ECU Masterclass slides August 2014

•

0 likes•895 views

The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms for those who already suffer from conditions like depression and anxiety.

Science

Цель нашего бизнеса: — Достигать цели вашего бизнеса. Вы знаете, каких вершин хотите достигнуть. Мы показываем самую удобную дорогу. — Вывести Новосибирск на федеральный уровень по качеству рекламы. Мы постоянно развиваемся и готовы вести за собой весь рекламный рынок Новосибирска. — Собрать команду из лучших специалистов города. И помочь талантливым и потенциальным молодым людям стать лучшими специалистами города.

Elements of scienceMeghansh Gautam

V miss u sweetheart!!

Vijayta Verma

2n. arjau ous tortuga platja far

nalsina

July 2013

tutoringasd

Conquering the NHMRC grant impact elements

Research Impact Academy

Behaviour styles for KT

Research Impact Academy

Research festival victoria university

Research Impact Academy

Drivers of practice change: Comparative look at health sector knowledge trans...

Research Impact Academy

Pdf

Research Impact Academy

Simple KT OverviewResearch Impact Academy

Lateral Ventricles.pdf very easy good diagrams comprehensive

silvermistyshot

Orion Air Quality Monitoring Systems - CWS

Columbia Weather Systems

insect morphology and physiology of insect

anitaento25

Richard's entangled aventures in wonderland

Richard Gill

Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.

platelets- lifespan -Clot retraction-disorders.pptx

muralinath2

Body fluids_tonicity_dehydration_hypovolemia_hypervolemia.pptx

muralinath2

Viewers also liked

Science ppt ixMeghansh Gautam

Junior java standard edition developer

Dmitriy Neguritsa

Test3djay

3r tema 1 com som . cos humànalsina

Com és que no tot sura

nalsina

Портфолио «Круче!». Website

Kruche!

Elements of scienceMeghansh Gautam

V miss u sweetheart!!

Vijayta Verma

2n. arjau ous tortuga platja far

nalsina

July 2013

tutoringasd

Viewers also liked (10)

Science ppt ix

Junior java standard edition developer

Test

3r tema 1 com som . cos humà

Com és que no tot sura

Портфолио «Круче!». Website

Elements of science

V miss u sweetheart!!

2n. arjau ous tortuga platja far

July 2013

Recently uploaded

Lateral Ventricles.pdf very easy good diagrams comprehensive

silvermistyshot

Orion Air Quality Monitoring Systems - CWS

Columbia Weather Systems

insect morphology and physiology of insect

anitaento25

Richard's entangled aventures in wonderland

Richard Gill

platelets- lifespan -Clot retraction-disorders.pptx

muralinath2

Body fluids_tonicity_dehydration_hypovolemia_hypervolemia.pptx

muralinath2

erythropoiesis-I_mechanism& clinical significance.pptx

muralinath2

Unveiling the Energy Potential of Marshmallow Deposits.pdf

Erdal Coalmaker

RNA INTERFERENCE: UNRAVELING GENETIC SILENCING

AADYARAJPANDEY1

Introduction: RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression. It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences. dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants. This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. What are small ncRNAs? micro RNA (miRNA) short interfering RNA (siRNA) Properties of small non-coding RNA: Involved in silencing mRNA transcripts. Called “small” because they are usually only about 21-24 nucleotides long. Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered). Silence an mRNA by base pairing with some sequence on the mRNA. Discovery of siRNA? The first small RNA: In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the development of the worm C. elegans. Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14. Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions. Types of RNAi ( non coding RNA) MiRNA Length (23-25 nt) Trans acting Binds with target MRNA in mismatch Translation inhibition Si RNA Length 21 nt. Cis acting Bind with target Mrna in perfect complementary sequence Piwi-RNA Length ; 25 to 36 nt. Expressed in Germ Cells Regulates trnasposomes activity MECHANISM OF RNAI: First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces. Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands. The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it. THE RISC COMPLEX: RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA Unwinding of double stranded Si RNA by ATP independent Helicase Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA. DICER: endonuclease (RNase Family III) Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC) One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute ARGONAUTE PROTEIN : 1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA 2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity. MiRNA: The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .

GBSN - Biochemistry (Unit 5) Chemistry of Lipids

Areesha Ahmad

Seminar of U.V. Spectroscopy by SAMIR PANDA

SAMIR PANDA

NuGOweek 2024 Ghent - programme - final version

pablovgd

Richard's aventures in two entangled wonderlands

Richard Gill

FAIR & AI Ready KGs for Explainable Predictions

Michel Dumontier

The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed. In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine. Bio Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.

The ASGCT Annual Meeting was packed with exciting progress in the field advan...

Health Advances

justice-and-fairness-ethics with example

azzyixes

THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.

Sérgio Sacani

The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.

filosofia boliviana introducción jsjdjd.pptx

IvanMallco1

EY - Supply Chain Services 2018_template.pptx

AlguinaldoKong

Hemostasis_importance& clinical significance.pptx

muralinath2

Recently uploaded (20)

Lateral Ventricles.pdf very easy good diagrams comprehensive

Orion Air Quality Monitoring Systems - CWS

insect morphology and physiology of insect

Richard's entangled aventures in wonderland

platelets- lifespan -Clot retraction-disorders.pptx

Body fluids_tonicity_dehydration_hypovolemia_hypervolemia.pptx

erythropoiesis-I_mechanism& clinical significance.pptx

Unveiling the Energy Potential of Marshmallow Deposits.pdf

RNA INTERFERENCE: UNRAVELING GENETIC SILENCING

GBSN - Biochemistry (Unit 5) Chemistry of Lipids

Seminar of U.V. Spectroscopy by SAMIR PANDA

NuGOweek 2024 Ghent - programme - final version

Richard's aventures in two entangled wonderlands

FAIR & AI Ready KGs for Explainable Predictions

The ASGCT Annual Meeting was packed with exciting progress in the field advan...

justice-and-fairness-ethics with example

THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.

filosofia boliviana introducción jsjdjd.pptx

EY - Supply Chain Services 2018_template.pptx

Hemostasis_importance& clinical significance.pptx

ECU Masterclass slides August 2014

Recommended

Recommended

More Related Content

Viewers also liked

Viewers also liked (10)

More from Research Impact Academy

More from Research Impact Academy (6)

Recently uploaded

Recently uploaded (20)