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Drugs inresus06122011
This document discusses drugs commonly used in cardiopulmonary resuscitation. It outlines several drugs including adrenaline, vasopressin, atropine, amiodarone, lignocaine, adenosine, and dopamine. For each drug, it describes the major indications, routes of administration, actions, and potential side effects. The objectives are to be able to state the commonly used resuscitation drugs, outline their major actions, and list two side effects for each.
Drugs inresus06122011
- 1. DRUGS IN CARDIOPULMONARY RESUSCITATION ALS Subcommittee 2010
- 2. OBJECTIVES Upon completion ofthis session, you will be able to: • state the drugs commonly used in resuscitation • outline the major actions of these drugs • list 2 side effects related to the use of the drugs ALS Subcommittee 2010
- 3. DRUGS USED INRESUSCITATION • Adrenaline • Vasopressin • Atropine • Amiodarone • Lignocaine • Adenosine • Dopamine ALS Subcommittee 2010
- 4. ACCESS TO DRUGADMINISTRATION • Intravenous Peripheral or central • Intra-osseous • Intra-tracheal – Larger dose – Only if intravenous and intraosseous not available ALS Subcommittee 2010
- 5. TECHNIQUE FOR IVDRUG ADMINISTRATION • Use upper extremity veins • Keep the access site elevated • Each IV drug administration to be followed by 20-30mls bolus of normal saline • The cannula should be as large as possible • Use normal saline as the fluid of resuscitation ALS Subcommittee 2010
- 6. TECHNIQUE FOR ENDOTRACHEAL DRUG ADMINISTRATION • Dilute the drug in 10 ml saline • Thread a long catheter through the ETT • Stop chest compressions • Inject the drug through the catheter • Follow with 3-4 manual lung inflations • Dosage: 2-2.5x the recommended IV dose ALS Subcommittee 2010
- 7. INTRAOSSEOUS • Available foradult usage • Site: Iliac crest, sternum • As effective as intravenous line for resuscitation ALS Subcommittee 2010
- 8. ADRENALINE 1st drug incardiac arrest ALS Subcommittee 2010
- 9. ADRENALINE • Indications:- VF Pulseless VT Pulseless electrical activity (PEA) Asystole ALS Subcommittee 2010
- 10. ADRENALINE • Routes ofadministration:- › IV push OR Intraosseus 1 mg Infusion (3mg in 50 mls N/S at 1ml/hr =1ug/min), titrate accordingly › ETT (2-2.5X IV dose) ALS Subcommittee 2010
- 11. ADRENALINE ---- ACTIONS •increases contractile force of the heart thus increasing cardiac output • increases conduction of SA node, AV node and ventricle thus increasing heart rate • increases systemic vascular resistance through peripheral vasoconstriction thus increasing perfusion pressure ALS Subcommittee 2010
- 12. ADRENALINE ---- SIDE-EFFECTS •Ventricular irritability – tachyarrthymias • ↑ Myocardial Oxygen demand - risk of ischaemia and MI • Cerebrovascular event ALS Subcommittee 2010
- 13. VASOPRESSIN • A naturallyoccurring hormone • At high doses of 40 units (recommended dosage during resuscitation) – shunting of blood to heart and brain – intense vasoconstriction – may not increase myocardial oxygen demand -- unlike adrenaline ALS Subcommittee 2010
- 14. VASOPRESSIN • Indications foruse – Considered as an alternative to adrenaline for shock due to refractory VF, asystole and PEA – Used as a single bolus 40 units IV to replace 1st or 2nd dose of adrenaline – As a hemodynamic support in septic shock ALS Subcommittee 2010
- 15. ATROPINE • Anticholinergic (parasympatholytic) – inhibits effect of acetylcholine on SA and AV node – increases SA node and AV node conduction velocity – decreases effective refractory period AV node • Increases heart rate and cardiac output ALS Subcommittee 2010
- 16. ATROPINE Indication: • Sinus, atrialor nodal bradycardia with hemodynamic instability ALS Subcommittee 2010
- 17. ATROPINE Routes of administration:- •IV: 0.5mg for Acute symptomatic bradycardia Max 3mg • ETT: 2-3 mg diluted in 10 mls saline ALS Subcommittee 2010
- 18. ATROPINE ---- SIDE-EFFECTS •Tachycardia • Palpitations • Paradoxical bradycardia (if dose < 0.5mg) • Seizure (rare) • Hypertension (rare) ALS Subcommittee 2010
- 19. AMIODARONE • Has characteristicsof all 4 antiarrhythmic drug classes – affect sodium, potassium and calcium channel – alpha and beta blocking properties • Used in BOTH supraventricular and ventricular tachyarrthymias – Refractory VT/VF – Stable monomorphic or polymorphic VT – PSVTs, atrial tachycardia, atrial fibrillation – Wide complex tachycardia of uncertain origin – Pre-excited atrial arrhythmia ALS Subcommittee 2010
- 20. AMIODARONE • VF, pulselessVT and refractory VT/VF – Drug of Choice • IV bolus dose 300 mg • repeat IV bolus 150 mg in 3-5 mins followed by IV Infusion 900 mg over 24h • Other arrhythmias › IV Infusion 150 mg over 10 min followed by IV infusion 900 mg over 24h ALS Subcommittee 2010
- 21. LIGNOCAINE Indication: • Refractory VT/VF (when amiodarone is not available) ALS Subcommittee 2010
- 22. LIGNOCAINE ---- ACTIONS •Raises fibrillatory threshold • enhances the effect of DC shock • Suppresses automaticity and shortens effective refractory period and action potential duration • slows down heart rate • Inhibits reentry mechanism – halts arrhythmias ALS Subcommittee 2010
- 23. LIGNOCAINE • Routes ofadministration:- – IV push (1.0 to 1.5 mg/kg) Additional 0.5-0.75 mg/kg Max: 3 mg/kg Infusion 1 gm Lignocaine in 500 ml N/S 30 to 120 ml/hr (1 – 4 mg/min) – ETT (2-2.5X IV dose) ALS Subcommittee 2010
- 24. LIGNOCAINE - SIDE-EFFECTS •Seizures • Respiratory depression / arrest • Widening of QRS complexes • Bradycardia - cardiac arrest ALS Subcommittee 2010
- 25. ADENOSINE • A shortacting agent that depresses SA node and AV node function • Used in narrow complex supraventricular tachycardia • Half life : 5 seconds • Initial dose of 6 mg rapid IV push (may be repeated at 12 mg ) ALS Subcommittee 2010
- 26. ADENOSINE - SIDE-EFFECTS • Transient bradycardia or even ASYSTOLE • Hypotension • Chest pain • Dyspnoea • Bronchospasm (caution in asthma ) • Transient flushing ALS Subcommittee 2010
- 27. DOPAMINE Indications: • cardiogenic shock •septicaemic shock • neurogenic shock • anaphylactic shock • hypovolaemic shock only after fluid resuscitation has failed to raise BP ALS Subcommittee 2010
- 28. DOPAMINE Route of administration: •Infusion via central vein ALS Subcommittee 2010
- 29. DOPAMINE - ACTIONS Dose dependant effects Usual dose: 5– 20ug/kg/min • Increases myocardial contractility – Increases cardiac output • Causes peripheral vasoconstriction – Increases blood pressure ALS Subcommittee 2010
- 30. DOPAMINE - SIDE-EFFECTS •Tachycardia • Tachyarrhythmias • Excessive peripheral vasoconstriction ALS Subcommittee 2010
- 31. SODIUM BICARBONATE • A significant sodium load • 8.4% solution is hypertonic => arterial vasodilatation and hypotension • Extravasation => tissue necrosis • Not to be injected via same IV line as catecholamines and calcium ALS Subcommittee 2010
- 32. SODIUM BICARBONATE • onlybeneficial in hyperkalaemia • probably beneficial in - bicarbonate responsive acidosis • possibly beneficial in - protracted cardiac arrest with effective ventilation - postresuscitation acidosis with effective ventilation ALS Subcommittee 2010
- 33. REVIEW OBJECTIVES Areyou be able to? • State the drugs commonly used in resuscitation • outline the major actions of these drugs • list 2 side effects related to the use of the drugs ALS Subcommittee 2010
- 34. THANK YOU NATIONAL COMMITTEEON RESUSCITATION TRAINING SUBCOMMITEE FOR ADVANCED LIFE SUPPORT Dr Tan Cheng Cheng Dr Luah Lean Wah Dr Ismail Tan Dr Wan Nasrudin Dr Chong Yoon Sin Dr Priya Gill Dr Ridzuan bin Dato’Mohd Isa Dr Thohiroh Abdul Razak Dr Adi Osman ALS Subcommittee 2010