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From the Fringes to
the Forefront:
A market research report on
mRNA is here to
Transform Global
Health
2
mRNA: The Understanding
Discovered in 1960, mRNA stands for “messenger ribonucleic acid” or “messenger RNA”; basically the mRNA is
software of life
Protein
mRNA
DNA
Storage
DNA stores
instructions for
proteins in the
nucleus
Software
mRNA is a
temporary set of
instructions for
cells to make a
protein
Application
Proteins form the
basis of life by
performing the
function required
by every cell
Advantages of mRNA:
• Speed of design and scalability of
manufacturing mRNA over other vaccines
and therapies has a very major advantage
• Another advantage that mRNA may offer over
other more traditional vaccine types (such as
live attenuated vaccines, inactivated vaccines
and sub-unit vaccines) and over DNA based
vaccines is safety
• mRNA is non-infectious and non-integrating
(i.e. it does not cause DNA insertions) which
gives it a further advantage over attenuated
and DNA based vaccines
3
mRNA Becomes the Rising Star of Nucleic Acid Therapy
• After decades of research and the accumulation of theoretical knowledge, the COVID-19 pandemic in early 2020 brought mRNA to
the forefront as a new modality, and finally reached the tipping point in demonstrating its utility in infectious diseases
• mRNA vaccines, upon delivery, tell our cells to synthetize proteins, e.g., resembling those from the coronavirus (the SARS-Cov-2
spike proteins)
• This cellular generation of proteins then elicits an immune response in which the body produces virus-neutralizing antibodies even
before infection with the real pathogen
How does the mRNA works?
mRNA provides genetic
instructions to make
viral proteins
Cellular machinery
follows the mRNA
instructions to produce
viral proteins
Viral proteins induce
an immune response
Antibodies are ready to
combat viral infection
1 2 3 4
4
mRNA made Headlines in 2020
Moderna is a leader in mRNA technology
mRNA made headlines in December 2020 when one of the world’s first COVID-19 vaccines, developed by US-based pharmaceutical
company Moderna, the National Institute of Allergy and Infectious Diseases (NIAID), and the Biomedical Advanced Research and
Development Authority (BARDA), began rolling out to members of the public
Moderna’s vaccine was developed at unprecedented speed, and its public launch marked a turning point in the pandemic. By the end of
last year, the company had shipped more than 800 million vaccines worldwide, with approximately 25 percent shipped to low-to-middle
income countries through direct sales or donations
The Company’s mRNA platform is intrinsically flexible, allowing the company to move mRNA medicines quickly from idea to
development candidate nomination. This means it can be used to contain future COVID outbreaks and manage yearly mutations,
staying ahead of the virus’ evolution
The company’s manufacturing platform was designed so that it would not need to amend production processes to produce new
boosters or mRNA vaccines
5
mRNA Therapies: Clinical Pipeline Assets
40
Unique
Products
15
Companies
44
Assets
Line Items Split by Therapeutic Areas Line Item Split by Clinical Phase
Who should buy this report?
MedTech
Players
HealthTech
Companies
Digital Health
Entities
Pharmaceutical
Players
Other Lifesciences
Companies
Cost of this report:
$2,500
Annual Subscription:
$125,000 $60,000
(Includes a total of 50 reports)
www.insights10.com
Will the Expiry of Humira Market Exclusivity and Entry of its
Biosimilars Move the Needle in BioPharma Market?
From the Fringes to the Forefront: mRNA is here to Transform
Global Health
Melting the Iron Triangle: 10 Healthcare Players aiming Beyond
Health Equality to Conquer Health Equity
Robotics: Embarking a New Era in Surgical Innovations
Metaverse: Paving the way for Health 4.0
Topics of Upcoming Reports
Healthcare Future Outlook 2023
Patient Engagement- a New Standpoint on Care that is
Patient-Centered
E-Rx, the Digital Version of Prescription Improvising the Chances
of Better Patient Outcomes
Integration of Healthcare Systems with Big Data and Data Silos
Methodology & Scope
9
Research Methodology
▪ Insights 10’s research methodology delves deeper into the market, covering the macro and micro aspects of the industry. We identify
the key growth drivers, opportunities, and restraints that might promote or hinder the future industry growth along with an expansive
overview of the competitive landscape to help our clients make informed strategic decisions
▪ We implement a mix of primary and secondary research for our market estimate and forecast. The secondary research forms the initial
phase of our study where we conduct extensive data mining, referring to verified data sources such as independent studies, government
and regulatory published material, technical journals, trade magazines, and paid data sources
▪ For forecasting, the following parameters are considered:
❑ Market drivers and restraints along with their current and expected impacts
❑ Technological scenario and expected developments
❑ End use industry trends and dynamics
❑ Trends in the consumer behavior
❑ Regulatory scenario and expected developments
❑ Current capacity and expected capacity additions up to 2030
▪ We assign weights to these parameters and quantify their market impacts using the weighted average analysis to derive the expected
market growth rate
▪ We appoint data triangulation strategies to explore different areas of the market. Our qualitative and quantitative assessments are
time-sensitive, reflecting the most recent value and volume of the market across regions
▪ All our estimates and forecasts are verified through exhaustive primary research with the Key Industry Participants (KIPs)
▪ Currency used in the report is the US dollar (USD), with the market size indicated in USD million/billion (Mn/Bn)
10
Analysis Methodology
Our Analysis Methodology involves three critical stages:
01
02
01
02
03
01
02
03
Primary
Research
Secondary
Research
Market Trends
Market Sizing &
Analysis
Data Triangulation &
Validation
Analysis &
Interpretation
Insights
Presentation &
Reporting
Data Collection Market Data Analysis
& Statistical Model
Interpretation &
Presentation
11
Data Triangulation & Data Validation
Bottom Up Approach
B
o
t
t
o
m
U
p
A
p
p
r
o
a
c
h
Summarization of revenue
generated from companies
to arrive at total market size
Revenue generated by products &
services offered by companies
Validation from
Primary Interview
Final
Market
Size
Top Down Approach
T
o
p
D
o
w
n
A
p
p
r
o
a
c
h
Final Market size break up to
rest of segmentation
Arriving at market size
of each segment
Validation from
Primary Interview
Final
Summary
12
Key Benefits for Stakeholders from this Report
Study provides an in-depth analysis of the market with current trends and future estimations to elucidate the imminent
investment pockets
Our tools provides stakeholders with a cohesive understanding of the industry outlook, considering the qualitative and
quantitative industry variables
Comprehensive analysis of factors that drive and restrict the market growth is provided
Comprehensive quantitative analysis of the industry from 2021 to 2030F is provided to enable the stakeholders to capitalize on
the prevailing market opportunities
Extensive analysis of the key segments of the industry helps understand the applications and technologies used globally
Our rigorous data collection, thorough statistical analysis and specialist assessments ensure that our clientele has a greater
understanding of the industry space, supply chain, price fluctuations, competitive landscape, and other vital factors
2021
2022-
2030
Report Attribute
Quantitative Units
Report Coverage
Customized Report
Pricing and purchase
options
Revenue in USD Million/Billion (Mn/Bn)
Market Overview, Revenue Forecast, Market
Segmentation, Growth Factors and Trends,
Company Profiles, Competitive Landscape,
Regulatory Landscape, Future Opportunities
Report Customization (5 working days) with
purchase. We will provide you with data that is
currently not a part of our scope as a part of
customization
Avail customized purchase options to meet
your exact research needs
Details
Time Frame
Base Year for
Estimation
Forecast
Period
The report is prepared
using a proven
methodology and
insightful research
Reliable
The data is prepared by
a team of highly qualified
& experienced research
analysts & vetted by our
local associates
Expert-verified
Allowing you to
confidently make
smarter business
and strategic
decisions
Real
Covers everything you
would need to know
about the market
including market size,
competitive analysis &
much more
Comprehensive
You do not have to be a
market expert to
understand what really is
happening on the market
and how it works
Easy to read
What kind of Data is Presented
in this Report?
This report presents data, which is:
www.insights10.com
About
www.insights10.com
A large database of over 30,000 syndicated market
research reports in pharmaceuticals and healthcare
sector at global, regional as well as country level. We
also provide customized research reports tailor made
to suit your needs
Lifesciences Market
Research Reports you
can trust
Insights10 is a healthcare focused market research
firm founded with an aim of being an insights driven
company in the data driven world and delivering
actionable insights that can drive decision and
strategy making process for businesses
Get Insights to take
informed Business
Decisions
www.insights10.com
Market Research Reports
across various domains of healthcare
Healthcare
Services
Clinical
Trials
OTC &
Nutraceuticals
Pharmaceuticals
(Diseases & Drugs)
Digital
Health
Medical
Devices
Our
Services
1
2
3
4
5
6
10
9
8
7
Market Research Reports
Customized Reports
Primary Research
Database Services
Full-Time Engagement
Conference Coverage
Competitive Intelligence
Strategic Research Projects Regulatory Compliance
Report Subscription Services
Our Research Process
01 03
02 04 05
Identification of
Data
Collection of
Data
Market
Dynamics
Collaboration
of Data
Verification &
Analysis
www.insights10.com
Statistical Databases
Data
Sources
We have access to multiple highly
reliable free and subscription data
sources. We have many years of
experience to understand which
sources are more dependable for what
and which to prefer for the reliable and
latest information.
Company Websites/Annual Reports
Trade Publications
Online Databases
Published Research Reports
Whitepapers
Press Releases of Key Market Players
www.insights10.com
Research Projects Done
Over the years, we have developed an in-depth experience of executing
market analysis at global, regional & country specific level in life sciences.
Our team has
conducted market
research across 62+
global markets in
America, Europe,
Middle East, Africa and
Asia Pacific regions
Mukesh is an engineering graduate
with an MBA in Marketing. He is a
seasoned healthcare market
research & marketing professional
with a progressive experience of over
20 years in Life Sciences, Pharma
and Medical Device sectors . With an
in-depth understanding of primary
research, he has conducted
hundreds of interviews of various
stakeholders in pharma & healthcare
& completed several research
Ritu has over 6 years of experience in
strategy building, market assessments,
market sizing, and RWE for global MNC
healthcare & biopharma clients across
diff. markets (America, Europe, Africa,
APAC and Middle East). Her areas of
expertise include: Indentifying emerging
trends in life sciences industry,
Competitor landscape assessment,
Disease opportunity assessments etc.
She is a pro in secondary and primary
research with a deep domain expertise
Purav is a physician and an
entrepreneur with 12+ years of
experience in Healthcare & Life
Sciences industry spanning across
strategy, market access, health
informatics and RWE, Digital
Healthcare, analytics and data science.
Purav studied medicine from Gujarat
University and also completed his MBA
from IIM-Kozhikode. Purav started his
career with Deloitte working on strategy
consulting engagements and also
Dhruv Joshi is an engineer and has done
Masters in Hospital Administration with
over 4 years of experience in the
healthcare and life science industry. He
has gained proficiency in market
research, market assessment, and
developing insights from it. He has
worked on various consulting projects
across different geographies including
Asia, Europe, US, MENA. He has been
aligned in working for sector reports of
various geographies along with market
Dr. Purav Gandhi
Founder & CEO
Mukesh Nayak
Head - Marketing
Ritu Baliya
Engagement Manager
Dhruv Joshi
Consultant
Project Leadership Team
7 years of experience working with leading organizations in pharma, MedTech
and healthcare domain. Some of our recent clients are mentioned below
… and many more
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From The Friengs To The Forefront mRAN is here to Transform Global Health

  • 1. From the Fringes to the Forefront: A market research report on mRNA is here to Transform Global Health
  • 2. 2 mRNA: The Understanding Discovered in 1960, mRNA stands for “messenger ribonucleic acid” or “messenger RNA”; basically the mRNA is software of life Protein mRNA DNA Storage DNA stores instructions for proteins in the nucleus Software mRNA is a temporary set of instructions for cells to make a protein Application Proteins form the basis of life by performing the function required by every cell Advantages of mRNA: • Speed of design and scalability of manufacturing mRNA over other vaccines and therapies has a very major advantage • Another advantage that mRNA may offer over other more traditional vaccine types (such as live attenuated vaccines, inactivated vaccines and sub-unit vaccines) and over DNA based vaccines is safety • mRNA is non-infectious and non-integrating (i.e. it does not cause DNA insertions) which gives it a further advantage over attenuated and DNA based vaccines
  • 3. 3 mRNA Becomes the Rising Star of Nucleic Acid Therapy • After decades of research and the accumulation of theoretical knowledge, the COVID-19 pandemic in early 2020 brought mRNA to the forefront as a new modality, and finally reached the tipping point in demonstrating its utility in infectious diseases • mRNA vaccines, upon delivery, tell our cells to synthetize proteins, e.g., resembling those from the coronavirus (the SARS-Cov-2 spike proteins) • This cellular generation of proteins then elicits an immune response in which the body produces virus-neutralizing antibodies even before infection with the real pathogen How does the mRNA works? mRNA provides genetic instructions to make viral proteins Cellular machinery follows the mRNA instructions to produce viral proteins Viral proteins induce an immune response Antibodies are ready to combat viral infection 1 2 3 4
  • 4. 4 mRNA made Headlines in 2020 Moderna is a leader in mRNA technology mRNA made headlines in December 2020 when one of the world’s first COVID-19 vaccines, developed by US-based pharmaceutical company Moderna, the National Institute of Allergy and Infectious Diseases (NIAID), and the Biomedical Advanced Research and Development Authority (BARDA), began rolling out to members of the public Moderna’s vaccine was developed at unprecedented speed, and its public launch marked a turning point in the pandemic. By the end of last year, the company had shipped more than 800 million vaccines worldwide, with approximately 25 percent shipped to low-to-middle income countries through direct sales or donations The Company’s mRNA platform is intrinsically flexible, allowing the company to move mRNA medicines quickly from idea to development candidate nomination. This means it can be used to contain future COVID outbreaks and manage yearly mutations, staying ahead of the virus’ evolution The company’s manufacturing platform was designed so that it would not need to amend production processes to produce new boosters or mRNA vaccines
  • 5. 5 mRNA Therapies: Clinical Pipeline Assets 40 Unique Products 15 Companies 44 Assets Line Items Split by Therapeutic Areas Line Item Split by Clinical Phase
  • 6. Who should buy this report? MedTech Players HealthTech Companies Digital Health Entities Pharmaceutical Players Other Lifesciences Companies
  • 7. Cost of this report: $2,500 Annual Subscription: $125,000 $60,000 (Includes a total of 50 reports) www.insights10.com Will the Expiry of Humira Market Exclusivity and Entry of its Biosimilars Move the Needle in BioPharma Market? From the Fringes to the Forefront: mRNA is here to Transform Global Health Melting the Iron Triangle: 10 Healthcare Players aiming Beyond Health Equality to Conquer Health Equity Robotics: Embarking a New Era in Surgical Innovations Metaverse: Paving the way for Health 4.0 Topics of Upcoming Reports Healthcare Future Outlook 2023 Patient Engagement- a New Standpoint on Care that is Patient-Centered E-Rx, the Digital Version of Prescription Improvising the Chances of Better Patient Outcomes Integration of Healthcare Systems with Big Data and Data Silos
  • 9. 9 Research Methodology ▪ Insights 10’s research methodology delves deeper into the market, covering the macro and micro aspects of the industry. We identify the key growth drivers, opportunities, and restraints that might promote or hinder the future industry growth along with an expansive overview of the competitive landscape to help our clients make informed strategic decisions ▪ We implement a mix of primary and secondary research for our market estimate and forecast. The secondary research forms the initial phase of our study where we conduct extensive data mining, referring to verified data sources such as independent studies, government and regulatory published material, technical journals, trade magazines, and paid data sources ▪ For forecasting, the following parameters are considered: ❑ Market drivers and restraints along with their current and expected impacts ❑ Technological scenario and expected developments ❑ End use industry trends and dynamics ❑ Trends in the consumer behavior ❑ Regulatory scenario and expected developments ❑ Current capacity and expected capacity additions up to 2030 ▪ We assign weights to these parameters and quantify their market impacts using the weighted average analysis to derive the expected market growth rate ▪ We appoint data triangulation strategies to explore different areas of the market. Our qualitative and quantitative assessments are time-sensitive, reflecting the most recent value and volume of the market across regions ▪ All our estimates and forecasts are verified through exhaustive primary research with the Key Industry Participants (KIPs) ▪ Currency used in the report is the US dollar (USD), with the market size indicated in USD million/billion (Mn/Bn)
  • 10. 10 Analysis Methodology Our Analysis Methodology involves three critical stages: 01 02 01 02 03 01 02 03 Primary Research Secondary Research Market Trends Market Sizing & Analysis Data Triangulation & Validation Analysis & Interpretation Insights Presentation & Reporting Data Collection Market Data Analysis & Statistical Model Interpretation & Presentation
  • 11. 11 Data Triangulation & Data Validation Bottom Up Approach B o t t o m U p A p p r o a c h Summarization of revenue generated from companies to arrive at total market size Revenue generated by products & services offered by companies Validation from Primary Interview Final Market Size Top Down Approach T o p D o w n A p p r o a c h Final Market size break up to rest of segmentation Arriving at market size of each segment Validation from Primary Interview Final Summary
  • 12. 12 Key Benefits for Stakeholders from this Report Study provides an in-depth analysis of the market with current trends and future estimations to elucidate the imminent investment pockets Our tools provides stakeholders with a cohesive understanding of the industry outlook, considering the qualitative and quantitative industry variables Comprehensive analysis of factors that drive and restrict the market growth is provided Comprehensive quantitative analysis of the industry from 2021 to 2030F is provided to enable the stakeholders to capitalize on the prevailing market opportunities Extensive analysis of the key segments of the industry helps understand the applications and technologies used globally Our rigorous data collection, thorough statistical analysis and specialist assessments ensure that our clientele has a greater understanding of the industry space, supply chain, price fluctuations, competitive landscape, and other vital factors
  • 13. 2021 2022- 2030 Report Attribute Quantitative Units Report Coverage Customized Report Pricing and purchase options Revenue in USD Million/Billion (Mn/Bn) Market Overview, Revenue Forecast, Market Segmentation, Growth Factors and Trends, Company Profiles, Competitive Landscape, Regulatory Landscape, Future Opportunities Report Customization (5 working days) with purchase. We will provide you with data that is currently not a part of our scope as a part of customization Avail customized purchase options to meet your exact research needs Details Time Frame Base Year for Estimation Forecast Period
  • 14. The report is prepared using a proven methodology and insightful research Reliable The data is prepared by a team of highly qualified & experienced research analysts & vetted by our local associates Expert-verified Allowing you to confidently make smarter business and strategic decisions Real Covers everything you would need to know about the market including market size, competitive analysis & much more Comprehensive You do not have to be a market expert to understand what really is happening on the market and how it works Easy to read What kind of Data is Presented in this Report? This report presents data, which is: www.insights10.com
  • 15. About
  • 16. www.insights10.com A large database of over 30,000 syndicated market research reports in pharmaceuticals and healthcare sector at global, regional as well as country level. We also provide customized research reports tailor made to suit your needs Lifesciences Market Research Reports you can trust
  • 17. Insights10 is a healthcare focused market research firm founded with an aim of being an insights driven company in the data driven world and delivering actionable insights that can drive decision and strategy making process for businesses Get Insights to take informed Business Decisions www.insights10.com
  • 18. Market Research Reports across various domains of healthcare Healthcare Services Clinical Trials OTC & Nutraceuticals Pharmaceuticals (Diseases & Drugs) Digital Health Medical Devices
  • 19. Our Services 1 2 3 4 5 6 10 9 8 7 Market Research Reports Customized Reports Primary Research Database Services Full-Time Engagement Conference Coverage Competitive Intelligence Strategic Research Projects Regulatory Compliance Report Subscription Services
  • 20. Our Research Process 01 03 02 04 05 Identification of Data Collection of Data Market Dynamics Collaboration of Data Verification & Analysis www.insights10.com
  • 21. Statistical Databases Data Sources We have access to multiple highly reliable free and subscription data sources. We have many years of experience to understand which sources are more dependable for what and which to prefer for the reliable and latest information. Company Websites/Annual Reports Trade Publications Online Databases Published Research Reports Whitepapers Press Releases of Key Market Players www.insights10.com
  • 22. Research Projects Done Over the years, we have developed an in-depth experience of executing market analysis at global, regional & country specific level in life sciences. Our team has conducted market research across 62+ global markets in America, Europe, Middle East, Africa and Asia Pacific regions
  • 23. Mukesh is an engineering graduate with an MBA in Marketing. He is a seasoned healthcare market research & marketing professional with a progressive experience of over 20 years in Life Sciences, Pharma and Medical Device sectors . With an in-depth understanding of primary research, he has conducted hundreds of interviews of various stakeholders in pharma & healthcare & completed several research Ritu has over 6 years of experience in strategy building, market assessments, market sizing, and RWE for global MNC healthcare & biopharma clients across diff. markets (America, Europe, Africa, APAC and Middle East). Her areas of expertise include: Indentifying emerging trends in life sciences industry, Competitor landscape assessment, Disease opportunity assessments etc. She is a pro in secondary and primary research with a deep domain expertise Purav is a physician and an entrepreneur with 12+ years of experience in Healthcare & Life Sciences industry spanning across strategy, market access, health informatics and RWE, Digital Healthcare, analytics and data science. Purav studied medicine from Gujarat University and also completed his MBA from IIM-Kozhikode. Purav started his career with Deloitte working on strategy consulting engagements and also Dhruv Joshi is an engineer and has done Masters in Hospital Administration with over 4 years of experience in the healthcare and life science industry. He has gained proficiency in market research, market assessment, and developing insights from it. He has worked on various consulting projects across different geographies including Asia, Europe, US, MENA. He has been aligned in working for sector reports of various geographies along with market Dr. Purav Gandhi Founder & CEO Mukesh Nayak Head - Marketing Ritu Baliya Engagement Manager Dhruv Joshi Consultant Project Leadership Team
  • 24. 7 years of experience working with leading organizations in pharma, MedTech and healthcare domain. Some of our recent clients are mentioned below … and many more
  • 25. Web: www.insights10.com Email: insights@insights10.com Call: (+91) 931 639 7935 Whatsapp: (+91) 931 639 7935 We would be happy to help.