Ian Shaw seeks revenge on Dominic Toretto for killing his brother Owen. Shaw endangers Toretto's team, who set out to find Shaw before he finds them. A virus genetically engineered to target cancer cells instead makes people highly aggressive. Years later, Robert Neville is the last human in New York as he works to develop a vaccine to cure the virus. He captures an infected woman to test a potential vaccine but it fails. A group of scientists and pilot Nolan travel in a spacecraft to search for new habitable planets to save humanity from a shortage crisis on Earth. They explore planets to check habitability and experience time relativity by passing through a wormhole to different dimensions.