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IJCP Group started its journey in June 1990 with its flagship medical journal, the
        Indian Journal of Clinical Practice, with a brilliant editorial team comprising of
        doctors and research analysts. Very soon, IJCP grew from this one journal to a Group
        of Publications. Today, IJCP’s network has traversed borders to win appreciation by
        the doctors from the different parts of the world.
        With a wide range of publications, Events & PR, audio & visual, and host of other
        information packed products, IJCP Group is the preferred partner of not only the
        Medical fraternity but also the Pharmaceutical companies.
        But the journey of IJCP does not end here…. We believe this is the beginning of
        our journey…..




                                          Contact us

        Head Office                     Dr Veena Aggarwal                      Mr Nilesh Aggarwal
 IJCP Publications Pvt. Ltd.           Group Executive Editor &                      Director
E-219, Greater Kailash Part - I        Joint Managing Director                     09818421222
     New Delhi - 110048                      09811036687
Our Management

             Dr KK Aggarwal
             Padma Shri & Dr B C Roy Awardee
             CMD, Publisher and Group Editor-in-Chief
             President, Heart Care Foundation of India
             emedinews@gmail.com


Dr KK Aggarwal is a Senior Consultant Physician and Cardiologist and Dean of the
Board of Medical Education Moolchand Medcity, New Delhi. He is the Founder,
Trustee and President of Heart Care Foundation of India.
Dr. KK Aggarwal has received many prestigious awards, including the Padma Shri
and Dr. B C Roy National Award from the 12th President of India, Smt. Pratibha
Devisingh Patil, for his unique contributions in the health sector. He is also known
as a writer, columnist and expert for newspapers and TV shows.




             Dr. Mrs. Veena Aggarwal
             Group Executive Editor & Joint Managing Director
             Director, Heart Care foundation of India
             drveenaijcp@gmail.com


Dr Veena Aggarwal, besides being a Consultant in Holistic and Antenatal Care, is a
Clinical Obstetrician and Gynecologist by profession.
Under her dynamic leadership, foresight and quest for perfection, the IJCP
Group has crossed many a milestone and is today a leading healthcare
communications group.
Journal
           Indexed with IndMED
           www.ijcpgroup.com           ISSN 0971-0876   Single Copy Rs. 250/-

           Indian Journal of


          CLINICAL
                                                                    IJCP



          PRACTICE
           Volume 21, Number 7
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                      rn                361-420 Pages           December 2010
          er
          Pe




                            Esophageal Ulceration Following
                                    Typhoid Fever


                                                              Dr KK Aggarwal
                                                              Group Editor-in-Chief
Indian Journal of Clinical Practice



                                                                                                                                                                 The flagship journal of IJCP Group of
                                                                                         From the Desk oF Group eDitor-in-ChieF
                                                                                         From the Desk oF Group eDitor-in-ChieF                                  Publications was launched in June 1990
ACS Updates Prostate Cancer Screening Guideline
                                                                                                                                                                 as a monthly medical journal to provide
                                                                                                                                                                 an insight into the proper diagnosis and
                                                                                                                                                                 treatment of diseases and conditions
                                                                                                                                                                 commonly encountered by an Indian
                                                                                                                                                                 physician. IJCP is unquestionably India’s
                                                                     Dr KK Aggarwal
                                                       Padma Shri and Dr BC Roy National Awardee
                                                                                                                                                                 leading medical journal.
                                                     Sr Physician and Cardiologist, Moolchand Medcity
                                                          President, Heart Care Foundation of India
                                                              Group Editor-in-Chief, IJCP Group
                                                                  Editor-in-chief, eMedinewS
                                                     Chairman Ethical Committee, Delhi Medical Council
                                                          Director, IMA AKN Sinha Institute (08-09)
                                                            Hony. Finance Secretary, IMA (07-08)
                                                                 Chairman, IMA AMS (06-07)
                                                        President, Delhi Medical Association (05-06)
                                                                    emedinews@gmail.com



                                                                                                                                                                 Specifications
                                                               http://twitter.com/DrKKAggarwal
                                                             Krishan Kumar Aggarwal (Facebook)




T
          he American Cancer Society (ACS) has updated its prostate cancer screening guideline. Men should only
          be screened after they receive information about the uncertainties, risks, and potential benefits associated
          with prostate cancer screening.
                                                                                                                                                                    Size: A4
    Prostate-specific antigen (PSA) testing is now recommended with or without the digital rectal exam (DRE).
    There is little evidence that the DRE adds significant benefit to the PSA test, except, perhaps, when the PSA
     is in the borderline range.                                                                                                                                    Pages: 56+4
    PSA value of 4.0 ng/ml be used as a reasonable threshold to trigger further evaluation.
    There is a new recommendation for men with PSA values between 2.5 and 4.0 ng/ml. Twenty-five percent
     of men with PSA levels between 2.5 and 4.0 ng/ml harbor prostate cancer and physicians should consider an                                                      Printing: 4+1 Color
     individualized risk assessment for these men.

                                                                                                                                                                    Paper: 210/90 GSM Indian Art Paper
    An individual assessment should take into account non-PSA risk factors, such as race, family history, results
     of previous biopsies and DRE results.
    ACS also now recommends that the PSA testing interval be reduced to every other year for men whose PSA
     level is under 2.5 ng/ml. Such a reduction in testing frequency will lead to significantly reduced false positives,
     unnecessary biopsies and overdiagnosis, with only a negligible increase in missed cancers.
                                                                                                Source: CA Cancer J Clin Published online March 3, 2010.
                                                                                                                                                                    Frequency: Quarterly
                                                                                                                                       n      n      n
                                                                                                                                                                    Readership: 50,000
                                                                                                                                                                    Cover Price: ` 300/-
Indian Journal of Clinical Practice, Vol. 21, No. 9, February 2011                                                                                         485

                                                                                                                                                                     Annual Subscription: ` 3500/-
Journal
IJCP’s Medinews
                                                                                                                                        Launched in June 1992, Medinews is
Controlled-Release Tramadol in Chronic Pain                                                                                             India’s first and most comprehensive
C     hronic pain is different from acute pain. It can be
      multifactorial; often it may not be possible to find out if    Advantages of CR Tramadol
                                                                                                                                        medical newspaper.
it is nociceptive, neuropathic, idiopathic or all of the above,      • Extended duration of action for reduced dosing

                                                                                                                                        Medinews features healthcare news as
which in turn affects the duration and treatment.1 More                  frequency
than 40-50% of patients in routine practice settings fail to
                                                                     • More constant plasma concentrations for improved
achieve adequate relief making chronic pain a particular
                                                                         efficacy and tolerability
challenging problem to treat. Besides its impact on quality-
of-life (QOL), chronic pain incurs great healthcare costs.2
Available analgesics include nonopioids such as
                                                                     • Improved compliance and therapeutic outcomes

                                                                    The bioavailability of the CR tramadol formulation is
                                                                                                                                        an unbiased and well reasoned analysis
                                                                                                                                        and covers medical events, nationally
acetaminophen, nonsteroidal anti inflammatory drugs
(NSAIDs), cyclo oxygenase-2 (COX-2) inhibitors, weak                comparable with IR (immediate release) formulations,
opioids such as codeine and tramadol and conventional               with a half-life 3-4 times longer (16 hours vs 4-6 hours)
opioids such as oxycodone and morphine.3 NSAIDs and                 and an extent of absorption similar to IR tramadol given

                                                                                                                                        and internationally in a well-illustrated
acetaminophen are the cornerstone of treating most pain             thrice-daily.11
conditions. But, their analgesic efficacy varies widely among       Tramadol has been widely studied in the treatment of chronic
individual patients. Gastrointestinal toxicity is present in        pain, such as osteoarthritis, low back pain, cancer pain and
50% of NSAIDs users and 5.4% develop a more serious
event requiring hospitalization due to their frequent use.4
NSAIDs may have a possible deleterious effect on articular
                                                                    neuropathic pain.6 CR tramadol is shown to be more effective
                                                                    in terms of analgesia compared to standard formulation of
                                                                    tramadol both six and 12 hours after administration. It also
                                                                                                                                        format. Medinews has enjoyed the
                                                                                                                                        OFFICIAL PRESS status at premium
cartilage metabolism.5 They may affect fluid and electrolyte        has fewer adverse effects than the standard formulation.12
balance, causing fluid retention, edema and hypertension.6          A double-blind crossover comparative study has reported
Most patients above 65 years have multiple co-morbid disease        significant improvement in pain intensity with CR tramadol
conditions such as heart disease, diabetes, hypertension,           as compared with IR tramadol and higher patient-rated
Alzheimer’s and renal disease that significantly complicate
treatment of pain.3
                                                                    treatment effectiveness.13 CR tramadol therefore provides
                                                                    the advantage of around-the-clock analgesic control with
                                                                    reduced dosing frequency which is essential to obtain patient
                                                                                                                                        National conferences like APICON, CSI,
Tramadol, an Atypical Opioid Analgesic
Tramadol is a synthetic, centrally acting analgesic that has
                                                                    compliance in conditions of chronic pain.

                                                                    CR Tramadol in Osteoarthritis
                                                                                                                                        AICOG, PEDICON, IMA-CON, IADVL and
been used to treat pain effectively in a variety of indications.7
It belongs to the second step of the WHO analgesic ladder.
Tramadol has an atypical pharmacological profile with
both opioid and monoaminergic mechanisms. It exerts its
                                                                    A chronic degenerative disorder of multifactorial
                                                                    etiology, osteoarthritis (OA) is the second most common
                                                                    rheumatological problem and is the most frequent joint
                                                                                                                                        NAPCON for the last 5 years.
analgesic effects by complementary mechanisms of action:            disease with prevalence of 22-39% in India. Pain along with
It binds weakly to µ-receptors and inhibits ascendent pain          functional limitation and stiffness are the major symptoms
transmission pathways in the spinal cord. At the same time,         making OA the most common cause of locomotor disability
it stimulates descendent inhibitory pathways by increasing          in the elderly.4 Effective pain control is one of the goals
release and decreasing re-uptake of noradrenaline and

                                                                                                                                        Specifications
                                                                    of treatment,5 which depends on the analgesic efficacy of
serotonin.8 The (+) enantiomer is more potent than                  the treatment and compliance with the dosing regimen.7
the (–) enantiomer in inhibiting serotonin reuptake. On the
other hand, the (–) enantiomer is more potent in inhibiting         CR tramadol is an efficacious and well-tolerated medication
norepinephrine reuptake and increasing presynaptic release.         for the treatment of OA pain.11 The American Pain Society
This differential interaction between the two enantiomers is        recommends tramadol for the management of OA pain
synergistic.6 The dual mechanism of action gives tramadol           when NSAIDs alone produce inadequate pain relief.11 The

                                                                                                                                            Size: A4 Size
                                                                    recommendations of the American Heart Association include
                                                                                                                                        
an efficacy that is equivalent to codeine, despite a 10-fold
lower affinity to µ-receptors.8 Tramadol does not have              tramadol, not NSAIDs or COX-2-specific inhibitors, as
the typical opioid adverse effects at the respiratory and           first-line therapy for musculoskeletal symptoms in patients
cardiovascular level and on intestinal motility at therapeutic      with cardiovascular disease or risk factors.6


                                                                                                                                            Pages: 12+4/20+4
doses.9 In addition, it avoids the ulcerogenic, renal/cardiac/
hepatic adverse effects of NSAIDs and COX-2 inhibitors.
This feature combined with the lower potential for abuse
                                                                    In a 12-week clinical trial of OA of the knee, CR formulation
                                                                    of tramadol provided patients with increased control over
                                                                    the management of their pain, fewer interruptions in sleep
                                                                                                                                        
or dependence, gives tramadol a significant advantage over          and improved compliance.14 Clinical data on tramadol and

                                                                                                                                            Paper: 70/130 GSM Indian Art Paper
nonopioids and also over conventional opioids, particularly
                                                                                                                                        
                                                                    paracetamol indicate that both the parent drug (tramadol)
in the elderly.3                                                    and its active metabolite achieved adequate concentrations in
Tramadol has a half-life of about 5.5 hours and the usual oral      synovial fluid in comparison to paracetamol.15 The results of
dosage regimen is 50-100 mg every 4-6 hours (maximum                a long-term open label study demonstrated that CR tramadol

                                                                                                                                           Printing: 4 Color
dose: 400 mg/day). To reduce the frequency of administration        is effective for the long-term management of OA pain.
and to improve patient compliance, a controlled-release             Reductions in pain intensity, improvements in sleep
(CR) formulation of tramadol has been developed.10                  and functionality and most QOL measures reported in



                                                                                                                                          Readership: 1,00,000
                                                                                                                                           Frequency: Monthly
                                                                                                                                           Cover Price ` 100/-
Advertisement Tariff                                                                                                                        Annual subscription ` 1200/-

Position                                                                                                         Dimension (H X W/Cm.)                          Amount (`/Advt.)
Front Solus                                                                                                      15 x 10                                        ` 40,000
Back Solus                                                                                                       22 x 34                                        ` 35000
Full Page                                                                                                                                                       ` 40,000/-
RHS Pages Economy                                                                                                15 x 10                                        ` 30,000/-
LHS Pages Economy                                                                                                15 x 10                                        ` 25,000/-
Journal

          Peer Review Journal   ISSN 0972-70035                             Single Copy Rs. 250/-
           www.ijcpgroup.com




                                                 Volume 13, Number 8, December 2010, Pages 197-236




                                Dr KK Aggarwal                             Dr Praveen Chandra
                                Group Editor-in-Chief                      Guest Editor
Asian Journal of Clinical Cardiology

                                                                                                                               Asian Journal of Clinical Cardiology (AJCC)
                                                                     From the Desk oF Group eDitor-in-ChieF
                                                                                            xxxxxxxxxxx
                                                                                                                               is an ambitious attempt by IJCP Group
New Test to Predict Cardiac Risk in Healthy
Patients                                                                                                                       to publish a journal of international
                                                                                                                               standards.
Highly sensitive assay for cardiac troponin T (cTnT) can predict cardiovascular events in apparently healthy
populations. As part of the Dallas Heart Study, cTnT levels were measured using both standard and highly
sensitive assays in more than 3,500 patients ages 30 to 65. The results were published in the Dec. 8 Journal of
                                                                                                                               Dr. Praveen Chandra, Interventional
                                                                                                                               Cardiologist, Medanta Medcity is the Editor
the American Medical Association 2010. The standard assay found detectable cTnT in only 0.7% of the study
participants, while the highly sensitive test found it in 25%. Only 7.5% of people in the lowest cTnT group
had left ventricular hypertrophy compared to 48.1% in the highest cTnT group. Mortality also increased from
1.9% in the lowest group to 28.4% in the highest. cTnT was independently associated with all–cause mortality
(adjusted hazard ratio, 2.8 in the highest cTnT group).                                                                        of the journal. Dr Chandra and a network
                                                                                                                               of eminent Indian and international
Another study in the same issue tested the highly sensitive cTnT assay’s ability to predict heart failure in more than
4,000 community–dwelling elderly patients. The biomarker was detectable in the majority of patients (66.2%)
and associated with an increased risk of heart failure and cardiovascular death at higher concentrations (4.8 deaths
per 100 in highest group compared to 1.1 in patients with undetectable levels). This study continued cTnT
measurements over time and found that increases of more than 50% were also associated with cardiovascular                      cardiologists are toiling tirelessly to make
events.
In both studies, there was significant overlap between cTnT and N–terminal pro–brain–type natriuretic peptide,
suggesting that more accurate predictions may be achieved by use of both tests together.
                                                                                                                               AJCC a world class cardiology journal.


                                                                                                                               Specifications
                                                                                                                                  Size: A4
                                                                                                                                  Pages: 36+4
Dr KK Aggarwal
Padma Shri and Dr BC Roy National Awardee
Sr Physician and Cardiologist, Moolchand Medcity
President, Heart Care Foundation of India

                                                                                                                                  Printing: 4+1 color
Group Editor-in-Chief, IJCP Group
Editor-in-Chief, eMedinewS
Chairman Ethical Committee, Delhi Medical Council
Director, IMA AKN Sinha Institute (08-09)

                                                                                                                                  Paper: 210/90 GSM Indian Art Paper
Hony. Finance Secretary, IMA (07-08)
Chairman, IMA AMS (06-07)
President, Delhi Medical Association (05-06)
emedinews@gmail.com

                                                                                                                                  Frequency: Monthly
http://twitter.com/DrKKAggarwal
Krishan Kumar Aggarwal (Facebook)



                                                                                                                                  Readership: 10,000
Asian Journal of Clinical Cardiology, Vol. 13, No. 9, January 2011                                                       237




                                                                                                                                  Cover Price ` 300/-
                                                                                                                                   Annual Subscription ` 3500/-
Journal

                                                                                                     Editorial



                                                                               Volume : 1 January-March 2011




          Indian Journal of Clinical Practice, Vol. 20, No. 6, November 2009
Asian Journal of Obstetrics  Gynecology

    From the desk oF group editor-in-chieF
                                                                                                                                                Asian Journal of Obs  Gynae Practice was
    Paracetamol for Fever in Pregnancy                                                                                                          launched in December 1996 as the first
                                                                                                                                                of the series of specialized journals under
                                                                                                                                                the ‘Asian Series’. The journal covers a
                            Dr KK Aggarwal
                            Padma Shri and Dr BC Roy National Awardee
                            Sr Physician and Cardiologist, Moolchand Medcity
                                                                                                                                                whole range of topics in the specialty,
                            President, Heart Care Foundation of India
                            Group Editor-in-Chief, IJCP Group
                            Editor-in-Chief, eMedinewS
                                                                                                                                                from antenatal care to general gynecology
                                                                                                                                                to operative obstetrics including its
                            Chairman Ethical Committee, Delhi Medical Council
                            Director, IMA AKN Sinha Institute (08-09)
                            Hony. Finance Secretary, IMA (07-08)
                            Chairman, IMA AMS (06-07)
                            President, Delhi Medical Association (05-06)
                            emedinews@gmail.com                                                                                                 subspecialities of Urogynecology, Oncology
                            http//twitter.com/DrKKAggarwal
                            Krishan Kumar Aggarwal (Facebook)
                                                                                                                                                and Reproductive Endocrinology.
    E
             levation of maternal core temperature from a febrile illness or other source (e.g. hot tub) in the first
             trimester of pregnancy may be associated with an increased risk for neural tube defects or miscarriage.
             The National Birth Defects Prevention Study, however observed that among women with infection-related
    fever, use of paracetamol was associated with a statistically significant reduction in neural tube defects, as well as
                                                                                                                                                Dr Alka Kriplani, Professor, Dept. of
    cleft lip/palate and gastroschisis. The data support the safety of paracetamol for relief of fever and pain; however,
    the reduction in birth defects should be confirmed in other studies before the drug can be recommended to febrile                           Obstetrics and Gynecology, AIIMS, is the
    women for this purpose.

    Evidence                                                                                                                                    Editor of the journal.
    To investigate whether exposure during the first trimester of pregnancy to single-ingredient acetaminophen
    increases the risk of major birth defects. Data from the National Birth Defects Prevention Study, a population-
    based, case-control study, were used. Women who delivered between January 1, 1997, and December 31, 2004

                                                                                                                                                Specifications
    and participated in the telephone interview were included. Type and timing of acetaminophen use were assigned
    based on maternal report. Women reporting first-trimester acetaminophen use in a combination product were
    excluded, resulting in a total of 11,610 children in the case group and 4,500 children in the control group
    for analysis. The prevalence of first-trimester single-ingredient-acetaminophen use was common: 46.9%
    (n = 5,440) among women in the case group and 45.8% (n = 2,059) among women in the control group

                                                                                                                                                   Readership: 25,000
    (p = 0.21). Overall, acetaminophen was not associated with an increased risk of any birth defect. Among women
    reporting a first-trimester infection and fever, use of acetaminophen was associated with a statistically significantly
    decreased odds ratio (OR) for an encephaly or craniorachischisis (adjusted OR 0.35, 95% confidence interval
    [CI] 0.08-0.80), encephalocele (adjusted OR 0.17, 95% CI 0.03-0.87), anotia or microtia (adjusted OR 0.25,
    95% CI 0.07-0.86), cleft lip with or without cleft palate (adjusted OR 0.44, 95% CI 0.26-0.75) and gastroschisis
    (adjusted OR 0.41, 95% CI 0.18-0.94).
                                                                                                                                                   Size: A4
    Single-ingredient-acetaminophen use during the first trimester does not appear to increase the risk of major
    birth defects. It may decrease the risk of selected malformations when used for a febrile illness.                                             Pages: 48+4
                                                      Source: Feldkamp ML, Meyer RE, Krikov S, Botto LD. Obstet Gynecol 2010;115(1):109-15.
                                                                                                                                                   Printing: 4+2 color
                                                                                                                            n      n      n

                                                                         Asian Journal of Obs and Gynae Practice, Vol. 1, January-March 2011
                                                                                                                                                   Paper: 170/90 GSM Indian Art Paper
                                                                                                                                                   Frequency: Quarterly
                                                                                                                                                   Cover Price: ` 300/-
                                                                                                                                                    Annual subscription ` 1200/-
Journal
Asian Journal of Diabetology

                                                                                         From the Desk oF Group eDitor-in-chieF                                    The Asian Journal of Diabetology is a
Changing Practice Guidelines: A1C                                                                                                                                  prestigious quarterly journal. Dr Vijay
                                                                                                                                                                   Vishwanathan, an eminent Diabetologist,
                                                                                                                                                                   Managing Director, MV Hospital for
                                                                                                                                                                   Diabetes and Diabetes Research Center,
                                                                                                                                                                   Chennai is the Editor of the journal.
                                                              Dr KK Aggarwal
                                                Padma Shri and Dr BC Roy Awardee
                                         Sr Physician and Cardiologist, Moolchand Medcity
                                                                                                                                                                   The journal focuses on informing
                                                                                                                                                                   Physicians and Diabetologists about
                                             President, Heart Care Foundation of India
                                                 Group Editor-in-Chief, IJCP Group
                                                     Editor-in-Chief, eMedinewS
                                                  Member, Delhi Medical Council
                                            Director, IMA AKN Sinha Institute (08-09)
                                               Hony. Finance Secretary, IMA (07-08)                                                                                managing various aspects of diabetes
                                                    Chairman, IMA AMS (06-07)
                                            President, Delhi Medical Association (05-06)
                                                           drkk@ijcp.com                                                                                           to provide better patient care to
                                                                                                                                                                   India’s continually rising population of
T                                                                                                                                                                  diabetics.
          he American Diabetes Association (ADA), the International Diabetes Federation (IDF) and the European
          Association for the Study of Diabetes (EASD) have joined forces to recommend the use of the hemoglobin
          A1C assay for the diagnosis of diabetes.
A1C values vary less than FPG (fasting plasma glucose) values and the assay for A1C has technical advantages
compared with the glucose assay. A1C gives a picture of the average blood glucose level over the preceding


                                                                                                                                                                   Specifications
2-3 months.
A1C has numerous advantages over plasma glucose measurement:
   It is a more stable chemical moiety.
   The patient does not need to fast.


                                                                                                                                                                       Readership: 5,000
    Measuring A1C is more convenient and easier for patients who will no longer be required to undergo a fasting
                                                                                                                                                                   

    or oral glucose tolerance test (OGTT).
   It correlated tightly with the risk of developing retinopathy.


                                                                                                                                                                       Size: A4
The committee has determined that an A1C value of 6.5% or greater should be used for the diagnosis of diabetes.
This cut-point, is where risk of retinopathy really starts to go up.                                                                                               
Avoid using estimated average glucose, or EAG, as this is just a way to convert the A1C into glucose levels.
                  Source: American Diabetes Association (ADA) 69th Scientific Sessions. Presented June 5, 2009. Diabetes Care Published online June 5, 2009.
                                                                                                                                                                      Pages: 36+4
                                                                                                                                                                      Printing: 4+2 color
                                                                                                                                                               
                                                                                                                                                                       Paper: 170/90 GSM Indian Art Paper
Asian Journal of Diabetology, Vol. 12, No. 1, January-March 2010

                                                                                                                                                                   
                                                                                                                                                                      Frequency: Quarterly
                                                                                                                                                                      Cover Price: ` 300/-
                                                                                                                                                                       Annual Subscription ` 1200/-
Journal




          Volume 6, Number 3                                July-September 2010




                Sedation Practices for the Patient in
                the ICU


                Should C-reactive Protein
                Concentration at ICU Discharge be
                Used as a Prognostic Marker?


                Clostridium Difficile: Moving Beyond
                Antimicrobial Therapy


                ICU Intubation Success Hampered by
                Non-ideal Conditions: Based on Small
                Cohort Study...


                Pain Not Minimized after Minimally
                Invasive Cardiac Surgery


                Still Asleep at the (Ventilator) Switch?


                Timing of Tracheotomy Linked to
                Length of Stay: Study Finds to Effect
                on Mortality from Early Procedure


                                                  more...
Asian Journal of Critical Care


                                                                                    From the desk oF Group editor-in-chieF
                                                                                                                                 Today, the demands on the intensivists
Nonresolving Pneumonia                                                                                                           are tremendous, making it necessary for
                                                                                                                                 them to be updated with the latest in the
                                                                                                                                 field.
                                                                                                                                 In view of this, IJCP has another specialty
                                                                                                                                 journal, Asian Journal of Critical Care. It
                                                                                                                                 discusses original research, review articles,
                                                                  Dr. KK Aggarwal
                                                                Dr BC Roy Awardee                                                technology in medicine for physicians
                                                 Sr Physician and Cardiologist Moolchand Medcity
                                                     President, Heart Care Foundation of India
                                                        Group Editor-in-Chief, IJCP Group                                        and allied health professionals involved
                                                          Member, Delhi Medical Council
                                                    Director, IMA AKN Sinha Institute (08-09)
                                                       Hony. Finance Secretary, IMA (0�-08)
                                                           Chairman, IMA AMS (06-0�)
                                                                                                                                 in treating the critically ill with the aim
                                                    President, Delhi Medical Association (05-06)
                                                                   drkk@ijcp.com                                                 to improve patient care.


S
     low or incomplete resolution of pneumonia despite treatment is a common clinical problem, estimated to
     be responsible for approximately 15% of inpatient pulmonary consultations and 8% of bronchoscopies.1
     Normal resolution of pneumonia is not easily defined. Patients typically note subjective improvement within
                                                                                                                                 Specifications
3-5 days of treatment; more specific clinical criteria for resolution include improvement in fever, cough, crackles,
leukocytosis, arterial oxygenation (PaO2) and level of C-reactive protein.2
Most studies on the natural history of pneumonia have focused upon the resolution of chest radiographic                             Size: A4
abnormalities, with ‘slow resolution’ often being defined as the persistence of radiographic abnormalities for
greater than one month in a clinically improved host.
The diagnostic evaluation of treatment failure in pneumonia should begin with a careful history, physical                           Pages: 36+4
examination, and review of the clinical picture.
One should first consider whether or not the rate of resolution is within the range of expected norms depending
on the patient’s underlying host factors, comorbidities, severity of illness and suspected pathogens. In stable or                  Printing: 4+2 color
slowly improving pneumonia, especially in the presence of comorbidities or host factors which are known to delay

                                                                                                                                     Paper: 170/90 GSM Indian Art Paper
the resolution of pneumonia, careful observation with or without therapy is warranted for 4-8 weeks.3
When needed, further evaluation should include chest CT to look for sequestered areas of infection or for findings               
that suggest an alternative diagnosis. When pneumonia fails to resolve or when there is clinical progression,

                                                                                                                                     Frequency: Quarterly
fiberoptic bronchoscopy should be considered.
                                                                                                                                 
                                                                                                                                    Readership: 20,000
Asian Journal of Critical Care Vol. 5, No. 4, October-December 2009                                                          




                                                                                                                                    Price: ` 300/-
                                                                                                                                     Annual Subscription ` 1200/-
Journal




          July-September 2010
Asian Journal of Paediatric Practice

    From the desk oF group editor-in-chieF                                                                                               From preventive health care to treatment
    Smokers in the House, a Risk Factor for                                                                                              of childhood diseases to emergency care
    Hospitalization of Children with Flu                                                                                                 and adolescence – all these subjects and
                                            Dr KK Aggarwal
                                                                                                                                         many more are covered in the much
                                                                                                                                         appreciated and read Asian Journal of
                            Padma Shri and Dr BC Roy National Awardee
                           Sr Physician and Cardiologist, Moolchand Medcity
                               President, Heart Care Foundation of India
                                   Group Editor-in-Chief, IJCP Group


                                                                                                                                         Paediatric Practice.
                                       Editor-in-Chief, eMedinewS
                           Chairman Ethical Committee, Delhi Medical Council
                                Director, IMA AKN Sinha Institute (08-09)
                                 Hony. Finance Secretary, IMA (07-08)
                                      Chairman, IMA AMS (06-07)
                              President, Delhi Medical Association (05-06)


                                                                                                                                         Under the able guidance of Dr Swati
                                         emedinews@gmail.com




    A                                                                                                                                    Bhave, Executive Editor, Association of
            large retrospective case-control study reported at the annual meeting of the Infectious Diseases Society of
            America (IDSA) says that having smokers in the house increases the possibility of a young child with flu
            needing inpatient care.
    Data from more than 1,300 laboratory-confirmed cases of children with influenza, collected by 10 sites in the
    CDC’s Emerging Infections Program in 2005-2008 were analyzed to identify risk factors for hospitalization
                                                                                                                                         Adolescent  Child Care in India (AACCI),
    associated with laboratory-confirmed influenza.
    Analysis showed that if more than half of household members were smokers it doubled the chances a child would
                                                                                                                                         the journal serves as a practical guide for
    have a serious case of flu. According to Nila Dharan, MD, of the division of infectious diseases at the NYU School
    of Medicine in New York City, a family member who had been vaccinated against flu was protective, even if the                        the continuing education of Pediatricians
    child was not fully protected by immunizations. The study included 290 children ages six to 59 months (median
    age 20 months) with serious cases of flu; 1,089 age- and zip code-matched children with the flu who did not need
    inpatient care during the three influenza seasons acted as controls. The salient observations were as below.
                                                                                                                                         and Neonatologists.
    Age of the mother: if ≤26 years, the odds were doubled. The odds ratio (OR) was 2.1, with a 95% confidence
    interval (CI) from 1.3 to 3.4. The risk was increased if the child’s vaccinations were not up-to-date. The OR was
    1.7, with a 95% CI from 1.1 to 2.7.
    If more than half of household members smoked, the child’s risk of needing inpatient care was doubled. The OR                        Specifications
    was 2.3, with a 95% CI from 1.0 to 5.3. The risk was similar to having any pulmonary condition, including
    asthma.
    If the child was not fully vaccinated for the flu, having any household member immunized was protective.
    The OR was 0.5, with a 95% CI from 0.3 to 0.8.                                                                                          Readership: 20,000
    Underlying medical conditions also had an important role; presence of a hematologic or oncologic condition
    increased the risk by a factor of 12.
    According to Dr Dharan, other researchers have examined a possible association between exposure to smoking and
                                                                                                                                            Size: A4
    a child’s risk of needing inpatient care for flu, but this is the largest study to date.
                                                                                                                    n      n       n        Pages: 36+4
                                                                                                                                            Printing: 4+2 color
                                                                                 Asian Journal of Paediatric Practice, Vol. 14, No. 1      Paper: 170/90 GSM Indian Art Paper
                                                                                                                                            Frequency: Quarterly
                                                                                                                                            Price: ` 300/-
                                                                                                                                             Annual Subscription ` 1200/-
Journal




          October-December 2010
Asian Journal of Ear, Nose  Throat

                                                                                                                           The management of diseases and the
                                                                              from the Desk of group eDitor-in-chief

New Daily Persistent Headache                                                                                              latest techniques in the subspecialties of
                                                                                                                           Otology, Rhinology and Laryngology need
                                                                                                                           to be discussed and informed at length
                                                                                                                           under a common platform efficiently
                                                                                                                           provided by the Asian Journal of Ear,
                                                              Dr KK Aggarwal
                                                                                                                           Nose  Throat.
                                                   Padma Shri and Dr BC Roy Awardee


                                                                                                                           It provides worldclass information to
                                             Sr Physician and Cardiologist Moolchand Medcity
                                                 President, Heart Care Foundation of India
                                                     Group Editor-in-Chief, IJCP Group
                                                          Chief Editor, eMedinewS
                                                      Member, Delhi Medical Council
                                                 Director, IMA AKN Sinha Institute (08-09)
                                                   Hony. Finance Secretary, IMA (07-08)
                                                                                                                           Indian ENT practitioners under the
                                                                                                                           guidance of its founder Editor, Dr VP Sood,
                                                        Chairman, IMA AMS (06-07)
                                                          President, Delhi Medical
                                                             Association (05-06)
                                                               drkk@ijcp.com

                                                                                                                           Secretary-cum-Managing Trustee, Dr Sood
N                                                                                                                          Nasal Research Foundation, Past President
            ew daily persistent headache (NDPH) is a primary headache disorder in which headache begins one
            day and does not remit, in an individual without a headache history. The pathophysiology is poorly
            understood. Onset of NDPH can be triggered by certain events, such as infection.
The incidence and prevalence of NDPH are unknown, but is rare. It is more frequent in children than in adults,
and affects women more often than men. A characteristic feature is that the headache starts abruptly and is
                                                                                                                           Association of Otorhinolaryngologists.
daily and unremitting from, or almost from, the moment of onset, typically in individuals without a prior
headache history.


                                                                                                                           Specifications
The diagnosis is clinical and requires ruling out secondary causes. Current diagnostic criteria exclude patients
with predominant migrainous features, many headache experts contend that the diagnosis of NDPH can be
made regardless of the presence of migrainous features. For patients with recent onset of suspected NDPH, one
should do neuroimaging upon presentation. A lumbar puncture is indicated if clinical features suggest a possible
central nervous system infection or idiopathic intracranial hypertension.


                                                                                                                               Readership: 20,000
The differential diagnosis includes a number of secondary and primary causes of headache. It is particularly
important to consider cerebral venous sinus thrombosis, headache secondary to spontaneous cerebrospinal fluid
leaks, idiopathic intracranial hypertension (pseudotumor cerebri), and giant cell arteritis.
                                                                                                                           
NDPH may take either of two subtypes: a self-limited one, or a persistent form which can last years or decades
and is challenging to treat.                                                                                                  Size: A4
For patients with primary NDPH, first classify the phenotype of NDPH as most similar to either migraine or
tension-type headache, and then treating with appropriate preventive headache therapy accordingly.

                                                                                                           n   n   n
                                                                                                                              Pages: 36+4
Asian Journal of Ear, Nose  Throat, April-June 2010                                                                   
                                                                                                                              Printing: 4+2 color
                                                                                                                              Paper: 170/90 GSM Indian Art Paper
                                                                                                                              Frequency: Quarterly
                                                                                                                              Price: ` 300/-
                                                                                                                               Annual Subscription ` 1200/-
Journal
Indian Journal of Medilaw

                                                                          From thE dEsk oF group Editor-in-ChiEF          There has been a considerable increase
                                                                                                      Editorial
Driving Restrictions for Patients with Seizures                                                                           in medicolegal cases in India in the
KK Aggarwal
                                                                                                                          past few years. This rise in medical law
                                                                                                                          litigations is due to Consumer Protection
                                                                                                                          Act (CPA) and awareness about protection
                                                                                                                          of patients’ rights and consistent public
                                                             Dr KK Aggarwal
                                            Padma Shri and Dr BC Roy National Awardee
                                          Sr Physician and Cardiologist, Moolchand Medcity
                                                                                                                          demands for professional accountability.
                                                                                                                          It is also a fact that, there are no apparent
                                               President, Heart Care Foundation of India
                                                   Group Editor-in-Chief, IJCP Group
                                                       Editor-in-Chief, eMedinewS
                                         Chairman Ethical Committee, Delhi Medical Council
                                              Director, IMA AKN Sinha Institute (08-09)
                                                 Hony. Finance Secretary, IMA (07-08)                                     and explicit guidelines in this regard.
                                                      Chairman, IMA AMS (06-07)
                                             President, Delhi Medical Association (05-06)
                                                         emedinews@gmail.com
                                                    http://twitter.com/DrKKAggarwal
                                                 Krishan Kumar Aggarwal (Facebook)
                                                                                                                          The Indian Journal of Medilaw was
                                                                                                                          launched with the objective to keep the
                                                                                                                          Indian Doctors updated about the current
     The seizure-free interval is the most practical and widely used measure of a patient’s driving risk.
                                                                                                                          laws and implications on their practice.


    Longer seizure-free intervals (6-12 months) are associated with reduced risk of seizure-related motor vehicle
     accidents (MVA).
    Shortening seizure-free intervals to three months by some states has not been associated with increased
     MVAs.
    High seizure frequency, medical noncompliance, a history of MVAs and other factors increase the risk of
     seizure-related MVA. These should be considered to extend the seizure-free interval requirement for driving
                                                                                                                          Specifications
     recommendations.
     An established pattern of purely nocturnal seizures, consistent and reliable seizure auras, clear provocation,
                                                                                                                              Size: A4


     or acute symptomatic seizures in a condition that is not associated with epilepsy or is unlikely to recur may
     reduce the seizure-free interval requirement.
                                                                                                                          
                                                                                                                              Pages: 36+4
     Doctors should also consider other neurologic contraindications for driving in their patients with epilepsy,
                                                                                                                          


     including impaired cognition and visual field defects.
    The Epilepsy Foundation is a good resource for the current state specific rules on driving and epilepsy.



     (www.epilepsyfoundation.org/living/wellness/transportation/driverlicensing.cfm)
     Doctors should discuss driving with patients and record this discussion in the medical record. This discussion          Printing: 4+2 color
     should include the risk of driving.


Indian Journal of Medilaw, September-November 2010                                                                    
                                                                                                                             Paper: 170/90 GSM Indian Art Paper
                                                                                                                             Quantity: 2-10,000.
                                                                                                                             Frequency: Quarterly
                                                                                                                             Price: ` 300/-
                                                                                                                              Annual Subscription ` 1200/-
IJCP International Journals



                        American Family Physician                                                                                           Indian Edition
                       A peer-reviewed journal of the American Academy of Family Physicians                                           November-December, 2006




                                      Diagnosis and                                              Diagnosing Rhinitis: Allergic vs.
                                                                                                  Nonallergic
                           Treatment of Community-                                               Assessment of Microscopic Hematuria in
                               Acquired Tuberculosis                                              Adults
                                                                                                 Diagnosis and Treatment of Chlamydia
                                                                                                  trachomatis Infection
                                                                                                 Diagnosis and Treatment of Neisseria
                                                                                                  gonorrhoeae Infections
                                                                                                 Diagnostic Approach to Pleural Effusion in
                                                                                                  Adults
                                                                                                 Hepatitis A
                                                                                                 Management of Hip Fracture:
                       With Best Compliments from                                                 The Family Physician’s Role


                          A Division of     Pharmaceuticals Ltd.
IJCP American Family Physician

                                                                                                                                     American Family Physician is the journal
Diagnosing Rhinitis:Allergic vs. Nonallergic                                                                                         of the American Academy of Family
DAVID M. QUILLEN, M.D., and DAVID B. FELLER, M.D.
University of Florida Family Medicine Residency Program, Gainesville, Florida                                                        Physicians (AAFP).
Allergic rhinitis, the most common type of rhinitis, generally can be
differentiated from the numerous types of nonallergic rhinitis through a
thorough history and physical examination. Allergic rhinitis may be                                                                  The American Academy of Family
seasonal, perennial, or occupational. The most common cause of nonallergic
rhinitis is acute viral infection. Other types of nonallergic rhinitis include
vasomotor, hormonal, drug-induced, structural, and occupational (irritant)                                                           Physicians is one of the largest national
                                                                                                                                     medical organizations, representing more
rhinitis, as well as rhinitis medicamentosa and nonallergic rhinitis with
eosinophilia syndrome. Since 1998, three large expert panels have made
recommendations for the diagnosis of allergic and nonallergic rhinitis.


                                                                                                                                     than 94,000 family physicians, family
Allergy testing (e.g., percutaneous skin testing, radioallergosorbent
testing) is not necessary in all patients but may be useful in ambiguous
or complicated cases. (Am Fam Physician 2006;73:1583-90. Copyright

                                                                                                                                     medicine residents, and medical students
© 2006 American Academy of Family Physicians.)




                                 R
                                            hinitis is an inflammation of the       diagnosis of rhinitis. This report is intended   nationwide. Founded in 1947, its mission
                                            nasal mucosa. Associated clinical       to be a complete evidence-based guideline
                                            symptoms include excessive
                                            mucus production, congestion,
                                                                                    on the diagnosis and management of allergic
                                                                                    rhinitis and asthma. The authors proposed
                                                                                                                                     has been to preserve and promote the
                                                                                                                                     science and art of family medicine and to
                                 sneezing paroxysm, watery eyes, and nasal          a new classification for allergic rhinitis,
                                 and ocular pruritus. The differential              arguing that the current subdivisions (i.e.,
                                 diagnosis of rhinitis is extensive (Table 11).     seasonal and perennial) were not
                                 Allergic rhinitis is considered a systemic
                                 illness and may be associated with
                                                                                    satisfactory. Traditionally, pollens and
                                                                                    molds were considered possible causes of         ensure high-quality, cost-effective health
                                 constitutional symptoms such as fatigue,           seasonal allergic rhinitis. However, in some
                                 malaise, and headache. It also may be a
                                 comorbidity in patients with asthma,
                                                                                    places, such as California and Florida, these
                                                                                    allergens are present year-round. The WHO
                                                                                                                                     care for patients of all ages.
                                 eczema, or chronic sinusitis. Differentiating      authors suggested a classification system
                                 allergic rhinitis from other causes of rhinitis    based on the symptoms of intermittent,
                                 can be difficult because the diagnostic
                                 criteria for various forms of rhinitis are not
                                                                                    persistent, mild, and moderate-severe
                                                                                    rhinitis.
                                                                                                                                     IJCP holds the sole printing rights for
                                 always clear-cut. Accurate diagnosis is
                                 important because therapies that are
                                 effective for allergic rhinitis (i.e.,
                                                                                         The third report2 was coordinated by
                                                                                    the Agency for Healthcare Research and
                                                                                    Quality (AHRQ) in collaboration with the
                                                                                                                                     American Family Physician in India.
                                 antihistamines and nasal corticosteroids)          American Academy of Family Physicians
                                 may be less effective for other types of           and the AAAAI. Unlike the first two reports,


                                                                                                                                     Specifications
                                 rhinitis.2                                         the AHRQ report is not a clinical guideline
                                      Since 1998, three expert panels1-3 have       but an evaluation of the evidence on rhinitis.
                                 published reviews of rhinitis. The first report1   The report did not identify any studies
                                 was created by the American Academy of             differentiating allergic rhinitis and
                                 Allergy, Asthma, and Immunology (AAAAI)            nonallergic rhinitis based on clinical
                                 as a complete guideline for the diagnosis and      symptoms, physical examination findings,
                                 management of rhinitis.
                                      The second report,3 coordinated by the
                                                                                    or associated comorbidities. The AHRQ
                                                                                    report noted that the treatment conclusions
                                                                                                                                        Size - A4
                                 World Health Organization (WHO), focuses           may have been biased because

                                                                                                                                         Pages - 36+4
                                 on allergic rhinitis and asthma but includes       pharmaceutical companies supported many
                                 an extensive section on the differential           of the trials.2                                  
                                                                                                                                         Printing - 4+2 printing
8
                                                                                                                                     
    American Family Physician (Indian Edition)                                       Volume 1, Number 4    October-December, 2006




                                                                                                                                        Paper- 170/90 GSM Indian Art Paper
                                                                                                                                        Frequency: Quarterly
                                                                                                                                        Binding: Center Stitch
Publishing Article in a Journal



                                                                                                                                               Publishing Articles in a Journal
                                                                                                                                               A scientific article, 4-6 pages long, can
                                                                                                                                               be published in any of our journals
                                                                                                                                               @ Rs 200,000/- per article inclusive
                                                                                                                                               of compilation, editing, layouting and
                                                                                                Special Reprint 2009
                                                                                                                                               printing subject to peer review/approval
      Methylcobalamin, Pyridoxine and Nicotinamide in                                                                                          by the Editorial Board.
              Diabetic Neuropathy: A Review
                                S Jayaram*, Akash Khobragade**, Deepak Langade†

                                                         ABstRAct
         Diabetes is the most common etiological factor for peripheral neuropathy (PN). While conventional
         theory says that prolonged hyperglycemia results in the complications associated with diabetes,
         including neuropathy, a recent study found that PN can manifest even in individuals with abnormal
                                                                                                                                               Journal Article Reprints
         glucose tolerance, a prediabetic condition. A combination of methylcobalamin, pyridoxine and
         nicotinamide thus has additive and synergistic effects on the damaged nerve in diabetic neuropathy
         which protect the nerve from further damage, restore its structural and functional integrity and
         cause a recovery of function.

      Key words: Hyperglycemia, prediabetic, polyneuropathy, adenosylcobalamin, vitamin B6, nicotinic acid,


                                                                                                                                               Specifications
      myelin sheath, axon


  Background                                                    incidence approaches 50% for patients with diabetes
  Peripheral neuropathy (PN) is characterized by pain,          for more than 25 years.1 A study conducted in South
  numbness and tingling in the extremities and slow             India to find the prevalence and risk factors, found
  nerve conduction. It affects a significant percentage         a PN prevalence of 19.1% among type 2 diabetics
  of the Indian population and can be extremely
  debilitating. Around 7% of patients usually have
                                                                attending the diabetic clinic. Neuropathy was
                                                                diagnosed if the vibratory threshold of the great toe
                                                                exceeded 25. The incidence of PN increases with
                                                                                                                                                  Size: A4
  neuropathy upon diagnosis of diabetes, and the
                                                                increase in age and duration of diabetes.2 Based on a

   *Hon. Professor of Medicine
                                                                compilation of studies from different parts of the world,
                                                                the World Health Organization (WHO) has projected                                 Paper: 110 GSM Indian Art Paper
   Bombay Hospital, Mumbai                                      that the maximum increase in diabetes would occur in
   **Resident                                                   India.3 Considering the large population and the high
   †
    Clinical Pharmacology, Ex-lecturer
   Dept. of Pharmacology
   Grant Medical College and Sir JJ Group of Hospitals
                                                                prevalence of diabetes, the burden of diabetes and it’s
                                                                complications in India would become enormous.                                     Printing: 4 + 2 color offset printing
   Mumbai                                                       Pathophysiology of diabetic neuropathy
                                                                                                                                                  Pages: 4/6/8 pages
   Address for correspondence
   Dr Deepak Langade                                            Diabetes is the most common etiological factor for PN
   503/E-7, Runwal Estate, Opp. Lawkim                          and it is also the most studied in terms of pathogenesis.
   Ghodbunder Road, Thane (W), Mumbai - 400 607                 While conventional theory says that prolonged
   E-mail: drdgl@hotmail.com                                    hyperglycemia results in the complications associated
                                                                                                                                   June 2009




                                                                       INDIAN JOURNAL OF CLINICAL PRACTICE    l VOL.   20, NO. 1
                                                                                                                                                  One full page Advertisement
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IJCP Health Information Products
Dr. Good Dr. Bad


                                                                                               Dr Good Dr Bad is a copyrighted cartoon
                                   
                                                                                               based product of IJCP, which depicts
                                                                                               a clinical situation that a doctor might
Situation :    A 30-year-old female with a diabetic mother came for
                                                                                               come across and the correct way to deal
               a check-up.
                                                                                               with it, in the form of caricatures. The
                                                                                               clinical lesson is supported by a scientific
                                                                                               reference.
                                              You cannot
            You are also at risk
              of heart disease                 be at risk                                      A Ready Reckoner, which a doctor
                                                                                               may refer to, when he encounters a
                                                                                               clinical situation that may be difficult to
                                                                                               handle.

                                                                                               Specifications
                                                                                © IJCP GROUP




LeSSon : As per results of the Fremantle Diabetes Study, a maternal
          family history of diabetes confers relative protection against                          Size: 4.0 x 5.5 inches or 8”x5.5” inches
          cardiovascular disease in female patients but not in male
          patients with type 2 diabetes. Paternal family history is
          associated with risks equivalent to those without a family                              Pages: 20 + 4/ 52+4
          history of diabetes.
                                            Diabetes Care 2010;33(7):1477-83.                     Paper: Inside - 90 GSM Maplitho
                                                                                                   Cover - 250 GSM Art Card/Hardbound
                                                              Dr. KK Aggarwal
                                                                                                  Printing: 4+2 Color
                                                                                                  Binding: Centre stitch/Hardbound/Perfect
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Handbooks
Handbooks


                                           ECG F ormulaE
                                                           IJCP’s Handbooks are a highly coveted
                                                           academic gifts for doctors. Covering
                Indications of ECG
     The main indications are for the evaluation of        various topics of relevance to clinicians,
1.   The electric axis of the heart                        these Handbooks give a complete insight
2.   Heart rate monitoring
3.   Arrhythmias
                                                           on the subject discussed therein.
      a. Supra ventricular arrhythmias
      b. Ventricular arrhythmias                           An ideal companion to doctors, Handbooks
      c. Disorders in the activation sequence- AV
          conduction defects
                                                           have a long shelf life.
      d. Bundle-branch block
      e. Wolff-Parkinson-White syndrome
4.   Increase in wall thickness or size of the atria and
     ventricles
      a) Atrial enlargement (hypertrophy)
      b) Ventricular enlargement (hypertrophy)
5.   Myocardial ischemia and infarction
      a. Ischemia
      b . Infarction
6.   Drug effect
      a Digitalis
      b. Quinidine                                         Specifications
7.   Electrolyte imbalance
      a. Potassium
      b. Calcium                                              Size: 7 x 4.5 inches
8.   Carditis
      a. Pericarditis                                         Pages: 32-56 +4 pages
      b. Myocarditis
9.   Pacemaker monitoring                                     Paper: 210/90 GSM Indian Art Paper
                                                              Printing: 4+2 color offset printing
                           
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Algorithms
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group
IJCP Group's journey from one medical journal to a leading healthcare communications group

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IJCP Group's journey from one medical journal to a leading healthcare communications group

  • 1.
  • 2. IJCP Group started its journey in June 1990 with its flagship medical journal, the Indian Journal of Clinical Practice, with a brilliant editorial team comprising of doctors and research analysts. Very soon, IJCP grew from this one journal to a Group of Publications. Today, IJCP’s network has traversed borders to win appreciation by the doctors from the different parts of the world. With a wide range of publications, Events & PR, audio & visual, and host of other information packed products, IJCP Group is the preferred partner of not only the Medical fraternity but also the Pharmaceutical companies. But the journey of IJCP does not end here…. We believe this is the beginning of our journey….. Contact us Head Office Dr Veena Aggarwal Mr Nilesh Aggarwal IJCP Publications Pvt. Ltd. Group Executive Editor & Director E-219, Greater Kailash Part - I Joint Managing Director 09818421222 New Delhi - 110048 09811036687
  • 3. Our Management Dr KK Aggarwal Padma Shri & Dr B C Roy Awardee CMD, Publisher and Group Editor-in-Chief President, Heart Care Foundation of India emedinews@gmail.com Dr KK Aggarwal is a Senior Consultant Physician and Cardiologist and Dean of the Board of Medical Education Moolchand Medcity, New Delhi. He is the Founder, Trustee and President of Heart Care Foundation of India. Dr. KK Aggarwal has received many prestigious awards, including the Padma Shri and Dr. B C Roy National Award from the 12th President of India, Smt. Pratibha Devisingh Patil, for his unique contributions in the health sector. He is also known as a writer, columnist and expert for newspapers and TV shows. Dr. Mrs. Veena Aggarwal Group Executive Editor & Joint Managing Director Director, Heart Care foundation of India drveenaijcp@gmail.com Dr Veena Aggarwal, besides being a Consultant in Holistic and Antenatal Care, is a Clinical Obstetrician and Gynecologist by profession. Under her dynamic leadership, foresight and quest for perfection, the IJCP Group has crossed many a milestone and is today a leading healthcare communications group.
  • 4. Journal Indexed with IndMED www.ijcpgroup.com ISSN 0971-0876 Single Copy Rs. 250/- Indian Journal of CLINICAL IJCP PRACTICE Volume 21, Number 7 R ev w Jo ie u al rn 361-420 Pages December 2010 er Pe Esophageal Ulceration Following Typhoid Fever Dr KK Aggarwal Group Editor-in-Chief
  • 5. Indian Journal of Clinical Practice The flagship journal of IJCP Group of From the Desk oF Group eDitor-in-ChieF From the Desk oF Group eDitor-in-ChieF Publications was launched in June 1990 ACS Updates Prostate Cancer Screening Guideline as a monthly medical journal to provide an insight into the proper diagnosis and treatment of diseases and conditions commonly encountered by an Indian physician. IJCP is unquestionably India’s Dr KK Aggarwal Padma Shri and Dr BC Roy National Awardee leading medical journal. Sr Physician and Cardiologist, Moolchand Medcity President, Heart Care Foundation of India Group Editor-in-Chief, IJCP Group Editor-in-chief, eMedinewS Chairman Ethical Committee, Delhi Medical Council Director, IMA AKN Sinha Institute (08-09) Hony. Finance Secretary, IMA (07-08) Chairman, IMA AMS (06-07) President, Delhi Medical Association (05-06) emedinews@gmail.com Specifications http://twitter.com/DrKKAggarwal Krishan Kumar Aggarwal (Facebook) T he American Cancer Society (ACS) has updated its prostate cancer screening guideline. Men should only be screened after they receive information about the uncertainties, risks, and potential benefits associated with prostate cancer screening.  Size: A4  Prostate-specific antigen (PSA) testing is now recommended with or without the digital rectal exam (DRE).  There is little evidence that the DRE adds significant benefit to the PSA test, except, perhaps, when the PSA is in the borderline range.  Pages: 56+4  PSA value of 4.0 ng/ml be used as a reasonable threshold to trigger further evaluation.  There is a new recommendation for men with PSA values between 2.5 and 4.0 ng/ml. Twenty-five percent of men with PSA levels between 2.5 and 4.0 ng/ml harbor prostate cancer and physicians should consider an  Printing: 4+1 Color individualized risk assessment for these men.  Paper: 210/90 GSM Indian Art Paper  An individual assessment should take into account non-PSA risk factors, such as race, family history, results of previous biopsies and DRE results.  ACS also now recommends that the PSA testing interval be reduced to every other year for men whose PSA level is under 2.5 ng/ml. Such a reduction in testing frequency will lead to significantly reduced false positives, unnecessary biopsies and overdiagnosis, with only a negligible increase in missed cancers. Source: CA Cancer J Clin Published online March 3, 2010.  Frequency: Quarterly n n n  Readership: 50,000  Cover Price: ` 300/- Indian Journal of Clinical Practice, Vol. 21, No. 9, February 2011 485 Annual Subscription: ` 3500/-
  • 7. IJCP’s Medinews Launched in June 1992, Medinews is Controlled-Release Tramadol in Chronic Pain India’s first and most comprehensive C hronic pain is different from acute pain. It can be multifactorial; often it may not be possible to find out if Advantages of CR Tramadol medical newspaper. it is nociceptive, neuropathic, idiopathic or all of the above, • Extended duration of action for reduced dosing Medinews features healthcare news as which in turn affects the duration and treatment.1 More frequency than 40-50% of patients in routine practice settings fail to • More constant plasma concentrations for improved achieve adequate relief making chronic pain a particular efficacy and tolerability challenging problem to treat. Besides its impact on quality- of-life (QOL), chronic pain incurs great healthcare costs.2 Available analgesics include nonopioids such as • Improved compliance and therapeutic outcomes The bioavailability of the CR tramadol formulation is an unbiased and well reasoned analysis and covers medical events, nationally acetaminophen, nonsteroidal anti inflammatory drugs (NSAIDs), cyclo oxygenase-2 (COX-2) inhibitors, weak comparable with IR (immediate release) formulations, opioids such as codeine and tramadol and conventional with a half-life 3-4 times longer (16 hours vs 4-6 hours) opioids such as oxycodone and morphine.3 NSAIDs and and an extent of absorption similar to IR tramadol given and internationally in a well-illustrated acetaminophen are the cornerstone of treating most pain thrice-daily.11 conditions. But, their analgesic efficacy varies widely among Tramadol has been widely studied in the treatment of chronic individual patients. Gastrointestinal toxicity is present in pain, such as osteoarthritis, low back pain, cancer pain and 50% of NSAIDs users and 5.4% develop a more serious event requiring hospitalization due to their frequent use.4 NSAIDs may have a possible deleterious effect on articular neuropathic pain.6 CR tramadol is shown to be more effective in terms of analgesia compared to standard formulation of tramadol both six and 12 hours after administration. It also format. Medinews has enjoyed the OFFICIAL PRESS status at premium cartilage metabolism.5 They may affect fluid and electrolyte has fewer adverse effects than the standard formulation.12 balance, causing fluid retention, edema and hypertension.6 A double-blind crossover comparative study has reported Most patients above 65 years have multiple co-morbid disease significant improvement in pain intensity with CR tramadol conditions such as heart disease, diabetes, hypertension, as compared with IR tramadol and higher patient-rated Alzheimer’s and renal disease that significantly complicate treatment of pain.3 treatment effectiveness.13 CR tramadol therefore provides the advantage of around-the-clock analgesic control with reduced dosing frequency which is essential to obtain patient National conferences like APICON, CSI, Tramadol, an Atypical Opioid Analgesic Tramadol is a synthetic, centrally acting analgesic that has compliance in conditions of chronic pain. CR Tramadol in Osteoarthritis AICOG, PEDICON, IMA-CON, IADVL and been used to treat pain effectively in a variety of indications.7 It belongs to the second step of the WHO analgesic ladder. Tramadol has an atypical pharmacological profile with both opioid and monoaminergic mechanisms. It exerts its A chronic degenerative disorder of multifactorial etiology, osteoarthritis (OA) is the second most common rheumatological problem and is the most frequent joint NAPCON for the last 5 years. analgesic effects by complementary mechanisms of action: disease with prevalence of 22-39% in India. Pain along with It binds weakly to µ-receptors and inhibits ascendent pain functional limitation and stiffness are the major symptoms transmission pathways in the spinal cord. At the same time, making OA the most common cause of locomotor disability it stimulates descendent inhibitory pathways by increasing in the elderly.4 Effective pain control is one of the goals release and decreasing re-uptake of noradrenaline and Specifications of treatment,5 which depends on the analgesic efficacy of serotonin.8 The (+) enantiomer is more potent than the treatment and compliance with the dosing regimen.7 the (–) enantiomer in inhibiting serotonin reuptake. On the other hand, the (–) enantiomer is more potent in inhibiting CR tramadol is an efficacious and well-tolerated medication norepinephrine reuptake and increasing presynaptic release. for the treatment of OA pain.11 The American Pain Society This differential interaction between the two enantiomers is recommends tramadol for the management of OA pain synergistic.6 The dual mechanism of action gives tramadol when NSAIDs alone produce inadequate pain relief.11 The Size: A4 Size recommendations of the American Heart Association include  an efficacy that is equivalent to codeine, despite a 10-fold lower affinity to µ-receptors.8 Tramadol does not have tramadol, not NSAIDs or COX-2-specific inhibitors, as the typical opioid adverse effects at the respiratory and first-line therapy for musculoskeletal symptoms in patients cardiovascular level and on intestinal motility at therapeutic with cardiovascular disease or risk factors.6 Pages: 12+4/20+4 doses.9 In addition, it avoids the ulcerogenic, renal/cardiac/ hepatic adverse effects of NSAIDs and COX-2 inhibitors. This feature combined with the lower potential for abuse In a 12-week clinical trial of OA of the knee, CR formulation of tramadol provided patients with increased control over the management of their pain, fewer interruptions in sleep  or dependence, gives tramadol a significant advantage over and improved compliance.14 Clinical data on tramadol and Paper: 70/130 GSM Indian Art Paper nonopioids and also over conventional opioids, particularly  paracetamol indicate that both the parent drug (tramadol) in the elderly.3 and its active metabolite achieved adequate concentrations in Tramadol has a half-life of about 5.5 hours and the usual oral synovial fluid in comparison to paracetamol.15 The results of dosage regimen is 50-100 mg every 4-6 hours (maximum a long-term open label study demonstrated that CR tramadol  Printing: 4 Color dose: 400 mg/day). To reduce the frequency of administration is effective for the long-term management of OA pain. and to improve patient compliance, a controlled-release Reductions in pain intensity, improvements in sleep (CR) formulation of tramadol has been developed.10 and functionality and most QOL measures reported in  Readership: 1,00,000  Frequency: Monthly  Cover Price ` 100/- Advertisement Tariff Annual subscription ` 1200/- Position Dimension (H X W/Cm.) Amount (`/Advt.) Front Solus 15 x 10 ` 40,000 Back Solus 22 x 34 ` 35000 Full Page ` 40,000/- RHS Pages Economy 15 x 10 ` 30,000/- LHS Pages Economy 15 x 10 ` 25,000/-
  • 8. Journal Peer Review Journal ISSN 0972-70035 Single Copy Rs. 250/- www.ijcpgroup.com Volume 13, Number 8, December 2010, Pages 197-236 Dr KK Aggarwal Dr Praveen Chandra Group Editor-in-Chief Guest Editor
  • 9. Asian Journal of Clinical Cardiology Asian Journal of Clinical Cardiology (AJCC) From the Desk oF Group eDitor-in-ChieF xxxxxxxxxxx is an ambitious attempt by IJCP Group New Test to Predict Cardiac Risk in Healthy Patients to publish a journal of international standards. Highly sensitive assay for cardiac troponin T (cTnT) can predict cardiovascular events in apparently healthy populations. As part of the Dallas Heart Study, cTnT levels were measured using both standard and highly sensitive assays in more than 3,500 patients ages 30 to 65. The results were published in the Dec. 8 Journal of Dr. Praveen Chandra, Interventional Cardiologist, Medanta Medcity is the Editor the American Medical Association 2010. The standard assay found detectable cTnT in only 0.7% of the study participants, while the highly sensitive test found it in 25%. Only 7.5% of people in the lowest cTnT group had left ventricular hypertrophy compared to 48.1% in the highest cTnT group. Mortality also increased from 1.9% in the lowest group to 28.4% in the highest. cTnT was independently associated with all–cause mortality (adjusted hazard ratio, 2.8 in the highest cTnT group). of the journal. Dr Chandra and a network of eminent Indian and international Another study in the same issue tested the highly sensitive cTnT assay’s ability to predict heart failure in more than 4,000 community–dwelling elderly patients. The biomarker was detectable in the majority of patients (66.2%) and associated with an increased risk of heart failure and cardiovascular death at higher concentrations (4.8 deaths per 100 in highest group compared to 1.1 in patients with undetectable levels). This study continued cTnT measurements over time and found that increases of more than 50% were also associated with cardiovascular cardiologists are toiling tirelessly to make events. In both studies, there was significant overlap between cTnT and N–terminal pro–brain–type natriuretic peptide, suggesting that more accurate predictions may be achieved by use of both tests together. AJCC a world class cardiology journal. Specifications  Size: A4  Pages: 36+4 Dr KK Aggarwal Padma Shri and Dr BC Roy National Awardee Sr Physician and Cardiologist, Moolchand Medcity President, Heart Care Foundation of India  Printing: 4+1 color Group Editor-in-Chief, IJCP Group Editor-in-Chief, eMedinewS Chairman Ethical Committee, Delhi Medical Council Director, IMA AKN Sinha Institute (08-09)  Paper: 210/90 GSM Indian Art Paper Hony. Finance Secretary, IMA (07-08) Chairman, IMA AMS (06-07) President, Delhi Medical Association (05-06) emedinews@gmail.com  Frequency: Monthly http://twitter.com/DrKKAggarwal Krishan Kumar Aggarwal (Facebook)  Readership: 10,000 Asian Journal of Clinical Cardiology, Vol. 13, No. 9, January 2011 237  Cover Price ` 300/- Annual Subscription ` 3500/-
  • 10. Journal Editorial Volume : 1 January-March 2011 Indian Journal of Clinical Practice, Vol. 20, No. 6, November 2009
  • 11. Asian Journal of Obstetrics Gynecology From the desk oF group editor-in-chieF Asian Journal of Obs Gynae Practice was Paracetamol for Fever in Pregnancy launched in December 1996 as the first of the series of specialized journals under the ‘Asian Series’. The journal covers a Dr KK Aggarwal Padma Shri and Dr BC Roy National Awardee Sr Physician and Cardiologist, Moolchand Medcity whole range of topics in the specialty, President, Heart Care Foundation of India Group Editor-in-Chief, IJCP Group Editor-in-Chief, eMedinewS from antenatal care to general gynecology to operative obstetrics including its Chairman Ethical Committee, Delhi Medical Council Director, IMA AKN Sinha Institute (08-09) Hony. Finance Secretary, IMA (07-08) Chairman, IMA AMS (06-07) President, Delhi Medical Association (05-06) emedinews@gmail.com subspecialities of Urogynecology, Oncology http//twitter.com/DrKKAggarwal Krishan Kumar Aggarwal (Facebook) and Reproductive Endocrinology. E levation of maternal core temperature from a febrile illness or other source (e.g. hot tub) in the first trimester of pregnancy may be associated with an increased risk for neural tube defects or miscarriage. The National Birth Defects Prevention Study, however observed that among women with infection-related fever, use of paracetamol was associated with a statistically significant reduction in neural tube defects, as well as Dr Alka Kriplani, Professor, Dept. of cleft lip/palate and gastroschisis. The data support the safety of paracetamol for relief of fever and pain; however, the reduction in birth defects should be confirmed in other studies before the drug can be recommended to febrile Obstetrics and Gynecology, AIIMS, is the women for this purpose. Evidence Editor of the journal. To investigate whether exposure during the first trimester of pregnancy to single-ingredient acetaminophen increases the risk of major birth defects. Data from the National Birth Defects Prevention Study, a population- based, case-control study, were used. Women who delivered between January 1, 1997, and December 31, 2004 Specifications and participated in the telephone interview were included. Type and timing of acetaminophen use were assigned based on maternal report. Women reporting first-trimester acetaminophen use in a combination product were excluded, resulting in a total of 11,610 children in the case group and 4,500 children in the control group for analysis. The prevalence of first-trimester single-ingredient-acetaminophen use was common: 46.9% (n = 5,440) among women in the case group and 45.8% (n = 2,059) among women in the control group  Readership: 25,000 (p = 0.21). Overall, acetaminophen was not associated with an increased risk of any birth defect. Among women reporting a first-trimester infection and fever, use of acetaminophen was associated with a statistically significantly decreased odds ratio (OR) for an encephaly or craniorachischisis (adjusted OR 0.35, 95% confidence interval [CI] 0.08-0.80), encephalocele (adjusted OR 0.17, 95% CI 0.03-0.87), anotia or microtia (adjusted OR 0.25, 95% CI 0.07-0.86), cleft lip with or without cleft palate (adjusted OR 0.44, 95% CI 0.26-0.75) and gastroschisis (adjusted OR 0.41, 95% CI 0.18-0.94).  Size: A4 Single-ingredient-acetaminophen use during the first trimester does not appear to increase the risk of major birth defects. It may decrease the risk of selected malformations when used for a febrile illness.  Pages: 48+4 Source: Feldkamp ML, Meyer RE, Krikov S, Botto LD. Obstet Gynecol 2010;115(1):109-15.  Printing: 4+2 color n n n Asian Journal of Obs and Gynae Practice, Vol. 1, January-March 2011  Paper: 170/90 GSM Indian Art Paper  Frequency: Quarterly  Cover Price: ` 300/- Annual subscription ` 1200/-
  • 13. Asian Journal of Diabetology From the Desk oF Group eDitor-in-chieF The Asian Journal of Diabetology is a Changing Practice Guidelines: A1C prestigious quarterly journal. Dr Vijay Vishwanathan, an eminent Diabetologist, Managing Director, MV Hospital for Diabetes and Diabetes Research Center, Chennai is the Editor of the journal. Dr KK Aggarwal Padma Shri and Dr BC Roy Awardee Sr Physician and Cardiologist, Moolchand Medcity The journal focuses on informing Physicians and Diabetologists about President, Heart Care Foundation of India Group Editor-in-Chief, IJCP Group Editor-in-Chief, eMedinewS Member, Delhi Medical Council Director, IMA AKN Sinha Institute (08-09) Hony. Finance Secretary, IMA (07-08) managing various aspects of diabetes Chairman, IMA AMS (06-07) President, Delhi Medical Association (05-06) drkk@ijcp.com to provide better patient care to India’s continually rising population of T diabetics. he American Diabetes Association (ADA), the International Diabetes Federation (IDF) and the European Association for the Study of Diabetes (EASD) have joined forces to recommend the use of the hemoglobin A1C assay for the diagnosis of diabetes. A1C values vary less than FPG (fasting plasma glucose) values and the assay for A1C has technical advantages compared with the glucose assay. A1C gives a picture of the average blood glucose level over the preceding Specifications 2-3 months. A1C has numerous advantages over plasma glucose measurement:  It is a more stable chemical moiety.  The patient does not need to fast. Readership: 5,000 Measuring A1C is more convenient and easier for patients who will no longer be required to undergo a fasting   or oral glucose tolerance test (OGTT).  It correlated tightly with the risk of developing retinopathy. Size: A4 The committee has determined that an A1C value of 6.5% or greater should be used for the diagnosis of diabetes. This cut-point, is where risk of retinopathy really starts to go up.  Avoid using estimated average glucose, or EAG, as this is just a way to convert the A1C into glucose levels. Source: American Diabetes Association (ADA) 69th Scientific Sessions. Presented June 5, 2009. Diabetes Care Published online June 5, 2009.  Pages: 36+4  Printing: 4+2 color Paper: 170/90 GSM Indian Art Paper Asian Journal of Diabetology, Vol. 12, No. 1, January-March 2010   Frequency: Quarterly  Cover Price: ` 300/- Annual Subscription ` 1200/-
  • 14. Journal Volume 6, Number 3 July-September 2010 Sedation Practices for the Patient in the ICU Should C-reactive Protein Concentration at ICU Discharge be Used as a Prognostic Marker? Clostridium Difficile: Moving Beyond Antimicrobial Therapy ICU Intubation Success Hampered by Non-ideal Conditions: Based on Small Cohort Study... Pain Not Minimized after Minimally Invasive Cardiac Surgery Still Asleep at the (Ventilator) Switch? Timing of Tracheotomy Linked to Length of Stay: Study Finds to Effect on Mortality from Early Procedure more...
  • 15. Asian Journal of Critical Care From the desk oF Group editor-in-chieF Today, the demands on the intensivists Nonresolving Pneumonia are tremendous, making it necessary for them to be updated with the latest in the field. In view of this, IJCP has another specialty journal, Asian Journal of Critical Care. It discusses original research, review articles, Dr. KK Aggarwal Dr BC Roy Awardee technology in medicine for physicians Sr Physician and Cardiologist Moolchand Medcity President, Heart Care Foundation of India Group Editor-in-Chief, IJCP Group and allied health professionals involved Member, Delhi Medical Council Director, IMA AKN Sinha Institute (08-09) Hony. Finance Secretary, IMA (0�-08) Chairman, IMA AMS (06-0�) in treating the critically ill with the aim President, Delhi Medical Association (05-06) drkk@ijcp.com to improve patient care. S low or incomplete resolution of pneumonia despite treatment is a common clinical problem, estimated to be responsible for approximately 15% of inpatient pulmonary consultations and 8% of bronchoscopies.1 Normal resolution of pneumonia is not easily defined. Patients typically note subjective improvement within Specifications 3-5 days of treatment; more specific clinical criteria for resolution include improvement in fever, cough, crackles, leukocytosis, arterial oxygenation (PaO2) and level of C-reactive protein.2 Most studies on the natural history of pneumonia have focused upon the resolution of chest radiographic  Size: A4 abnormalities, with ‘slow resolution’ often being defined as the persistence of radiographic abnormalities for greater than one month in a clinically improved host. The diagnostic evaluation of treatment failure in pneumonia should begin with a careful history, physical  Pages: 36+4 examination, and review of the clinical picture. One should first consider whether or not the rate of resolution is within the range of expected norms depending on the patient’s underlying host factors, comorbidities, severity of illness and suspected pathogens. In stable or  Printing: 4+2 color slowly improving pneumonia, especially in the presence of comorbidities or host factors which are known to delay Paper: 170/90 GSM Indian Art Paper the resolution of pneumonia, careful observation with or without therapy is warranted for 4-8 weeks.3 When needed, further evaluation should include chest CT to look for sequestered areas of infection or for findings  that suggest an alternative diagnosis. When pneumonia fails to resolve or when there is clinical progression, Frequency: Quarterly fiberoptic bronchoscopy should be considered.   Readership: 20,000 Asian Journal of Critical Care Vol. 5, No. 4, October-December 2009  Price: ` 300/- Annual Subscription ` 1200/-
  • 16. Journal July-September 2010
  • 17. Asian Journal of Paediatric Practice From the desk oF group editor-in-chieF From preventive health care to treatment Smokers in the House, a Risk Factor for of childhood diseases to emergency care Hospitalization of Children with Flu and adolescence – all these subjects and Dr KK Aggarwal many more are covered in the much appreciated and read Asian Journal of Padma Shri and Dr BC Roy National Awardee Sr Physician and Cardiologist, Moolchand Medcity President, Heart Care Foundation of India Group Editor-in-Chief, IJCP Group Paediatric Practice. Editor-in-Chief, eMedinewS Chairman Ethical Committee, Delhi Medical Council Director, IMA AKN Sinha Institute (08-09) Hony. Finance Secretary, IMA (07-08) Chairman, IMA AMS (06-07) President, Delhi Medical Association (05-06) Under the able guidance of Dr Swati emedinews@gmail.com A Bhave, Executive Editor, Association of large retrospective case-control study reported at the annual meeting of the Infectious Diseases Society of America (IDSA) says that having smokers in the house increases the possibility of a young child with flu needing inpatient care. Data from more than 1,300 laboratory-confirmed cases of children with influenza, collected by 10 sites in the CDC’s Emerging Infections Program in 2005-2008 were analyzed to identify risk factors for hospitalization Adolescent Child Care in India (AACCI), associated with laboratory-confirmed influenza. Analysis showed that if more than half of household members were smokers it doubled the chances a child would the journal serves as a practical guide for have a serious case of flu. According to Nila Dharan, MD, of the division of infectious diseases at the NYU School of Medicine in New York City, a family member who had been vaccinated against flu was protective, even if the the continuing education of Pediatricians child was not fully protected by immunizations. The study included 290 children ages six to 59 months (median age 20 months) with serious cases of flu; 1,089 age- and zip code-matched children with the flu who did not need inpatient care during the three influenza seasons acted as controls. The salient observations were as below. and Neonatologists. Age of the mother: if ≤26 years, the odds were doubled. The odds ratio (OR) was 2.1, with a 95% confidence interval (CI) from 1.3 to 3.4. The risk was increased if the child’s vaccinations were not up-to-date. The OR was 1.7, with a 95% CI from 1.1 to 2.7. If more than half of household members smoked, the child’s risk of needing inpatient care was doubled. The OR Specifications was 2.3, with a 95% CI from 1.0 to 5.3. The risk was similar to having any pulmonary condition, including asthma. If the child was not fully vaccinated for the flu, having any household member immunized was protective. The OR was 0.5, with a 95% CI from 0.3 to 0.8.  Readership: 20,000 Underlying medical conditions also had an important role; presence of a hematologic or oncologic condition increased the risk by a factor of 12. According to Dr Dharan, other researchers have examined a possible association between exposure to smoking and  Size: A4 a child’s risk of needing inpatient care for flu, but this is the largest study to date. n n n  Pages: 36+4  Printing: 4+2 color Asian Journal of Paediatric Practice, Vol. 14, No. 1  Paper: 170/90 GSM Indian Art Paper  Frequency: Quarterly  Price: ` 300/- Annual Subscription ` 1200/-
  • 18. Journal October-December 2010
  • 19. Asian Journal of Ear, Nose Throat The management of diseases and the from the Desk of group eDitor-in-chief New Daily Persistent Headache latest techniques in the subspecialties of Otology, Rhinology and Laryngology need to be discussed and informed at length under a common platform efficiently provided by the Asian Journal of Ear, Dr KK Aggarwal Nose Throat. Padma Shri and Dr BC Roy Awardee It provides worldclass information to Sr Physician and Cardiologist Moolchand Medcity President, Heart Care Foundation of India Group Editor-in-Chief, IJCP Group Chief Editor, eMedinewS Member, Delhi Medical Council Director, IMA AKN Sinha Institute (08-09) Hony. Finance Secretary, IMA (07-08) Indian ENT practitioners under the guidance of its founder Editor, Dr VP Sood, Chairman, IMA AMS (06-07) President, Delhi Medical Association (05-06) drkk@ijcp.com Secretary-cum-Managing Trustee, Dr Sood N Nasal Research Foundation, Past President ew daily persistent headache (NDPH) is a primary headache disorder in which headache begins one day and does not remit, in an individual without a headache history. The pathophysiology is poorly understood. Onset of NDPH can be triggered by certain events, such as infection. The incidence and prevalence of NDPH are unknown, but is rare. It is more frequent in children than in adults, and affects women more often than men. A characteristic feature is that the headache starts abruptly and is Association of Otorhinolaryngologists. daily and unremitting from, or almost from, the moment of onset, typically in individuals without a prior headache history. Specifications The diagnosis is clinical and requires ruling out secondary causes. Current diagnostic criteria exclude patients with predominant migrainous features, many headache experts contend that the diagnosis of NDPH can be made regardless of the presence of migrainous features. For patients with recent onset of suspected NDPH, one should do neuroimaging upon presentation. A lumbar puncture is indicated if clinical features suggest a possible central nervous system infection or idiopathic intracranial hypertension. Readership: 20,000 The differential diagnosis includes a number of secondary and primary causes of headache. It is particularly important to consider cerebral venous sinus thrombosis, headache secondary to spontaneous cerebrospinal fluid leaks, idiopathic intracranial hypertension (pseudotumor cerebri), and giant cell arteritis.  NDPH may take either of two subtypes: a self-limited one, or a persistent form which can last years or decades and is challenging to treat.  Size: A4 For patients with primary NDPH, first classify the phenotype of NDPH as most similar to either migraine or tension-type headache, and then treating with appropriate preventive headache therapy accordingly. n n n  Pages: 36+4 Asian Journal of Ear, Nose Throat, April-June 2010  Printing: 4+2 color  Paper: 170/90 GSM Indian Art Paper  Frequency: Quarterly  Price: ` 300/- Annual Subscription ` 1200/-
  • 21. Indian Journal of Medilaw From thE dEsk oF group Editor-in-ChiEF There has been a considerable increase Editorial Driving Restrictions for Patients with Seizures in medicolegal cases in India in the KK Aggarwal past few years. This rise in medical law litigations is due to Consumer Protection Act (CPA) and awareness about protection of patients’ rights and consistent public Dr KK Aggarwal Padma Shri and Dr BC Roy National Awardee Sr Physician and Cardiologist, Moolchand Medcity demands for professional accountability. It is also a fact that, there are no apparent President, Heart Care Foundation of India Group Editor-in-Chief, IJCP Group Editor-in-Chief, eMedinewS Chairman Ethical Committee, Delhi Medical Council Director, IMA AKN Sinha Institute (08-09) Hony. Finance Secretary, IMA (07-08) and explicit guidelines in this regard. Chairman, IMA AMS (06-07) President, Delhi Medical Association (05-06) emedinews@gmail.com http://twitter.com/DrKKAggarwal Krishan Kumar Aggarwal (Facebook) The Indian Journal of Medilaw was launched with the objective to keep the Indian Doctors updated about the current The seizure-free interval is the most practical and widely used measure of a patient’s driving risk. laws and implications on their practice.   Longer seizure-free intervals (6-12 months) are associated with reduced risk of seizure-related motor vehicle accidents (MVA).  Shortening seizure-free intervals to three months by some states has not been associated with increased MVAs.  High seizure frequency, medical noncompliance, a history of MVAs and other factors increase the risk of seizure-related MVA. These should be considered to extend the seizure-free interval requirement for driving Specifications recommendations. An established pattern of purely nocturnal seizures, consistent and reliable seizure auras, clear provocation, Size: A4  or acute symptomatic seizures in a condition that is not associated with epilepsy or is unlikely to recur may reduce the seizure-free interval requirement.  Pages: 36+4 Doctors should also consider other neurologic contraindications for driving in their patients with epilepsy,   including impaired cognition and visual field defects.  The Epilepsy Foundation is a good resource for the current state specific rules on driving and epilepsy.  (www.epilepsyfoundation.org/living/wellness/transportation/driverlicensing.cfm) Doctors should discuss driving with patients and record this discussion in the medical record. This discussion  Printing: 4+2 color should include the risk of driving. Indian Journal of Medilaw, September-November 2010  Paper: 170/90 GSM Indian Art Paper  Quantity: 2-10,000.  Frequency: Quarterly  Price: ` 300/- Annual Subscription ` 1200/-
  • 22. IJCP International Journals American Family Physician Indian Edition A peer-reviewed journal of the American Academy of Family Physicians November-December, 2006 Diagnosis and  Diagnosing Rhinitis: Allergic vs. Nonallergic Treatment of Community-  Assessment of Microscopic Hematuria in Acquired Tuberculosis Adults  Diagnosis and Treatment of Chlamydia trachomatis Infection  Diagnosis and Treatment of Neisseria gonorrhoeae Infections  Diagnostic Approach to Pleural Effusion in Adults  Hepatitis A  Management of Hip Fracture: With Best Compliments from The Family Physician’s Role A Division of Pharmaceuticals Ltd.
  • 23. IJCP American Family Physician American Family Physician is the journal Diagnosing Rhinitis:Allergic vs. Nonallergic of the American Academy of Family DAVID M. QUILLEN, M.D., and DAVID B. FELLER, M.D. University of Florida Family Medicine Residency Program, Gainesville, Florida Physicians (AAFP). Allergic rhinitis, the most common type of rhinitis, generally can be differentiated from the numerous types of nonallergic rhinitis through a thorough history and physical examination. Allergic rhinitis may be The American Academy of Family seasonal, perennial, or occupational. The most common cause of nonallergic rhinitis is acute viral infection. Other types of nonallergic rhinitis include vasomotor, hormonal, drug-induced, structural, and occupational (irritant) Physicians is one of the largest national medical organizations, representing more rhinitis, as well as rhinitis medicamentosa and nonallergic rhinitis with eosinophilia syndrome. Since 1998, three large expert panels have made recommendations for the diagnosis of allergic and nonallergic rhinitis. than 94,000 family physicians, family Allergy testing (e.g., percutaneous skin testing, radioallergosorbent testing) is not necessary in all patients but may be useful in ambiguous or complicated cases. (Am Fam Physician 2006;73:1583-90. Copyright medicine residents, and medical students © 2006 American Academy of Family Physicians.) R hinitis is an inflammation of the diagnosis of rhinitis. This report is intended nationwide. Founded in 1947, its mission nasal mucosa. Associated clinical to be a complete evidence-based guideline symptoms include excessive mucus production, congestion, on the diagnosis and management of allergic rhinitis and asthma. The authors proposed has been to preserve and promote the science and art of family medicine and to sneezing paroxysm, watery eyes, and nasal a new classification for allergic rhinitis, and ocular pruritus. The differential arguing that the current subdivisions (i.e., diagnosis of rhinitis is extensive (Table 11). seasonal and perennial) were not Allergic rhinitis is considered a systemic illness and may be associated with satisfactory. Traditionally, pollens and molds were considered possible causes of ensure high-quality, cost-effective health constitutional symptoms such as fatigue, seasonal allergic rhinitis. However, in some malaise, and headache. It also may be a comorbidity in patients with asthma, places, such as California and Florida, these allergens are present year-round. The WHO care for patients of all ages. eczema, or chronic sinusitis. Differentiating authors suggested a classification system allergic rhinitis from other causes of rhinitis based on the symptoms of intermittent, can be difficult because the diagnostic criteria for various forms of rhinitis are not persistent, mild, and moderate-severe rhinitis. IJCP holds the sole printing rights for always clear-cut. Accurate diagnosis is important because therapies that are effective for allergic rhinitis (i.e., The third report2 was coordinated by the Agency for Healthcare Research and Quality (AHRQ) in collaboration with the American Family Physician in India. antihistamines and nasal corticosteroids) American Academy of Family Physicians may be less effective for other types of and the AAAAI. Unlike the first two reports, Specifications rhinitis.2 the AHRQ report is not a clinical guideline Since 1998, three expert panels1-3 have but an evaluation of the evidence on rhinitis. published reviews of rhinitis. The first report1 The report did not identify any studies was created by the American Academy of differentiating allergic rhinitis and Allergy, Asthma, and Immunology (AAAAI) nonallergic rhinitis based on clinical as a complete guideline for the diagnosis and symptoms, physical examination findings, management of rhinitis. The second report,3 coordinated by the or associated comorbidities. The AHRQ report noted that the treatment conclusions  Size - A4 World Health Organization (WHO), focuses may have been biased because Pages - 36+4 on allergic rhinitis and asthma but includes pharmaceutical companies supported many an extensive section on the differential of the trials.2  Printing - 4+2 printing 8  American Family Physician (Indian Edition) Volume 1, Number 4 October-December, 2006  Paper- 170/90 GSM Indian Art Paper  Frequency: Quarterly  Binding: Center Stitch
  • 24. Publishing Article in a Journal Publishing Articles in a Journal A scientific article, 4-6 pages long, can be published in any of our journals @ Rs 200,000/- per article inclusive of compilation, editing, layouting and Special Reprint 2009 printing subject to peer review/approval Methylcobalamin, Pyridoxine and Nicotinamide in by the Editorial Board. Diabetic Neuropathy: A Review S Jayaram*, Akash Khobragade**, Deepak Langade† ABstRAct Diabetes is the most common etiological factor for peripheral neuropathy (PN). While conventional theory says that prolonged hyperglycemia results in the complications associated with diabetes, including neuropathy, a recent study found that PN can manifest even in individuals with abnormal Journal Article Reprints glucose tolerance, a prediabetic condition. A combination of methylcobalamin, pyridoxine and nicotinamide thus has additive and synergistic effects on the damaged nerve in diabetic neuropathy which protect the nerve from further damage, restore its structural and functional integrity and cause a recovery of function. Key words: Hyperglycemia, prediabetic, polyneuropathy, adenosylcobalamin, vitamin B6, nicotinic acid, Specifications myelin sheath, axon Background incidence approaches 50% for patients with diabetes Peripheral neuropathy (PN) is characterized by pain, for more than 25 years.1 A study conducted in South numbness and tingling in the extremities and slow India to find the prevalence and risk factors, found nerve conduction. It affects a significant percentage a PN prevalence of 19.1% among type 2 diabetics of the Indian population and can be extremely debilitating. Around 7% of patients usually have attending the diabetic clinic. Neuropathy was diagnosed if the vibratory threshold of the great toe exceeded 25. The incidence of PN increases with  Size: A4 neuropathy upon diagnosis of diabetes, and the increase in age and duration of diabetes.2 Based on a *Hon. Professor of Medicine compilation of studies from different parts of the world, the World Health Organization (WHO) has projected  Paper: 110 GSM Indian Art Paper Bombay Hospital, Mumbai that the maximum increase in diabetes would occur in **Resident India.3 Considering the large population and the high † Clinical Pharmacology, Ex-lecturer Dept. of Pharmacology Grant Medical College and Sir JJ Group of Hospitals prevalence of diabetes, the burden of diabetes and it’s complications in India would become enormous.  Printing: 4 + 2 color offset printing Mumbai Pathophysiology of diabetic neuropathy  Pages: 4/6/8 pages Address for correspondence Dr Deepak Langade Diabetes is the most common etiological factor for PN 503/E-7, Runwal Estate, Opp. Lawkim and it is also the most studied in terms of pathogenesis. Ghodbunder Road, Thane (W), Mumbai - 400 607 While conventional theory says that prolonged E-mail: drdgl@hotmail.com hyperglycemia results in the complications associated June 2009 INDIAN JOURNAL OF CLINICAL PRACTICE l VOL. 20, NO. 1  One full page Advertisement
  • 25. Advertisement Tariff (Code A 20) Position Dimension Amount Cover Double Spread 24.5 × 39.5 ` 200,000 Gate Fold False Cover 24.5 X 17.5 ` 150,000 Front page strip 19.5 X 5.0 ` 150,000 Inside Front Cover 24.5 X 17.5 ` 100,000 Front Solus Quarter 14.5 X 11.0 ` 100,000 Back Cover 24.5 X 17.5 ` 1, 50,000 Inside Back Cover 24.5 X 17.5 ` 100,000 Full Page 4 Color 24.5 X 17.5 ` 40,000 Half page 4 Color 12.25 X 17.5 ` 25,000 Full Page 2 Color 24.5 X 17.5 ` 30,000 Half Page 2 Color 12.5 X 17.5 ` 20,000 B/W Full Page 24.5 X 17.5 ` 15,000 B/W Half Page 12.25 X 17.5 ` 12,000 Utility Corner 4 Color Quarter 7.0 X 5.0 ` 50,000
  • 27. Dr. Good Dr. Bad Dr Good Dr Bad is a copyrighted cartoon based product of IJCP, which depicts a clinical situation that a doctor might Situation : A 30-year-old female with a diabetic mother came for come across and the correct way to deal a check-up. with it, in the form of caricatures. The clinical lesson is supported by a scientific reference. You cannot You are also at risk of heart disease be at risk A Ready Reckoner, which a doctor may refer to, when he encounters a clinical situation that may be difficult to handle. Specifications © IJCP GROUP LeSSon : As per results of the Fremantle Diabetes Study, a maternal family history of diabetes confers relative protection against  Size: 4.0 x 5.5 inches or 8”x5.5” inches cardiovascular disease in female patients but not in male patients with type 2 diabetes. Paternal family history is associated with risks equivalent to those without a family  Pages: 20 + 4/ 52+4 history of diabetes. Diabetes Care 2010;33(7):1477-83.  Paper: Inside - 90 GSM Maplitho Cover - 250 GSM Art Card/Hardbound Dr. KK Aggarwal  Printing: 4+2 Color  Binding: Centre stitch/Hardbound/Perfect binding
  • 29. Handbooks ECG F ormulaE IJCP’s Handbooks are a highly coveted academic gifts for doctors. Covering Indications of ECG The main indications are for the evaluation of various topics of relevance to clinicians, 1. The electric axis of the heart these Handbooks give a complete insight 2. Heart rate monitoring 3. Arrhythmias on the subject discussed therein. a. Supra ventricular arrhythmias b. Ventricular arrhythmias An ideal companion to doctors, Handbooks c. Disorders in the activation sequence- AV conduction defects have a long shelf life. d. Bundle-branch block e. Wolff-Parkinson-White syndrome 4. Increase in wall thickness or size of the atria and ventricles a) Atrial enlargement (hypertrophy) b) Ventricular enlargement (hypertrophy) 5. Myocardial ischemia and infarction a. Ischemia b . Infarction 6. Drug effect a Digitalis b. Quinidine Specifications 7. Electrolyte imbalance a. Potassium b. Calcium  Size: 7 x 4.5 inches 8. Carditis a. Pericarditis  Pages: 32-56 +4 pages b. Myocarditis 9. Pacemaker monitoring  Paper: 210/90 GSM Indian Art Paper  Printing: 4+2 color offset printing  Binding: Centre stitch/ perfect binding