Thioguanine , Theophylline, Mercaptopurine This synthesis is used for Anticancer activity

1. SYNTHESIS, MECHANISM,
USES & IT’S SIDE EFFECTS.
Smt. Kishoritai Bhoyar College Of Pharmacy Kamptee
Department Of Pharmaceutical Chemistry
1st Semestar
Ms. Shweta Raut.
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2. Theophylline
Name: Theophylline
Structure:
Melting Point: 272ºC
IUPAC Name: 1,3-dimethyl-7H-purine-2,6-dione
Mole. Wt. : 180.167g/mol
Formula : C₇H₈N₄O₂
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3. Synthesis:
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4. Mechanism:
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5. Uses: 1) treat wheezing, shortness, of breath & chest tightness caused by asthma.
2) chronic bronchitis, emphysema, & other lung disease.
3) it relaxes & air passages in the lungs, making is easier to breath
Side Effects: 1) nausea/ vomiting , stomach abdominal pain, headache , trouble sleeping.
2) diarrhea, irritability, restlessness, nervousness,.
3) increased urination may occur.
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6. Thioguanine:
Name: Thioguanine
Structure:
Melting Point: ≥300ºC
IUPAC Name: 2-amino-1H-purine-6(7H)-thione
Molar Mass: 167.193g/mol
Formula: C5H5N5S
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7. Synthesis:
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8. Mechanism:
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9. Uses: 1) treating acute myeloid leukemia
2) chronic myeloid leukemia especially combination with cytarbine
Side Effects: 1) nausea, vomiting, diarrhea, hair loss, itching or skin rash.
2) darkened skin color.
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10. Mercaptopurine
Name: Mercaptopurine
Structure:
Melting Point: 313ºC
IUPAC Name: 3,7-dihydropurine-6-thione
Molar Mass:152.18gmolˉ¹
Formula: C5H4N4S
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11. Synthesis:
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12. Mechanism:
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13. Properties: 1)yellow crystalline powder
2) insoluble in water
3) slightly soluble in alcohol & dissolves in alkali hydroxide.
Uses: 1) treatment of monocytic leukemia
2) ulcerative colitis
Side effects: 1) black tarry stools
2) decreased appetite
3) fever chills
4) stomach pain or tiredness.
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14. THANK
YOU.
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