This document discusses the influence of vertical irregularities on the seismic response of reinforced concrete structures through nonlinear static (pushover) analysis. Five 17-story reinforced concrete building models with different vertical setback configurations are analyzed: one regular model and four models with increasing mass, stiffness and vertical setback irregularities. The results show that vertical irregularities reduce lateral load capacity and increase lateral displacement, base shear, and performance point compared to the regular structure. Plastic hinges form at different stages for each model based on their performance level. It is concluded that increasing vertical irregularities negatively impact seismic performance by decreasing flexural and shear strength demands.