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Influence of Serum Levels of Vitamin D on Insulin Resistance in Patients with Type II Diabetes Mellitus.pptx
1. Influence of Serum Levels of Vitamin D on Insulin Resistance
in Patients with Type II Diabetes Mellitus
BY DR ARCHAN
DR CHEERYALA RAVI TEJA / AMUJALA MAHESH
MODERATOR : DR S.T.KALSAD
2. BACKGROUND
• Vitamin D plays an important role in bone and modulates mineral metabolism and immune
function with probable link to several chronic and infectious conditions.
• In vivo studies have revealed that vitamin D deficiency reduces insulin secretion capacity of the
islet beta cells in pancreas.
• Several studies have shown a correlation between vitamin D levels and insulin resistance,
nonetheless, extensive studies showing the relationship between the two are lacking especially
among southern Indian population.
• So the present study was aimed at evaluating the relationship between vitamin D and insulin
resistance by using homeostatic model assessment-insulin resistance (HOMA-IR).
3. OBJECTIVES
• To estimate vitamin D deficiency among diabetic and nondiabetic.
• To calculate insulin resistance between diabetic and nondiabetic.
• To correlate insulin resistance in vitamin D deficient and nondeficient
among the diabetic cases.
4.
5. MATERIALS AND METHODS
• Fasting serum insulin (I0), fasting plasma glucose (G0), hemoglobin
A1c (HbA1C), renal function test, liver function test (LFT), lipid profile,
and vitamin D levels were estimated.
• IBM SPSS version 22 was used for statistical analysis.
6. • STUDY DESIGN : cross-sectional study
• STUDY DURATION : 1 year
• STUDY POPULATION : A total of 184 people were recruited into the study, among which 92 were
diabetic and 92 were nondiabetic population.
• PLACE : RL Jalappa Hospital, Kolar.
• Inclusion criteria :
• Age >40 years.
• Newly diagnosed T2DM
• Type II diabetes already on oral hypoglycemic drugs.
Exclusion criteria :
Patients with hepatic, pancreatic, renal,
and bone diseases, malignancy, any
history of the use of drugs such as insulin,
anticonvulsants, calcium, and vitamin D.
7. RESULTS
• The prevalence of vitamin D deficiency in our study was (72) 78.2%
among diabetic cases and (59) 64.1% among the nondiabetic controls,
with the diabetic cases showing lower levels of vitamin D than the
controls, however, it was not statistically significant.
• There was no significant difference in homeostatic model assessment-
beta-cell function (HOMA-B) and HOMA-IR between vitamin D
deficient and nondeficient groups among cases and controls.
8. • LIMITATIONS :
• We have not gathered the current information of patient’s medication use.
• Observed levels of vitamin D can be due to their routine medications like thiazide diuretics
and some hypertension medications that are known to increase vitamin D levels.
CONCLUSION:
• Vitamin D deficiency is prevalent in both T2DM as well as nondiabetic.
• There is no association between vitamin D deficiency and insulin resistance
or beta-cell function.
