Immunovaccine
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Immunovaccine Inc. is developing a DepoVax platform for vaccine delivery that has the potential to revolutionize vaccines across multiple disease areas. The platform encapsulates antigens in a liposome that is then lyophilized and suspended in oil, providing long-term protection and exposure of antigens to stimulate the immune system. Immunovaccine has clinical trials underway for DepoVax vaccines against various cancers like ovarian and brain cancer, as well as infectious diseases like RSV and anthrax. They are also exploring DepoVax vaccines for Zika virus, contraception, and bovine viral diarrhea virus.
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This document provides an overview of Inovio Pharmaceuticals, a company developing DNA-based immunotherapies and vaccines. It summarizes that Inovio is a global leader in active immune therapy, with the best T cell responses shown in clinical studies. It notes that key upcoming value drivers in 2014 include Phase II efficacy data for their lead drug VGX-3100 for cervical dysplasia, and the initiation of multiple new clinical trials for various cancer and infectious disease indications. The document emphasizes Inovio's ability to generate best-in-class T cell responses for immunotherapy using their proprietary DNA delivery technology and development of synthetic vaccines.
Inovio - Corporate Presentation - July 2014
Dr. Joseph Kim, President & CEO of Inovio Pharmaceuticals, discussed Inovio's progress in developing DNA immunotherapies to treat cancers and infectious diseases. Key highlights included Phase II clinical trial results for VGX-3100 showing it met efficacy endpoints for treating HPV-related cervical dysplasia, additional cancer trials starting in 2014, and the potential for Inovio's therapies to provide non-surgical treatments and preventive vaccines. Inovio is a global leader in active immune therapies and aims to transform the fight against diseases through its SynCon DNA immunotherapy platform.
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Immunovaccine
- 1. Immunovaccine Inc. (TSX: IMV; OTCQX: IMMVF)
- 2. Our DepoVax™ Platform Has the Potential to Revolutionize Vaccines in Multiple Therapeutic Areas THE IMV VALUE PROPOSITION 2 Immuno-oncology Infectious diseases Survivin RSV Partners
- 3. Encapsulate in a Liposome + Lyophilize + Suspend in Oil DEPOVAX™ • Protection and prolonged exposure of antigens to the immune system • Broad applications • Established GMP manufacturing process • Years of shelf life stability 3
- 4. Indication Product (n) Trials Timing Partners Ovarian DPX Survivac 19 Completed DPX Survivac 24 Completed DPX Survivac + Epacadostat 16 First patient in May DPX Survivac + Checkpoint 20 Initiation in 2016 Discussions ongoing with Big Pharma DLBCL DPX Survivac Ongoing DPX Survivac + Checkpoint 25 Initiation in 2016 Discussions ongoing with Big Pharma Glioblastoma DPX Survivac + Temolozomide 44 First patient Q3 HPV cervical cancer DPX E7 50 First patient Q4 IMMUNO-ONCOLOGY PIPELINE AND PARTNERS 4 Phase 1 Phase 2 Phase 2 Phase 1b Phase 1b Phase 1b Phase 2 Phase 1/2
- 5. Indication Product (n) Trials Timing Partners RSV DPX-SHe Antigen 40 Results in Q2 2016 Anthrax DPX-rPA TBD 2016/2017 ZIKA Antigen Preclinical Vet vaccines Contraception Animal trials 2021 market BVDV INFECTIOUS DISEASES PIPELINE AND PARTNERS Phase 1 Phase 1 5