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fMRI Results
Re-Mission is a video game designed to improve cancer treatment adherence in children and teenagers. It contains 20 levels across 7 cancer types with objectives like killing cancer cells and managing side effects. Research shows Re-Mission improves treatment adherence, with patients having 16% more antibiotic doses and 20% higher blood chemo levels, as well as greater cancer knowledge and self-efficacy. Studies aim to identify the mechanisms behind Re-Mission's effectiveness, examining the roles of knowledge, emotion, motivation and how interactivity activates reward centers in the brain linked to learning and behavior change. Results suggest game-based interventions can powerfully influence health behaviors through psychological and neural pathways.
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fMRI Results
- 2. Harnessing the power and appeal of technology to improve kids’ health 2!
- 3. Our Model! research! innovation! customer input! 3!
- 4. Re-Mission! • 20 levels! • 7 cancer types! • Objectives: kill cells, manage side-effects and complications! • Weapons: chemo, radiation, antibiotics, stool softener! 4!
- 5. PEDIATRICS August 2008! RE-MISSION WORKS! • Improved treatment adherence! – 16% increase in antibiotic doses! – Blood chemo levels 20% higher! • Improved cancer knowledge! • Greater self-efficacy: Increased belief in ability to control/cope with cancer! 5!
- 6. Identifying the mechanismsof action in Re-Mission! Knowledge and learning are only part of the story 6!
- 7. Identifying the mechanismsof action in Re-Mission! ? Treatment! adherence! 7 7!
- 8. Re-Mission Works –But How? Identifying the mechanisms of action in Re-Mission! Emotion/! Motivation! Treatment! adherence! Knowledge! Re-Mission Attitudes Study! Jennifer Aaker, Ph.D., Stanford University! 8 8!
- 9. Identifying the mechanismsof action in Re-Mission! How does videogame play influence real-life behavior?! ? Interactivity and Reward-Related Neural Activation During a Serious Videogame! ! h#p://dx.plos.org/10.1371/journal.pone.0033909 ! 9 9!
- 10. Identifying the mechanismsof action in Re-Mission! 10 min fMRI T2*! Rest! Rest Rest Rest Rest Rest Rest Play! Rest! 10!
- 11. Identifying the mechanismsof action in Re-Mission! Interactive play ! Passive exposure! Caudate! Caudate! Thalamus! Thalamus! Hippocampus! Hippocampus! 11 11!
- 12. iden%fying mechanisms of ac%on Identifying the mechanisms of action in Re-Mission! Results! • Game-based interventions can be powerful tools for activating health-supportive behaviors! • Psychological outcomes (knowledge, self-efficacy)! • Treatment-related behavior (chemo / antibiotic adherence)! • Interactive game-play has wide impact on the brain! • Learning / knowledge ! Interactivity and Reward-Related Neural • Motivation / emotion! Activation! During a Serious Videogame! • Hippocampal activation may play a role in generalizing in-game experience to real-life behavior! Brian Knutson, Ph.D., Stanford University ! http://dx.plos.org/10.1371/journal.pone.0033909! Implications! • Psychological “recipe” for positive behavior change! • Neural biomarkers for optimizing interventions ! 12 12!
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