Jayslide

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This short poem expresses how a father is always someone to admire and respect, even as a child grows up and becomes taller than their father. It also notes that while a mother holds their child's hand for a brief time, they hold their child's heart forever in their lifetime.

Dad, you're someone to look up to no
matter how tall I've grown.

Mothers hold their child's hand for a
moment, and their heart for a
lifetime.

Seminar led by Rui Moreno, MD, PhD, from the Hospital de Santo António dos Capuchos Unidad de Cuidados Intensivos Polivalente Centro Hospitalar de Lisboa Central- Portugal. Abstract: The impact of SSC 2012 on the planning and evaluation of my hospital's performance Â The 2012 revision of the Surviving Sepsis Guidelines, together with the new sepsis bundles, will, have a profound impact on the evaluation of the performance of health care systems dealing with the recognition and early treatment of the patient with severe sepsis and septic shock. Â With the application and evaluation of the new bundles (now at 3 hours and 6 hours after triage), most of the evaluation will focus in the very early stages of the process of care, when in a significant number of patients will be still in the Emergency Department (ED). This constitutes a major change when compared to the 2008 revision of the SSC, since at that time part of the evaluation was done after 24 hours of diagnosis, when most of the patients was already on the ICU. Â An immediate consequence of this will be a major pressure on the ED and in the early connection of the ED with the ICU. This will can be done by creating dedicated admission pathways to patients with suspected severe sepsis and septic shock, to the presence of intensivists on the ED or even to the direct admission (by-passing the ED) to the ICU of theses patients. More than focusing in new therapies, the 2012 revision of the SSC will put the emphasis on the planning and creation of systems able to work fast and flexibly, delivering fast care where it is needed more.Â Only systems of care able to control and deal with these timing problems will be in condition to offer first quality care to the patient with severe sepsis and septic shock and consequently to have a good evaluation of their performance.

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Impacte de la sepsia greu a Catalunya

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Es constata un increment de la incidència de sèpsia greu a Catalunya també observat en la majoria de països. L’envelliment de la població i el conseqüent augment de la pluripatologia podrien influir en aquesta tendència. Tot i això, la mortalitat disminueix, probablement per la millora de les tècniques assistencials a les unitats de cures intensives i la utilització de guies de pràctica clínica, entre d’altres factors. Cal doncs, adreçar els esforços per a afavorir la detecció precoç de la sèpsia greu i la instauració, al més aviat possible, del tractament necessari en el lloc més adequat

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A99c92136e05179ebe7fe1b2cf4dce74MICHELE SILVA

La infección activa (IA) por el CMV es frecuente en el paciente crítico sin inmunosupresión canónica (0-55% de los pacientes seropositivos para el CMV). Esta es comúnmente el resultado de la reactivación viral en el tracto respiratorio inferior, sin que pueda descartarse la reinfección como origen, en algunos casos. La IA por el CMV se ha asociado consistentemente con una mayor mortalidad, especialmente relacionada con el desarrollo de ALI/ARDS, una estancia en UCI más prolongada, una mayor duración del período de ventilación mecánica y un riesgo mayor de “superinfección” bacteriana y fúngica. No existen, sin embargo, vínculos incontestables de causalidad. Solo un ensayo clínico controlado puede precisar el papel del CMV como agente patogénico en este grupo de pacientes. En este seminario se tratarán los siguientes temas: (i) posible patogenia de la infección por el CMV en el paciente crítico; (ii) ensayos clínicos de tratamiento antiviral en marcha; (iii) factores biológicos (genómicos e inmunológicos) de riesgo para el desarrollo de IA en estos pacientes.

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*Watch the video at the end of the presentation Seminar led by Dr. Xavier de la Cruz, ICREA Research Professor. Head of the Translational Bioinformatics in Neuroscience group of VHIR, at VHIR (22nd November 2012). Content: The need to identify the pathological character of mutations may arise in different contexts in biomedical research. However, the methods available to address this problem essentially depend on the number of cases under analysis. When we work with only a few mutations we can use an artisan-like approach, where all information available on protein sequence, structure and function is manually retrieved and studied. However, when we need to characterize many variants, as can be the case in exome projects, faster methods are required to assess their pathogenicity. In my talk I will illustrate the principles underlying these two approaches with examples from the study of Fabry disease mutations, resulting from our collaborative work at the VHIR.

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La recerca bàsica i traslacional en malalties rares és fonamental per entendre la fisiologia humana i per desenvolupar teràpies innovadores sovint útils també per malalties molt més prevalents. L’anèmia de Fanconi, caracteritzada per disfunció de la medul·la òssia i predisposició tumoral, n’és un exemple edificant. El primer transplantament de cordó umbilical de la història de la medicina fou en un pacient Fanconi. El primer nen medicament va néixer per curar un pacient Fanconi. El primer cop que s’han generat teixits sans per auto-transplantament curant, desprogramant i re-diferenciant cèl·lules de la pell d’un malalt ha estat en anèmia de Fanconi. I els primers assajos clínics de teràpia gènica s’estan desenvolupat també en malalties de la sang com l’anèmia de Fanconi. Aquests són alguns exemples de com l’estudi de malalties rares por transcendir més enllà del pacient afecte en benefici de tota la societat.

Human Cell Line Authentication. Why is it so important?

Vall d'Hebron Institute of Research (VHIR)

The differences between a cow and a monkey are clear. It is easy to tell a moth from a mosquito. So why are there still scientific studies that mix them up? The answer is simple: hundreds of cell lines stored and used by modern laboratories have been wrongly identified. Some pig cells are labelled as coming from a chicken; cell lines advertised as human have been shown to contain material from hamsters, rats, mice and monkeys. Problems have already been found with more than 400 cell lines. (Cited from Nature 520 (2015)). An increasing number of scientific publications (i.e. Nature journals) are now sistematically asking for cell line authentication at the moment of paper submission. To help researchers to meet this requirement, UAT is starting to offer a new service for human cell line authentication.

The Microcirculation in Sepsis

Vall d'Hebron Institute of Research (VHIR)

VHIR Seminar led by Daniel De Backer, PhD., from the Dpt of Intensive Care Erasme University Hospital Brussels - Belgium. Abstract: Multiple studies have shown that alterations in microcirculatory perfusion are frequently observed in patients with septic shock. These alterations are characterized by heterogeneity of perfusion with capillaries with stop flow in close vicinity to well perfused capillaries. What are the consequences of these alterations? The presence of stop flow capillaries favours development of zones of tissue hypoxia, even though total perfusion to the organ is preserved. In addition, the heterogeneity in perfusion is associated with inadequate matching of flow to metabolism and is hence less well tolerated by tissues than an homogeneous decrease in perfusion. In patients with septic shock, the severity of the microvascular alterations was associated with development of organ dysfunction and an increase risk of death. Different mechanisms have been implicated in the development of these alterations including loss of communication between vascular segments, impaired endothelial reactivity, alterations in red and white blood cells rheology, alteration in endothelial glycocalyx, platelet aggregation and microthrombosis. In view of the various mechanisms implicated in the development of these alterations, it is unlikely that therapies used in usual hemodynamic resuscitation. Novel therapies should aim at improving the matching of perfusion to metabolism rather than further increasing flow in the already perfused vessels or non selectively dilating microvessels.

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3. Dad, you're someone to look up to no matter how tall I've grown.

4. Mothers hold their child's hand for a moment, and their heart for a lifetime.

Jayslide

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