journal club

1. DR ANAND JHA
2ND YEAR RESIDENT, ENT-HNS
KISTMCTH, LALITPUR

2.  Dennis E. Curry
 David Forner
 Matthew H. Rigby
 Jonathan R. Trites
 Martin Corsten
 S. Mark Taylor
 Received: 6 September 2019
 Accepted: 19 December 2021
 Published online: 20 January, 2022.
 Journal of Otolaryngology - Head & Neck Surgery

3.  TLM is effective treatment option for early glottic
cancer over past three decade
 Advantages of TLM
 Shorter treatment
 Periods limited to a single surgical day
 Non-invasive
 Surgical approach leading to rapid recovery time
 The ability for repeat procedures
 Cost-efectiveness

4.  Early stage glottic cancer studies from North
America there is a paucity of data detailing
both oncologic and functional outcomes for T1a
glottic squamous cell carcinoma (SCC).

5.  Functional and oncologic outcomes in the
treatment of T1a glottic SCC with TLM.
 With excellent survival, organ preservation,
and improved voice outcomes.

6.  Study design: retrospective cohort study
 Study duration: January 2002 to August 2018
 Sample size: 48
 Study population: Patients diagnosed with T1a
glottic SCC and underwent TLM as their
primary treatment.
 Study place: Division of Otolaryngology –
Head and Neck Surgery, Dalhousie University

7.  INCLUSION CRITERIA:
 ≥ 18 years old diagnosed with cT1aN0M0
squamous cell carcinoma of the glottis were
included in the study
 If they received CO2-based TLM as their
primary treatment modality
 EXCLUSION CRITERIA:
 Patients who were treated primarily with RT or
open surgery before their initial TLM

8.  TOOLS:
 SPSS Statistics(IBM Corp, Version 24.0. Armonk, NY:
IBM Corp.)
 Microsoft Excel for Office 365 (Microsoft, Version 1907)
 DATA ANALYSIS:
 Student’s t-test .
 Kaplan–Meier survival analysis.
 ETHICAL CONSIDERATION:
 The project received institutional research ethics board
approval prior to the beginning of the study from the
Nova Scotia Health Authority Research Ethics Board.

9.  ONCHOLOGIC AND FUNCTIONAL OUTCOME
 Oncologic outcomes studied included:
 overall survival (OS)
 disease-specifc survival (DSS)
 loco-regional control (LRC)
 ultimate control with TLM only
 laryngeal preservation
 Functional outcomes studies included:
 voice handicap index-10 (VHI-10) laryngeal outcome tool, a 10-
part questionnaire
 assesses patients subjective perception of their voice quality.
 Extent of initial surgical resection is reported as the European
Laryngological Society (ELS) cordectomy classifcation

12.  DEMOGRAPHIC INFORMATION:

13. Top: 5-year overall survival (left) and laryngeal preservation (right). Bottom: 5-year
locoregional control (left) and ultimate control with TLM only (right)

16.  Treatment options for early stage glottic cancer
include radiation therapy and transoral laser
microsurgical
 open surgical procedures have become less
favored in recent decades
 non-invasive nature, cost-efectiveness and
excellent outcomes, TLM is preffered now days
 Radiation therapy is still considered the
mainstay in many institutions

17.  Transoral laser microsurgery established itself
as a primary treatment option in early stage
glottic cancer
 It is minimally invasive , short treatment
duration, ability for repeat laser procedures
and low cost

18. CITATION : 1
IMPACT FACTOR: 4.856
Received: 6 September 2019
Accepted: 19 December 2021
Published online: 20 January, 2022.

19.  TITLE:
 self explanatory:
 6 authors
 Author’s name: stated
 Academic degree: not stated
 Adress of correspondence: stated

20.  ABSTRACT:
 231 words( 150-250 words)
 Concrete information about study
 Introduction/objective/methods/results:
mentioned
 Keywords mentioned: 4 in number (3-6)

21.  LEVEL OF EVIDENCE:

22.  INTRODUCTION:
 Objective: included
 Rationale: briefly stated
 Justification of current study: not explained
 Sufficient background information: provided
with reference

23. MATERIALS AND METHODS:
 Not Listed in separate headings
 Study design: retrograde cohort study
 Study place: mentioned ( dalhousie university)
 Duration of study: January 2002 to August 2018
 Ethical clearance and consent from study subject:
mentioned
 Inclusion and exclusion criteria: mentioned
 Conflict of interest: no any
 Statistical methods :mentioned

24.  Sample size and technique: mentioned
RESULTS:
 3 tables and 2 figures : well illustrarive
 Author’s main finding:
 clearly presented
 Met the objective mentioned.

25. DISCUSSIONS:
 Explanation of
individual research
finding: elaborated.
 Comparision with
other studies: done
adequately
 Limitation of the
study : briefly
mentioned

26.  CONCLUSION: as per objective