The 1099-MISC form is used in the U.S. to report miscellaneous income that doesn't fall under traditional employee wages, including various payments such as rent, royalties, and medical expenses. Businesses must issue this form if payments to non-employees total $600 or more in a calendar year, and recipients must report this income on their taxes. It's essential to verify the information on the form, maintain records, and comply with IRS regulations to avoid penalties.