Glucagon is a 29 amino acid hormone secreted by the pancreas that functions opposite to insulin, being released when blood glucose levels fall to stimulate the liver to break down glycogen into glucose and increase gluconeogenesis from other substrates to raise blood sugar. Cortisol is a steroid hormone produced in the adrenal cortex that also impacts metabolism, being a glucocorticoid that helps regulate metabolic processes.

1. Hormonal Regulations of
Metabolism

2. Glucagon
• Glucagon is secreted from α- cells of Pancreas
• 29 Amino Acids,
• Function of Glucagon is exact opposite of insulin (antagonist)
• Glucoagon is secreted when “GLUCOSE is GONE”
• “When Blood Glucose level is decreasing , Secretion of
glucagon will takes place
• HYPERGLYCEMIC HPORMONE”

3. ACTIONS OF GLUCAGON
• Physiological role of Glucagon is to stimulate
hepatic production and secretion of glucose
accomplishes by
 Glycogenolysis
 Increased Gluconeogenesis
– It exerts it effects on liver and adipose tissue

11. Role of Cortisol in Regulations of
Metabolism

12. • Cortisol is a steroid hormone
• Glucocorticoid class of hormones.
• Produced mainly in zona
fasciculata of the adrenal cortex in
the adrenal gland