
Jie Zheng at #ICG12: PhenoSpD: an atlas of phenotypic correlations and a mult...GigaScience, BGI Hong Kong
Jie Zheng at the #ICG12 GigaScience Prize Track: PhenoSpD: an atlas of phenotypic correlations and a multiple testing correction for the human phenome. ICG12, Shenzhen, 26th October 2017
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
The ASGCT Annual Meeting was packed with exciting progress in the field advan...
Jesse Xiao at CODATA2017: Updates to the GigaDB open access data publishing platform
1. Updates to the GigaDB open
access data publishing platform
Jesse Xiao
Jesse@gigasciencejournal.com
ORCID ID:0000-0003-3408-2852
2. About the Journal
GigaScience is an open access, open data,
open peer-review journal focusing on ‘big
data’ research from the life and biomedical
sciences
3. What is the point of publishing?
• To disseminate
information/knowledge/ideas.
• To present material so it can be
reasonably assessed for its level of
quality (and interest).
• To gain credit for career advancement.
4. Kahn, Goodman, & Mittleman. Dragging Scientific Publishing into the 21st Century 2014
http://genomebiology.com/2014/15/12/556
From Journal Delivery to PDF Delivery
5. Lack of Data and Software Availability
Impacts Reproducibility
1. Ioannidis et al., (2009). Repeatability of published microarray gene expression analyses. Nature Genetics 41: 14
2. Ioannidis JPA (2005) Why Most Published Research Findings Are False. PLoS Med 2(8)
Out of 18 microarray papers, results
from 10 could not be reproduced
6. Deconstructing a paper into accessible,
useable, trackable, interlinked units
Need to provide credit to
reward sharing and proper
organization of:
• Narrative
• Data/Metadata
availability/curation
• Software availability
• Interoperability
• Availability of workflows
• Transparent analyses
Data/
MetaData
Software
Methods
Narrative
7. Deconstructing a paper into accessible,
useable, trackable, interlinked units
Currently we provide credit
for this:
• Narrative
• Data/Metadata
availability/curation
• Software availability
• Interoperability
• Availability of workflows
• Transparent analyses
Data/
MetaData
Software
Methods
Narrative
Sometimes we publish these
as Methods Papers
12. FAIR DATA in GigaDB
Findable Accessible Interoperable Reusable
13. Findable
We have 373 published datasets in GigaDB,
& around 30 TB data. Every dataset has a DOI
and the individual dataset page.
Provides powerful search engine
and API search function
e.g.
http://gigadb.org/api/search
14. Accessible
All data in GigaDB can be accessed in the public ftp server.
We provide three stable ftp sites in 2 geographic locations (HK & Shenzhen)
1. ftp://penguin.genomics.cn // The main ftp server
2. ftp://ftp.cngb.org/pub/gigadb/ // The mirror ftp server in the cloud
3. ftp://ftp2.cngb.org/pub/gigadb// The mirror ftp server in the cloud
Download Speed
We are working with China National Gene Bank and will to use UDP protocol software
(Data Expedition) to provide faster data download speed.
The source code for all software and tools published in GigaDB can access in the Github
https://github.com/gigascience
15. Accessible via API
We provide a REST API to allow user retrieve and search all metadata held in GigaDB.
The current API returns result in XML (the XML file based on the database schema), and
we plan to have the option to also return results in JSON or ISA2.0-JSON in our next
version
16. Accessible via API
The website
http://www.gigadb.org/site/help#0
.1_API provides detailed
instructions on how to use the
GigaDB API
18. First journal with deep integration with
Launched 2nd June 2016
Reward better handling of “wet” protocols…
• Create, share, modify forkeable protocols in repo.
• Download & run on smartphone app.
• Get discoverability, credit, DOIs for sharing methods.
• Create your own, or let us set up & you claim.
http://protocols.io/
19. The GigaDB dataset page embeds
the protocol.io in the iframe.
e.g. RNA extraction protocol
20. Interoperable and reusable
GigaDB provides an online submission wizard and excel spreadsheet to help
users curate their own metadata
21. https://codeocean.com/
Cloud-based executable research platform
Browse, share & run code on AWS
Creates compute capsule: encapsulation of
the data, code, and computation
environment
Integration into the paper, share via DOIs
First examples published in GigaScience
Integrated plugin into GigaDB
Share your code this way!
Interoperable and reusable
24. How FAIR can we get?
Data sets
Analyses
Open-Paper
Open-Review
DOI:10.1186/2047-217X-1-18
>50,000 accesses
& >1000 citations
Open-Code
7 reviewers tested data in ftp server & named reports published
DOI:10.5524/100044
Open-Pipelines
Open-Workflows
DOI:10.5524/100038
Open-Data
78GB CC0 data
Code in sourceforge under GPLv3: http://soapdenovo2.sourceforge.net/
>40,000 downloads
Enabled code to being picked apart by bloggers in wiki
http://homolog.us/wiki/index.php?title=SOAPdenovo2
27. www.gigasciencejournal.com
Give us your data, papers
& pipelines
Help GigaPanda
make it happen!
editorial@gigasciencejournal.com
database@gigasciencejournal.com
Contact us:
28. Thanks to:
Laurie Goodman, Editor in Chief
Nicole Nogoy, Editor
Hans Zauner, Assistant Editor
Peter Li, Lead Data Manager
Chris Hunter, Lead BioCurator
Xiao (Jesse) Si Zhe, Database Developer
Chen Qi, Shenzhen Office.
All of BGI
@GigaScience
facebook.com/GigaScience
gigasciencejournal.com/blog/
Follow us:
www.gigasciencejournal.com
www.gigadb.org
+
Weibo
& WeChat
Editor's Notes
9
Quantified this in a case study (still found some small errors)