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Healthcare 2020: A New Vision
Toward a New Business Model: Intelligent Pharmaceuticals


                        Patient-Centric Product System Model

                                              10-30 Years

    $ Cash Flow

            +
                                                               New System Features




                  4-8 Years
                                               10-12 Years

                                                                       Time
            -



                     10-12 Years

2
Patient-Centric Product Systems: CureTogether Users Share What Works




                Data from 944 online depression community participants
              sharing symptoms and treatments with each other over 2 years
3
Raisin Intelligent Pharmaceutical System




4
Networking the Daily Pill


                Proteus Edible Sensor
                                                     •   Single < 1mm chip
                                                     •   Senses and signals unique
                                                         identifier when swallowed
                                                     •   Accurate: >97% detection in
                                                         human clinical trials
                                                     •   Safe: made from ingredients
                                                         in food
                                                     •   Cheap: 250,000 produced on
                                                         $1,000 wafer
                                                     •   Private: EKG-like signal
                                                         conducted only in body



          Enables Device-Based Sensing and Monitoring of Pharmaceuticals


5
Monitoring via a Band-Aid Familiar to Consumers

                     Proteus Personal Health Companion (PHC)


                                             •   Wearable sensing device
                                                 − Sensors for intelligent
                                                   pharmaceuticals
                                                 − Sensors for physiological
                                                   response
                                                 − Wireless connection to
                                                   mobile devices/computers

                                             •   Sensing of drug ingestion,
                                                 HR, respiration, physical
                                                 activity and body angle
                                             •   Current design for 7-day,
                                                 disposable use case



          Enables Continuous Correlation of Therapeutic Event and Response

6
Proteus Intelligent Pharmaceuticals and Information Flow


                                                        Informed
                                                  Family Communication
                                                       And Support



                                                                                                                 - Alerts
                                                     - Patient Alerts
                                                   - Patient Incentives                                          - Trends
                                                                                                                 - Support



             Consumer
                                                                                             Family Caregivers
                                                                                               & Community




  Intelligent              Continuous            Wireless                   Patient
Pharmaceutical          Medication Sensing       Email to                   Directed                             - Wellness Index
with integrated                                 Web Server                Permissions                             Summary
 Edible Sensor             Physiologic                                                                           - Alerts
                            Sensing                                Web Server IT Interface                       - Cross-Patient
                                                                                                                  Benchmarks
                            Wireless                                RaisinRx Population
                           Upload To                                 Data Aggregation          RN/Physician
                  Raisin-Enabled Mobile Phone


                                                            Informed
                                                    Clinical Communication
                                                          And Support
7
Whole Product Solution For Consumers and Family Caregivers




                                         Applications
           Therapy        Monitoring                      Incentives
                                         & Community




8

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Healthcare 2020: A New Vision

  • 1. Healthcare 2020: A New Vision
  • 2. Toward a New Business Model: Intelligent Pharmaceuticals Patient-Centric Product System Model 10-30 Years $ Cash Flow + New System Features 4-8 Years 10-12 Years Time - 10-12 Years 2
  • 3. Patient-Centric Product Systems: CureTogether Users Share What Works Data from 944 online depression community participants sharing symptoms and treatments with each other over 2 years 3
  • 5. Networking the Daily Pill Proteus Edible Sensor • Single < 1mm chip • Senses and signals unique identifier when swallowed • Accurate: >97% detection in human clinical trials • Safe: made from ingredients in food • Cheap: 250,000 produced on $1,000 wafer • Private: EKG-like signal conducted only in body Enables Device-Based Sensing and Monitoring of Pharmaceuticals 5
  • 6. Monitoring via a Band-Aid Familiar to Consumers Proteus Personal Health Companion (PHC) • Wearable sensing device − Sensors for intelligent pharmaceuticals − Sensors for physiological response − Wireless connection to mobile devices/computers • Sensing of drug ingestion, HR, respiration, physical activity and body angle • Current design for 7-day, disposable use case Enables Continuous Correlation of Therapeutic Event and Response 6
  • 7. Proteus Intelligent Pharmaceuticals and Information Flow Informed Family Communication And Support - Alerts - Patient Alerts - Patient Incentives - Trends - Support Consumer Family Caregivers & Community Intelligent Continuous Wireless Patient Pharmaceutical Medication Sensing Email to Directed - Wellness Index with integrated Web Server Permissions Summary Edible Sensor Physiologic - Alerts Sensing Web Server IT Interface - Cross-Patient Benchmarks Wireless RaisinRx Population Upload To Data Aggregation RN/Physician Raisin-Enabled Mobile Phone Informed Clinical Communication And Support 7
  • 8. Whole Product Solution For Consumers and Family Caregivers Applications Therapy Monitoring Incentives & Community 8