This document presents a recommended protocol for reducing hazards for workers collecting and composting road-killed deer carcasses in New York State. The protocol discusses biological and other hazards from roadkill, routes of exposure, and recommends hazard reduction through engineering controls, personal protective equipment, administrative controls, training, vaccinations, and response to potential infections. It was developed as part of a project by Cornell University to analyze pathogens in NYSDOT roadkill compost facilities.