GR 10 SICKLE CELL DISEASES.pptx77777777666

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MODULE: PEDIATRICS AND CHILD HEALTH
TOPIC: SICKLE CELL DISEASES
LECTURER: DR.AMADU JALLOH
PRESENTED BY: GROUP 10
4/16/2024
1
SCHOOL OF CLINICAL
SCIENCES
MAKAMBO, MAKENI.

GROUP MEMBERS
4/16/2024
2
 Mohamed Kamara 1
 IsataHasanatu Kamara
 Fatmata Kamara
 Alex Kamara
 Mariatu H Kamara

CONTENT
4/16/2024
3
 Learning objectives
 Background
 Defination
 Ethiology
 Risk factors
 Clinical manifestation
 Diagnosis/Management
 Complications
 Preventions

LEARNING OBJECTIVES
4/16/2024
4
 Describe the causes and consequuences of increase
mobidity and mortality of sickle cell diseases.
 Integrate key sickle cell management
recommendations into practice.
 Employ education and communication strategies to
help patient improve their quality of life, prevent
diseases worsening and have fewer less symptoms.

TYPES OF SCD
4/16/2024
8
 Sickle cell anemia.[full blown]: Homozygous
form , in which both hemoglobin are HBS.
 Sickle cell trait : Heterozygous type with one
being nomal and the other sickle. [ HBA and HBS]
 Sickle cell beta thalasemias: Heterozygous form
but with concentration of normal HB being higher
than the sickle HB.
 Hemoglobin S&C: Similar presentation to
sickle cell anemia except mild and less
fequent.[second most common SCD]
Glutamic acid is subtituted b lycine]

EPIDEMIOLOGY
4/16/2024
9
 Sickle gene originate from Africa and India. But
because of globalization, it has now spread
worldwide.[1 per625 birth in USA. Medscape]
 Highest incidence found in subsahaan Afica, India
and Middle east.
 Life expectancy : 42-47 yrs [ASH in Octobe 3, 2016]

CLINICAL FEATURES
4/16/2024
14
 Chief cause for admission of patient is sickle cell
crisis. These includes;
 Vaso-occlusive [painful sequestraion,pain crisis,acute chest syndrome].
 Aplastic crisis.
 Hemolytic crisis.

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