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ENHANCED RECOVERY AFTER SURGERY IN
RADICAL CYSTECTOMY
DR YAAM KUMAR
1st YEAR DrNB
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ERAS
• Also referred as “enhanced recovery
programs” or “fast-track protocols”
• They are evidence-based, collaborative
perioperative care pathways designed
to improve recovery after major surgical
procedures.
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• AIM - To maintain preoperative organ function and reduce the body’s stress response
after surgery.
• ERAS protocols contain preoperative, intraoperative, and postoperative components
that include patient counseling, nutritional optimization, standardized analgesic and
anesthetic regimens, and early mobilization (Melnyk et al., 2011)
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• ERAS – first described by Henrik Kehlet in 1990.
• Meta-analyses of studies of colorectal surgery
patients have provided evidence for reduction of complications (50%) and hospital stay (2.5
days) by application of ERAS pathways (Varadhan et al., 2010).
• This has led to adoption of ERAS protocols in many surgical Specialties including
gynecologic,thoracic,vascular, pediatric, and orthopedic surgery, and most recently urology
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• Evidence based multimodal approach focused on peri-
operative period
• Improve patient recovery after surgery
- Modifyphysiologicandpsychologicalresponse
- Enabledischargehome earlier
- Without compromisingsafetyandwellbeing
• Several meta-analyses have shown accelerated
recovery and decreased hospital stay with ERASin
colorectal surgery.
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• In urology, the best studied ERAS
protocols are in patients
undergoing radical cystectomy and
urinary diversion.
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• In 2010, the ERAS Society was founded and headquartered in Kista,
Sweden.
• The mission of the ERAS Society is to “develop perioperative care and
to improve recovery through research, audit education and
implementation of evidence-based practice.”
• The Society website (http://www.erassociety.org/) offers procedure-
specific guidelines, useful information, and resources related to
enhanced recovery
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• The ERAS Society, the main society dedicated to the study of multimodal perioperative care pathways, has published guidelines that include 22
ERAS recommendations for patients undergoing
radical cystectomy (Cerantola et al., 2013).
• Majority of these recommendations are extrapolated from colorectal surgery literature without any direct
evidence from the cystectomy population supporting their use.
• Only 7 of the 22 ERAS recommendations, as outlined by the ERAS Society guidelines are backed by direct evidence from urology patients
(Cerantola et al., 2013)
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Bladder Cancer
 Invasivebladder canceradisease of the elderly
- Most patientsare 65yrs or older
- Increasing %are 80+yrs
 Multiple medicalconditions
 Cumulative cigarette smokeexposure
- Cardiacdisease
- Decreased pulmonary function
 Up to 1/3receiveneoadjuvantchemotherapy
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RadicalCystectomy
 Among the most complex urologic
operations
- Associated with considerable morbidity and
prolonged inpatientstay
 LOSremainsin the 8-9 day rangeandis
- the most reported quality indicator for RC
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Traditional Care
 Surgeryisplanned ‘assoonaspossible’
- No training or conditioning
 Bowel prep (mechanicalandantibiotic)
 NPO(clear liquids only for preop1-2 days)
 Compensatory overhydration at onset of case
- aggressivehydration during case–fluid overload
 NGTand NPO untilflatus
 Opioid analgesia
- Limiting mentalacuity and mobility
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Traditional Hospital Course
 Typical stay ~10days inUS*
 ~60%complication rate (15%high-grade
complications)
 ~30%hospital readmissionrate
*15-20daysin Europe/Asia
v
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Framework of Enhanced
Recovery
Pre
operative
Post
operative
Enhanced
Recovery
Intra
operative
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Preoperative EnhancedRecovery
Framework
 Optimization of medicalco-morbidities
 Smoking cessation
 NutritionAssessment
- Evenshort termdietary modification helpful
- Decrease alcohol intake
 Prehabilitation
- Physical conditioning, even 1week ishelpful
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Preoperative EnhancedRecovery
Framework
Written and oral pre-admission
information describing:
 What will happensduring
hospitalization
 What they shouldexpect
- Length of stay
- Home plan
 Whowill be at homewith you after
discharge?
 Their role in the preparation
and recoveryprocess
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Intra-operative Enhanced
Recovery Framework
 Efficient and expeditioussurgery
 Smaller incision
 Lessbowel manipulation
 Minimization ofblood loss and transfusion
 Non-narcotic analgesiaintraoperatively
 Instillation of local anesthetic at incision sites
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GIRecovery is an Important Driver for
Length of Stay and Readmission
 Delayed GIrecovery (POI, “ileus”) is the most
common causefor prolonged hospital stay after
radical cystectomy
- Rate of POI:12and25%
 POI-related increased LOScontributes to morbidity
- Increaserisk of secondaryclinicalconsequences(eg
nosocomialinfections,readmissions)
 POI adds substantive cost burden to the healthcare
system
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Enhanced Recovery Framework
 Avoid intense bowelpreparation
 Avoid NGtubes
 Pharmacological prophylaxis of
postoperative nausea orvomiting
 Enforcedearlyenteral feeding diet POD#1
 Liberal useoflaxatives
 Alvimopan
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Take home messages
 ERASFramework
- BeginsPRIORto the actual admission
- Communicate expectations
 Identify and treatcomorbidities
Physical Conditioning
Carbohydrate loading
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Take home messages
 GIoptimization
- Avoid bowel prep
- Minimize bowel handlingintra-op
- No NGtubes
 Reduceeffects ofopioids
- Alvimopan –start prior to surgery
- Non narcotic useintra-operative
- Long acting localanesthetic
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Take home messages
 SurgeonFactors
- Expeditious surgery
- Minimize blood loss
 EarlyMobilization
- Feedearly
- Walkearly
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Take home messages
 Earlydetection, screening & prevention
- Thefirst 2 weeksafter discharge are critical
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ERAS(Enhanced Recovery After
Surgery)
 A multidisciplinary approach involving
surgeons, anesthesiologists, nurses,
dieticians, and allied health professionals is
one of the key paradigm shifts that is now
neededto optimise recoveryof our patients
.
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Framework of Enhanced Recovery
Pre
operative
• Counseling
• Teaching(written
and verbal)
• Expectations
• Discharge plan
• Stomateaching
• Stomamarking
• Optimization
• Lungs
• Cardiac
• Prehabilitation
• Nutrition
• Carbloading
• No prolongedfast
• No bowelprep
• VTE prophylaxis
Post
operative
• Paincontrol
• Avoidance of opioids
and toxicity
• Early mobilization
• Early oralnutrition
• Nutrition drinks
• Avoid salt andwater
overload
• IleusControl
• Prevention ofN/V
• No NGtubes
• No aggressivebowel
regimen
• VTE prophylaxis
• Early follow-up
Enhanced
Recovery
Intra
operative
• Avoidance of saltand
water overload
• Maintenance of
normothermia
• Localanesthesia
• Antibiotics accordingto
AUA BestPractices
• Alvimopan(FDAapproved)
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Thank You

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ERAS.pptx

  • 2. 23-03-2023 2 2 ENHANCED RECOVERY AFTER SURGERY IN RADICAL CYSTECTOMY DR YAAM KUMAR 1st YEAR DrNB 23-03-2023 2
  • 3. 23-03-2023 3 ERAS • Also referred as “enhanced recovery programs” or “fast-track protocols” • They are evidence-based, collaborative perioperative care pathways designed to improve recovery after major surgical procedures. 23-03-2023 3
  • 4. 23-03-2023 4 • AIM - To maintain preoperative organ function and reduce the body’s stress response after surgery. • ERAS protocols contain preoperative, intraoperative, and postoperative components that include patient counseling, nutritional optimization, standardized analgesic and anesthetic regimens, and early mobilization (Melnyk et al., 2011) 23-03-2023 4
  • 5. 23-03-2023 5 • ERAS – first described by Henrik Kehlet in 1990. • Meta-analyses of studies of colorectal surgery patients have provided evidence for reduction of complications (50%) and hospital stay (2.5 days) by application of ERAS pathways (Varadhan et al., 2010). • This has led to adoption of ERAS protocols in many surgical Specialties including gynecologic,thoracic,vascular, pediatric, and orthopedic surgery, and most recently urology 23-03-2023 5
  • 6. 23-03-2023 6 • Evidence based multimodal approach focused on peri- operative period • Improve patient recovery after surgery - Modifyphysiologicandpsychologicalresponse - Enabledischargehome earlier - Without compromisingsafetyandwellbeing • Several meta-analyses have shown accelerated recovery and decreased hospital stay with ERASin colorectal surgery. 23-03-2023 6
  • 7. 23-03-2023 7 • In urology, the best studied ERAS protocols are in patients undergoing radical cystectomy and urinary diversion. 23-03-2023 7
  • 8. 23-03-2023 8 • In 2010, the ERAS Society was founded and headquartered in Kista, Sweden. • The mission of the ERAS Society is to “develop perioperative care and to improve recovery through research, audit education and implementation of evidence-based practice.” • The Society website (http://www.erassociety.org/) offers procedure- specific guidelines, useful information, and resources related to enhanced recovery 23-03-2023 8
  • 9. 23-03-2023 9 • The ERAS Society, the main society dedicated to the study of multimodal perioperative care pathways, has published guidelines that include 22 ERAS recommendations for patients undergoing radical cystectomy (Cerantola et al., 2013). • Majority of these recommendations are extrapolated from colorectal surgery literature without any direct evidence from the cystectomy population supporting their use. • Only 7 of the 22 ERAS recommendations, as outlined by the ERAS Society guidelines are backed by direct evidence from urology patients (Cerantola et al., 2013) 23-03-2023 9
  • 13. 23-03-2023 13 Bladder Cancer  Invasivebladder canceradisease of the elderly - Most patientsare 65yrs or older - Increasing %are 80+yrs  Multiple medicalconditions  Cumulative cigarette smokeexposure - Cardiacdisease - Decreased pulmonary function  Up to 1/3receiveneoadjuvantchemotherapy
  • 14. 23-03-2023 14 RadicalCystectomy  Among the most complex urologic operations - Associated with considerable morbidity and prolonged inpatientstay  LOSremainsin the 8-9 day rangeandis - the most reported quality indicator for RC
  • 15. 23-03-2023 15 Traditional Care  Surgeryisplanned ‘assoonaspossible’ - No training or conditioning  Bowel prep (mechanicalandantibiotic)  NPO(clear liquids only for preop1-2 days)  Compensatory overhydration at onset of case - aggressivehydration during case–fluid overload  NGTand NPO untilflatus  Opioid analgesia - Limiting mentalacuity and mobility
  • 16. 23-03-2023 16 Traditional Hospital Course  Typical stay ~10days inUS*  ~60%complication rate (15%high-grade complications)  ~30%hospital readmissionrate *15-20daysin Europe/Asia v
  • 18. 23-03-2023 18 Preoperative EnhancedRecovery Framework  Optimization of medicalco-morbidities  Smoking cessation  NutritionAssessment - Evenshort termdietary modification helpful - Decrease alcohol intake  Prehabilitation - Physical conditioning, even 1week ishelpful
  • 19. 23-03-2023 19 Preoperative EnhancedRecovery Framework Written and oral pre-admission information describing:  What will happensduring hospitalization  What they shouldexpect - Length of stay - Home plan  Whowill be at homewith you after discharge?  Their role in the preparation and recoveryprocess
  • 20. 23-03-2023 20 Intra-operative Enhanced Recovery Framework  Efficient and expeditioussurgery  Smaller incision  Lessbowel manipulation  Minimization ofblood loss and transfusion  Non-narcotic analgesiaintraoperatively  Instillation of local anesthetic at incision sites
  • 21. 23-03-2023 21 GIRecovery is an Important Driver for Length of Stay and Readmission  Delayed GIrecovery (POI, “ileus”) is the most common causefor prolonged hospital stay after radical cystectomy - Rate of POI:12and25%  POI-related increased LOScontributes to morbidity - Increaserisk of secondaryclinicalconsequences(eg nosocomialinfections,readmissions)  POI adds substantive cost burden to the healthcare system
  • 22. 23-03-2023 22 Enhanced Recovery Framework  Avoid intense bowelpreparation  Avoid NGtubes  Pharmacological prophylaxis of postoperative nausea orvomiting  Enforcedearlyenteral feeding diet POD#1  Liberal useoflaxatives  Alvimopan
  • 23. 23-03-2023 23 Take home messages  ERASFramework - BeginsPRIORto the actual admission - Communicate expectations  Identify and treatcomorbidities Physical Conditioning Carbohydrate loading
  • 24. 23-03-2023 24 Take home messages  GIoptimization - Avoid bowel prep - Minimize bowel handlingintra-op - No NGtubes  Reduceeffects ofopioids - Alvimopan –start prior to surgery - Non narcotic useintra-operative - Long acting localanesthetic
  • 25. 23-03-2023 25 Take home messages  SurgeonFactors - Expeditious surgery - Minimize blood loss  EarlyMobilization - Feedearly - Walkearly
  • 26. 23-03-2023 26 Take home messages  Earlydetection, screening & prevention - Thefirst 2 weeksafter discharge are critical
  • 27. 23-03-2023 27 ERAS(Enhanced Recovery After Surgery)  A multidisciplinary approach involving surgeons, anesthesiologists, nurses, dieticians, and allied health professionals is one of the key paradigm shifts that is now neededto optimise recoveryof our patients .
  • 28. 23-03-2023 28 Framework of Enhanced Recovery Pre operative • Counseling • Teaching(written and verbal) • Expectations • Discharge plan • Stomateaching • Stomamarking • Optimization • Lungs • Cardiac • Prehabilitation • Nutrition • Carbloading • No prolongedfast • No bowelprep • VTE prophylaxis Post operative • Paincontrol • Avoidance of opioids and toxicity • Early mobilization • Early oralnutrition • Nutrition drinks • Avoid salt andwater overload • IleusControl • Prevention ofN/V • No NGtubes • No aggressivebowel regimen • VTE prophylaxis • Early follow-up Enhanced Recovery Intra operative • Avoidance of saltand water overload • Maintenance of normothermia • Localanesthesia • Antibiotics accordingto AUA BestPractices • Alvimopan(FDAapproved)