1. The document describes the Human Aging System Diagram (HASD) project, which aims to systematically organize knowledge about human aging processes and determine future directions for solving aging issues. 2. HASD is a multidisciplinary project between gerontology and cognitive science that uses a visual diagram to qualitatively describe the cause-and-effect relationships between aging processes, moving from primary causes to pathologies and death. 3. The diagram is developed through expert interviews with gerontologists and distributed work aided by visualization software, with the goal of providing sufficiently detailed aging process information to identify potential interventions.

1. HUMAN AGIND
SYSTEM DIAGRAM
(HASD)
RCAT – Research center
of advanced technologies
Imminst Conference-2010, 10-th October, 2010
by Valerija Pride
http://www.sciencevsaging.org/

2. HistorySeptember 2008
Medvedev D.

3. The goal
A systemic organization of
accumulated knowledge
and determination of
future directions to solve
the problem of aging of
human organism
Фото: Corbis

4. A project of Russian Transhumanist Movement started
in 2010
Some of the projects it operates:
 CAD software NanoInventor
 Human Aging System Diagram
 Telepresence robot “Teleput”
 “Path of upgrade” training center
 Industry report of the fight against aging field
RCAT – Research center
of advanced technologies
Place

6. Gerontologists
have their
puzzles too

7. Multidiscipline project
HASD – is a multidiscipline project between
gerontology and cognitive science
1. Геронтологи, молекулярные биологи
и иные специалисты
 обладают знанием предмета
2. Методологи-когнитивщики
 обладают знанием о знании
 как получить знания от специалистов
 как их оценить
 как организовать полученные знания
 как сделать их доступными
 определить требуемую меру полноты
 как получить новые знания и возможности
Specific

8. Three pillars in the basic
of our results
1.scientificmethodology
2.methodologyofworking
3.visualmethods
Methodology

9. WHAT ?
1. Our diagram describes human aging.
We ignore the aging of other species. At
the same time we may extrapolate
some data from laboratory animals to
humans.
 Comment: This is quite common in hot areas of
science of human biology.
Scientific methodology

10. What ?
2. We think it’s necessary to extract the cause-
and-effect relationships between the aging
processes (properly described), not all
processes that happen in the organism. At the
same time, constant processes, such as
“digestion” are not included, but more specific
processes, such as “decrease of gastric juice”,
can be (if it’s related to aging).
Scientific HASD methodology

11. HOW ?
3. So how do we describe aging? In the
Human Aging System Diagram we have
concentrated on describing the human
aging processes. So the basic units of
information are different processes
connected to blocks.
So, HASD is not a diagram of metabolic
pathways.
Scientific HASD methodology

12. HOW ?
4. We describe aging starting at the top
(natural primary causes) through cell
disruption, decrease of function in tissues and
organs and ending in pathologies and
organism death (at the bottom). The entire
process is one-directional (from top to
bottom).
↓
Scientific HASD methodology

13. The initial aging-related HASD

14. HOW ?
5. No feedback loops
Scientific methodology

15. Scientific methodology
6. The diagram should give sufficiently
detailed elaboration of processes of
ageing. The degree of elaboration is
defined by internal logic of processes and
the need to display sufficient details of
aging process.

16. Additionally
 The diagram qualitatively describes, but
does not model the aging processes. In
particular, the scheme is not equivalent to
a computer model. Entering of numerical
values into the diagram is supposed to
happen at later stages of development of
the project.
 Other diagrams can be connected with
HASD during the project.
Scientific methodology

17. Working methodology
Collecting knowledge (work with
gerontologists and others)
 expert interview using our methodology
 distributed work
Computer’s instruments
 CmapTools
 Get Satisfaction
Analysis
 TRIZ and other tools
HASD work
methodology

18. CMAP Tools

19. GetSatisfaction

20. GetSatisfaction

21. Cognitive convenience and more
Visualization

22. Источник: www.math.yorku.ca/SCS/Gallery/
Visualization
“Report on the collapse of a bridge
over the Rhone” in 1840 by visual
engineer C. J. Minard:
Can you see why did
the bridge collapse?

23. Источник: VisualComplexity.com
Scientific evidence of effectiveness of
modern supplements (for heart disease)
Visualization

24. HASD
HASD, var. № 50
meet

25. Top level diagram HASDFirstversion
Second version

26. Our first experience in visualization

27. The authors
1. The concept author & first director of the project:
Danila Medvedev, PhD, Research center for advanced
technologies (RCAT), Moscow, Russia;
2. Artyuhov I.V., Institute of the Biology of Aging , Moscow,
Russia;
3. Kaurov B.A., The Russian Roszdrav Research and Clinical
Gerontological Center, Moscow, Russia;
4. Krementsova A.B., PhD, Institute of Biochemical Physics
named after N.M. Emmanuel, Moscow, Russia;
5. Moskalev A.A., PhD, The Komi Institute of Biology of the
Ural Region Research Center of the RF Academy of
Sciences, Syktyvkar, The Komi Republic, Russia;
6. Mamayev V.B., PhD, Institute of Biochemical Physics
named after N.M. Emmanuel, Moscow, Russia;

28. And…
6. Pasyukova E.H., PhD, Institute of Molecular Genetics,
Moscow, Russia;
7. Sarvilina I.V., PhD, ООО «Medical Center
«Novomeditcina», Rostov-on-Don, Russia;
8. Pride V., Research center for advanced technologies
(RCAT), Moscow, Russia;
9. Yezhov M.D., Research center for advanced technologies
(RCAT), Moscow, Russia;
10. Ilyin P.A., Research center for advanced technologies
(RCAT), Moscow, Russia;
11. Maybe You ????
;

29. Thank you for your attention!
Research center of advanced technologies
Human Aging System Diagram
www.sciencevsaging.org
sva.org@gmail.com
Our Sponsor: Group «Rostok»
www.grostock.ru , A. Chikunov
Russian Transhumanism Movement
www.transhumanism-russia.ru
Valerija Pride
pride@transhuman.ru +7 962 947-50-79