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GENERAL ANESTHESIA
PURPOSE/GOALS OF ANESTHESIA
I.WHAT IS ANESTHESIA?
 General anesthesia
 Unconscious in reversible, controlled manner
 Binds to receptors:
 Brain - unconsciousness
 Brainstem - immobility
 spinal cord
 5 components of anesthesia:
 Unconsciousness
 Amnesia
 Analgesia
 Immobility
 Attenuation of anatomic responses to
noxious stimulation
 Sympathetic response
 Hypertension
 Tachycardia
 tachypnea
ACTIONS OF COMMONLY USED
ANESTHETIC DRUGS
ACTIONS OF COMMONLY USED
ANESTHETIC DRUGS
I. WHO GIVES ANESTHESIA?
I. WHAT ARETHE RISKS OF ANESTHESIA?
 Sore throat
 Postoperative nausea or vomiting
 Dental damage
 Corneal abrasion
 Awareness
 Brain damage
 Death
PREOPERATIVE EVALUATION
II. PATIENT ASSESSMENT
 Causes stress and physiologic effects
 Past and current medical and surgical conditions
 Who:
 Anesthesiologist
 nurse
 Where:
 In person
 preoperative clinic
 phone interview
 web-based questionnaire
 Healthy patients and emergency surgery – same day evaluation
Chief complaint
Age, height, weight
Surgical history
Previous anesthetics
Family history
Medications and allergies
Medical problems and systems review
PREANESTHETIC
EVALUATION
II. ANESTHETIC PLAN
 Best approach:
 Patient
 Medical history
 Proposed procedure
 Ideal anesthetic:
 Minimum physiologic trespass
 Optimal surgical conditions
 Comfortable
 Expeditious recovery
II. NIL PER OS STATUS
 Complications:
 Regurgitation
 aspiration
 Exceptions:
 Emergency surgeries
 Trauma
 Severe pain
 Nausea and vomiting
 Intestinal obstruction
RAPID SEQUENCE
INDUCTION
II. INFORMED CONSENT
 Last step
 Disclose pertinent risks
 Allow questions
 Legal guardian or medical proxy
SOAP-ME
 S – suction
 O – oxygen (pre-oxygenate with 100% FiO2 for 5mins)
 A – airway (appropriately sized tubes, blades and oral/nasal airway)
 P – personnel (RT, nurse, fellow/attending, sedation provider)
 M – medications: premeds, induction, paralytic, rescue meds (epi,
atropine, fluids)
 E – equipment: vent, ET, stylet, syringe, stylet, tapes, IV
II. PREMEDICATION
 Thorough preoperative consultation --- BEST way
 IV Benzodiazepine (ie. Midazolam)
III. INTRAOPERATIVE MANAGEMENT
 Complications may occur at any time during anesthetic
 Induction:
 Unconscious
 Cardiac and respiratory effects
 Lower BP
 Diminished upper airway muscle tone
III. MONITORING
 Assess:
 Oxygenation and perfusion
 Breath sounds to detect airway problems
 Body temperature
 Routine noninvasive monitor
 ECG
 BP
 Pulse oximeter
 Capnography
 Temperature
III. INDUCTION
 Babies and small children –
inhalation induction
 IV induction is rapid and reliable
 Combination of drugs
 Propofol – most common, rapid
onset (<60 seconds)
 Lidocaine
Agent Advantages Disadvantages Comments
Propofol • Rapid onset
• Short duration
• Rapid recovery
• No residual
effects
• Burns on injection
• Hypotension
• Can cause
respiratory
depression,
especially when
given with opioids
• Not an analgesic
• Most commonly used
induction agent
Methohexital • Rapid onset
• Short duration
• Postoperative
nausea and
vomiting more
likely vs. propofol
• Contraindicated
with acute
intermittent
porphyria
• Often used to induce
anesthesia for
electroconvulsive shock
treatment
Etomidate • Minimal
hemodynamic
effects
• Adrenal
suppression
• May increase
mortality
Ketamine • Minimal
hemodynamic
depression
(release
catecholamines)
• Maintains
respiration and
airway reflexes
• Has analgesic
effects
• Dysphoria and
hallucinations
• Hypertension and
tachycardia
III. INDUCTION
Muscle Relaxants
Agent Mechanism of
action
Onset Duration Side Effects Comments
Succinylcholine Depolarizing Rapid: 30-60 sec Short: 10-15min
Can cause
prolonges blockade
if given as an
infusion, in repeat
doses, or patients
with atypical or
absent pseudo-
cholinesterase
• Tachycardia
• Bradycardia
• Myalgia
• Hyperkalemia
• Rhabdomyolysi
s
• Malignant
hyperthermia
• Increased
intraocular
pressure
Almosst never used
in children
Pancuronium Nondepolarizing 4-5 min 75-90 min • Hypertension
• Tachycardia
Cecuronium Nondepolarizing 3 min 30-45min Duration may
increase with
repeat doses in
patients with renal
failure
Rocuronium Nondepolarizing 1-2 min 30-45 min
Cisatracurium Nondepolarizing 2-3 min 45 min
III. AIRWAY
 Preoxygenation
 Denitrogenation
 3 minutes to complete
 4 tidal breaths
CORMACK LEHANE SCORE
III. MAINTENANCE
 Begins after induction when the airway is
secured.
 May use various IV or inhaled agents
 The goal of anesthesia
 ensure unconsciousness and amnesia
 Immobility
 muscle relaxation
 blunted sympathetic reflexes
Inhaled Anesthetics
Agent Comment
Desflurane Most insoluble agent of the potent agents. Most rapid wake up. Pungent
aroma can irritate airway.Causes sympathetic stimulation during induction.
Isoflurane Most potent and most soluble of the currently used agents. Slowest
emergence, especially after longer cases. Pungent aroma. Can cause
tachycardia during induction
Nitrous oxide Not potent enough to produce anesthesia on its own. Often used in
combination with other potent agents
Sevoflurane Pleasant arome. Good choice for inhalation induction. No sympathetic
stimulation
Opioids
Opioid Onset Duration Comment
Remifentanil Rapid Brief Rapidly hydrolyzed by
nonspecific esterases.
Does not accumulate even
with prolonged
administration
Fentanyl 1-2 min (maximum effect
within 30 min)
15-20 min Small doses have a short
duration because they are
rapidly redistributed from
central to peripheral
tissues. Larger doses or
repeat injection causes
accumulation of drug in
the peripheral tissues
producing longer duration
of analgesia
Hydromorphone 15-30 min (maximum
effect may not occur for
up to 150 min)
Duration: 3-5 hr
III. EMERGENCE
 Review patient’s hemodynamics and temperature
 Degree of residual neuromuscular blockade
 Ensure adequate analgesia for the transition to recovery
 While assessing readiness for emergence, the anesthesiologist begins to decrease
or discontinue IV or inhaled anesthetics.
 Timing of these changes depends on the type of drugs given and the duration of
the administration
CRITERIA FOR EXTUBATION
 Awake and responsive
 Stable vital signs
 Reversal of paralysis
 Good hand grip
 Sustained head lift for 5 seconds
 Negative inspiratory force ≥20mmHg
 Vital capacity > 15ml/kg
IV. POSTOPERATIVE CARE
 Transfer care to recovery room nurse
 Requires effective and clear communication to avoid error and harm
 The person assuming the care must respond and confirm that he/she heard and
understands the relayed information
 Must be hemodynamically stable and normothermic
 Unstable patient is better left intubated, ventilated and sedated until stable
END
 Thank you for listening!

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General anesthesia (for INTERNS).pptx

  • 2. PURPOSE/GOALS OF ANESTHESIA I.WHAT IS ANESTHESIA?  General anesthesia  Unconscious in reversible, controlled manner  Binds to receptors:  Brain - unconsciousness  Brainstem - immobility  spinal cord  5 components of anesthesia:  Unconsciousness  Amnesia  Analgesia  Immobility  Attenuation of anatomic responses to noxious stimulation  Sympathetic response  Hypertension  Tachycardia  tachypnea
  • 3. ACTIONS OF COMMONLY USED ANESTHETIC DRUGS
  • 4. ACTIONS OF COMMONLY USED ANESTHETIC DRUGS
  • 5. I. WHO GIVES ANESTHESIA?
  • 6. I. WHAT ARETHE RISKS OF ANESTHESIA?  Sore throat  Postoperative nausea or vomiting  Dental damage  Corneal abrasion  Awareness  Brain damage  Death
  • 7. PREOPERATIVE EVALUATION II. PATIENT ASSESSMENT  Causes stress and physiologic effects  Past and current medical and surgical conditions  Who:  Anesthesiologist  nurse  Where:  In person  preoperative clinic  phone interview  web-based questionnaire  Healthy patients and emergency surgery – same day evaluation
  • 8. Chief complaint Age, height, weight Surgical history Previous anesthetics Family history Medications and allergies Medical problems and systems review PREANESTHETIC EVALUATION
  • 9. II. ANESTHETIC PLAN  Best approach:  Patient  Medical history  Proposed procedure  Ideal anesthetic:  Minimum physiologic trespass  Optimal surgical conditions  Comfortable  Expeditious recovery
  • 10. II. NIL PER OS STATUS  Complications:  Regurgitation  aspiration  Exceptions:  Emergency surgeries  Trauma  Severe pain  Nausea and vomiting  Intestinal obstruction RAPID SEQUENCE INDUCTION
  • 11. II. INFORMED CONSENT  Last step  Disclose pertinent risks  Allow questions  Legal guardian or medical proxy
  • 12. SOAP-ME  S – suction  O – oxygen (pre-oxygenate with 100% FiO2 for 5mins)  A – airway (appropriately sized tubes, blades and oral/nasal airway)  P – personnel (RT, nurse, fellow/attending, sedation provider)  M – medications: premeds, induction, paralytic, rescue meds (epi, atropine, fluids)  E – equipment: vent, ET, stylet, syringe, stylet, tapes, IV
  • 13. II. PREMEDICATION  Thorough preoperative consultation --- BEST way  IV Benzodiazepine (ie. Midazolam)
  • 14. III. INTRAOPERATIVE MANAGEMENT  Complications may occur at any time during anesthetic  Induction:  Unconscious  Cardiac and respiratory effects  Lower BP  Diminished upper airway muscle tone
  • 15. III. MONITORING  Assess:  Oxygenation and perfusion  Breath sounds to detect airway problems  Body temperature  Routine noninvasive monitor  ECG  BP  Pulse oximeter  Capnography  Temperature
  • 16.
  • 17. III. INDUCTION  Babies and small children – inhalation induction  IV induction is rapid and reliable  Combination of drugs  Propofol – most common, rapid onset (<60 seconds)  Lidocaine Agent Advantages Disadvantages Comments Propofol • Rapid onset • Short duration • Rapid recovery • No residual effects • Burns on injection • Hypotension • Can cause respiratory depression, especially when given with opioids • Not an analgesic • Most commonly used induction agent Methohexital • Rapid onset • Short duration • Postoperative nausea and vomiting more likely vs. propofol • Contraindicated with acute intermittent porphyria • Often used to induce anesthesia for electroconvulsive shock treatment Etomidate • Minimal hemodynamic effects • Adrenal suppression • May increase mortality Ketamine • Minimal hemodynamic depression (release catecholamines) • Maintains respiration and airway reflexes • Has analgesic effects • Dysphoria and hallucinations • Hypertension and tachycardia
  • 18. III. INDUCTION Muscle Relaxants Agent Mechanism of action Onset Duration Side Effects Comments Succinylcholine Depolarizing Rapid: 30-60 sec Short: 10-15min Can cause prolonges blockade if given as an infusion, in repeat doses, or patients with atypical or absent pseudo- cholinesterase • Tachycardia • Bradycardia • Myalgia • Hyperkalemia • Rhabdomyolysi s • Malignant hyperthermia • Increased intraocular pressure Almosst never used in children Pancuronium Nondepolarizing 4-5 min 75-90 min • Hypertension • Tachycardia Cecuronium Nondepolarizing 3 min 30-45min Duration may increase with repeat doses in patients with renal failure Rocuronium Nondepolarizing 1-2 min 30-45 min Cisatracurium Nondepolarizing 2-3 min 45 min
  • 19. III. AIRWAY  Preoxygenation  Denitrogenation  3 minutes to complete  4 tidal breaths
  • 20.
  • 21.
  • 22.
  • 23.
  • 25.
  • 26. III. MAINTENANCE  Begins after induction when the airway is secured.  May use various IV or inhaled agents  The goal of anesthesia  ensure unconsciousness and amnesia  Immobility  muscle relaxation  blunted sympathetic reflexes Inhaled Anesthetics Agent Comment Desflurane Most insoluble agent of the potent agents. Most rapid wake up. Pungent aroma can irritate airway.Causes sympathetic stimulation during induction. Isoflurane Most potent and most soluble of the currently used agents. Slowest emergence, especially after longer cases. Pungent aroma. Can cause tachycardia during induction Nitrous oxide Not potent enough to produce anesthesia on its own. Often used in combination with other potent agents Sevoflurane Pleasant arome. Good choice for inhalation induction. No sympathetic stimulation
  • 27. Opioids Opioid Onset Duration Comment Remifentanil Rapid Brief Rapidly hydrolyzed by nonspecific esterases. Does not accumulate even with prolonged administration Fentanyl 1-2 min (maximum effect within 30 min) 15-20 min Small doses have a short duration because they are rapidly redistributed from central to peripheral tissues. Larger doses or repeat injection causes accumulation of drug in the peripheral tissues producing longer duration of analgesia Hydromorphone 15-30 min (maximum effect may not occur for up to 150 min) Duration: 3-5 hr
  • 28. III. EMERGENCE  Review patient’s hemodynamics and temperature  Degree of residual neuromuscular blockade  Ensure adequate analgesia for the transition to recovery  While assessing readiness for emergence, the anesthesiologist begins to decrease or discontinue IV or inhaled anesthetics.  Timing of these changes depends on the type of drugs given and the duration of the administration
  • 29. CRITERIA FOR EXTUBATION  Awake and responsive  Stable vital signs  Reversal of paralysis  Good hand grip  Sustained head lift for 5 seconds  Negative inspiratory force ≥20mmHg  Vital capacity > 15ml/kg
  • 30. IV. POSTOPERATIVE CARE  Transfer care to recovery room nurse  Requires effective and clear communication to avoid error and harm  The person assuming the care must respond and confirm that he/she heard and understands the relayed information  Must be hemodynamically stable and normothermic  Unstable patient is better left intubated, ventilated and sedated until stable
  • 31. END  Thank you for listening!

Editor's Notes

  1. -General anesthesia is a process whereby the patient is rendered unconscious in a reversible, controlled manner. -unconsciousness is induced by binding to specific receptors throughout the brain, brainstem and spinal cord -anesthetics most likely make patients unconscious by acting on the brain, while immobility results from effects on the brainstem **complete paralysis can produce immobility in response to surgical stimulation, although paralysis without unconsciousness can lead to awareness with recall, an uncommon but potentially horrifying complication **muscle relaxation provides optimal conditions for endotracheal intubation and improves surgical exposure during intra-abdominal and intrathoracic procedures Even while paralyzed, the body can mount a robust SYMPATHETIC RESPONSE to surgical stimulation with hypertension, tachycardia and tachypnea. The last element of general anesthesia aims to controll these changes
  2. Most anesthesia consent forms include a list of possible complications. Some of these are.. -nausea and vomiting – common but transient -dental damage and corneal abrasion – less common but self-limited or repairable -awareness, brain damage, or death – rare but catastrophic **awareness – happens 1 in 10,000 patients, and patient with awareness with recall are at increased risk of this complication after a subsequent anesthetic ** death due to anesthesia is very rare, occurring in fewer than 1 in 100,000 anesthetics
  3. So in the OR, we use this acronym para guide natin kung okay na ang usual set-up
  4. The World Health Organization has developed a checklist called “the WHO Surgical Safety checklist” used in operating rooms worldwide to increase safety and reliability Eto po ung routine q&a pagpasok natin ng OR