This document summarizes research on applications of microtechnology and bioengineering in liver modeling and transplantation. It discusses topics like micropatterning co-cultures, encapsulation, bioartificial and transplantable engineered livers, and using microfluidics and biomaterials for drug screening and disease modeling. Specific techniques covered include differentiating stem cells into liver cells, constructing 3D liver organoids, developing liver-on-chip devices, and applying organoids to study bile acid recycling and treat cholangiopathy. The overall goal is to build functional artificial livers through multidisciplinary approaches like microengineering, stem cell differentiation, organoid development, and organ-chip systems.
Osteoprotegerin, a secreted cytokine receptor, is not only present in the nuclei of Caco 2 cells but its expression and secretion from Caco 2 cells is increased several folds when treated with TNF alpha or Interleukin 1 beta but not by Interleukin 18.
Click Colorimetric EdU Proliferation and TUNEL: Click Chemistry for Bright Fi...Thermo Fisher Scientific
We present the conversion of click chemistry EdU and TUNEL fluorescence assay to colorimetric detection of proliferation and apoptosis for use with bright field microscopy. Advantages of having a click colorimetric signal are retaining the work flow of click chemistry labeling while allowing for compatibility with standard H&E staining and protocols.
Osteoprotegerin, a secreted cytokine receptor, is not only present in the nuclei of Caco 2 cells but its expression and secretion from Caco 2 cells is increased several folds when treated with TNF alpha or Interleukin 1 beta but not by Interleukin 18.
Click Colorimetric EdU Proliferation and TUNEL: Click Chemistry for Bright Fi...Thermo Fisher Scientific
We present the conversion of click chemistry EdU and TUNEL fluorescence assay to colorimetric detection of proliferation and apoptosis for use with bright field microscopy. Advantages of having a click colorimetric signal are retaining the work flow of click chemistry labeling while allowing for compatibility with standard H&E staining and protocols.
Creative Bioarray offers human colonic epithelial cells with most professional service and reasonable price.
https://www.creative-bioarray.com/Human-Colonic-Epithelial-Cells-CSC-C1488-item-39325.htm
Today around 47 million people survive with dementia, globally. This number is projected to increase to more than 131 million by 2050. About 2.1 million Alzheimer's patients having age of 85 years or older were reported in year 2017.
Sequencing and functional genomics Unit_Biomedical Research Center of Aragon_...Pilar Mozas
Documento que presenta la cartera de servicios y el equipamiento del Servicio Científico Técnico de Secuenciación y Genómica Funcional de la Universidad de Zaragoza y el Instituto Aragonés de Ciencias de la Salud.
Development of quality control assays for cell-based medicinal products (ISCT...Quality Assistance s.a.
Dr. Fabian Vandermeers from Quality Assistance spoke on Development of quality control assays for cell-based medicinal products at ISCT 2017 in London.
For more information on this topic, visit: http://www.quality-assistance.com/analytical-services/CBMPs
For more information on our expertise and services, visit: www.quality-assistance.com
Follow us on social media:
LinkedIn: https://www.linkedin.com/company/quality-assistance
Twitter: https://twitter.com/QA_Belgium
Facebook: https://www.facebook.com/QualityAssistanceBelgium
Google +: https://plus.google.com/103676189647965359292
Quality Assistance S.A. is a leading European Contract Research Organisation providing the pharmaceutical industry with all the analytical services required by EMA and FDA regulations for the development and marketing of innovative human medicinal products.
We assist our clients from candidate selection, through non-clinical and clinical studies, to marketing authorisation, using our state-of-the-art, product-dedicated expertise in analytical sciences.
For each customer and each project, we design customised solutions, define analytical protocols, develop and validate specific new analytical methods and perform characterisation, stability, pharmacokinetic, biomarker and immunogenicity studies as well as batch release testing, in order to evaluate the Quality, Safety and Efficacy of the given drugs.
Detection and Subtype Identification of Blastocystis Isolates from Wastewater...gon0603
Presented during the 6th Asian-Pacific Organization for Cell Biology (APOCB) International Congress, EDSA Shangri-La, Manila, Philippines, 25 to 28 February 2011
The occurrence of AmpC β-lactamase and ESBL producing Gram-negative bacteria ...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Réunion des Infirmières - JCHB 2020
Les bio organes, une voie pour éviter la pénurie d’organe : comment ça marche ? - À propos de la biofabrication hépatique - Jean-Charles DUCLOS-VALLEE
Jeudi 30 janvier 2020
Poster HCSPHARMA (OncoLilleDays2022) - Mechanobiological characterization of ...HCS Pharma
Thomas Meynard, PhD student in OncoLille (under the supervision of Vincent Senez and Isabelle Van Seuningen) in collaboration with HCS Pharma too, presented a poster showing that it is possible to include BIOMIMESYS® in a microfluidic chip to co-culture Cancer-Associated fibroblasts and cancerous cells, with the aim to increase the complexity and the relevance of in vitro cancer models.
Creative Bioarray offers human colonic epithelial cells with most professional service and reasonable price.
https://www.creative-bioarray.com/Human-Colonic-Epithelial-Cells-CSC-C1488-item-39325.htm
Today around 47 million people survive with dementia, globally. This number is projected to increase to more than 131 million by 2050. About 2.1 million Alzheimer's patients having age of 85 years or older were reported in year 2017.
Sequencing and functional genomics Unit_Biomedical Research Center of Aragon_...Pilar Mozas
Documento que presenta la cartera de servicios y el equipamiento del Servicio Científico Técnico de Secuenciación y Genómica Funcional de la Universidad de Zaragoza y el Instituto Aragonés de Ciencias de la Salud.
Development of quality control assays for cell-based medicinal products (ISCT...Quality Assistance s.a.
Dr. Fabian Vandermeers from Quality Assistance spoke on Development of quality control assays for cell-based medicinal products at ISCT 2017 in London.
For more information on this topic, visit: http://www.quality-assistance.com/analytical-services/CBMPs
For more information on our expertise and services, visit: www.quality-assistance.com
Follow us on social media:
LinkedIn: https://www.linkedin.com/company/quality-assistance
Twitter: https://twitter.com/QA_Belgium
Facebook: https://www.facebook.com/QualityAssistanceBelgium
Google +: https://plus.google.com/103676189647965359292
Quality Assistance S.A. is a leading European Contract Research Organisation providing the pharmaceutical industry with all the analytical services required by EMA and FDA regulations for the development and marketing of innovative human medicinal products.
We assist our clients from candidate selection, through non-clinical and clinical studies, to marketing authorisation, using our state-of-the-art, product-dedicated expertise in analytical sciences.
For each customer and each project, we design customised solutions, define analytical protocols, develop and validate specific new analytical methods and perform characterisation, stability, pharmacokinetic, biomarker and immunogenicity studies as well as batch release testing, in order to evaluate the Quality, Safety and Efficacy of the given drugs.
Detection and Subtype Identification of Blastocystis Isolates from Wastewater...gon0603
Presented during the 6th Asian-Pacific Organization for Cell Biology (APOCB) International Congress, EDSA Shangri-La, Manila, Philippines, 25 to 28 February 2011
The occurrence of AmpC β-lactamase and ESBL producing Gram-negative bacteria ...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Réunion des Infirmières - JCHB 2020
Les bio organes, une voie pour éviter la pénurie d’organe : comment ça marche ? - À propos de la biofabrication hépatique - Jean-Charles DUCLOS-VALLEE
Jeudi 30 janvier 2020
Poster HCSPHARMA (OncoLilleDays2022) - Mechanobiological characterization of ...HCS Pharma
Thomas Meynard, PhD student in OncoLille (under the supervision of Vincent Senez and Isabelle Van Seuningen) in collaboration with HCS Pharma too, presented a poster showing that it is possible to include BIOMIMESYS® in a microfluidic chip to co-culture Cancer-Associated fibroblasts and cancerous cells, with the aim to increase the complexity and the relevance of in vitro cancer models.
Derivation of highly enriched cultures of differentiated cells from human par...Nikolay Turovets
California Institute for Regenerative Medicine (CIRM) & Medical Research Council (MRC)
Human SCNT Workshop.
14 June, 2010, San Francisco, CA
Workshop report: http://www.cirm.ca.gov/files/PDFs/Publications/Human_SCNT_Workshop_Report.pdf
Organs-on-chips (OoCs) are systems containing engineered or natural miniature tissues grown inside microfluidic chips. To better mimic human physiology, the chips are designed to control cell microenvironments and maintain tissue-specific functions. Combining advances in tissue engineering and microfabrication, OoCs have gained interest as a next-generation experimental platform to investigate human pathophysiology and the effect of therapeutics in the body. There are as many examples of OoCs as there are applications, making it difficult for new researchers to understand what makes one OoC more suited to an application than another.
Determination and comparison rate of expression markers of osteoblast derived...IJERD Editor
Nowadays high accident rates, fractures leading to permanent bone disorders and the impossibility of bone transplant have made scientists to look for new methods of repairing injured bones. Considering the application of stem cells in bone tissue engineering, there exists the necessity to investigate various culture methods and suitable fields and scaffolds. Thus, we decided to induce adipose-derived stem cells into osteoblast cells in two systems of pellet culture and monolayer and compare osteogenic markers. Methods: Stem cells have been separated via mechanical and enzymatic methods and cultured in monolayer and pellet culture models with osteogenic medium. Then, RNA was separated from differentiated cells, complementary DNA (cDNA) was synthesized and amplified. Polymerase chain reaction (PCR) product was transferred to electrophoresis gel. The intensity of the bands was measured by Image-J software and analyzed by SPSS.
Poster - A single procedure to generate functional hiPSCs-derived liver organ...HCS Pharma
metabolic diseases upon hepatocyte-like cell (HLC) differentiation. In particular, HLCs have been used to model cholesterol metabolism regulation, by mimicking the main disease features in vitro. Human iPSCs can be generated from urine samples of patients with a well-described phenotype and carrying specific genotypes. This non-invasive approach allowed the study of LDLR- and PCSK9-mediated autosomal dominant hypercholesterolemia (ADH) as well as PCSK9-mediated familial hypobetalipoproteinemia (FHBL). While the direct link between hiPSCs and patients, as well as the abundance of HLCs provide promising advantages of such strategy, it is impaired mainly by the neonatal characteristic of HLCs as well as the difficulty to perform high throughput studies for pharmacological investigations.
Presentation summarising the 2013 ICSB conference in Copenhagen, a requirement of James Hutton Institute Visits Abroad funding. Presented at the Cellular and Molecular Sciences seminar series.
BIOMIMESYS®Liver, a 3D cell culture model for maintaining and promoting hepat...HCS Pharma
BIOMIMESYS® range are hyaluronan based hydroscaffold developed to overcome the 2D flat culture limitations by recreating an in vivo-like physiology within the in vitro environment.
BIOMIMESYS®Liver hydroscaffold is made of RGDS and galactosamine-grafted Hyaluronic acid, Adipic acid dihydrazide crosslinker and extracellular matrix (ECM) proteins (collagen type I and collagen type IV) to mimic liver ECM composition.
BIOMIMESYS® Liver, a 3D cell culture model for maintaining and promoting hep...HCS Pharma
BIOMIMESYS® range are hyaluronan based hydroscaffold developed to overcome the 2D flat culture limitations by recreating an in vivo-like physiology within the in vitro environment.
BIOMIMESYS®Liver scaffold is made of RGDS and galactosamine-grafted Hyaluronic acid, Adipic acid dihydrazide crosslinker and extracellular matrix (ECM) proteins (collagen type I and collagen type IV) to mimic liver-ECM composition.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
1. Top 5 in
Liver and bioengineering
Jean-Charles Duclos-Vallée
Centre Hépato-Biliaire
Paul-Brousse Hospital
2. Microtechnology and
applications in liver bioengineering
Microatterning
Co-culture
Encapsulation
Bioartificial/
Transplantable
bioengineered liver
Drug screening
Disease modelling
3. Microtechnology and
applications in liver bioengineering
Micropatterning
Co-culture
Encapsulation
Bioartificial/
Transplantable
bioengineered liver
Drug screening
Disease modelling
Microfluidics/
On chip devices
Biomaterials
Biomaterials
2D
Cell culture
4. Two main types of devices
Artificial Bio Artificial
Living component
A Necessity !
Figaro S, Pereira U, …, Legallais C et al. Int J Organs 2017
5. Global representation of the differentiation
protocol of hiPSCs into hepatocytes and
encapsulation into alginate beads
CHIR,
Activin A,
LY
FGF2,
BMP4,
FGF4, HGF
Definitive
endoderm (DE)
hiPSCs
Hepatoblasts
(iHBs)
Spheroid
HGF, OSM, Dex, SB, CE, Vk
iHBs spheroid encapsulation and
hepatocyte differentiation Encapsulated
spheroids
(E-3D)
Day 10-11
iHB self-
aggregation
iHBs differentiation
Day 26
Day 20
Day 16
Day 11
500 µm 500 µm 500 µm 500 µm
Encapsulation
Day 10
500 µm
Morphology of encapsulated spheroids
From Marwa Hussein
6.
7. Distribution of PLL and elastic modulus of
the surface
PLL
Permeability of empty beads
(coated or not with PLL) to
fluorescent markers (albumin,
IgG, nanoparticles of different
diameters)
8. Distribution of PLL and elastic modulus of the
surface
PLL
Permeability of empty beads
(coated or not with PLL) to
fluorescent markers (albumin, IgG,
nanoparticles of different
diameters)
Metabolic activities of cells in
alginate‐PLL beads, measured on
Day 14, over 6 h' incubation in
equivalent pathological plasma
medium
Ammonia
detoxification rate
Lactate
detoxification rate
Albumin
production
12. Definition of organoid: in vitro 3D
cellular cluster derived from tissue-
resident stem/progenitor cells,
embryonic stem cells (ESCs) or
induced pluripotent stem cells
(iPSCs) that recapitulates the
functionality of the tissue of origin
Lancaster MA and Knoblich JA. Science 2014
Huch M and Koo BK. Development 2015
13. Organogenesis and stages
for organoid progenitor isolation
Tremblay and Zaret, Dev Biol 2005
SI-Tayeb et al. Dev Cell 2010
Fiorotot et al. Acta 2018
Douarin Med Biol1975
Gualdi et al. Genes Dev 1996
Jung et al Science1999
Kamiya et al EMBO J 1999
Rossi et al; Genes Dev2001
Zaret et al Nat Rev Genet 2002
D’Amour Nat Biotechnol 2005
Han et al. Stem Cells 2011
Adapted from Prior N, Inacio P and Huch M Gut 2019
Activin/
Nodal
WNT
FGF
BMP
Hepatocytes
+
Cholangiocytes
14. Construction of liver organoids
Messina A et al. Cells 2022
500 µm 200 µm 200 µm 200 µm
hiPSCs iDE (day 5) iHE (day 8) iHB (day 10)
3D
0
1
2
3
4
5
6
7
d13 d16 d18 d20 d25
µg*millioncells/24h
2D 3D AFP secretion
0
0,2
0,4
0,6
0,8
1
d13 d16 d18 d20 d25
µg
*millioncells/24h
3D 2D
ALB secretion
ActivinA
hiPSC BMP4
DE
• FGF4
• EGF
• HGF
HE
• HGF
• OSM
• Dex
HB
• HGF
• OSM
• Dex
IH MH
1h 2 weeks
Phall
Nuclei
Confocal images of spheroid at day 25 of the differentiation protocol.
ALB HNF4α
Nuclei
200 µm
Self-assembling
3D configuration allows to generate hiPSC-derived liver
organoids with hepatic functions equivalent to PHHs
15. Bile acid secretion and bile canaliculi network
analysis of iHep-Orgs
Messina A et al. Cells 2022
Bile acid production and secretion by iHep-
Orgs in culture supernatants at day 20
Live imaging of the bile canaliculi network
formed by excretion of the fluorescent probe DCFA
in iHep-Org at day 38
Immunofluorescence staining for the apical
Membrane transporter BSEP in iHep-Org
at day 38
18. Chip response to acetaminophen (APAP) exposure.
Cell viability in control and treated chips
(CTRL n = 3 chips, 2 mM APAP n = 2 chips)
Immunofluorescent images of
a control chip, a chip treated with APAP.
nuclei (blue), ZO-1 (green) and MDR3 (red)
Boul M Sci Reports 2021
19.
20.
21.
22. At high-dose, the common
signature of the three
treatments reflected liver
steatosis profile highlighted by
the modulation
of genes related to PPAR
signaling, fatty acid, lipid
metabolism and
steroid biosynthesis.
23. Metabolomic, profiled
showed high level of fatty acids
and lipids (decanoic,
tetradecanoic and
palmitic acids), glucose,
fructose and tagatose
24.
25. Schematic of key components of the
enterohepatic bile acid synthesis and
recycling pathways.
30. Cholangiocyte organoids (COs) rescue cholangiopathy
following transplantation and assume an identity
corresponding to the site of engraftment.
Sampaziotis F et al. Science 2021
31. Transplantation of cholangiocyte
organoids in human
Up regulation of intrahepatic
(SOX4) And loss of gallbladder Sox17
and improvement of bile properties
Absence of RFP cells
in the perfusate
Sampaziotis F et al. Science 2021
33. Differentiation
of
liver cells
from
human pluripotent
stem cells
and
applications
Alexis Bernatets
Alan J Rajendran
Ana Mesic
Bruno
Le Pioufle
Sakina
Bensallem
Microfluidics/
Liver On chip devices
Anne Dubart-Kupperschmitt
Nassima Benzoubir
Mano Boul
Marwa Hussein
Eleanor Luce
Antonietta Messina