Efruzhu cancer carci̇nogenesi̇s theory 30
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Inadequate energy levels can cause mutations by affecting the functions of proteins involved in gates, channels, transporters, DNA transcription and expression, as well as the degree of misfolding of immature proteins.
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Efruzhu cancer carci̇nogenesi̇s theory 30
Inadequate energy levels can cause mutations by affecting the functions of protein gates, channels, and transporters as well as the degree of DNA transcription, expression, and misfolding or immaturity of proteins.
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This document summarizes a research article that presents the Network of Cancer Genes (NCG) database. NCG analyzes and stores data on over 730 cancer genes, including their duplicability, orthology, and network properties. It collects data on whether genes are duplicated in the human genome, when they first evolutionarily appeared, and their interactions in protein-protein interaction networks. NCG is the first database to analyze cancer genes from a systems-level perspective and integrate multiple types of genomic and protein interaction data. It aims to be continuously updated as more cancer gene data becomes available from projects like the Cancer Genome Project.
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Nowadays, oncolytic virotherapy has gradually become a powerful immunotherapeutic modality for cancer treatment. Immunogenicity manipulation is quite necessary, and with genetic modifications, oncolytic viruses are able to improve the oncolytic effects on tumor cells and stimulate antitumor immunity.
https://www.creative-biolabs.com/oncolytic-virus/immunogenicity-manipulation.htm
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- Early observations in the early 1900s found that some cancer patients experienced tumor regression after acquiring viral illnesses, which led researchers to hypothesize that genetically engineered viruses could be used to treat cancer.
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Efruzhu cancer carci̇nogenesi̇s theory 30
Inadequate energy levels can cause mutations by affecting the functions of protein gates, channels, and transporters as well as the degree of DNA transcription, expression, and misfolding or immaturity of proteins.
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This document discusses the role of Merkel cell polyomavirus (MCPyV) in the skin cancer Merkel cell carcinoma (MCC). It outlines three aims: 1) to determine if MCPyV can transform human cells and cause tumors in animals, 2) to identify wild-type MCPyV and test its infectivity and lytic potential, and 3) to investigate the mechanism of MCPyV-induced transformation through viral protein expression and interactions with cellular proteins. The identification of MCPyV in the majority of MCC tumors suggests it may be the first known human polyomavirus to cause cancer, which could lead to new treatment strategies if the virus's role is fully characterized.
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Immunogenicity manipulation
Nowadays, oncolytic virotherapy has gradually become a powerful immunotherapeutic modality for cancer treatment. Immunogenicity manipulation is quite necessary, and with genetic modifications, oncolytic viruses are able to improve the oncolytic effects on tumor cells and stimulate antitumor immunity.
https://www.creative-biolabs.com/oncolytic-virus/immunogenicity-manipulation.htm
Oncolytic virus basis
- Oncolytic viruses (OVs) are viral strains that can infect and kill malignant cells without harming normal cells, while simultaneously stimulating the immune system and creating antitumor immunity.
- Early observations in the early 1900s found that some cancer patients experienced tumor regression after acquiring viral illnesses, which led researchers to hypothesize that genetically engineered viruses could be used to treat cancer.
- Since the first OV entered clinical trials in 1996, various OVs have been successfully tested against many cancer types and numerous clinical trials are currently evaluating their efficacy and safety.
PICS: Pathway Informed Classification System for cancer analysis using gene e...
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Oncolytic virus immunotherapy knowledge
Due to the in-depth knowledge of immunology and tumor biology, scientists of Creative Biolabs keep devoting endless effort to the development of immunotherapy strategies and reagents aiming at specific categories and features of various cancers.
https://www.creative-biolabs.com/oncolytic-virus/disease-specific-oncolytic-virotherapy-development.htm
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Creative Biolabs uses the advanced SuPrecision™ platform to support researchers all over the world with their sequencing needs for cancer. https://www.creative-biolabs.com/suprecision/
Oligonucleotide ligation assay
Colony hybridization is a technique to identify bacterial colonies containing a specific DNA sequence or gene of interest. It involves transferring DNA from bacterial colonies onto a membrane, then probing the membrane with a complementary DNA or RNA sequence. Only colonies with matching DNA sequences will hybridize with the probe. The oligonucleotide ligation assay (OLA) is a technique used to detect mutations by hybridizing PCR primers and ligating adjacent probes only when the target sequence is present. It has advantages of being rapid, easy, and high-throughput but requires an automated sequencer.
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2) PARP inhibitors are being tested for ovarian cancer patients with BRCA1/BRCA2 mutations or other damaged DNA repair proteins.
3) Research is exploring an earlier genetic molecule called TNA that may have preceded DNA and RNA due to its simpler structure and ability to self-replicate, providing insights into the origins of life.
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https://www.creative-biolabs.com/oncolytic-virus/oncolytic-herpes-simplex-virus.htm
oncolytic virus immunotherapy
Oncolytic virus immunotherapy is a therapeutic approach to cancer treatment that utilizes native or genetically modified viruses that selectively replicate within tumor cells.
https://www.creative-biolabs.com/oncolytic-virus/
Oncolytic Virotherapy
Oncolytic viruses (OVs) are therapeutically useful viruses which selectively infect and damage cancerous tissues without causing harm to normal tissues. Every virus has a specific cellular tropism that determines which tissues are preferentially infected, and what disease is caused. A number of naturally occurring viruses have a preferential, although non-exclusive, tropism for tumors and tumor cells. This probably has more to do with tumor biology than with virus biology as most tumors have evolved not only to avoid immune detection and destruction but also to resist apoptosis and translational suppression, which are the crucial responses used by normal cells to limit a virus infection. OVs can kill infected cancer cells in a number of different ways, ranging from direct virus-mediated cytotoxicity through various cytotoxic immune effector mechanisms.
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This document provides an overview of oncolytic viruses (OVs) as a potential cancer treatment. It discusses how OVs selectively target and kill cancer cells through direct lysis and stimulation of anti-tumor immunity. The mechanisms of OV action and various strategies for enhancing their efficacy are described, such as arming OVs with immunostimulatory genes or anti-angiogenic factors. Several OVs currently in clinical trials are highlighted, including T-VEC which was approved in 2015 for melanoma treatment. The document concludes that OVs show promise as a novel cancer immunotherapy but further research is still needed to address issues like viral resistance and toxicity.
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Creative Biolabs uses the advanced SuPrecision™ platform to support researchers all over the world with their sequencing needs for cancer. https://www.creative-biolabs.com/suprecision/
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1) A study found that faulty proteins involved in DNA repair may be linked to ovarian cancer recurrence and response to PARP inhibitor drugs.
2) PARP inhibitors are being tested for ovarian cancer patients with BRCA1/BRCA2 mutations or other damaged DNA repair proteins.
3) Research is exploring an earlier genetic molecule called TNA that may have preceded DNA and RNA due to its simpler structure and ability to self-replicate, providing insights into the origins of life.
4) Understanding DNA repair mechanisms and how they relate to disease could help develop new treatments, such as genomic therapies that insert missing genes.
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https://www.creative-biolabs.com/oncolytic-virus/
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Transcriptomics is the study of transcriptomes, which are the complete set of RNA transcripts produced in a cell or tissue under a specific set of conditions. Next-generation sequencing techniques like Illumina sequencing have enabled comprehensive analysis of transcriptomes. Transcriptomics has many applications in biotechnology including agriculture, stem cell research, disease studies, and assessing chemical safety. It can be used to discover gene functions, biomarkers, and responses to environmental changes. Common transcriptomics techniques are real-time PCR, microarrays, and next-generation sequencing which provide information on RNA expression levels.
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