In Aplysia long-term facilitation (long-term memory): the transcriptional activator C/EBP acts to increase expression of CREB1 transcription is increased by replacing CREB 2 with CREB 1 on the DNA protein kinase A and MAP kinase together phosphorylate CREB 1 1 pts Question 11 In Aplysia long-term facilitation (long-term memory): Expression of ribosomal proteins is decreased in order to inhibit CREB2 production Expression of MAPK regulatory subunits are decreased Increased expression of ubiquitin hydrolyase leads to degradation of specific proteins.