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Global DNA
Methylation Market
Focus on Products, Technologies,
Applications, End Users, Country Data (14
Countries), and Competitive Landscape:
Analysis and Forecast: 2019-2030
June 2020
TOC
Global DNA Methylation Market
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Global DNA Methylation Market
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Table of Contents
Executive Summary………...……………………………………….………....20
1. Product Definition ................................................................................................ 28
1.1 Inclusion and Exclusion ............................................................................. 28
2. Market Scope ........................................................................................................ 29
2.1 Scope of Work............................................................................................. 29
2.2 Key Questions Answered in the Report.................................................... 30
3. Research Methodology ........................................................................................ 31
3.1 Global DNA Methylation Market: Research Methodology ....................... 31
3.2 Data Sources ............................................................................................... 32
3.3 Secondary Data Sources............................................................................ 33
3.4 Market Estimation Model............................................................................ 34
3.5 Criteria for Company Profiling................................................................... 37
4. Market Overview................................................................................................... 38
4.1 Market Definition......................................................................................... 38
4.2 DNA Methylation: Impact on Human Health ............................................. 38
4.3 Market Size and Growth Potential, $Million, 2019-2030 ........................... 39
4.4 Future Potential........................................................................................... 40
4.5 COVID-19 Impact on the Global DNA Methylation Market ....................... 41
5. Global DNA Methylation Market: Industry Analysis .......................................... 43
5.1 Overview ...................................................................................................... 43
5.2 Legal Requirements and Framework in the U.S....................................... 43
5.3 Legal Requirements and Framework in Europe ....................................... 46
5.4 Legal Requirements and Framework in Asia-Pacific ............................... 52
5.4.1 China ............................................................................................. 52
5.4.2 Japan............................................................................................. 54
6. Global DNA Methylation Market: Market Dynamics........................................... 57
6.1 Overview ...................................................................................................... 57
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6.2 Iceberg Analysis.......................................................................................... 57
6.3 Impact Analysis........................................................................................... 59
6.4 Market Drivers ............................................................................................. 60
6.4.1 Global Increase in Cancer Prevalence........................................ 60
6.4.2 Increasing Government Funding for Healthcare ....................... 61
6.4.3 Declining Costs and Increasing Output of Sequencing............ 63
6.5 Market Restraints ........................................................................................ 64
6.5.1 High Cost of Instrument............................................................... 64
6.5.2 Lack of High-Complexity Testing Centers and Skilled
Professionals in High-Growth Regions...................................... 65
6.5.3 Low Adoption in Diagnostic Applications.................................. 66
6.6 Market Opportunities .................................................................................. 68
6.6.1 Growing Trend of Methylome Sequencing for Precision
Medicine........................................................................................ 68
6.6.2 Advancing Technological Developments for Methylome
Sequencing................................................................................... 69
6.6.3 Growth in Non-Oncology Applications of DNA Methylation..... 71
7. Competitive Landscape ....................................................................................... 72
7.1 Product Launches and Upgrades .............................................................. 72
7.2 Synergistic Activities.................................................................................. 73
7.3 Acquisitions................................................................................................. 74
7.4 Product Approvals, Business Expansion, and Other Activities ............. 75
7.5 Market Share Analysis, 2018-2019............................................................. 75
7.6 Growth Share Analysis............................................................................... 77
7.6.1 Growth Share Analysis (by Company) ....................................... 77
7.6.2 Growth Share Analysis (by Technology).................................... 80
7.6.3 Growth Share Analysis (by Application) .................................... 83
8. Global DNA Methylation Market (by Product Type)........................................... 85
8.1 Overview ...................................................................................................... 85
8.2 Consumables............................................................................................... 86
8.3 Instruments.................................................................................................. 90
8.4 Software....................................................................................................... 93
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9. Global DNA Methylation Market (by Technology).............................................. 95
9.1 Overview ...................................................................................................... 95
9.2 Polymerase Chain Reaction (PCR) ............................................................ 97
9.3 Sequencing.................................................................................................. 99
9.3.1 Next-Generation Sequencing (NGS) ......................................... 101
9.3.2 Traditional Sequencing.............................................................. 102
9.4 Microarray.................................................................................................. 103
9.5 Other Technologies .................................................................................. 105
10. Global DNA Methylation Market (by Application) ............................................ 107
10.1 Overview .................................................................................................... 107
10.2 Clinical Applications................................................................................. 108
10.3 Translational Research............................................................................. 111
10.3.1 Oncology Research.................................................................... 112
10.3.2 Non-Oncology Research............................................................ 114
10.3.3 Other Research Applications .................................................... 116
11. Global DNA Methylation Market (by End User)................................................ 118
11.1 Overview .................................................................................................... 118
11.2 Pharmaceutical and Biotechnology Companies .................................... 119
11.3 Research and Academic Institutions ...................................................... 120
11.4 Contract Research Organizations ........................................................... 122
11.5 Other End Users........................................................................................ 123
12. Global DNA Methylation Market (by Region).................................................... 124
12.1 Overview .................................................................................................... 124
12.2 North America ........................................................................................... 126
12.2.1 U.S. .............................................................................................. 128
12.2.2 Canada ........................................................................................ 130
12.2.3 North America DNA Methylation Market (by Translational
Research), 2019-2030................................................................. 131
12.3 Europe........................................................................................................ 133
12.3.1 Germany...................................................................................... 136
12.3.2 U.K. .............................................................................................. 137
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12.3.3 France.......................................................................................... 138
12.3.4 Italy .............................................................................................. 140
12.3.5 Spain............................................................................................ 141
12.3.6 Rest-of-Europe ........................................................................... 142
12.3.7 Europe DNA Methylation Market (by Translational Research),
2019-2030 .................................................................................... 144
12.4 Asia-Pacific................................................................................................ 145
12.4.1 China ........................................................................................... 147
12.4.2 Japan........................................................................................... 149
12.4.3 India............................................................................................. 150
12.4.4 South Korea ................................................................................ 152
12.4.5 Australia...................................................................................... 153
12.4.6 Rest-of-APAC.............................................................................. 154
12.4.7 Asia-Pacific DNA Methylation Market (by Translational
Research), 2019-2030................................................................. 155
12.5 Latin America ............................................................................................ 156
12.5.1 Brazil............................................................................................ 159
12.5.2 Mexico ......................................................................................... 160
12.5.3 Rest-of-Latin America ................................................................ 161
12.5.4 Latin America DNA Methylation Market (by Translational
Research), 2019-2030................................................................. 162
12.6 Rest-of-the-World...................................................................................... 163
13. Company Profiles............................................................................................... 165
13.1 Overview .................................................................................................... 165
13.2 Abcam plc.................................................................................................. 166
13.2.1 Company Overview .................................................................... 166
13.2.2 Role of Abcam plc in the Global DNA Methylation Market ..... 166
13.2.3 Financials.................................................................................... 167
13.2.4 Key Insights About Financial Health of the Company ............ 169
13.2.5 SWOT Analysis........................................................................... 170
13.3 Active Motif, Inc......................................................................................... 171
13.3.1 Company Overview .................................................................... 171
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13.3.2 Role of Active Motif, Inc. in the Global DNA Methylation
Market.......................................................................................... 171
13.3.3 SWOT Analysis........................................................................... 173
13.4 Agilent Technologies, Inc......................................................................... 174
13.4.1 Company Overview .................................................................... 174
13.4.2 Role of Agilent Technologies, Inc. in the Global DNA
Methylation Market..................................................................... 174
13.4.3 Financials.................................................................................... 176
13.4.4 Key Insights About Financial Health of the Company ............ 179
13.4.5 SWOT Analysis........................................................................... 180
13.5 Bio-Rad Laboratories, Inc......................................................................... 181
13.5.1 Company Overview .................................................................... 181
13.5.2 Role of Bio-Rad Laboratories, Inc. in the Global DNA
Methylation Market..................................................................... 181
13.5.3 Financials.................................................................................... 183
13.5.4 Key Insights About Financial Health of the Company ............ 185
13.5.5 SWOT Analysis........................................................................... 186
13.6 Diagenode Diagnostics S.A...................................................................... 187
13.6.1 Company Overview .................................................................... 187
13.6.2 Role of Diagenode Diagnostics S.A. in the Global DNA
Methylation Market..................................................................... 187
13.6.3 SWOT Analysis........................................................................... 189
13.7 EpiGentek Group Inc................................................................................. 190
13.7.1 Company Overview .................................................................... 190
13.7.2 Role of EpiGentek Group Inc. in the Global DNA Methylation
Market.......................................................................................... 190
13.7.3 SWOT Analysis........................................................................... 192
13.8 Exact Sciences Corporation..................................................................... 193
13.8.1 Company Overview .................................................................... 193
13.8.2 Role of Exact Sciences Corporation in the Global DNA
Methylation Market..................................................................... 193
13.8.3 Financials.................................................................................... 195
13.8.4 Key Insights About Financial Health of the Company ............ 197
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13.8.5 SWOT Analysis........................................................................... 198
13.9 F. Hoffmann-La Roche Ltd. ...................................................................... 199
13.9.1 Company Overview .................................................................... 199
13.9.2 Role of F. Hoffmann-La Roche Ltd in the Global DNA
Methylation Market..................................................................... 199
13.9.3 Financials.................................................................................... 200
13.9.4 Key Insights About Financial Health of the Company ............ 203
13.9.5 SWOT Analysis........................................................................... 204
13.10Illumina, Inc. .............................................................................................. 205
13.10.1 Company Overview .................................................................... 205
13.10.2 Role of Illumina, Inc. in the Global DNA Methylation Market.. 205
13.10.3 Financials.................................................................................... 207
13.10.4 Key Insights About Financial Health of the Company ............ 210
13.10.5 SWOT Analysis........................................................................... 211
13.11Merck KGaA............................................................................................... 212
13.11.1 Company Overview .................................................................... 212
13.11.2 Role of Merck KGaA in the Global DNA Methylation Market .. 212
13.11.3 Financials.................................................................................... 214
13.11.4 Key Insights About Financial Health of the Company ............ 217
13.11.5 SWOT Analysis........................................................................... 218
13.12New England Biolabs, Inc......................................................................... 219
13.12.1 Company Overview .................................................................... 219
13.12.2 Role of New England Biolabs, Inc. in the Global DNA
Methylation Market..................................................................... 219
13.12.3 SWOT Analysis........................................................................... 221
13.13Pacific Biosciences of California, Inc...................................................... 222
13.13.1 Company Overview .................................................................... 222
13.13.2 Role of Pacific Biosciences of California, Inc. in the
Global DNA Methylation Market................................................ 222
13.13.3 Financials.................................................................................... 224
13.13.4 Key Insights About Financial Health of the Company ............ 226
13.13.5 SWOT Analysis........................................................................... 227
13.14PerkinElmer, Inc........................................................................................ 228
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13.14.1 Company Overview .................................................................... 228
13.14.2 Role of PerkinElmer, Inc. in the Global DNA Methylation
Market.......................................................................................... 228
13.14.3 Financials.................................................................................... 230
13.14.4 Key Insights About Financial Health of the Company ............ 232
13.14.5 SWOT Analysis........................................................................... 233
13.15QIAGEN N.V.*............................................................................................. 234
13.15.1 Company Overview .................................................................... 234
13.15.2 Role of QIAGEN N.V. in the Global DNA Methylation Market . 234
13.15.3 Financials.................................................................................... 236
13.15.4 Key Insights About Financial Health of the Company ............ 239
13.15.5 SWOT Analysis........................................................................... 240
13.16Thermo Fisher Scientific Inc. ................................................................... 241
13.16.1 Company Overview .................................................................... 241
13.16.2 Role of Thermo Fisher Scientific Inc. in the Global DNA
Methylation Market..................................................................... 241
13.16.3 Financials.................................................................................... 243
13.16.4 Key Insights About Financial Health of the Company ............ 246
13.16.5 SWOT Analysis........................................................................... 247
13.17Zymo Research Corporation.................................................................... 248
13.17.1 Company Overview .................................................................... 248
13.17.2 Role of Zymo Research Corporation in the Global DNA
Methylation Market..................................................................... 248
13.17.3 SWOT Analysis........................................................................... 250
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List of Tables
Table 5.1: Classification Rules of IVDs Under the IVDR..................................................................48
Table 5.2: Registration Criteria for IVD Medical Devices as per the NMPA .....................................53
Table 8.1: Examples of Consumables in the Global DNA Methylation Market.................................88
Table 8.2: Examples of Instruments in Global DNA Methylation Market..........................................91
Table 8.3: Examples of Software in the Global DNA Methylation Market.........................................94
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List of Figures
Figure 1: Cancer Epigenetic Biomarker Publications Per Annum Vs. Cumulative Registered
DNA Methylation-based In Vitro Diagnostics, 2010-2019 ............................................21
Figure 2: Impact Analysis of Market Drivers and Market Challenges on the Global DNA
Methylation Market.......................................................................................................22
Figure 3: Global DNA Methylation Market (by Product), 2019 vs. 2030 ($Million)............................23
Figure 4: Global DNA Methylation Market (by Technology), 2019 vs. 2030 ($Million) .....................24
Figure 5: Global DNA Methylation Market (by Application), 2019 vs. 2030 ($Million).......................25
Figure 6: Global DNA Methylation Market (by End User), 2019 vs. 2030 ($Million).........................26
Figure 7: Global DNA Methylation Market Snapshot........................................................................27
Figure 2.1: Global DNA Methylation Market Segmentation..............................................................29
Figure 3.1: Global DNA Methylation Market Research Methodology...............................................31
Figure 3.2: Primary Research Methodology.....................................................................................32
Figure 3.3: Bottom-Up Approach (Segment-Wise Analysis) ............................................................34
Figure 3.4: Top-Down Approach (Segment-Wise Analysis).............................................................35
Figure 4.1: Global DNA Methylation Market, 2019-2030..................................................................39
Figure 4.2: Global DNA Methylation Market: COVID-19 Impact.......................................................41
Figure 5.1: Components Considered for Clinical Evidence as per the IVDR....................................51
Figure 5.2: Medical Device Designation Process by MHLW and PMDA..........................................56
Figure 6.1: Iceberg Analysis – Global DNA Methylation Market.......................................................58
Figure 6.2: Impact Analysis..............................................................................................................59
Figure 6.3: Global Cancer Burden, 2018 .........................................................................................60
Figure 6.4: Increasing Government Spending for Healthcare, 2017 ................................................62
Figure 6.5: Decreasing Cost and Increasing Output (TB) of Genome Sequencing
(2009-2025) .................................................................................................................63
Figure 6.6: Milestones for Clinical Implementation of a Candidate DNA Methylation Biomarker......67
Figure 6.7: Evolution of NGS-Based Techniques Applied to DNA Methylation Profiling ..................70
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Figure 7.1: Share of Key Developments and Strategies, January 2017–May 2020.........................72
Figure 7.2: Product Launches Share (by Company), January 2017–May 2020...............................73
Figure 7.3: Synergistic Activities Share (by Company), January 2017–May 2020...........................74
Figure 7.4: Share of Acquisitions (by Company), January 2016–February 2020.............................75
Figure 7.5: Market Share Analysis for Global DNA Methylation Market, 2018 and 2019 .................76
Figure 7.6: Growth Share Analysis for Global DNA Methylation Market (by Company), 2019.........78
Figure 7.7: Growth Share Analysis for Global DNA Methylation Market (by Technology),
2019-2030....................................................................................................................80
Figure 7.8: Growth Share Analysis for Global DNA Methylation Sequencing Market (by
Application), 2019-2030...............................................................................................83
Figure 8.1: Global DNA Methylation Market (by Product Type) .......................................................85
Figure 8.2: Global DNA Methylation Market (by Product Type), 2019 and 2030..............................85
Figure 8.3: Global DNA Methylation Market (by Consumable), 2019-2030 .....................................87
Figure 8.4: Global DNA Methylation Market (by Consumable), 2019 and 2030...............................88
Figure 8.5: Global DNA Methylation Market (Consumable, by Technology), 2019 and 2030 .........89
Figure 8.6: Global DNA Methylation Market (by Instruments), 2019-2030.......................................91
Figure 8.7: Global DNA Methylation Market (Instrument, by Technology), 2019 and 2030..............92
Figure 8.8: Global DNA Methylation Market (by Software), 2019-2030 ...........................................93
Figure 9.1: Global DNA Methylation Market (by Technology)..........................................................95
Figure 9.2: Global DNA Methylation Market (by Technology), 2019-2030.......................................96
Figure 9.3: Global DNA Methylation Market (by PCR), 2019-2030..................................................98
Figure 9.4: Evolution of Sequencing for Molecular Diagnostics .......................................................99
Figure 9.5: Global DNA Methylation Market (by Sequencing), 2019 and 2030..............................100
Figure 9.6: Global DNA Methylation Market (by NGS), 2019-2030................................................101
Figure 9.7: Global DNA Methylation Market (by Traditional Sequencing), 2019-2030 ...................103
Figure 9.8: Global DNA Methylation Market (by Microarray), 2019-2030.......................................104
Figure 9.9: Global DNA Methylation Market (by Other Technologies), 2019-2030 ........................106
Figure 10.1: Global DNA Methylation Market (by Application) .......................................................107
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Figure 10.2: Global DNA Methylation Market (by Application), 2019-2030 ....................................108
Figure 10.3: Global DNA Methylation Market (by Clinical Applications), 2019-2030......................110
Figure 10.4: Global DNA Methylation Market (by Translational Research), 2019 and 2030 ..........111
Figure 10.5: Global DNA Methylation Market (by Oncology Research), 2019-2030 ......................113
Figure 10.6: Global DNA Methylation Market (by Non-Oncology Research), 2019-2030...............114
Figure 10.7: Global DNA Methylation Market (by Non-Oncology Research), 2019 and 2030.......115
Figure 10.8: Global DNA Methylation Market (by Other Research Applications), 2019-2030 .......116
Figure 11.1: Global DNA Methylation Market (by End User)..........................................................118
Figure 11.2: Global DNA Methylation Market (by Pharmaceutical and Biotechnology
Companies), 2019-2030 ............................................................................................119
Figure 11.3: Global DNA Methylation Market (by Research and Academic Institutions),
2019-2030..................................................................................................................121
Figure 11.4: Global DNA Methylation Market (by Contract Research Organizations),
2019-2030..................................................................................................................122
Figure 11.5: Global DNA Methylation Market (by Other End Users), 2019-2030...........................123
Figure 12.1: Global DNA Methylation Market (by Region) .............................................................124
Figure 12.2: Global DNA Methylation Market (by Region), 2019-2030 ..........................................125
Figure 12.3: North America DNA Methylation Market, 2019-2030 .................................................126
Figure 12.4: North America: Market Dynamics ..............................................................................127
Figure 12.5: North America DNA Methylation Market (by Country), 2019-2030.............................128
Figure 12.6: U.S. DNA Methylation Market, 2019-2030.................................................................129
Figure 12.7: Canada DNA Methylation Market, 2019-2030 ...........................................................130
Figure 12.8: North America DNA Methylation Market (by Translational Research), 2019-2030....132
Figure 12.9: Europe DNA Methylation Market, 2019-2030 ............................................................133
Figure 12.10: Europe: Market Dynamics........................................................................................134
Figure 12.11: Europe DNA Methylation Market (by Country), 2019-2030......................................135
Figure 12.12: Germany DNA Methylation Market, 2019-2030 .......................................................136
Figure 12.13: U.K. DNA Methylation Market, 2019-2030...............................................................137
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Figure 12.14: France DNA Methylation Market, 2019-2030...........................................................139
Figure 12.15: Italy DNA Methylation Market, 2019-2030................................................................140
Figure 12.16: Spain DNA Methylation Market, 2019-2030.............................................................142
Figure 12.17: Rest-of-Europe DNA Methylation Market, 2019-2030..............................................143
Figure 12.18: Europe DNA Methylation Market (by Translational Research), 2019-2030..............144
Figure 12.19: Asia-Pacific DNA Methylation Market, 2019-2030 ...................................................145
Figure 12.20: APAC: Market Dynamics .........................................................................................146
Figure 12.21: APAC DNA Methylation Market (by Country), 2019-2030........................................147
Figure 12.22: China DNA Methylation Market, 2019-2030.............................................................148
Figure 12.23: Japan DNA Methylation Market, 2019-2030 ............................................................149
Figure 12.24: India DNA Methylation Market, 2019-2030 ..............................................................151
Figure 12.25: South Korea DNA Methylation Market, 2019-2030..................................................152
Figure 12.26: Australia DNA Methylation Market, 2019-2030 ........................................................153
Figure 12.27: RoAPAC DNA Methylation Market, 2019-2030........................................................154
Figure 12.28: Asia-Pacific DNA Methylation Market (by Translational Research), 2019-2030......155
Figure 12.29: Latin America DNA Methylation Market, 2019-2030 ................................................156
Figure 12.30: Latin America: Market Dynamics .............................................................................157
Figure 12.31: Latin America DNA Methylation Market (by Country), 2019-2030............................158
Figure 12.32: Brazil DNA Methylation Market, 2019-2030.............................................................159
Figure 12.33: Mexico DNA Methylation Market, 2019-2030...........................................................160
Figure 12.34: Rest-of-Latin America DNA Methylation Market, 2019-2030....................................161
Figure 12.35: Latin America DNA Methylation Market (by Translational Research), 2019-2030...162
Figure 12.36: RoW DNA Methylation Market, 2019-2030..............................................................163
Figure 13.1: Total Number of Companies Profiled.........................................................................165
Figure 13.2: Abcam plc: Product Portfolio......................................................................................167
Figure 13.3: Abcam plc: Overall Financials, 2016-2018.................................................................167
Figure 13.4: Abcam plc: Revenue (by Region), 2016-2018 ...........................................................168
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Figure 13.5: Abcam plc: R&D Expenditure, 2016-2018 .................................................................169
Figure 13.6: Abcam plc: SWOT Analysis.......................................................................................170
Figure 13.7: Active Motif, Inc.: Product Portfolio ............................................................................172
Figure 13.8: Active Motif, Inc.: SWOT Analysis..............................................................................173
Figure 13.9: Agilent Technologies, Inc.: Product Portfolio..............................................................175
Figure 13.10: Agilent Technologies, Inc.: Overall Financials, 2017-2019.......................................176
Figure 13.11: Agilent Technologies, Inc.: Revenue (by Segment), 2017-2019 ..............................177
Figure 13.12: Agilent Technologies, Inc.: Revenue (by Region), 2017-2019 .................................178
Figure 13.13: Agilent Technologies, Inc.: R&D Expenditure, 2017-2019 .......................................179
Figure 13.14: Agilent Technologies, Inc.: SWOT Analysis.............................................................180
Figure 13.15: Bio-Rad Laboratories, Inc.: Portfolio ........................................................................182
Figure 13.16: Bio-Rad Laboratories, Inc.: Overall Financials, 2017-2019......................................183
Figure 13.17: Bio-Rad Laboratories, Inc.: Revenue (by Segment), 2017-2019..............................184
Figure 13.18: Bio-Rad Laboratories, Inc.: Revenue (by Region), 2017-2019.................................184
Figure 13.19: Bio-Rad Laboratories, Inc.: R&D Expenditure, 2017-2019.......................................185
Figure 13.20: Bio-Rad Laboratories...............................................................................................186
Figure 13.21: Diagenode Diagnostics S.A.: Product Portfolio........................................................188
Figure 13.22: Diagenode Diagnostics S.A.: SWOT Analysis .........................................................189
Figure 13.23: EpiGentek Group Inc.: Product Portfolio ..................................................................191
Figure 13.24: EpiGentek Group Inc.: SWOT Analysis ...................................................................192
Figure 13.25: Exact Sciences Corporation: Portfolio......................................................................194
Figure 13.26: Exact Sciences Corporation: Overall Financials, 2017-2019 ...................................195
Figure 13.27: Exact Sciences Corporation: Revenue (by Segment), 2017-2019...........................196
Figure 13.28: Exact Sciences Corporation: Revenue (by Region), 2017-2019..............................196
Figure 13.29: Exact Sciences Corporation: R&D Expenditure, 2017-2019....................................197
Figure 13.30: Exact Sciences Corporation.....................................................................................198
Figure 13.33: F. Hoffmann-La Roche Ltd: Sales (by Segment), 2017-2019 ..................................201
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Figure 13.34: F. Hoffmann-La Roche Ltd: Sales (by Region), 2017-2019 .....................................202
Figure 13.35: F. Hoffmann-La Roche Ltd: R&D Expenditure, 2017-2019......................................203
Figure 13.36: F. Hoffmann-La Roche: SWOT Analysis..................................................................204
Figure 13.37: Illumina, Inc.: Product Portfolio.................................................................................206
Figure 13.38: Illumina, Inc.: Overall Financials, 2017-2019............................................................207
Figure 13.39: Illumina, Inc.: Revenue (by Segment), 2017-2019...................................................208
Figure 13.40: Illumina, Inc.: Revenue (by Region), 2016-2018......................................................209
Figure 13.41: Illumina, Inc.: R&D Expenditure, 2016-2018 ............................................................210
Figure 13.42: Illumina, Inc.: SWOT Analysis..................................................................................211
Figure 13.43: Merck KGaA: Overall Product Portfolio....................................................................213
Figure 13.44: Merck KGaA: Overall Financials, 2017-2019...........................................................214
Figure 13.45: Merck KGaA: Revenue (by Segment), 2017-2019...................................................215
Figure 13.46: Merck KGaA: Revenue (by Region), 2017-2019......................................................216
Figure 13.47: Merck KGaA: Life Science Segment Revenue (by Region), 2017-2019..................216
Figure 13.48: Merck KGaA: R&D Expenditure, 2016-2018............................................................217
Figure 13.49: Merck KGaA: SWOT Analysis .................................................................................218
Figure 13.50: New England Biolabs, Inc.: Product Portfolio...........................................................220
Figure 13.51: New England Biolabs, Inc.: SWOT Analysis............................................................221
Figure 13.52: Pacific Biosciences of California, Inc.: Overall Product Portfolio ..............................223
Figure 13.53: Pacific Biosciences of California, Inc.: Overall Financials, 2017-2019 .....................224
Figure 13.54: Pacific Biosciences of California, Inc.: Revenue (by Segment), 2017-2019.............225
Figure 13.55: Pacific Biosciences of California, Inc.: Revenue (by Region), 2017-2019................226
Figure 13.56: Pacific Biosciences of California, Inc.: R&D Expenditure, 2017-2019......................226
Figure 13.57: Pacific Biosciences of California, Inc.: SWOT Analysis............................................227
Figure 13.58: PerkinElmer, Inc.: Portfolio.......................................................................................229
Figure 13.59: PerkinElmer, Inc.: Overall Financials, 2017-2019 ....................................................230
Figure 13.60: PerkinElmer, Inc.: Revenue (by Segment), 2017-2019............................................231
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Figure 13.61: PerkinElmer, Inc.: Revenue (by Region), 2017-2019...............................................231
Figure 13.62: PerkinElmer, Inc.: R&D Expenditure, 2017-2019.....................................................232
Figure 13.63: PerkinElmer, Inc.: SWOT Analysis...........................................................................233
Figure 13.64: QIAGEN N.V.: Portfolio............................................................................................235
Figure 13.65: QIAGEN N.V.: Overall Financials, 2017-2019 .........................................................236
Figure 13.66: QIAGEN N.V.: Revenue (by Segment), 2017-2019.................................................237
Figure 13.67: QIAGEN N.V.: Revenue (by Region), 2017-2019....................................................238
Figure 13.68: QIAGEN N.V.: R&D Expenditure, 2017-2019 ..........................................................239
Figure 13.69: QIAGEN N.V.: SWOT Analysis................................................................................240
Figure 13.70: Thermo Fisher Scientific Inc.: Product Portfolio .......................................................242
Figure 13.71: Thermo Fisher Scientific Inc.: Overall Financials, 2017-2019 ..................................243
Figure 13.72: Thermo Fisher Scientific Inc.: Revenue (by Segment), 2017-2019..........................244
Figure 13.73: Thermo Fisher Scientific Inc.: Revenue (by Region), 2017-2019.............................245
Figure 13.74: Thermo Fisher Scientific Inc.: R&D Expenditure, 2017-2019...................................246
Figure 13.75: Thermo Fisher Scientific Inc.: SWOT Analysis.........................................................247
Figure 13.76: Zymo Research Corporation: Product Portfolio........................................................249
Figure 13.77: Zymo Research Corporation: SWOT Analysis.........................................................250
Global DNA Methylation Market
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DNA Methylation Market _ Industry Analysis & Report

  • 1. Global DNA Methylation Market Focus on Products, Technologies, Applications, End Users, Country Data (14 Countries), and Competitive Landscape: Analysis and Forecast: 2019-2030 June 2020 TOC
  • 2. Global DNA Methylation Market All rights reserved at BIS Research 2 BIS Research is a leading market intelligence and technology research company. BIS Research publishes in-depth market intelligence reports focusing on the market estimations, technology analysis, emerging high-growth applications, deeply segmented granular country-level market data and other important market parameters useful in the strategic decision making for s0065nior management. BIS Research provides multi-client reports, company profiles, databases, and custom research services. Copyright © 2020 BIS Research All Rights Reserved. This document contains highly confidential information and is the sole property of BIS Research. Disclosing, copying, circulating, quoting or otherwise reproducing any or all contents of this document is strictly prohibited. Access to this information is provided exclusively for the benefit of the people or organization concerned. It may not be accessed by or offered whether for sale or otherwise to any third party.
  • 3. Global DNA Methylation Market All rights reserved at BIS Research 3 Table of Contents Executive Summary………...……………………………………….………....20 1. Product Definition ................................................................................................ 28 1.1 Inclusion and Exclusion ............................................................................. 28 2. Market Scope ........................................................................................................ 29 2.1 Scope of Work............................................................................................. 29 2.2 Key Questions Answered in the Report.................................................... 30 3. Research Methodology ........................................................................................ 31 3.1 Global DNA Methylation Market: Research Methodology ....................... 31 3.2 Data Sources ............................................................................................... 32 3.3 Secondary Data Sources............................................................................ 33 3.4 Market Estimation Model............................................................................ 34 3.5 Criteria for Company Profiling................................................................... 37 4. Market Overview................................................................................................... 38 4.1 Market Definition......................................................................................... 38 4.2 DNA Methylation: Impact on Human Health ............................................. 38 4.3 Market Size and Growth Potential, $Million, 2019-2030 ........................... 39 4.4 Future Potential........................................................................................... 40 4.5 COVID-19 Impact on the Global DNA Methylation Market ....................... 41 5. Global DNA Methylation Market: Industry Analysis .......................................... 43 5.1 Overview ...................................................................................................... 43 5.2 Legal Requirements and Framework in the U.S....................................... 43 5.3 Legal Requirements and Framework in Europe ....................................... 46 5.4 Legal Requirements and Framework in Asia-Pacific ............................... 52 5.4.1 China ............................................................................................. 52 5.4.2 Japan............................................................................................. 54 6. Global DNA Methylation Market: Market Dynamics........................................... 57 6.1 Overview ...................................................................................................... 57
  • 4. Global DNA Methylation Market All rights reserved at BIS Research 4 6.2 Iceberg Analysis.......................................................................................... 57 6.3 Impact Analysis........................................................................................... 59 6.4 Market Drivers ............................................................................................. 60 6.4.1 Global Increase in Cancer Prevalence........................................ 60 6.4.2 Increasing Government Funding for Healthcare ....................... 61 6.4.3 Declining Costs and Increasing Output of Sequencing............ 63 6.5 Market Restraints ........................................................................................ 64 6.5.1 High Cost of Instrument............................................................... 64 6.5.2 Lack of High-Complexity Testing Centers and Skilled Professionals in High-Growth Regions...................................... 65 6.5.3 Low Adoption in Diagnostic Applications.................................. 66 6.6 Market Opportunities .................................................................................. 68 6.6.1 Growing Trend of Methylome Sequencing for Precision Medicine........................................................................................ 68 6.6.2 Advancing Technological Developments for Methylome Sequencing................................................................................... 69 6.6.3 Growth in Non-Oncology Applications of DNA Methylation..... 71 7. Competitive Landscape ....................................................................................... 72 7.1 Product Launches and Upgrades .............................................................. 72 7.2 Synergistic Activities.................................................................................. 73 7.3 Acquisitions................................................................................................. 74 7.4 Product Approvals, Business Expansion, and Other Activities ............. 75 7.5 Market Share Analysis, 2018-2019............................................................. 75 7.6 Growth Share Analysis............................................................................... 77 7.6.1 Growth Share Analysis (by Company) ....................................... 77 7.6.2 Growth Share Analysis (by Technology).................................... 80 7.6.3 Growth Share Analysis (by Application) .................................... 83 8. Global DNA Methylation Market (by Product Type)........................................... 85 8.1 Overview ...................................................................................................... 85 8.2 Consumables............................................................................................... 86 8.3 Instruments.................................................................................................. 90 8.4 Software....................................................................................................... 93
  • 5. Global DNA Methylation Market All rights reserved at BIS Research 5 9. Global DNA Methylation Market (by Technology).............................................. 95 9.1 Overview ...................................................................................................... 95 9.2 Polymerase Chain Reaction (PCR) ............................................................ 97 9.3 Sequencing.................................................................................................. 99 9.3.1 Next-Generation Sequencing (NGS) ......................................... 101 9.3.2 Traditional Sequencing.............................................................. 102 9.4 Microarray.................................................................................................. 103 9.5 Other Technologies .................................................................................. 105 10. Global DNA Methylation Market (by Application) ............................................ 107 10.1 Overview .................................................................................................... 107 10.2 Clinical Applications................................................................................. 108 10.3 Translational Research............................................................................. 111 10.3.1 Oncology Research.................................................................... 112 10.3.2 Non-Oncology Research............................................................ 114 10.3.3 Other Research Applications .................................................... 116 11. Global DNA Methylation Market (by End User)................................................ 118 11.1 Overview .................................................................................................... 118 11.2 Pharmaceutical and Biotechnology Companies .................................... 119 11.3 Research and Academic Institutions ...................................................... 120 11.4 Contract Research Organizations ........................................................... 122 11.5 Other End Users........................................................................................ 123 12. Global DNA Methylation Market (by Region).................................................... 124 12.1 Overview .................................................................................................... 124 12.2 North America ........................................................................................... 126 12.2.1 U.S. .............................................................................................. 128 12.2.2 Canada ........................................................................................ 130 12.2.3 North America DNA Methylation Market (by Translational Research), 2019-2030................................................................. 131 12.3 Europe........................................................................................................ 133 12.3.1 Germany...................................................................................... 136 12.3.2 U.K. .............................................................................................. 137
  • 6. Global DNA Methylation Market All rights reserved at BIS Research 6 12.3.3 France.......................................................................................... 138 12.3.4 Italy .............................................................................................. 140 12.3.5 Spain............................................................................................ 141 12.3.6 Rest-of-Europe ........................................................................... 142 12.3.7 Europe DNA Methylation Market (by Translational Research), 2019-2030 .................................................................................... 144 12.4 Asia-Pacific................................................................................................ 145 12.4.1 China ........................................................................................... 147 12.4.2 Japan........................................................................................... 149 12.4.3 India............................................................................................. 150 12.4.4 South Korea ................................................................................ 152 12.4.5 Australia...................................................................................... 153 12.4.6 Rest-of-APAC.............................................................................. 154 12.4.7 Asia-Pacific DNA Methylation Market (by Translational Research), 2019-2030................................................................. 155 12.5 Latin America ............................................................................................ 156 12.5.1 Brazil............................................................................................ 159 12.5.2 Mexico ......................................................................................... 160 12.5.3 Rest-of-Latin America ................................................................ 161 12.5.4 Latin America DNA Methylation Market (by Translational Research), 2019-2030................................................................. 162 12.6 Rest-of-the-World...................................................................................... 163 13. Company Profiles............................................................................................... 165 13.1 Overview .................................................................................................... 165 13.2 Abcam plc.................................................................................................. 166 13.2.1 Company Overview .................................................................... 166 13.2.2 Role of Abcam plc in the Global DNA Methylation Market ..... 166 13.2.3 Financials.................................................................................... 167 13.2.4 Key Insights About Financial Health of the Company ............ 169 13.2.5 SWOT Analysis........................................................................... 170 13.3 Active Motif, Inc......................................................................................... 171 13.3.1 Company Overview .................................................................... 171
  • 7. Global DNA Methylation Market All rights reserved at BIS Research 7 13.3.2 Role of Active Motif, Inc. in the Global DNA Methylation Market.......................................................................................... 171 13.3.3 SWOT Analysis........................................................................... 173 13.4 Agilent Technologies, Inc......................................................................... 174 13.4.1 Company Overview .................................................................... 174 13.4.2 Role of Agilent Technologies, Inc. in the Global DNA Methylation Market..................................................................... 174 13.4.3 Financials.................................................................................... 176 13.4.4 Key Insights About Financial Health of the Company ............ 179 13.4.5 SWOT Analysis........................................................................... 180 13.5 Bio-Rad Laboratories, Inc......................................................................... 181 13.5.1 Company Overview .................................................................... 181 13.5.2 Role of Bio-Rad Laboratories, Inc. in the Global DNA Methylation Market..................................................................... 181 13.5.3 Financials.................................................................................... 183 13.5.4 Key Insights About Financial Health of the Company ............ 185 13.5.5 SWOT Analysis........................................................................... 186 13.6 Diagenode Diagnostics S.A...................................................................... 187 13.6.1 Company Overview .................................................................... 187 13.6.2 Role of Diagenode Diagnostics S.A. in the Global DNA Methylation Market..................................................................... 187 13.6.3 SWOT Analysis........................................................................... 189 13.7 EpiGentek Group Inc................................................................................. 190 13.7.1 Company Overview .................................................................... 190 13.7.2 Role of EpiGentek Group Inc. in the Global DNA Methylation Market.......................................................................................... 190 13.7.3 SWOT Analysis........................................................................... 192 13.8 Exact Sciences Corporation..................................................................... 193 13.8.1 Company Overview .................................................................... 193 13.8.2 Role of Exact Sciences Corporation in the Global DNA Methylation Market..................................................................... 193 13.8.3 Financials.................................................................................... 195 13.8.4 Key Insights About Financial Health of the Company ............ 197
  • 8. Global DNA Methylation Market All rights reserved at BIS Research 8 13.8.5 SWOT Analysis........................................................................... 198 13.9 F. Hoffmann-La Roche Ltd. ...................................................................... 199 13.9.1 Company Overview .................................................................... 199 13.9.2 Role of F. Hoffmann-La Roche Ltd in the Global DNA Methylation Market..................................................................... 199 13.9.3 Financials.................................................................................... 200 13.9.4 Key Insights About Financial Health of the Company ............ 203 13.9.5 SWOT Analysis........................................................................... 204 13.10Illumina, Inc. .............................................................................................. 205 13.10.1 Company Overview .................................................................... 205 13.10.2 Role of Illumina, Inc. in the Global DNA Methylation Market.. 205 13.10.3 Financials.................................................................................... 207 13.10.4 Key Insights About Financial Health of the Company ............ 210 13.10.5 SWOT Analysis........................................................................... 211 13.11Merck KGaA............................................................................................... 212 13.11.1 Company Overview .................................................................... 212 13.11.2 Role of Merck KGaA in the Global DNA Methylation Market .. 212 13.11.3 Financials.................................................................................... 214 13.11.4 Key Insights About Financial Health of the Company ............ 217 13.11.5 SWOT Analysis........................................................................... 218 13.12New England Biolabs, Inc......................................................................... 219 13.12.1 Company Overview .................................................................... 219 13.12.2 Role of New England Biolabs, Inc. in the Global DNA Methylation Market..................................................................... 219 13.12.3 SWOT Analysis........................................................................... 221 13.13Pacific Biosciences of California, Inc...................................................... 222 13.13.1 Company Overview .................................................................... 222 13.13.2 Role of Pacific Biosciences of California, Inc. in the Global DNA Methylation Market................................................ 222 13.13.3 Financials.................................................................................... 224 13.13.4 Key Insights About Financial Health of the Company ............ 226 13.13.5 SWOT Analysis........................................................................... 227 13.14PerkinElmer, Inc........................................................................................ 228
  • 9. Global DNA Methylation Market All rights reserved at BIS Research 9 13.14.1 Company Overview .................................................................... 228 13.14.2 Role of PerkinElmer, Inc. in the Global DNA Methylation Market.......................................................................................... 228 13.14.3 Financials.................................................................................... 230 13.14.4 Key Insights About Financial Health of the Company ............ 232 13.14.5 SWOT Analysis........................................................................... 233 13.15QIAGEN N.V.*............................................................................................. 234 13.15.1 Company Overview .................................................................... 234 13.15.2 Role of QIAGEN N.V. in the Global DNA Methylation Market . 234 13.15.3 Financials.................................................................................... 236 13.15.4 Key Insights About Financial Health of the Company ............ 239 13.15.5 SWOT Analysis........................................................................... 240 13.16Thermo Fisher Scientific Inc. ................................................................... 241 13.16.1 Company Overview .................................................................... 241 13.16.2 Role of Thermo Fisher Scientific Inc. in the Global DNA Methylation Market..................................................................... 241 13.16.3 Financials.................................................................................... 243 13.16.4 Key Insights About Financial Health of the Company ............ 246 13.16.5 SWOT Analysis........................................................................... 247 13.17Zymo Research Corporation.................................................................... 248 13.17.1 Company Overview .................................................................... 248 13.17.2 Role of Zymo Research Corporation in the Global DNA Methylation Market..................................................................... 248 13.17.3 SWOT Analysis........................................................................... 250
  • 10. Global DNA Methylation Market All rights reserved at BIS Research 10 List of Tables Table 5.1: Classification Rules of IVDs Under the IVDR..................................................................48 Table 5.2: Registration Criteria for IVD Medical Devices as per the NMPA .....................................53 Table 8.1: Examples of Consumables in the Global DNA Methylation Market.................................88 Table 8.2: Examples of Instruments in Global DNA Methylation Market..........................................91 Table 8.3: Examples of Software in the Global DNA Methylation Market.........................................94
  • 11. Global DNA Methylation Market All rights reserved at BIS Research 11 List of Figures Figure 1: Cancer Epigenetic Biomarker Publications Per Annum Vs. Cumulative Registered DNA Methylation-based In Vitro Diagnostics, 2010-2019 ............................................21 Figure 2: Impact Analysis of Market Drivers and Market Challenges on the Global DNA Methylation Market.......................................................................................................22 Figure 3: Global DNA Methylation Market (by Product), 2019 vs. 2030 ($Million)............................23 Figure 4: Global DNA Methylation Market (by Technology), 2019 vs. 2030 ($Million) .....................24 Figure 5: Global DNA Methylation Market (by Application), 2019 vs. 2030 ($Million).......................25 Figure 6: Global DNA Methylation Market (by End User), 2019 vs. 2030 ($Million).........................26 Figure 7: Global DNA Methylation Market Snapshot........................................................................27 Figure 2.1: Global DNA Methylation Market Segmentation..............................................................29 Figure 3.1: Global DNA Methylation Market Research Methodology...............................................31 Figure 3.2: Primary Research Methodology.....................................................................................32 Figure 3.3: Bottom-Up Approach (Segment-Wise Analysis) ............................................................34 Figure 3.4: Top-Down Approach (Segment-Wise Analysis).............................................................35 Figure 4.1: Global DNA Methylation Market, 2019-2030..................................................................39 Figure 4.2: Global DNA Methylation Market: COVID-19 Impact.......................................................41 Figure 5.1: Components Considered for Clinical Evidence as per the IVDR....................................51 Figure 5.2: Medical Device Designation Process by MHLW and PMDA..........................................56 Figure 6.1: Iceberg Analysis – Global DNA Methylation Market.......................................................58 Figure 6.2: Impact Analysis..............................................................................................................59 Figure 6.3: Global Cancer Burden, 2018 .........................................................................................60 Figure 6.4: Increasing Government Spending for Healthcare, 2017 ................................................62 Figure 6.5: Decreasing Cost and Increasing Output (TB) of Genome Sequencing (2009-2025) .................................................................................................................63 Figure 6.6: Milestones for Clinical Implementation of a Candidate DNA Methylation Biomarker......67 Figure 6.7: Evolution of NGS-Based Techniques Applied to DNA Methylation Profiling ..................70
  • 12. Global DNA Methylation Market All rights reserved at BIS Research 12 Figure 7.1: Share of Key Developments and Strategies, January 2017–May 2020.........................72 Figure 7.2: Product Launches Share (by Company), January 2017–May 2020...............................73 Figure 7.3: Synergistic Activities Share (by Company), January 2017–May 2020...........................74 Figure 7.4: Share of Acquisitions (by Company), January 2016–February 2020.............................75 Figure 7.5: Market Share Analysis for Global DNA Methylation Market, 2018 and 2019 .................76 Figure 7.6: Growth Share Analysis for Global DNA Methylation Market (by Company), 2019.........78 Figure 7.7: Growth Share Analysis for Global DNA Methylation Market (by Technology), 2019-2030....................................................................................................................80 Figure 7.8: Growth Share Analysis for Global DNA Methylation Sequencing Market (by Application), 2019-2030...............................................................................................83 Figure 8.1: Global DNA Methylation Market (by Product Type) .......................................................85 Figure 8.2: Global DNA Methylation Market (by Product Type), 2019 and 2030..............................85 Figure 8.3: Global DNA Methylation Market (by Consumable), 2019-2030 .....................................87 Figure 8.4: Global DNA Methylation Market (by Consumable), 2019 and 2030...............................88 Figure 8.5: Global DNA Methylation Market (Consumable, by Technology), 2019 and 2030 .........89 Figure 8.6: Global DNA Methylation Market (by Instruments), 2019-2030.......................................91 Figure 8.7: Global DNA Methylation Market (Instrument, by Technology), 2019 and 2030..............92 Figure 8.8: Global DNA Methylation Market (by Software), 2019-2030 ...........................................93 Figure 9.1: Global DNA Methylation Market (by Technology)..........................................................95 Figure 9.2: Global DNA Methylation Market (by Technology), 2019-2030.......................................96 Figure 9.3: Global DNA Methylation Market (by PCR), 2019-2030..................................................98 Figure 9.4: Evolution of Sequencing for Molecular Diagnostics .......................................................99 Figure 9.5: Global DNA Methylation Market (by Sequencing), 2019 and 2030..............................100 Figure 9.6: Global DNA Methylation Market (by NGS), 2019-2030................................................101 Figure 9.7: Global DNA Methylation Market (by Traditional Sequencing), 2019-2030 ...................103 Figure 9.8: Global DNA Methylation Market (by Microarray), 2019-2030.......................................104 Figure 9.9: Global DNA Methylation Market (by Other Technologies), 2019-2030 ........................106 Figure 10.1: Global DNA Methylation Market (by Application) .......................................................107
  • 13. Global DNA Methylation Market All rights reserved at BIS Research 13 Figure 10.2: Global DNA Methylation Market (by Application), 2019-2030 ....................................108 Figure 10.3: Global DNA Methylation Market (by Clinical Applications), 2019-2030......................110 Figure 10.4: Global DNA Methylation Market (by Translational Research), 2019 and 2030 ..........111 Figure 10.5: Global DNA Methylation Market (by Oncology Research), 2019-2030 ......................113 Figure 10.6: Global DNA Methylation Market (by Non-Oncology Research), 2019-2030...............114 Figure 10.7: Global DNA Methylation Market (by Non-Oncology Research), 2019 and 2030.......115 Figure 10.8: Global DNA Methylation Market (by Other Research Applications), 2019-2030 .......116 Figure 11.1: Global DNA Methylation Market (by End User)..........................................................118 Figure 11.2: Global DNA Methylation Market (by Pharmaceutical and Biotechnology Companies), 2019-2030 ............................................................................................119 Figure 11.3: Global DNA Methylation Market (by Research and Academic Institutions), 2019-2030..................................................................................................................121 Figure 11.4: Global DNA Methylation Market (by Contract Research Organizations), 2019-2030..................................................................................................................122 Figure 11.5: Global DNA Methylation Market (by Other End Users), 2019-2030...........................123 Figure 12.1: Global DNA Methylation Market (by Region) .............................................................124 Figure 12.2: Global DNA Methylation Market (by Region), 2019-2030 ..........................................125 Figure 12.3: North America DNA Methylation Market, 2019-2030 .................................................126 Figure 12.4: North America: Market Dynamics ..............................................................................127 Figure 12.5: North America DNA Methylation Market (by Country), 2019-2030.............................128 Figure 12.6: U.S. DNA Methylation Market, 2019-2030.................................................................129 Figure 12.7: Canada DNA Methylation Market, 2019-2030 ...........................................................130 Figure 12.8: North America DNA Methylation Market (by Translational Research), 2019-2030....132 Figure 12.9: Europe DNA Methylation Market, 2019-2030 ............................................................133 Figure 12.10: Europe: Market Dynamics........................................................................................134 Figure 12.11: Europe DNA Methylation Market (by Country), 2019-2030......................................135 Figure 12.12: Germany DNA Methylation Market, 2019-2030 .......................................................136 Figure 12.13: U.K. DNA Methylation Market, 2019-2030...............................................................137
  • 14. Global DNA Methylation Market All rights reserved at BIS Research 14 Figure 12.14: France DNA Methylation Market, 2019-2030...........................................................139 Figure 12.15: Italy DNA Methylation Market, 2019-2030................................................................140 Figure 12.16: Spain DNA Methylation Market, 2019-2030.............................................................142 Figure 12.17: Rest-of-Europe DNA Methylation Market, 2019-2030..............................................143 Figure 12.18: Europe DNA Methylation Market (by Translational Research), 2019-2030..............144 Figure 12.19: Asia-Pacific DNA Methylation Market, 2019-2030 ...................................................145 Figure 12.20: APAC: Market Dynamics .........................................................................................146 Figure 12.21: APAC DNA Methylation Market (by Country), 2019-2030........................................147 Figure 12.22: China DNA Methylation Market, 2019-2030.............................................................148 Figure 12.23: Japan DNA Methylation Market, 2019-2030 ............................................................149 Figure 12.24: India DNA Methylation Market, 2019-2030 ..............................................................151 Figure 12.25: South Korea DNA Methylation Market, 2019-2030..................................................152 Figure 12.26: Australia DNA Methylation Market, 2019-2030 ........................................................153 Figure 12.27: RoAPAC DNA Methylation Market, 2019-2030........................................................154 Figure 12.28: Asia-Pacific DNA Methylation Market (by Translational Research), 2019-2030......155 Figure 12.29: Latin America DNA Methylation Market, 2019-2030 ................................................156 Figure 12.30: Latin America: Market Dynamics .............................................................................157 Figure 12.31: Latin America DNA Methylation Market (by Country), 2019-2030............................158 Figure 12.32: Brazil DNA Methylation Market, 2019-2030.............................................................159 Figure 12.33: Mexico DNA Methylation Market, 2019-2030...........................................................160 Figure 12.34: Rest-of-Latin America DNA Methylation Market, 2019-2030....................................161 Figure 12.35: Latin America DNA Methylation Market (by Translational Research), 2019-2030...162 Figure 12.36: RoW DNA Methylation Market, 2019-2030..............................................................163 Figure 13.1: Total Number of Companies Profiled.........................................................................165 Figure 13.2: Abcam plc: Product Portfolio......................................................................................167 Figure 13.3: Abcam plc: Overall Financials, 2016-2018.................................................................167 Figure 13.4: Abcam plc: Revenue (by Region), 2016-2018 ...........................................................168
  • 15. Global DNA Methylation Market All rights reserved at BIS Research 15 Figure 13.5: Abcam plc: R&D Expenditure, 2016-2018 .................................................................169 Figure 13.6: Abcam plc: SWOT Analysis.......................................................................................170 Figure 13.7: Active Motif, Inc.: Product Portfolio ............................................................................172 Figure 13.8: Active Motif, Inc.: SWOT Analysis..............................................................................173 Figure 13.9: Agilent Technologies, Inc.: Product Portfolio..............................................................175 Figure 13.10: Agilent Technologies, Inc.: Overall Financials, 2017-2019.......................................176 Figure 13.11: Agilent Technologies, Inc.: Revenue (by Segment), 2017-2019 ..............................177 Figure 13.12: Agilent Technologies, Inc.: Revenue (by Region), 2017-2019 .................................178 Figure 13.13: Agilent Technologies, Inc.: R&D Expenditure, 2017-2019 .......................................179 Figure 13.14: Agilent Technologies, Inc.: SWOT Analysis.............................................................180 Figure 13.15: Bio-Rad Laboratories, Inc.: Portfolio ........................................................................182 Figure 13.16: Bio-Rad Laboratories, Inc.: Overall Financials, 2017-2019......................................183 Figure 13.17: Bio-Rad Laboratories, Inc.: Revenue (by Segment), 2017-2019..............................184 Figure 13.18: Bio-Rad Laboratories, Inc.: Revenue (by Region), 2017-2019.................................184 Figure 13.19: Bio-Rad Laboratories, Inc.: R&D Expenditure, 2017-2019.......................................185 Figure 13.20: Bio-Rad Laboratories...............................................................................................186 Figure 13.21: Diagenode Diagnostics S.A.: Product Portfolio........................................................188 Figure 13.22: Diagenode Diagnostics S.A.: SWOT Analysis .........................................................189 Figure 13.23: EpiGentek Group Inc.: Product Portfolio ..................................................................191 Figure 13.24: EpiGentek Group Inc.: SWOT Analysis ...................................................................192 Figure 13.25: Exact Sciences Corporation: Portfolio......................................................................194 Figure 13.26: Exact Sciences Corporation: Overall Financials, 2017-2019 ...................................195 Figure 13.27: Exact Sciences Corporation: Revenue (by Segment), 2017-2019...........................196 Figure 13.28: Exact Sciences Corporation: Revenue (by Region), 2017-2019..............................196 Figure 13.29: Exact Sciences Corporation: R&D Expenditure, 2017-2019....................................197 Figure 13.30: Exact Sciences Corporation.....................................................................................198 Figure 13.33: F. Hoffmann-La Roche Ltd: Sales (by Segment), 2017-2019 ..................................201
  • 16. Global DNA Methylation Market All rights reserved at BIS Research 16 Figure 13.34: F. Hoffmann-La Roche Ltd: Sales (by Region), 2017-2019 .....................................202 Figure 13.35: F. Hoffmann-La Roche Ltd: R&D Expenditure, 2017-2019......................................203 Figure 13.36: F. Hoffmann-La Roche: SWOT Analysis..................................................................204 Figure 13.37: Illumina, Inc.: Product Portfolio.................................................................................206 Figure 13.38: Illumina, Inc.: Overall Financials, 2017-2019............................................................207 Figure 13.39: Illumina, Inc.: Revenue (by Segment), 2017-2019...................................................208 Figure 13.40: Illumina, Inc.: Revenue (by Region), 2016-2018......................................................209 Figure 13.41: Illumina, Inc.: R&D Expenditure, 2016-2018 ............................................................210 Figure 13.42: Illumina, Inc.: SWOT Analysis..................................................................................211 Figure 13.43: Merck KGaA: Overall Product Portfolio....................................................................213 Figure 13.44: Merck KGaA: Overall Financials, 2017-2019...........................................................214 Figure 13.45: Merck KGaA: Revenue (by Segment), 2017-2019...................................................215 Figure 13.46: Merck KGaA: Revenue (by Region), 2017-2019......................................................216 Figure 13.47: Merck KGaA: Life Science Segment Revenue (by Region), 2017-2019..................216 Figure 13.48: Merck KGaA: R&D Expenditure, 2016-2018............................................................217 Figure 13.49: Merck KGaA: SWOT Analysis .................................................................................218 Figure 13.50: New England Biolabs, Inc.: Product Portfolio...........................................................220 Figure 13.51: New England Biolabs, Inc.: SWOT Analysis............................................................221 Figure 13.52: Pacific Biosciences of California, Inc.: Overall Product Portfolio ..............................223 Figure 13.53: Pacific Biosciences of California, Inc.: Overall Financials, 2017-2019 .....................224 Figure 13.54: Pacific Biosciences of California, Inc.: Revenue (by Segment), 2017-2019.............225 Figure 13.55: Pacific Biosciences of California, Inc.: Revenue (by Region), 2017-2019................226 Figure 13.56: Pacific Biosciences of California, Inc.: R&D Expenditure, 2017-2019......................226 Figure 13.57: Pacific Biosciences of California, Inc.: SWOT Analysis............................................227 Figure 13.58: PerkinElmer, Inc.: Portfolio.......................................................................................229 Figure 13.59: PerkinElmer, Inc.: Overall Financials, 2017-2019 ....................................................230 Figure 13.60: PerkinElmer, Inc.: Revenue (by Segment), 2017-2019............................................231
  • 17. Global DNA Methylation Market All rights reserved at BIS Research 17 Figure 13.61: PerkinElmer, Inc.: Revenue (by Region), 2017-2019...............................................231 Figure 13.62: PerkinElmer, Inc.: R&D Expenditure, 2017-2019.....................................................232 Figure 13.63: PerkinElmer, Inc.: SWOT Analysis...........................................................................233 Figure 13.64: QIAGEN N.V.: Portfolio............................................................................................235 Figure 13.65: QIAGEN N.V.: Overall Financials, 2017-2019 .........................................................236 Figure 13.66: QIAGEN N.V.: Revenue (by Segment), 2017-2019.................................................237 Figure 13.67: QIAGEN N.V.: Revenue (by Region), 2017-2019....................................................238 Figure 13.68: QIAGEN N.V.: R&D Expenditure, 2017-2019 ..........................................................239 Figure 13.69: QIAGEN N.V.: SWOT Analysis................................................................................240 Figure 13.70: Thermo Fisher Scientific Inc.: Product Portfolio .......................................................242 Figure 13.71: Thermo Fisher Scientific Inc.: Overall Financials, 2017-2019 ..................................243 Figure 13.72: Thermo Fisher Scientific Inc.: Revenue (by Segment), 2017-2019..........................244 Figure 13.73: Thermo Fisher Scientific Inc.: Revenue (by Region), 2017-2019.............................245 Figure 13.74: Thermo Fisher Scientific Inc.: R&D Expenditure, 2017-2019...................................246 Figure 13.75: Thermo Fisher Scientific Inc.: SWOT Analysis.........................................................247 Figure 13.76: Zymo Research Corporation: Product Portfolio........................................................249 Figure 13.77: Zymo Research Corporation: SWOT Analysis.........................................................250
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