Fortezza is a gated Italian-themed community located in Cabuyao, Laguna, Philippines. It consists of two phases, with Phase 1 having 288 salable lots covering 7.3 hectares and Phase 2 having approximately 350 units covering 7.2 hectares, for a total development area of over 15 hectares. The homes feature Italian architectural influences and range in lot size from 88 to 250 square meters. Amenities include a clubhouse, basketball court, children's playground, landscape parks, and picnic areas.
Villa 994 is a beautiful and luxurious villa built around the middle of 17th century near the medieval
town of Lucca. Secluded and protected by an enclosure wall, the villa is the true expression of Lucca's
traditional architecture. The layout of the property is typical of an old era and lifestyle featuring a
symmetrical distribution of rooms around a central salon and a noble floor located on the upper level.
Villa 994 is a beautiful and luxurious villa built around the middle of 17th century near the medieval
town of Lucca. Secluded and protected by an enclosure wall, the villa is the true expression of Lucca's
traditional architecture. The layout of the property is typical of an old era and lifestyle featuring a
symmetrical distribution of rooms around a central salon and a noble floor located on the upper level.
What: A low density Modern Minimalist themed high-rise enclave in Quezon City.
How: That offers intimate and tranquil environment with lush landscapes.
Who: For the discerning and growing upper middle-income families.
Why: Seeking to live in a private, secured, and serviced neighborhood.
Where: Within reach from city’s activity and business centers
When: In a time of increasing cramped living spaces in the city.
If you're looking for a smart real estate investment for you or your family, look no further. Premier developer Megaworld offers master-planned communities built to world-class standards in the most strategic locations. Learn about its current projects including Megaworld at The Fort.
Visit www.megaworldatthefort.com
HOME FOR SALE / VENDO CASA - JUAYUA, EL SALVADOR - RUTA DE LAS FLOREShrginmobiliaria
HOMER FOR SALE / VENDO CASA - JUAYUA - RUTA DE LAS FLORES, EL SALVADOR. 3 BEDROOMS, 2 BATHS, BEAUTIFUL COUNTRY SIDE. EXCELLENT INVESTMENT, THIS COULD BE YOUR RETIREMENT PROPERTY. ONLY 45 MIN FROM THE CAPITAL. 2.5 HOUR FLIGHT FROM MIAMI, FL
The Angela Apartments is one of Manila’s heritage buildings… a building of pedigree… and deserves to reclaim its heritage status.
Built in the 1930’s by renowned architect Fernando Ocampo ,The Angela Apartments was among the first multi-story residential buildings that raised Manila’s skyline during the Commonwealth Period
It remains today as one of the few surviving examples of the Art-Deco style of architecture in pre-war Manila.
The Angela Apartments will be restored to its former glory and yet imbued with a new life that is sure to add value to contemporary Manila, while preserving what little remains of its heritage.
What: A low density Modern Minimalist themed high-rise enclave in Quezon City.
How: That offers intimate and tranquil environment with lush landscapes.
Who: For the discerning and growing upper middle-income families.
Why: Seeking to live in a private, secured, and serviced neighborhood.
Where: Within reach from city’s activity and business centers
When: In a time of increasing cramped living spaces in the city.
If you're looking for a smart real estate investment for you or your family, look no further. Premier developer Megaworld offers master-planned communities built to world-class standards in the most strategic locations. Learn about its current projects including Megaworld at The Fort.
Visit www.megaworldatthefort.com
HOME FOR SALE / VENDO CASA - JUAYUA, EL SALVADOR - RUTA DE LAS FLOREShrginmobiliaria
HOMER FOR SALE / VENDO CASA - JUAYUA - RUTA DE LAS FLORES, EL SALVADOR. 3 BEDROOMS, 2 BATHS, BEAUTIFUL COUNTRY SIDE. EXCELLENT INVESTMENT, THIS COULD BE YOUR RETIREMENT PROPERTY. ONLY 45 MIN FROM THE CAPITAL. 2.5 HOUR FLIGHT FROM MIAMI, FL
The Angela Apartments is one of Manila’s heritage buildings… a building of pedigree… and deserves to reclaim its heritage status.
Built in the 1930’s by renowned architect Fernando Ocampo ,The Angela Apartments was among the first multi-story residential buildings that raised Manila’s skyline during the Commonwealth Period
It remains today as one of the few surviving examples of the Art-Deco style of architecture in pre-war Manila.
The Angela Apartments will be restored to its former glory and yet imbued with a new life that is sure to add value to contemporary Manila, while preserving what little remains of its heritage.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. CONCEPT P hase 1 is about 7.3 hectares with 288 salable lots while Phase 2 is 7.2 hectares with approximately 350 units. This over 15-hectare gated community offers Italian-themed houses. Fortezza means “ fortress ”. Fortress which means castle , citadel , or large fort , which describes the project’s magnificence.
3. The picturesque countryside offers the ambience of an idyllic life… in spite of the bustling population & reputation as an emerging destination of multinational companies. CONCEPT
4. CONCEPT The homes are Italian-inspired ; with architectural touches that give them charm & grace. An elegantly planned community, Fortezza offers homes that are spacious enough for a young family; two-storey italian houses that sit on a lot areas of 88 sqm to 250 sqm.
6. From Manila, QC, PASIG, MAKATI, LAS PIÑAS, ALABANG & Parts of Laguna via SLEX – take Cabuyao exit or take the National Road from Alabang, Muntinlupa to Brgy. San Isidro, Cabuyao, Laguna. ACCESS ROADS
11. And if you’re looking out for fun, it is good to know that Fortezza is complete with first-class amenities & verdant landscape. A whole new lifestyle of comfort complete with well-integrated facilities & amenities such as clubhouse, basketball court, children’s playground, landscape parks, picnics & promenade areas. AMENITIES
12. AMENITIES Landscape parks Basketball court Children’s playground Picnics & Promenade Areas Clubhouse
