Scientists have developed a new RNA repair technology that can help fix defects in RNA that cause diseases. The technology involves finding compounds that target RNA with expanded triplet repeats, which are sequences of three repeated nucleotides associated with neurological and neuromuscular disorders. Researchers were able to demonstrate that small molecules can reverse RNA defects of this type. This development could accelerate treatments for incurable diseases caused by RNA defects, such as Huntington's disease.
The mechanisms of DNA repair help us maintain the body in a normal physiological state, despite of the constant inducing damage that we are exposed.
But if these repair mechanisms fail for some reason it could cause mutations, cell death and many diseases.
Therefore, a low mutation rate indicates the efficiency of repair mechanisms, but a failure of these will be the cause of several mutations.
Several studies point to the discovery of new mechanisms of repair, so try to create treatments for diseases.
The mechanisms of DNA repair help us maintain the body in a normal physiological state, despite of the constant inducing damage that we are exposed.
But if these repair mechanisms fail for some reason it could cause mutations, cell death and many diseases.
Therefore, a low mutation rate indicates the efficiency of repair mechanisms, but a failure of these will be the cause of several mutations.
Several studies point to the discovery of new mechanisms of repair, so try to create treatments for diseases.
Discover the cutting-edge Gene Silencing approach in cardiovascular disease. Explore RNAi, ASOs, and their therapeutic applications for a healthier heart.
RNA interference (RNAi) is a system within living cells that takes part in controlling which genes are active and how active they are. RNA interference has an important role in defending cells against parasitic genes – viruses and transposons – but also in directing development as well as gene expression in general.
The Central Roles of Non-coding RNAs in Neurodegenerative Disorders: Neurode...QIAGEN
Non-coding RNAs (ncRNAs), especially microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have shown aberrant expression profiles in neurodegenerative disorders. This slideshow reviews the roles of lncRNAs and their mechanisms of action in the regulation of neurodegeneration. Learn more about novel solutions to isolate RNAs from blood and cerebral spinal fluid (CSF). A new qPCR-based lncRNA platform for lncRNA detection and profiling is also presented.
Chemical structural-advances-and-hurdles-to-clinical-translation-of-rn ai-the...Al Baha University
RNAi can wipe out the disease-causing proteins from being translated. Now RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. At the same time, both scientific and industrial communities started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to be addressed by current treatment strategies.
Discover the cutting-edge Gene Silencing approach in cardiovascular disease. Explore RNAi, ASOs, and their therapeutic applications for a healthier heart.
RNA interference (RNAi) is a system within living cells that takes part in controlling which genes are active and how active they are. RNA interference has an important role in defending cells against parasitic genes – viruses and transposons – but also in directing development as well as gene expression in general.
The Central Roles of Non-coding RNAs in Neurodegenerative Disorders: Neurode...QIAGEN
Non-coding RNAs (ncRNAs), especially microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have shown aberrant expression profiles in neurodegenerative disorders. This slideshow reviews the roles of lncRNAs and their mechanisms of action in the regulation of neurodegeneration. Learn more about novel solutions to isolate RNAs from blood and cerebral spinal fluid (CSF). A new qPCR-based lncRNA platform for lncRNA detection and profiling is also presented.
Chemical structural-advances-and-hurdles-to-clinical-translation-of-rn ai-the...Al Baha University
RNAi can wipe out the disease-causing proteins from being translated. Now RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. At the same time, both scientific and industrial communities started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to be addressed by current treatment strategies.
Search and Society: Reimagining Information Access for Radical FuturesBhaskar Mitra
The field of Information retrieval (IR) is currently undergoing a transformative shift, at least partly due to the emerging applications of generative AI to information access. In this talk, we will deliberate on the sociotechnical implications of generative AI for information access. We will argue that there is both a critical necessity and an exciting opportunity for the IR community to re-center our research agendas on societal needs while dismantling the artificial separation between the work on fairness, accountability, transparency, and ethics in IR and the rest of IR research. Instead of adopting a reactionary strategy of trying to mitigate potential social harms from emerging technologies, the community should aim to proactively set the research agenda for the kinds of systems we should build inspired by diverse explicitly stated sociotechnical imaginaries. The sociotechnical imaginaries that underpin the design and development of information access technologies needs to be explicitly articulated, and we need to develop theories of change in context of these diverse perspectives. Our guiding future imaginaries must be informed by other academic fields, such as democratic theory and critical theory, and should be co-developed with social science scholars, legal scholars, civil rights and social justice activists, and artists, among others.
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
"Impact of front-end architecture on development cost", Viktor TurskyiFwdays
I have heard many times that architecture is not important for the front-end. Also, many times I have seen how developers implement features on the front-end just following the standard rules for a framework and think that this is enough to successfully launch the project, and then the project fails. How to prevent this and what approach to choose? I have launched dozens of complex projects and during the talk we will analyze which approaches have worked for me and which have not.
Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024Tobias Schneck
As AI technology is pushing into IT I was wondering myself, as an “infrastructure container kubernetes guy”, how get this fancy AI technology get managed from an infrastructure operational view? Is it possible to apply our lovely cloud native principals as well? What benefit’s both technologies could bring to each other?
Let me take this questions and provide you a short journey through existing deployment models and use cases for AI software. On practical examples, we discuss what cloud/on-premise strategy we may need for applying it to our own infrastructure to get it to work from an enterprise perspective. I want to give an overview about infrastructure requirements and technologies, what could be beneficial or limiting your AI use cases in an enterprise environment. An interactive Demo will give you some insides, what approaches I got already working for real.
GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using Deplo...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
GenAISummit 2024 May 28 Sri Ambati Keynote: AGI Belongs to The Community in O...
Folding - Molecular Biology
1. Texto adicional Texto adicional Texto adicional texto adicional Texto adicional texto adicional New RNA Repair Technology and Therapeutic Strategies for Controlling Gene Expression Anny Carolina Sarria Mena Medicine Student, 3rd semester Teacher: Lina María Martinez Sánchez Molecular Biology UPB - 2012
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4. INTRODUCTION The proper use of the tools offered by molecular biology would be of great benefit to modern medicine, as with so many technological advances, to the heart of mutations and would reduce the pathologies that they can be repaired. Interestingly travésde as identifyingRNA sequences and errors in the maturation of the same drugs can create and repair mechanisms such as RNA.
16. Medical Utility The RNA may represent one of the great advances in medicine, if used properly and that the viruses that plague humanity are involved in transcription and maturation of the same. And with the proper identification of the processing and maturation of these viruses can find a solution by using drugs that can attack in its genome .
18. Medical Utility Through the years and with the expertise of researchers have made significant progress in the field of medicine have been established treatments and therapies, drugs and instruments which act on the genome and polymorphisms reduce all thanks to Molecular Biology.
