This document contains information from various sources about population trends around the world. It discusses current global population figures from the US Census Bureau. It also includes population pyramids showing the age distribution of populations in Germany and Japan. Charts from the World Bank show historical fertility rate trends. Articles are cited discussing population decline issues in South Korea and the US. The demographic transition model is depicted, showing the shift from high birth and death rates to low rates as countries develop.
Slides from a webinar talk presented for Tableau describing my latest thinking about the challenges of displaying nothing (null, zero values), the opportunities of utilising emptiness and the invisibilities connected with the experience of consuming a visualisation.
Slides from a class given at the University of Oregon School of Journalism and Communication on 16th November 2015, covering examples of different stories, sources, tools and tips.
Slides from a webinar talk presented for Tableau describing my latest thinking about the challenges of displaying nothing (null, zero values), the opportunities of utilising emptiness and the invisibilities connected with the experience of consuming a visualisation.
Slides from a class given at the University of Oregon School of Journalism and Communication on 16th November 2015, covering examples of different stories, sources, tools and tips.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
1. US Census Bureau. U.S. and World Population Clock.
http://www.census.gov/popclock/
https://www.livepopulation.com/country/germany.html
https://www.livepopulation.com/country/japan.html
3. Population pyramids in this slideshow, unless noted otherwise, from: PopulationPyramid.net.
Retrieved February 2, 2019: https://www.populationpyramid.net/
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14. World Bank. Fertility rate, total (births per woman).
Retrieved Feb 3, 2019:
https://data.worldbank.org/indicator/SP.DYN.TFRT.IN
15. Economist. Raving ravens. 8/19/07:
http://www.economist.com/world/europe/displaystory.cfm?story_id=9122814
Noack, Rick. 2014. Why South Korea predicts its end will come in 2750. Washington
Post. August 30:
http://www.washingtonpost.com/blogs/worldviews/wp/2014/08/30/why-south-korea-
predicts-its-end-will-come-in-2750/
16. Cha, Ariana E. 2018. As U.S. fertility rates collapse, finger-
pointing and blame follow. Washington Post. October 19:
https://www.washingtonpost.com/health/2018/10/19/us-
fertility-rates-collapse-finger-pointing-blame-follow/
17. From University of Miami
Biology. Retrieved 3/6/06:
http://fig.cox.miami.edu/~cmalle
ry/150/handouts/fertility.jpg
Demographic
transition
18. Ellen Byron. From Diapers to
'Depends': Marketers Discreetly Retool
for Aging Boomers. Wall Street
Journal. February 5, 2011:
http://online.wsj.com/article/SB1000142
4052748704013604576104394209062
996.html
