This document summarizes a systematic review that compares the frictional resistance between self-ligating brackets and conventionally ligated brackets based on in vitro studies. A total of 19 studies met the selection criteria for inclusion in the review. The review found that self-ligating brackets produce lower friction than conventional brackets when used with small round archwires in the absence of tipping or torque in an ideally aligned arch. However, the evidence was insufficient to claim that self-ligating brackets produce lower friction than conventional brackets when used with large rectangular wires that involve tipping and/or torque or in arches with malocclusion. The variability in experimental methods among the selected studies may explain the inconsistent results.