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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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1. OVER PAGE (1st page)
PROJECT SHEET
SPECIAL TELEFOOD FUND
COUNTRY: CAMEROON
Project title: ______________________________________________________
Name of Beneficiary Group: __________________________________________
Project site (region, district, village, etc.) _________________________________
Planned start date: ___________________________________
Expected closing date: ___________________________
Budget (FAO contribution, in FCFA): ______________________
Name of the co-financing organization (if applicable):
__________________________________________________________________
Project links: _____________________________________________________
2. CONTENT OF THE PROJECT
1. Beneficiary group
Project targeting is essential for the success of a project. We will describe here the group (s)
of small farmers, shepherds, fishermen, manufacturers, or schools that will lead the project
and will benefit directly from it. This description must indicate the name of the group (or
school) and its site (name of the town or village, the date on which it was constituted /
organized, its purpose, the number of members (including the percentage women and / or
young people), etc.
Direct beneficiaries are those who participate in the project, on the one hand by contributing
financially or in kind to the community fund and on the other hand by receiving financial
benefits from the latter.
With regard to schools, orphanages and similar institutes, the benefits for the direct
beneficiaries (children) must be indicated very clearly in the project documentation and the
amount of their contribution (in terms of work) must also be specified. .
The description of direct beneficiaries should include their level of (economic) poverty and
their food security status. Parameters such as: Gross national product (GNP) / capita (if
available), income relative to the national poverty line (if available), family size, housing
conditions, land, other assets, etc., must be used as determining elements.
The proposal should also identify and assess the number of secondary (indirect)
beneficiaries - families or communities of people involved in the project - who will benefit
from the project, for example, through improved diets or 'purchase of agricultural products
from project activities.
2. General and justification of the project
This section should describe the geographic area concerned (site, climate, cropping system,
etc.). It will be necessary to highlight the poverty level of the beneficiary group and among
the problems of the beneficiary group, those that the project will seek to resolve. Any
development initiatives implemented by the government and local populations will also be
reported. We will also indicate the organizations, institutions or local NGOs participating
concretely (and / or financially) in the activities of the project, and we will illustrate their role.
Special attention will be given to FAO activities, more particularly those of FAO Programs -
MINADER / DOPA or other - in the project area, emphasizing the synergies between the
TeleFood project and the broader ongoing program.
3. Project objective
This section will describe, in a short and clear manner, the objective that the project is
expected to achieve. It could be for example "to help the members of the group (or of the
cooperative) to increase their production of fruits and vegetables", to "provide inputs to
improve the production of small animals", to "improve income by reducing post-harvest
losses in artisanal fisheries ", etc. The immediate objectives must be mentioned in concrete
and measurable terms.
The project should not promote the introduction of complex or particularly innovative
techniques, new to the community concerned or likely to be unsustainable. TeleFood cannot
be used to fund adaptive research or the dissemination of the latest techniques.
4. Description and duration of the Project
A very detailed description of the project is requested, clearly explaining how the project will
be carried out. All quantifiable project parameters should be included, for example: cultivated
area and description of crops, number of animals provided to each family, indication of how
tools and construction materials will be distributed among all beneficiaries, or managed
individually. Parameters like: yield per hectare, milk production per animal, egg production,
slaughter weight etc. Should be used to describe the quantities of products expected during
the first year of operation.
The duration of the project (i.e. from TeleFood fund to project), should be specified in the
proposal. The duration should not exceed 12 months. It should be mentioned in the project
documentation whether the project implementation period refers to: the sowing or harvesting
season, the rainy season, the fishing ban period, etc.
3. 5. Project activities or activity schedule
The proposal should contain a list of the main activities to be carried out month by month
(giving a precise timetable) to achieve the objective of the project. They should be presented
in the form of a simple work plan, indicating for each activity the entity that will have to
ensure its implementation and the period of execution.
6. Project Results
It will be necessary to indicate here the results that the project should allow to obtain. These
results should be tangible and measurable products of the activities undertaken under the
project, and compatible with the intended objectives. This could be, for example, the
establishment of a marketing system intended to open up more lucrative markets for
producers; establishing a low-cost post-harvest system to reduce crop losses; the
establishment of a fruit tree nursery of a certain size, well managed and the start of a
process of multiplication of the plants; the production, breeding and marketing of a certain
number of lambs or kids, etc. Unit selling prices must be mentioned.
7. Inputs / Budget or descriptive estimate
A detailed list of inputs will need to be drawn up. All inputs should, as far as possible, be
obtained locally (see above, in section B of the General Guidelines, for inputs which may or
may not be financed by TeleFood. (Ineligible inputs will delay, or prevent, approval of the
project proposal).
A detailed list of all inputs is required, including quantities and unit price. It refers to the
following supplies: building materials, tools, seeds, fertilizer, animal feed, veterinary
equipment, irrigation equipment, etc.
Exemple de plan de travail concernant un hypothétique projet d’apiculture (Il s'agit là d'un
exemple. Les responsabilités effectives peuvent différer d'un projet à l'autre, selon les nécessités).
- Organisation des bénéficiaires en groupe Bénéficiaires Mois 1
- Spécification du matériel et des fournitures Fonctionnaire National (Ministère) Mois 1
- Recherche de devis pour le matériel/fournitures FAO Mois 1
- Constitution d'un fonds communautaire Bénéficiaires Mois 1
- Commande du matériel et des fournitures FAO Mois 1 – 2
- Livraison du matériel et des fournitures FAO/Ministère Mois 3
- Construction et peinture des ruches Bénéficiaires Mois 3-4
- Préparation/présentation du rapport intérimaire Fonctionnaire National /FAO Mois 4
- Récolte du miel (ruches en exploitation) Bénéficiaires Mois 4 – 12
- Formation aux méthodes d'apiculture modernes FonctionnaireTechnique (Ministère)Mois 5
- Formation à la petite entreprise/commercialisation ONG collaborant au projet Mois 6
- Traitement du miel (ruches en exploitation) Bénéficiaires Mois 4 – 12
- Distribution et vente Bénéficiaires Mois 4 – 12
- Préparation/présentation du rapport final Fonctionnaire national /FAO Mois 13
Example of a work plan for a hypothetical beekeeping project (This is an example. The actual
responsibilities may differ from project to project, depending on the needs).
- Organization of beneficiaries as a group Beneficiaries Month 1
- Specification of equipment and supplies National Civil Servant (Ministry) Month 1
- Search for quotes for CAM equipment / supplies Month 1
- Constitution of a community fund Beneficiaries Month 1
- Order CAM equipment and supplies Months 1 - 2
- Delivery of equipment and supplies FAO / Ministry Month 3
- Construction and painting of beehives Beneficiaries Months 3-4
- Preparation / presentation of the interim report National Official / FAO Month 4
- Honey harvest (hives in operation) Beneficiaries Months 4 - 12
- Training in modern beekeeping methods Technical Officer (Ministry) Month 5
- Small business training / NGO marketing collaborating in the project Month 6
- Honey treatment (beehives in operation) Beneficiaries Months 4 - 12
- Distribution and sale Beneficiaries Months 4 - 12
- Preparation / presentation of the final report National official / FAO Month 13
4. The contribution of the group (s), for example in the form of labor, land, buildings or other
inputs, should be declared in the project proposal in order to indicate their degree of
commitment and level of participation. In the case of school vegetable gardens, the
participation of parents will be promoted.
A budget summary should be presented, showing the subtotal by type of input, including
contributions from FAO and cofinancing agencies / institutions, indicated by name:
Fournitures FAO
(FCFA)
OTHER
DONOR
(FCFA)
Total
(FCFA)
Tools
Construction materials
Food for animals
Fertilizer
Veterinary equipment and supplies
Pesticides
Cheptel, alevins Livestock, fry
seeds, planting material
Other field supplies / transport
Total (maximum FAO contribution 5,000,000
FCFA)
8. Simple cost / benefit analysis
A simple cost / benefit analysis will be presented to highlight the financial viability of the
project and its long term sustainability. The project must be able to create enough funds to
cover operational costs (seeds, fertilizers, feed, fry, animals, etc.) as well as the annual
depreciation of non-consumable inputs (buildings, greenhouses, boats, tools, etc.). water
tanks, treatment, installation and equipment, fishing nets, etc.).
To simplify the calculation, we consider a fixed rate of depreciation of 20% for all non-
consumable inputs. Therefore, the annual cost will equal the sum of operating costs plus
20% of the value of non-consumable inputs.
9. Risks
Most projects involve risks that could jeopardize their success (for example, adverse weather
conditions, social unrest or insecurity, interruption of the supply of inputs, pest or disease
outbreaks that may cause death or reduce yield, etc.). If this is the case, the possible risks
should be pointed out in the project document, with indications of how the project participants
will deal with such risks, should they arise.
10. Project links
Links with other ongoing development projects should be indicated in the project proposal,
specifying whether they are projects financed by FAO (preferably within the framework of
MINADER / DOPA, where the latter is operational, but also Decentralized Cooperation
projects (PCDG) PCT, GCP, UTF, or other) or by other sources (other United Nations
agencies, bilateral aid projects, NGOs, etc.). The decentralized services of MINADER will be
involved. These links must be clearly indicated in the evaluation form when presenting the
project.
11. Community fund
The community fund is an important instrument to ensure the smooth running of operations
and the long-term sustainability of the project. All beneficiaries (except in school vegetable
garden projects) should participate in the fund. All contributions in cash or in kind paid by
beneficiaries or by a third party must go into the fund.
Project profits must be deposited in the fund so that there is sufficient liquidity to meet the
needs of the project, and cover operational costs, maintenance costs and annual
depreciation. The management of the fund must be clearly indicated.
12. Technical support, supervision, monitoring and reporting arrangements
5. The project proposal should specify who is responsible for the overall management and
monitoring of project activities and how this monitoring will be carried out. The person in
charge is usually the designated national official (MINADER / DOPA executive), but it could
equally well be the representative of an NGO participating in the project or (although more
rarely) an official from the target group. himself.
The proposal should also indicate which organization and / or individuals will provide any
necessary technical guidance and advice, or provide training to the group if necessary.
Technical guidelines should emanate from FAO (through a MINADER / DOPA framework, for
example) or from a source approved by the Organization. Finally, it will be necessary to
indicate who will be responsible for preparing the interim report (three months after the start
of the project) and the final report (after TeleFood funding).