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Occurrence of failed shock therapy in implantable cardioverter defibrillator patients in
spite of adequate defibrillation testing
A.H. Maass, M.E. De Plaa, R.P. Vermeulen, M. Rienstra, I.C. Van Gelder
Introduction: Necessity of defibrillation threshold (DFT) testing during or after implantable
cardioverter defibrillator (ICD) implantation has recently been questioned. Large trials have
not shown a benefit of DFT vs not testing. We have investigated the incidence of failed shock
therapy in ICD patients and relation to DFT testing.
Methods: 2738 ICDs were implanted in our center from 2004-2013. Our electronic database
records information about shock therapy as well as other device-related measurements. We
identified patients with multiple shocks in a single day of follow-up and these patients were
further characterized.
Results: 38 (1.4%) patients had at least one failed shock therapy and were compared with 27
patients with multiple shocks in a single day that were all effective. All 38 patients with
failed shock therapy had adequate DFT testing with 2 successful shocks at least 10J below
the programmed shock energy. There was a trend (p=0.07) towards a longer interval between
DFT testing and multiple shocks in the failing group (median 1740 days; IQR 697-2450) vs.
the multiple effective shock group (median 892; IQR 449-1703). Amiodarone use was lower
in patients with failed shocks than with those with multiple effective shocks (6% vs. 30%,
respectively, p=0.01) possibly as a reflection of more severe arrhythmic substrate in the
group with multiple effective shocks.
Conclusions: Adequate DFT testing does not rule out occurrence of failed shock therapy in a
significant number of ICD patients. The reported number is probably an underestimation
because death due to failed shock therapy was not identified with our search method. These
data support the abandonment of standard DFT tests in unselected patients. If repeat DFT
testing late after ICD implantation can reduce failed shock therapy needs to be investigated
further.

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EP 2015

  • 1. Occurrence of failed shock therapy in implantable cardioverter defibrillator patients in spite of adequate defibrillation testing A.H. Maass, M.E. De Plaa, R.P. Vermeulen, M. Rienstra, I.C. Van Gelder Introduction: Necessity of defibrillation threshold (DFT) testing during or after implantable cardioverter defibrillator (ICD) implantation has recently been questioned. Large trials have not shown a benefit of DFT vs not testing. We have investigated the incidence of failed shock therapy in ICD patients and relation to DFT testing. Methods: 2738 ICDs were implanted in our center from 2004-2013. Our electronic database records information about shock therapy as well as other device-related measurements. We identified patients with multiple shocks in a single day of follow-up and these patients were further characterized. Results: 38 (1.4%) patients had at least one failed shock therapy and were compared with 27 patients with multiple shocks in a single day that were all effective. All 38 patients with failed shock therapy had adequate DFT testing with 2 successful shocks at least 10J below the programmed shock energy. There was a trend (p=0.07) towards a longer interval between DFT testing and multiple shocks in the failing group (median 1740 days; IQR 697-2450) vs. the multiple effective shock group (median 892; IQR 449-1703). Amiodarone use was lower in patients with failed shocks than with those with multiple effective shocks (6% vs. 30%, respectively, p=0.01) possibly as a reflection of more severe arrhythmic substrate in the group with multiple effective shocks. Conclusions: Adequate DFT testing does not rule out occurrence of failed shock therapy in a significant number of ICD patients. The reported number is probably an underestimation because death due to failed shock therapy was not identified with our search method. These data support the abandonment of standard DFT tests in unselected patients. If repeat DFT
  • 2. testing late after ICD implantation can reduce failed shock therapy needs to be investigated further.