DELOITTE: 2017 Global Health Sciences Outlook Report - A global perspective on the healthcare industry and its strategic sectors. Deloitte efficiently delivers an uncomplicated but in-depth look at worldwide healthcare. Rising demand and associated spending are being fueled by an aging population; the growing prevalence of chronic diseases and comorbidities; development of costly clinical innovations; increasing patient awareness, knowledge, and expectations; and continued economic uncertainty despite regional pockets of recovery are just a few of the key issues and trends impacting the global health care sector.
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John Baresky Healthcare Marketing Leader, Pharmaceutical Marketing, Digital Marketing Strategy, Content Marketing Strategy, Market Access Strategy, Healthcare RPA Software Marketing Strategy
Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that impacts an individual ability to focus, self-control, and perform other skills important in daily life. ADHD is caused due to biochemical, connectivity, and the structural difference in the mind. Symptoms of Attention Deficit Hyperactivity Disorder (ADHD) mostly advances over a period and vary according to the type of causing factor and according to the age group of the person. The common symptoms in patient population are trouble at work, low self-esteem and substance abuse or ADHD, low-stress tolerance level, mood swings, and many more. Further, based on symptoms, ADHD is classified into three key categories including the predominantly inattentive, predominantly hyperactive-impulsive, and combined type. ADHD is diagnosed using a comprehensive evaluation of the patient’s mental and behavioral condition. Various treatment options are pharmacological treatment, educational interventions & other behavioral therapies, and EEG biofeedback therapies, physicians could reduce the disorder symptoms and their effects on the individual health.
The global attention deficit hyperactivity disorder (ADHD) market is expected to grow with increasing pharmaceutical R&D spending, growing healthcare expenditure, accelerating economic growth, unmet treatment needs, and mounting occurrence of ADHD. Key trends and developments of this market include progressing drugs under pipeline, high demand for dual therapy, and rising preference for EEG biofeedback therapy. However, there are some factors that can hinder the growth of the market including Medical complications of existing drug therapies, high domination of the generic pharmaceutical market, and strict government protocols
Visit https://insights10.com/ for more healthcare industry insights.
Connect with us at info@insights10.com
Rising prevalence of breast cancer pertaining to factors such as prolonged exposure to endogenous oestrogens, early menarche, late age at first childbirth and late menopause will be a high impact rendering factor for the industry growth. Increasing technological advances in cancer biology and launch of several diagnostic and screening programs worldwide should drive the business size. Growing adoption of therapeutics owing to factors such as blocking estrogenic from binding to tumour cells, risk of distant reappearance, lowering jeopardy of reappearance in the breast that had tumour and reducing risk of developing disease in another breast will propel the industry growth.
Growing awareness regarding breast cancer, rising shift towards adoption of western lifestyle, short breast-feeding timeframe and rising prevalence of obesity in women after menopause will drive the industry size. Increasing rate of alcohol consumption in women, rising use of hormone replacement therapy (HRT) and oral birth control pills resulting in increased levels of oestrogen will boost the business size over the forecast period. Growing exposure to certain carcinogens and endocrine disruptors, for example in the workplace, working night shifts results in increased risk are surging up the U.S. market
Prohibitive cost associated with the use of breast cancer therapeutics may hamper the industry growth. Increasing cost of early and late-stage disease therapy, continuing care on a per-unit time basis, accounting for the major share of lifetime cost owing to relatively extended survival of breast cancer patients may further restrain the business growth
Visit https://insights10.com/ for more healthcare industry insights.
Connect with us at info@insights10.com
Electronic prescribing or E-Prescribing (e-Rx) is electronic transmission of prescriptions from physician to pharmacists using computer and other mobile devices, such as cell phone and tablets. E-Prescribing system has replaced the phone, paper and fax based method of prescription. The system improves patient safety by reducing prescribing errors due to various reasons, such as illegible handwriting and ambiguous abbreviations. It also reduces healthcare costs over the paper based prescription systems. It permits the physician and other healthcare professionals to regenerate a new prescription, when any prescription error occurs during pharmacy operation.
Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that impacts an individual ability to focus, self-control, and perform other skills important in daily life. ADHD is caused due to biochemical, connectivity, and the structural difference in the mind. Symptoms of Attention Deficit Hyperactivity Disorder (ADHD) mostly advances over a period and vary according to the type of causing factor and according to the age group of the person. The common symptoms in patient population are trouble at work, low self-esteem and substance abuse or ADHD, low-stress tolerance level, mood swings, and many more. Further, based on symptoms, ADHD is classified into three key categories including the predominantly inattentive, predominantly hyperactive-impulsive, and combined type. ADHD is diagnosed using a comprehensive evaluation of the patient’s mental and behavioral condition. Various treatment options are pharmacological treatment, educational interventions & other behavioral therapies, and EEG biofeedback therapies, physicians could reduce the disorder symptoms and their effects on the individual health.
The global attention deficit hyperactivity disorder (ADHD) market is expected to grow with increasing pharmaceutical R&D spending, growing healthcare expenditure, accelerating economic growth, unmet treatment needs, and mounting occurrence of ADHD. Key trends and developments of this market include progressing drugs under pipeline, high demand for dual therapy, and rising preference for EEG biofeedback therapy. However, there are some factors that can hinder the growth of the market including Medical complications of existing drug therapies, high domination of the generic pharmaceutical market, and strict government protocols
Visit https://insights10.com/ for more healthcare industry insights.
Connect with us at info@insights10.com
Rising prevalence of breast cancer pertaining to factors such as prolonged exposure to endogenous oestrogens, early menarche, late age at first childbirth and late menopause will be a high impact rendering factor for the industry growth. Increasing technological advances in cancer biology and launch of several diagnostic and screening programs worldwide should drive the business size. Growing adoption of therapeutics owing to factors such as blocking estrogenic from binding to tumour cells, risk of distant reappearance, lowering jeopardy of reappearance in the breast that had tumour and reducing risk of developing disease in another breast will propel the industry growth.
Growing awareness regarding breast cancer, rising shift towards adoption of western lifestyle, short breast-feeding timeframe and rising prevalence of obesity in women after menopause will drive the industry size. Increasing rate of alcohol consumption in women, rising use of hormone replacement therapy (HRT) and oral birth control pills resulting in increased levels of oestrogen will boost the business size over the forecast period. Growing exposure to certain carcinogens and endocrine disruptors, for example in the workplace, working night shifts results in increased risk are surging up the U.S. market
Prohibitive cost associated with the use of breast cancer therapeutics may hamper the industry growth. Increasing cost of early and late-stage disease therapy, continuing care on a per-unit time basis, accounting for the major share of lifetime cost owing to relatively extended survival of breast cancer patients may further restrain the business growth
Visit https://insights10.com/ for more healthcare industry insights.
Connect with us at info@insights10.com
Electronic prescribing or E-Prescribing (e-Rx) is electronic transmission of prescriptions from physician to pharmacists using computer and other mobile devices, such as cell phone and tablets. E-Prescribing system has replaced the phone, paper and fax based method of prescription. The system improves patient safety by reducing prescribing errors due to various reasons, such as illegible handwriting and ambiguous abbreviations. It also reduces healthcare costs over the paper based prescription systems. It permits the physician and other healthcare professionals to regenerate a new prescription, when any prescription error occurs during pharmacy operation.
Medicines outlook through_2016_report
source of info:
http://www.imshealth.com/deployedfiles/ims/Global/Content/Insights/IMS%20Institute%20for%20Healthcare%20Informatics/Global%20Use%20of%20Meds%202011/Medicines_Outlook_Through_2016_Report.pdf
Canada Cannabis for GI Disease Market ReportInsights10
Medical cannabinoid products are widely used in Canada to treat medical symptoms of all kinds, and gastrointestinal (GI) symptoms are among the most commonly cited reasons for use. Cannabis is also widely used recreationally, and legalization of recreational use has occurred in Canada. Cannabis can be beneficial for individuals taking opioid medications for abdominal pain. Research shows that cannabis helps patients cut down on or eliminate their need for opioids and provides treatment with fewer side effects. Cannabis also helps individuals who have difficulty eating enough by increasing appetite and can help reduce diarrhoea and nausea.
Key factors supporting the growth are rise in prevalence of cannabis intake for GI disease. The need to develop better product delivery systems and sustainable product strains. This need has, in turn, led to many companies coming up with R&D, which extensively investigates several genetic improvement strategies for cannabis. While the public opinion of cannabis has gone through many shifts, public interest in Canada has continued to grow in recent years. With the legalization of cannabis in Canada and more research, people are getting a deeper understanding of how cannabis works in humans.
Visit https://insights10.com/ for more healthcare industry insights.
Connect with us at info@insights10.com
Identify the leading healthcare trends in Latin America. With information on Brazil, Mexico, Colombia, Chile, Peru, Argentina. Pharmaceuticals and Hospitals, as well as hospital demographics.
China pharmaceutical industry research & forecast to 2016 sample reportAMMindpower
The present title on “China Pharmaceutical Industry Research and Forecast to 2016” offer detailed study on drugs market in terms of OTC, Patent and Generic drugs. Also assess industry performance in terms of recent developments, driving forces, regulatory structure, economy environment and political situation.
Analysts at Ken Research in their latest publication “Vietnam Pharmaceutical Market Outlook To 2022 - by Generic and Patented drugs, by Prescribed Drugs and OTC Drugs and Therapeutic Drugs (Metabolism and Nutritional Medicine, Cardiovascular, Central Nervous System, System Infection, Oncology, Musculoskeletal, Respiratory” believe that incline in demand for hepatic treatment, rise in health supplements and increasing demand for traditional / herbal medicines will have positive impact on market.
Growth in Leading Regional and National Markets – North America, Europe, Asia-Pacific, Middle-East & Africa, Latin America, US, Canada, Germany, France, UK, Italy, Spain, India, China, Australia, South Korea, Japan, South Africa, Saudi Arabia, U.A.E, Brazil, Argentina, Mexico
IPHA Healthcare Facts and Figures provides detailed facts and figures about healthcare in Ireland and the pharmaceutical and healthcare industry both nationally and globally across the following areas: Healthcare Today, Self-Care Today, Demographic Trends, Healthcare Tomorrow, The Medicines Industry, Medicines in the Community and Medicines and Global Health
Medical second opinion market Size, Share, Growth Business Strategy and Forec...jitendra more
Increasing number of errors in medical billing is also one of the prominent factors responsible for the growth of the market. For instance,according to a study published by the Medical Billing Advocates of America in2019, an estimated 80.0% of medical bills contain at least one error. Further,problems in medical billing errors cost a total of ~US$ 210 billion each year in the US. These possibilities and occurrences of financial errors areprojected to accelerate the growth of the medical second opinion market by 2027.
The pharmaceutical industry will be characterised by heightened uncertainty in 2017, mainly due to inevitable changes to the politicised US health system.
Pricing is expected to remain the key issue, and providers of goods and services, especially those with questionable cost-benefit profiles, can expect further scrutiny. Emerging pharmaceutical markets are also in a cycle of under-performance compared with developed markets.
Despite all the challenges facing the healthcare sector, we nevertheless maintain a positive outlook. Investors will continue to be attracted to the robust fundamentals that support innovation and the consequential generation of high margins.
The future level of global spending on medicines underscores the similar challenges of access and affordability which face those who
consume and pay for healthcare around the world.
In the developed markets, including the United States and Europe, the current economic downturn will amplify many of the long-term
concerns about aging populations afflicted with expensive chronic diseases and the desire by all healthcare stakeholders to control costs.
Across countries, similar policies are already being implemented to rein in spending on expensive therapies, increase the use of generics,
address pricing directly through price cuts or indirectly via discounts or rebates, and develop a market for biosimilars as a lower-cost
alternative to original biologics.
Alternatively, the fast growing pharmerging markets will be driven predominantly by economic gains and rising incomes. This rise in
incomes, particularly for the lowest earners, coupled with government commitments to support expanded access to basic healthcare services,
will make medicines more broadly available and affordable to millions of people.
Further, new therapies for a range of diseases affecting both developed and developing world populations are currently, or will soon become,
available transforming patient care. Despite this progress, however, significant gaps remain in the drug arsenal.
In this report we quantify these factors and examine the spending and usage of medicines globally through 2016. We intend this report to
provide a foundation for meaningful discussion about the value, cost and role of medicines in healthcare over the next five years. Our report
was developed as a public service without industry or government funding.
Michael Kleinrock
Director, Research Development
IMS Institute for Healthcare Informatics
The Global Use of Medicines: Outlook Through 2016. Report by the IMS Institute for Healthcare Informatics.
source of info: http://www.imshealth.com/deployedfiles/ims/Global/Content/Insights/IMS%20Institute%20for%20Healthcare%20Informatics/Global%20Use%20of%20Meds%202011/Medicines_Outlook_Through_2016_Report.pdf
Medicines outlook through_2016_report
source of info:
http://www.imshealth.com/deployedfiles/ims/Global/Content/Insights/IMS%20Institute%20for%20Healthcare%20Informatics/Global%20Use%20of%20Meds%202011/Medicines_Outlook_Through_2016_Report.pdf
Canada Cannabis for GI Disease Market ReportInsights10
Medical cannabinoid products are widely used in Canada to treat medical symptoms of all kinds, and gastrointestinal (GI) symptoms are among the most commonly cited reasons for use. Cannabis is also widely used recreationally, and legalization of recreational use has occurred in Canada. Cannabis can be beneficial for individuals taking opioid medications for abdominal pain. Research shows that cannabis helps patients cut down on or eliminate their need for opioids and provides treatment with fewer side effects. Cannabis also helps individuals who have difficulty eating enough by increasing appetite and can help reduce diarrhoea and nausea.
Key factors supporting the growth are rise in prevalence of cannabis intake for GI disease. The need to develop better product delivery systems and sustainable product strains. This need has, in turn, led to many companies coming up with R&D, which extensively investigates several genetic improvement strategies for cannabis. While the public opinion of cannabis has gone through many shifts, public interest in Canada has continued to grow in recent years. With the legalization of cannabis in Canada and more research, people are getting a deeper understanding of how cannabis works in humans.
Visit https://insights10.com/ for more healthcare industry insights.
Connect with us at info@insights10.com
Identify the leading healthcare trends in Latin America. With information on Brazil, Mexico, Colombia, Chile, Peru, Argentina. Pharmaceuticals and Hospitals, as well as hospital demographics.
China pharmaceutical industry research & forecast to 2016 sample reportAMMindpower
The present title on “China Pharmaceutical Industry Research and Forecast to 2016” offer detailed study on drugs market in terms of OTC, Patent and Generic drugs. Also assess industry performance in terms of recent developments, driving forces, regulatory structure, economy environment and political situation.
Analysts at Ken Research in their latest publication “Vietnam Pharmaceutical Market Outlook To 2022 - by Generic and Patented drugs, by Prescribed Drugs and OTC Drugs and Therapeutic Drugs (Metabolism and Nutritional Medicine, Cardiovascular, Central Nervous System, System Infection, Oncology, Musculoskeletal, Respiratory” believe that incline in demand for hepatic treatment, rise in health supplements and increasing demand for traditional / herbal medicines will have positive impact on market.
Growth in Leading Regional and National Markets – North America, Europe, Asia-Pacific, Middle-East & Africa, Latin America, US, Canada, Germany, France, UK, Italy, Spain, India, China, Australia, South Korea, Japan, South Africa, Saudi Arabia, U.A.E, Brazil, Argentina, Mexico
IPHA Healthcare Facts and Figures provides detailed facts and figures about healthcare in Ireland and the pharmaceutical and healthcare industry both nationally and globally across the following areas: Healthcare Today, Self-Care Today, Demographic Trends, Healthcare Tomorrow, The Medicines Industry, Medicines in the Community and Medicines and Global Health
Medical second opinion market Size, Share, Growth Business Strategy and Forec...jitendra more
Increasing number of errors in medical billing is also one of the prominent factors responsible for the growth of the market. For instance,according to a study published by the Medical Billing Advocates of America in2019, an estimated 80.0% of medical bills contain at least one error. Further,problems in medical billing errors cost a total of ~US$ 210 billion each year in the US. These possibilities and occurrences of financial errors areprojected to accelerate the growth of the medical second opinion market by 2027.
The pharmaceutical industry will be characterised by heightened uncertainty in 2017, mainly due to inevitable changes to the politicised US health system.
Pricing is expected to remain the key issue, and providers of goods and services, especially those with questionable cost-benefit profiles, can expect further scrutiny. Emerging pharmaceutical markets are also in a cycle of under-performance compared with developed markets.
Despite all the challenges facing the healthcare sector, we nevertheless maintain a positive outlook. Investors will continue to be attracted to the robust fundamentals that support innovation and the consequential generation of high margins.
The future level of global spending on medicines underscores the similar challenges of access and affordability which face those who
consume and pay for healthcare around the world.
In the developed markets, including the United States and Europe, the current economic downturn will amplify many of the long-term
concerns about aging populations afflicted with expensive chronic diseases and the desire by all healthcare stakeholders to control costs.
Across countries, similar policies are already being implemented to rein in spending on expensive therapies, increase the use of generics,
address pricing directly through price cuts or indirectly via discounts or rebates, and develop a market for biosimilars as a lower-cost
alternative to original biologics.
Alternatively, the fast growing pharmerging markets will be driven predominantly by economic gains and rising incomes. This rise in
incomes, particularly for the lowest earners, coupled with government commitments to support expanded access to basic healthcare services,
will make medicines more broadly available and affordable to millions of people.
Further, new therapies for a range of diseases affecting both developed and developing world populations are currently, or will soon become,
available transforming patient care. Despite this progress, however, significant gaps remain in the drug arsenal.
In this report we quantify these factors and examine the spending and usage of medicines globally through 2016. We intend this report to
provide a foundation for meaningful discussion about the value, cost and role of medicines in healthcare over the next five years. Our report
was developed as a public service without industry or government funding.
Michael Kleinrock
Director, Research Development
IMS Institute for Healthcare Informatics
The Global Use of Medicines: Outlook Through 2016. Report by the IMS Institute for Healthcare Informatics.
source of info: http://www.imshealth.com/deployedfiles/ims/Global/Content/Insights/IMS%20Institute%20for%20Healthcare%20Informatics/Global%20Use%20of%20Meds%202011/Medicines_Outlook_Through_2016_Report.pdf
The 2019 edition of the Global Innovation Index (GII) focuses
on the theme Creating Healthy Lives—The Future of Medical
Innovation. In the years to come, medical innovations such
as artificial intelligence (AI), genomics, and mobile health
applications will transform the delivery of healthcare in both
developed and emerging nations.
The key questions addressed in this edition of the GII include:
• What is the potential impact of medical innovation on
society and economic growth, and what obstacles must
be overcome to reach that potential?
• How is the global landscape for research and development
(R&D) and medical innovation changing?
• What health challenges do future innovations need to address
and what types of breakthroughs are on the horizon?
• What are the main opportunities and obstacles to future
medical innovation and what role might new policies play?
In this report we set out ten provocative statements predicting the world of 2020. Each prediction is articulated and brought to life through a series of portraits which imagine how patients, healthcare professionals and life sciences organizations might behave in this new world. Our predictions lean more towards an optimistic view of the future, although we organized that many in our industry are organized about the constraints and therefore pace of change. We describe the big trends rolled forward to 2020 and some of the constraints that will need to be overcome.
We also provide examples and evidence, based on the here and now, that show that the predictions are perfectly plausible, perhaps inspiring and surprising!
Our industry is changing quickly – requiring a bold response that is often difficult to implement – and yet organizations struggle to understand how to respond effectively and build a sense of urgency. We hope this report creates rich dialogue and enables a move to action.– we have had enormous fun discussing these predictions and sharing our experiences. We hope you have the same experience within your own organizations as you peruse this report and reflect on your current situation and future scenarios.
Future of the Global Pharmaceutical IndustryTim Opler
Key points in presentation from Torreya Partners.
Despite concerns regarding research productivity and pricing pressure, Torreya is optimistic about the pharma sector. There is huge growth ahead driven by expanding global wealth.
The global pharma sector is going to at least triple in scale between now and 2060.
The pharmaceutical sector is 30% larger than shown by prior data.
New technologies in manufacture, biologics, nucleic acids and implantables will dramatically alter the pharma sector.
5 Trends to Watch in the Medical Device Industry in 2016Mercer Capital
Demographic shifts underlie the long-term market opportunity for medical device manufacturers. While efforts to control costs on the part of the government insurer in the U.S. may limit future pricing growth for incumbent products, a growing global market provides domestic device manufacturers with an opportunity to broaden and diversify their geographic revenue base. Developing new products and procedures is risky and usually more resource intensive compared to some other growth sectors of the economy. However, barriers to entry in the form of existing regulations provide a measure of relief from competition, especially for newly developed products.
The pen needles market refers to the segment of the medical device industry that produces and sells pen needles used for injecting insulin and other medications for diabetes treatment.
Early in August, President Trump issued an executive order focused on improving rural health. In response, the U.S. Department of Health and Human Services (HHS) is moving forward with a series of assertive measures featured in a formal strategic plan to remedy the significant healthcare challenges of farmers and others living in rural communities. It addresses access to quality care, medical staffing, technology, clinical innovation, reimbursement and sustainability.Read the story and contact John Baresky for further details.
Walgreens (NASDAQ: WBA) has signed on a second consumer home delivery service partner. Based in San Francisco, DoorDash will provide home delivery services spanning more than 2,300 items including over-the-counter (OTC) medications to consumers for Walgreens stores.
Read the story and contact John Baresky for further details
Authentic, fact-based healthcare content writing for medical, business, academic, patient and consumer audiences.
Review the presentation then go to the Bare Sky Marketing Healthcare Content Writing Services website. Visit the Examples page that features 2 portfolios and a satellite blog and visit the main Blog page on the website as well.
Both pages feature numerous examples of my healthcare marketing and healthcare content writing work.
The FDA has issued approval for Lynparza (olaparib) in the treatment of adult patients with deleterious or suspected deleterious germline or somatic homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC) who have progressed following prior treatment with Xtandi (enzalutamide by Pfizer/Astellas) or Zytiga (abiraterone by Centocor/Johnson & Johnson).
HRR gene mutations occur in approximately 20–30% of patients with mCRPC. Lynparza is a poly (ADB ribose) polymerase (PARP) inhibitor. The poly ADP-ribose polymerase (PARP) enzyme fixes DNA damage in both healthy and cancerous cells. Lynparza is available by prescription only and produced in 100mg and 150mg tablet strengths.
Read the story and contact John Baresky for further details...
Alexion Pharmaceuticals (NASDAQ: ALXN) has announced it is acquiring Portola Pharmaceuticals (NASDAQ: PTLA) for $1.41 billion in cash. Founded in 2003, Portola is based in South San Francisco and produces about $116 million in annual sales.
Closing rural hospitals are reducing access to care in multiple states
Between January 2010 and January 2020, 114 rural hospitals closed. More than 30 of these were critical access facilities. Data from the University of North Carolina Cecil G. Sheps Center for Research provides further insights showing that from 2005 to 2020 a total of 170 rural hospitals shut down. There seems to be no indication this trend is subsiding and a sizable portion of it has occurred during a time of record economic expansion. There is no telling how many more would have closed their doors had a weakened economy continued.
Read the complete story here and contact John Baresky for further details...
Learn about the 7 drivers of pharmaceutical television advertising. Television advertising for prescription drugs is a controversial practice but is an important component of the marketing strategy for many pharmaceutical manufacturers plus other healthcare product manufacturers. The FDA’s Center for Drug Evaluation and Research (CDER) and its Office of Prescription Drug Promotion(OPDG) closely monitor what pharmaceutical companies display and communicate within their television, print, radio or digital ads.
Get the complete insights through this article from Bare Sky Marketing Healthcare Content Writing Services
The World Health Organization has declared the Coronavirus 2019-nCoV a Public Health Emergency of International Concern (PHEIC). The declaration of PHEIC is rare. Upon its designation, various government agencies, healthcare institutions and other stakeholders are officially organized to act and escalate measures in collaboration with each other to combat the issue. The decision was made at a point as 171 persons in China have succumbed to the illness and the disease has spread to at least 18 other nations.
PHEIC events of the past: Ebola, H1N1 Swine Flu, Polio
WHO has deployed the emergency designation five times since the rules were implemented in the mid-2000s:
Ebola virus, 2019, Zika virus, 2016, Polio outbreak, 2014. Ebola outbreak, 2014, Swine flu, 2009
Learn more about the World Health Organization and the PHEIC designation by reading this article from Bare Sky Marketing
Alphabet / Google ( NASDAQ: GOOGL ) continue to build out their healthcare organization with distinguished leadership staff additions encompassing medical, commercial and government experience.
Dr. Karen B. DeSalvo, currently a professor at the Dell Medical School, University of Texas in Austin, will be the first person to have the title of Chief Health Officer for Alphabet / Google / Verily.
The company made the announcement as they progress through a steady workstream of healthcare-centered initatives involving Google Health and Verily Life Sciences. At Dell Medical School, she has two roles as Professor, Department of Internal Medicine and Professor, Department of Population Health. Dr. DeSalvo possesses exceptional medical, business and government experience.
Dr. DeSalvo’s academic and medical credentials include:
- M.D. — Tulane University School of Medicine
- MSc — Clinical Epidemiology — Harvard University
- MS — Public Health — Tulane University
- BA — Biology / Political Science — Suffolk University
In addition to medical academics, Dr. DeSalvo has worked in the commercial healthcare space ( Welltower and Humana ), the Federal Government ( Health and Human Services and Office of Health Information Technology ) and the Municipal Government Sector ( City of New Orleans ).
Alphabet clearly has long term, large scale plans for the healthcare industry. Their present enterprises span pharmaceutical research & development, medical device engineering, cloud computing, genetics, voice recognition technology ( VRT ), artificial intelligence ( AI ) and medical imaging (with advanced focus in oncology diagnosis and treatment).
The bandwidth of their ventures demonstrates the array of uses Alphabet’s growing technology innovation has throughout healthcare and life sciences industries.
Read the story to learn more about Dr. DeSalvo and Alphabet's plans ongoing healthcare initiatives...
Contact John Baresky with your questions and comments...
May Walgreens Boots Alliance be strategically signalling it is up for sale to the highest bidder by presumably going through the motions of taking itself private?
A consumer retail, pharmacy, healthcare services, supply chain leader...
Taking Walgreens private may involve an estimated range of $50 billion to $60 billion to execute the transaction. Most of the company’s global scope and scale are overlooked by consumers and even those in the healthcare sector:
• Founded in 1901, their present CEO, billionaire Stefano Pessina, owns about 16% of the company
• On a daily basis, Walgreens interacts with over 8 million customers in stores and online
• They operate more than 9,000 stores in the United States and more than 13,000 units worldwide in 11 countries.
• Walgreens owns 26% of AmerisourceBergen; one of the world’s largest drug wholesalers
• They are a minority share owner of Option Care Health, the largest home infusion and alternate site care provider in the nation servicing patients in all 50 states and administers over 2 million doses of various IV therapies per month; Option Care Health ( NASDAQ: BIOS ) was formed through the merger of Option Care and BioScrip in 2019
• The company has a pilot venture underway with grocery retail giant Kroger involving Walgreens health and beauty brands being sold in Kroger stores and Walgreens selling select Kroger grocery goods in their stores plus supporting Kroger online ordering consumer pickup services at participating stores
• Microsoft and Walgreens are collaborating on a suite of chronic disease management and patient engagement applications plus a portfolio of connected Internet of Things (IoT) devices for nonacute chronic care management, delivered by Microsoft’s cloud, AI and IoT technologies
• About 78% of the population in the United States lives within 5 miles of a Walgreens store or a Walgreens-owned Rite Aid or Duane Reed store.
• Walgreens has an active partnership with Blue Cross Blue Shield affiliated prescription benefit manager Prime Therapeutics known as AllianceRx Walgreens Prime)
Key Considerations:
• Boots Alliance ( WBA ) is reportedly consulting KKR, a leading global private equity firm, about its options to go private
• With an estimated market capitalization of $50 to $60 billion it would be one of the largest public to private deals in history
• The current debt load of Walgreens is about $15 billion and is a pivotal cost element undertaking such a deal
• If KKR were to orchestrate the public to private deal with Walgreens, it would likely enlist additional financial partners such as other private equity firms and investment bankers
Read the complete details on who may be interested in and most importantly, financially and organizationally qualified, to acquire Walgreens Boots Alliance... Contact John Baresky with your questions or comments...
Amazon has purchased a healthcare technology startup known as “Health Navigator”. Health Navigator, based in Chicago, Illinois, is a clinical healthcare information firm founded by an emergency medicine physician, Dr. David Thompson. Dr. Thompson is board certified in Emergency Medicine and Internal Medicine; his academic background includes the University of Illinois College of Medicine with a residency at McGaw Medical Center of Northwestern University.
Health Navigator encompasses a deep selection of features which account for the core elements of patient care interaction and documentation:
- After Care Instruction ( ACI ): provides health information and care advice for telehealth patients
- Clinical Documentation Support ( CDS ): a telehealth dialogue tool orchestrating patient visit details including initial patient intake, emergency screening and prioritization, consumer-facing health checker or health bot, CarePath ( formulates questions for patients based on their initial reasons for health visit to begin diagnosis ), consumer e-visit form and provider documentation checklist
- Coded Chief Complaints ( CCC ): supports definition, identification of patient’s primary reason for visit ( RFV ) seeking care
- Diagnosis Engine: a proprietary knowledge-based inference engine or processor generating a list of possible causes or pre-diagnoses for a specific symptom or problem that can be aligned with digital health assistants (health bots, diagnosis symptom checkers) and electronic health records ( EHR or EMR ).
- Natural Language Processing ( NLP ): a digital translator program used in patient and clinician dialogue for visit free-text into the Coded Chief Complaint clinical vocabulary
- Non-Commercial Resource Database: features over 25,000 Internet resources comprised of non-commercial websites linked to more than 2,800 clinical concepts (plus over 7,200 references of which many are directly linked through a PubMedIC )
- Triage Engine: calculates a triage score, level of care recommendation ( disposition ) for use in consumer health bots and triage symptom checker applications
As Amazon forges ahead, it will be interesting to see how its actions are reflected within the realm of Haven Healthcare, its healthcare management partnership initiative with Berkshire Hathaway ( NYSE: BRK.A ) and JPMorgan Chase ( NYSE: JPM ). The organization is seeking ways to improve quality of care while reducing cost.
Read the article for the complete details of Amazon's latest acquisition and contact John Baresky for further information...
Oncology initiatives in Women’s Healthcare have gained another valuable therapy to improve patient care and outcomes…
Merck & Co.’s ( NYSE: MRK )Keytruda and combination partner therapy Eisai’s ( OTCMKTS: ESALY ) Lenvima will keep their respective marketing and sales units very busy in the upcoming months. Regulatory agencies in the United States, Canada and Australia have concurrently approval to the Keytruda-Lenvima tandem for women with certain advanced endometrial carcinoma. It represents a significant accomplishment by Merck and Eisai and for government regulatory agencies working together to accelerate the process of advancing medicine whether it’s for completely new products or clinically strategic new indications.
Project Orbis: Improve accuracy and accelerate new drug and indication approvals across multiple nation government agencies...
The parallel decisions are the first made through Project Orbis ;a collaborative initiative of the Food And Drug Administration ( FDA ), the Australian Therapeutic Goods Administration ( TGA ) and Health Canada that seeks to reduce new oncology therapy review turnaround between nations. It champions concurrent submissions by drug manufacturers and collaborative assessments by each of the three government regulatory agencies, sponsors and collaborative reviews by all three agencies.
Project Orbis: A winning initiative for patients and clinicians
New drug approvals and the process of approving additional indications is a detail heavy exercise necessary to qualify performance and safety of medications. By improving the processes within nations and cultivating collaboration between them, patients and clinicians benefit from having access to approved therapies sooner. For advanced medication, payers are often reluctant to cover their costs without specific regulatory approval of precise indications. Project Orbis initiatives helps to overcome this hurdle.
Read the article for complete details and contact John Baresky for further information...
Walgreens Boots Alliance ( NASDAQ: WBA ) ranks at number 17 on the Fortune 500 list of largest firms. Reportedly they are exploring options to take the company private which may also be a strong signal to other industry leaders that it is open to takeover offers. Regardless of what their ultimate goals are, they remain a global force in retail, pharmacy, wholesaler and other sectors. The company’s CEO, Stefano Pessina, has communicated Walgreens is actively pursuing more partnerships as a business strategy that enable it to generate revenue by asserting its corporate, financial, clinical and operations resources to build market access and revenue while disrupting competitors — without having to deploy funding for complete acquisitions that contribute to further to debt loads.
Primary elements of Walgreens Boots Alliance financial profile:
- Market capitalization of $50 billion
- Annual sales: $136.86 billion ( 2019 figures which represented a 5.8% increase over 2018 )
- Earnings: $3.982 billion
- Debt: $15 billion
- Ownership stake of 16% held by CEO Stefano Pessina
Strategic global attributes of WBA
- Business operations in more than 25 nations
- Over 415,000 employees
- More than 18,500 stores located in 11 countries
- Over 390 distribution centers servicing pharmacies ( including pharmacies not owned by WBA ), physician offices and healthcare provider organizations
- Ownership stake of 26% in AmerisourceBergen ( NYSE: ABC ), a global leader in healthcare wholesaler operations ranked at number 12 on the Fortune 500 list; annual sales of $153 billion
Key Points:
- Leading companies seeking strategic alliances with Walgreens
Kroger, McKesson, Microsoft and Prime Therapeutics collaborating with Walgreens
- Brand marketing, pharmacy, market access and technology partnerships driving revenue for Walgreens and partners
- Global and domestic market access, commercial synergies and profit in strategic partnerships
Read the article for complete details on each of the strategic partnerships Walgreens has in place with Kroger, McKesson, Microsoft, Prime Therapeutics
Contact John Baresky for additional details
Amazon (NASDAQ: AMZN ) and its online pharmacy unit, PillPack, have a significant challenge. On the surface, it appears to involve only a small, Iowa-based healthcare and prescription data technology company, ReMyHealth, but drastically scales up and potentially involves some of the largest retail and mail order pharmacy, MCO / PBMs and pharmacy associations in the nation — and a somewhat ambiguous organization known as Surescripts.
Prior to being acquired by Amazon, PillPack had contracts in place with many managed care organizations, PBMs and other entities to be a providing pharmacy in their networks. PillPack’s success in building market access early as an integral part of their business model was just one of the reasons Amazon was impressed enough to acquire them.
As an online mail order pharmacy, PillPack is a competitor to the retail pharmacies represented by the NACDS and NCPA that have part ownership in Surescripts. These same retailers compete with PillPack’s parent company, Amazon, for other consumer product sales. CVS Health / Aetna and Cigna / Express Scripts, the two other ownership stakeholders in Surescripts, operate substantial mail order pharmacies PillPack would compete against.
Amazon has been entering into healthcare-focused partnerships and collaborations with such notable organizations as Accenture, Berkshire Hathaway, Carnegie Mellon, Cedars-Sinai, Cerner, Change Healthcare, JPMorganChase, Merck, National Institute of Health, University of Pittsburgh, University of Pittsburgh Medical Center and others. Amazon has steeply ramped up its understanding of the healthcare sector and identifying opportunities to develop and deploy commercial actions to succeed within it.
Read the complete story and contact John Baresky with any questions...
State Of Digital Healthcare In 2017 - HIMSS - • Healthcare Marketing Leadership Index
• Online and Digital Marketing Techniques Used
• CMS, CRM, and Marketing Automation
• ROI and KPIs
• Web Innovations
• Importance/Effectiveness of Digital Marketing Efforts
• Driving Digital Transformation of the Healthcare Brand
• Resources
• Key Take-aways
• Recommendations From the Research for Providers
My background is healthcare marketing; products (injectable & oral pharmaceuticals, IV pumps, disposables), healthcare services (market access programs, pharmacy benefits), managed care and healthcare digital marketing. Connect with me at LinkedIn and Twitter, visit my healthcare website -an industry resource since 2004...
Twitter: @johngbaresky
LinkedIn: https://www.linkedin.com/in/johngbaresky
My website: www.healthcaremedicalpharmaceuticaldirectory.com
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#IOT #digital #healthcare #marketing #medical #pharmaceutical #doctor #patient #consumer
... Healthcare Marketing Leader: Pharmaceutical, Medical Device, RPA, SaaS, Digital Marketing Strategy, Managed Care, Market Access - John G. Baresky
These guidelines will enable you to develop assertively effective healthcare digital marketing initiatives with infographs. Launching a brand or seeking strategic options to promote an established brand?...Infographs have powerful attributes making them strategic assets to improve healthcare digital marketing performance, social sharing, brand awareness and ROI.
They can be strategically deployed across digital / social / mobile venues to engage clinicians (doctors, nurses, pharmacists), consumers / patients, managed care / payers, employers, employee benefit consultants and other stakeholders......
HMPD, AbelsonTaylor, Hospira, Takeda / Abbott (TAP), Walgreens and Pfizer. My experience spans advanced medical specialties and healthcare industry sectors. I am the interconnection of brand marketing, digital marketing, managed care marketing and sales...
My healthcare website:
www.healthcaremedicalpharmaceuticaldirectory.com
LinkedIn profile:
www.linkedin.com/in/johngbaresky/
Twitter:
@johngbaresky
Feel free to connect with me on LinkedIn and follow me on Twitter...
... Healthcare Marketing Leader: Pharmaceutical, Medical Device, RPA, SaaS, Digital Marketing Strategy, Managed Care, Market Access - John G. Baresky
These guidelines will enable you to develop assertively effective healthcare digital marketing initiatives with infographs. Launching a brand or seeking strategic options to promote an established brand?...Infographs have powerful attributes making them strategic assets to improve healthcare digital marketing performance, social sharing, brand awareness and ROI.
They can be strategically deployed across digital / social / mobile venues to engage clinicians (doctors, nurses, pharmacists), consumers / patients, managed care / payers, employers, employee benefit consultants and other stakeholders.
HMPD, AbelsonTaylor, Hospira, Takeda / Abbott (TAP), Walgreens and Pfizer. My experience spans advanced medical specialties and healthcare industry sectors. I am the interconnection of brand marketing, digital marketing, managed care marketing and sales...
My healthcare website:
www.healthcaremedicalpharmaceuticaldirectory.com
LinkedIn profile:
www.linkedin.com/in/johngbaresky/
Twitter:
@johngbaresky
Feel free to connect with me on LinkedIn and follow me on Twitter...
... Healthcare Marketing Leader: Pharmaceutical, Medical Device, RPA, SaaS, Digital Marketing Strategy, Managed Care, Market Access - John G. Baresky
Launching a brand or seeking strategic options to promote an established brand? These guidelines will enable you to develop assertively effective healthcare digital marketing initiatives with infographs...Infographs have powerful attributes making them strategic assets to improve healthcare digital marketing performance, social sharing, brand awareness and ROI.
They can be strategically deployed across digital / social / mobile venues to engage clinicians (doctors, nurses, pharmacists), consumers / patients, managed care / payers, employers, employee benefit consultants and other stakeholders. These guidelines will enable you to develop assertively effective healthcare digital marketing initiatives with infographs.
HMPD, AbelsonTaylor, Hospira, Takeda / Abbott (TAP), Walgreens and Pfizer. My experience spans advanced medical specialties and healthcare industry sectors. I am the interconnection of brand marketing, digital marketing, managed care marketing and sales...
My healthcare website:
www.healthcaremedicalpharmaceuticaldirectory.com
LinkedIn profile:
www.linkedin.com/in/johngbaresky/
Twitter:
@johngbaresky
Feel free to connect with me on LinkedIn and follow me on Twitter...
John Baresky Healthcare Marketing Leader, Pharmaceutical Marketing, Digital Marketing Strategy, Content Marketing Strategy, Market Access Strategy, Healthcare RPA Software Marketing Strategy
Get to know the mechanics of how deductibles work, how they are perceived and big data's role and impact. For healthcare marketers, pharmaceutical marketers, health insurance marketers and other healthcare / managed care stakeholders, the deductible feature in health benefit plans has wide reaching impact as does the data and analytics which support it.
... Healthcare Marketing Leader: Pharmaceutical, Medical Device, RPA, SaaS, Digital Marketing Strategy, Managed Care, Market Access - John G. Baresky
United Healthcare's business model is deepening and widening. Originally a managed care plan, it encompasses a PBM, medical group practices, a data analytics unit, a national ACO and more to come...
The healthcare market is evolving throughout the United States as well as globally. UHC is competing against Aetna, Cigna, Humana, Kaiser as well as Blue Cross Blue Shield plans and other healthcare plans ---and now healthcare provider organizations as well!
... Healthcare Marketing Leader: Pharmaceutical, Medical Device, RPA, SaaS, Digital Marketing Strategy, Managed Care, Market Access - John G. Baresky
More from Bare Sky Marketing Healthcare Content Writing Services (20)
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
DELOITTE: 2017 Global Health Sciences Outlook Report - - John G. Baresky
1. 2017 global life sciences outlook
Thriving in today’s uncertain market
2. 2017 Global health care outlook | Making progress against persistent challenges
2
Introduction 2
Overview outlook 4
Global life sciences sector trends in 2017 9
Appendix 25
Endnotes 28
Contacts 31
3. 2017 Global health care outlook | Making progress against persistent challenges
3
4. 2017 global life sciences outlook | Thriving in today’s uncertain market
2
Introduction
Life sciences companies have always operated in a world of uncertainty. Issues around cost and pricing, clinical and
operational innovation, customer and consumer engagement, and regulatory compliance have existed for decades. In
addition, new and evolving technology advancements–more sophisticated electronic medical records (EMRs), wearable
health care devices, next-generation sequencing, breakthroughs in genomics, immunotherapy, and gene therapy, and
use of real-world evidence (RWE) and data analytics–have primed the life sciences sector for disruption. Each year brings
changes and challenges, and 2017 is likely to follow suit.
Life sciences sector growth is closely tied to global health care expenditures which, in 2017 and successive years, are
expected to be fuelled by increasing demand from an aging population and the prevalence of chronic and communicable
diseases (Figure 1, next page). Other potential growth drivers include improved (if uneven) economic activity in
key geographies, especially developing nations in the Middle East and Asia; continuing industry consolidation and
collaboration; and new business models enabled by scientific and technology advances.
Life sciences companies of all sizes and in all segments–pharmaceuticals, biotechnology, generics and biosimilars,
medical technology, and wholesale and distribution–will continue to focus on achieving profitable and sustainable growth
in 2017. But this growth won’t come easy in an industry heavily influenced by health reform, cost pressures, price- and
valued-based care models, disintermediation from downstream vertical integration, economic fluidity, and political
instability. Looking across a landscape of challenges, the mismatch between increasing RD expenses and the payer
and public demand for lower-cost treatments is a game-changing issue because it will likely affect both the direction and
speed of the sector’s future development.
How should life sciences companies invest and operate to thrive in today’s world of uncertainty? What capabilities do
they need to leverage massive (and growing) quantities of electronic health information across the enterprise, from RD
through product commercialization? How can company leaders develop incremental and breakthrough strategies that
de-risk clinical, business, and operating models and create added value for patients, payers, and shareholders? This
2017 outlook reviews the current state of the global life sciences sector; explores trends and issues impacting market
segments and individual organizations; and suggests considerations for stakeholders as they seek to grow revenue and
market share.
5. 2017 global life sciences outlook | Thriving in today’s uncertain market
3
Global health care
expenditures are projected to
reach $8.7 trillion by 2020,
from $7 trillion in 2015, driven
by improving treatments in
therapeutic areas (TA) coupled
with rising labor costs and
increased life expectancy.1
Life expectancy is projected to
increase by one year by 2020,
which will increase the aging
population (over 65 years old)
by 8%, from 559 million4
in
2015 to 604 million5
in 2020.
China and India have the
largest number of diabetes
sufferers in the world, at
around 110 million and 69
million, respectively. Globally,
the number is expected to rise
from the current 415 million to
642 million by 2040.8
Communicable diseases are an
ongoing threat. HIV-AIDS
continues to affect 36.9 million
people worldwide, with around
70% of them living in
Sub-Sahara Africa. The Zika
virus and associated upsurge in
microcephaly are major threats
in Latin America.10
Health care spending as a
percentage of gross domestic
product (GDP) should also rise
slightly, from an estimated
10.4 % in 2015 to 10.5 % in
2020.2
Government health care
expenditures as a percentage
of GDP are projected to rise
more quickly in low-income
countries than other income
groups.3
Chronic diseases are on the
rise, assisted by rapid
urbanization, sedentary
lifestyles, changing diets, and
rising obesity levels.6
By 2020,
50% of global health care
expenditures—about
$4 trillion—will be spent on
three leading causes of death:
cardiovascular diseases, cancer
and respiratory diseases.7
From 2015 to 2050 the
prevalence of dementia is
forecast to increase in every
region of the world. In 2015,
46.8 million people worldwide
are estimated to be living with
dementia. This number is
anticipated to double every 20
years, reaching 74.7 million in
2030 and 131.5 million
in 2050.9
Figure 1: Global health care by the numbers
6. 2017 global life sciences outlook | Thriving in today’s uncertain market
4
Pharmaceuticals segment
Although pharma companies continue to deal with the repercussions of patent expiries and payers’ cost control efforts, the growing
acceptance of sometimes high-priced innovative orphan drugs and ongoing industry consolidation are expected to drive sales growth for the
next several years.
2015 saw a drop in total global pharma sales, in nominal US-dollar terms, due to exchange-rate effect and the impact of cost control efforts
in several markets; however, sales are expected to improve over the 2016-2020 period, growing at an average of 4.4 percent annually to total
a projected $1.2 trillion in 2020 (Figure 2).11
Sales from the top 10 pharmaceutical companies accounted for ~35 percent of the 2015 global
pharma market.12
Overview outlook
Source: World Industry Outlook, Healthcare and Pharmaceuticals, The Economic Intelligence Unit, June 2016
984
2011
979
-0.5%
2.0%
5.9%
-3.8%
2.1%
4.6% 4.6%
5.3%
5.6%
2012
999
2013
1,058
2014
1,017
2015
1,038
2016(P)
1,085
2017(P)
1,135
2018(P)
1,195
2019(P)
1,263
2020(P)
Impact of cost
control efforts in
several markets
Figure 2: Worldwide pharmaceutical sales, 2011-202021
USD$billions
Pharma sales
Growth
7. 2017 global life sciences outlook | Thriving in today’s uncertain market
5
Increased pharma spending is projected across all regions: North America and Asia Australasia, with 46 percent and 23.4 percent shares,
respectively, dominate current and projected global pharmaceutical spending. Asia continues to surpass Western Europe (18.8 percent) in
terms of projected 2016 global pharma spending. Russia and Latin America’s pharma markets should be lifted by the anticipated recovery of
their economies by 2017.
•• Growth in specialty medicines used in hepatitis and oncology, the ability to detect diseases and diagnose patients earlier, the
slower-than-anticipated roll-out of biosimilars, and possible expansions of certain government health programs are some of the factors
driving the North America region’s pharma sales growth.13
•• Norway and Sweden are expected to lead improved pharmaceutical spending growth in Western Europe, after Euro devaluation led to
a slump in USD terms in 2015.14
The United Kingdom likely will grow considerably slower than the regional average, at 3.4 percent, due to
pressure on its health care budget, wider use of generics, and pricing pressures.15
•• The Latin America region’s pharma spending, at a projected 6.3 percent compound annual growth rate (CAGR), is anticipated to improve
through 2020; however, economic pressures, currency decline, focus on generics, and restrictions on pharma imports may offset growth.16
•• India and Indonesia are the Asia Australasia region’s fastest-growing countries in pharma sales from 2016 to 2020, at 13 percent17
and 11
percent18
CAGR, respectively, due to the rising incidence of chronic diseases and increasing demand from the growing middle class for more
advanced medicines. China, meanwhile, is projected to sustain an above-average CAGR of 5.8 percent19
through 2020.
Biotechnology segment
Biotech products continue to slowly gain share from conventional drugs. Between
2010 and 2016 the global biotech segment grew at a CAGR of 3.7 percent, from
$263.7 billion to a projected $293.5 billion,20
with biotechs comprising seven of the
top 10 drugs in global sales in 2015.21
Over the five years from 2016 to 2021, global
biotech revenue is estimated to rise to $314.7 billion (Figure 3).22
Greater global
investment in biotechnology, particularly in emerging economies, will largely drive
this growth, and the industry is expected to undergo further commercialization to
cater to an aging population in more developed economies.23
Products from the biotech segment are mainly targeted at oncology, Alzheimer's
disease, cardiovascular disease, diabetes, multiple sclerosis, HIV/AIDS and arthritis.
Therapeutic areas (TAs) such as obesity offer significant growth opportunity; that
market is projected to reach $8.4 billion by 2022, up from $407 million in 2012.24
Generics and biosimilars segment
The generic prescription drug market continues to thrive due to pro-generic
policies in several regions, including Western Europe. (The increased use
of generics has been one of the main reasons for Western Europe’s lower
pharmaceutical spending over the years.25
)
Generic prescription drug sales reached $79 billion in 2015,26
and are expected to
grow to $112 billion by 2020 (Figure 4, next page).27
The high-volume/low-margin
generics market is generally fragmented–among the top 20 companies, only the
two leading players had double-digit market share (a combined 23.7 percent) in
2014.29
Analysts expect that the lower price advantage associated with generic
drugs may be partially offset by increasing industry consolidation.28
Figure 3: Global biotechnology
industry revenue (USD $ B), 2011-201633
USD$billion
263.7
2010
293.5
2016F
314.7
2021F
Source: IBISWorld Industry Report, “Global
Biotechnology,” October 2016
8. 2017 global life sciences outlook | Thriving in today’s uncertain market
6
Similar to generics’ impact on branded pharmaceuticals, biosimilars threaten to steal market share from more costly biotech drugs. Since the
first biosimilar approval in the European Union (EU) in 2006, there are now more than 700 biosimilars approved (~450) or in the pipeline (~250)
globally.29
In major markets like the EU, regulators and payers have recognized the potential financial benefit of biosimilars and are driving
their uptake. For example, France has initiated automatic substitution of select biosimilars over the reference products.
Analysts expect the biosimilars market to reach $25 billion-$35 billion by 2020.30
However, biosimilars’ uptake faces several challenges, as
illustrated by the key differences between biosimilars and generic medications (Figure 5).31
Figure 4: Worldwide generic prescription sales, 2011-202021
Figure 5: Key differences between biosimilars and generics
USD$billions
65
2011
66
2012
69
2013
74
2014
79
2015(P)
93
2017(P)
105
2019(P)
86
2016(P)
99
2018(P)
112
2020(P)
Source: World Industry Outlook, Healthcare and Pharmaceuticals, The Economic Intelligence Unit, June 2016
Source: Winning with biosimilars: Opportunities in global markets, Deloitte, 2015
*France allows automatic substitution for biosimilars under certain conditions
Similar to, and not identical to reference product Bioequivalent and identical to reference product
$100M – $200M in development costs $1M – $5M in development costs
20-30% discount over reference product 80 – 90% discount over reference product
8 – 10 year development timeline 3 – 5 year development timeline
No interchangeability or automatic substitution* Interchangeable with reference product
Biosimilars Generics
9. 2017 global life sciences outlook | Thriving in today’s uncertain market
7
Most biosimilars manufacturers have been and remain focused on developed markets—whether it is for their historic and current
opportunities (EU) or for their future market potential (United States, Japan). However, a considerable opportunity for long-term growth exists
in emerging markets, where biosimilars have little-to-no presence.
Medical technology segment
Global medical device and technology (medtech) market growth was stagnant (CAGR of 1.3 percent) from 2011-2015 due to the lasting impact
of the 2009 recession, which resulted in lean financing from investors.32
However, it is projected to gain momentum in 2016, and grow at
a CAGR of 5.3 percent from 2016 to 2020 (Figure 6), strengthened by government support for the use of diagnostics to improve clinical
outcomes and patient affordability; the rising preference for minimally invasive procedures; dramatic advances in digital health applications;
and endorsements for branded devices such as diagnostic imaging and accessories.
In vitro diagnostics (IVD) continues to be one of the fastest-growing areas, and is projected to expand at a CAGR of 5.1 percent from 2014
to 2020, to reach $67.3 billion by 2020.33
The rise in demand for IVD testing is being driven by the prevalence of chronic diseases, especially
among people aged 65 years and above, and new, value-based reimbursement scenarios such as the United States’ Medicare Access and
CHIP Reauthorization Act of 2015 (MACRA), a payment law intended to drive major health care payment and delivery system reform for
clinicians, health systems, Medicare, and other government and commercial payers.34
Advances in genomics, including gene editing and
proteomics, are also expected to create new growth opportunities for the IVD market through 2020.35
Medtech manufacturers are also focused on developing minimally invasive devices. For example, increasing adoption of MRI-compatible
implantable cardioverter-defibrillators (ICDs), next-generation insertable cardiac monitors, and drug-coated balloons, as a result of increased
minimally invasive cardiac procedures, should help drive the cardiology diagnostics market through 2020.
Many industry players–both traditional medtech organizations and new market entrants–are capitalizing on recent and emerging
technological advancements and providing digitally enabled health care solutions using mobile health applications, sensor technology, data
analytics, and artificial intelligence (AI).36
In 20 or even 10 years, the vast majority of devices are anticipated to have imbedded sensors. New
handheld diagnostics with built-in AI will revolutionize the way primary care is delivered outside the physician office. Diagnostics and AI will
truly usher in the “personalized medicine” era. These new offerings will produce a huge new growth engine with the power to transform
clinical care.
Source: EvaluatePharma: World Preview 2015, Outlook to 2020
Figure 6: Global medical device sales (USD $ B), 2011-2020
350
2011
369
2015
-1.6%
366
2013
1.9%
409
2017(P)
5.4%
359
2012
2.6%
388
2016(P)
5.1%
375
2014
2.5%
431
2018(P)
5.4%
454
2019(P)
5.3%
478
2020(P)
5.3%
Weakness in the euro resulted in lower
sales dollars in the U.S. companies.
USD$billions
Medical Device Sales
Growth
10. 2017 global life sciences outlook | Thriving in today’s uncertain market
8
Even though medtech companies are focusing considerable attention and resources on IVD, minimally invasive devices, and digital health
applications, the biggest challenges many face are not at the product development level; rather, they are on the commercial side and along
the supply chain. Questions such as which strategies and tactics should be employed to more efficiently and cost-effectively manage a
changing customer base, how best to right-size the organization, where to streamline distribution channels, or how to wrap services around
products to differentiate themselves in the marketplace will be key to ongoing market success.
Wholesale distribution segment
The global life sciences wholesale and distribution market is expected to see steady growth of 6.8 percent annually during 2014-2019 due
to increased demand for pharmaceutical products (led by the Americas region) as well as technology advances.37
Revenues are projected to
increase from $752 billion to $1.04 trillion during the period (Figure 7).38
The U.S. market is expected to have a 37 percent share of the overall
market by 2024.39
The life sciences wholesale and
distribution process involves the storage
and movement of products from
manufacturing plants to key customer
segments including hospitals and clinics,
patients, and specialty/traditional
wholesalers.40
Two market developments
have the potential to disrupt traditional
distribution channels and pose challenges
for drug manufacturers. The practice
of parallel importation, which allows
certain countries to import original
pharmaceutical products at a lower
price,41,42
is resulting in the emergence of
new and numerous channel intermediaries
(e.g., repackaging agents, wholesalers,
distributors). This increase in players
combined with parallel supply chains’
intricacy and lack of transparency, may
undermine channel security and increase
the opportunity for counterfeits to enter
the system. Pharmaceutical companies are concerned that parallel importation could put public health and safety at risk and result in
diminished profits that could lead to a reduction in RD funding for new, innovative drugs.
The second channel-related market development is an increase in online pharmacy operators, which may require manufacturers to change
their traditional sales and distribution models. Leading distributors in Southeast Asia and other regions are countering online pharmacy
operators, parallel importation, and other channel disruptions by offering more value-added services to pharmaceutical and device
companies, such as analytics support, patient assistance program execution, training, and product/device monitoring.
Figure 7: Global pharmaceuticals wholesale and distribution market, 2014-2019
1200
2014 20162015 2017 2018 2019
0%
2%
4%
6%
8%
10%
12%
800
1000
600
400
200
0
USD$billions
Source: DTTL Life Sciences and Health Care group analysis of TechNavio analysis
Revenue Growth rate
11. 2017 global life sciences outlook | Thriving in today’s uncertain market
9
Given the number of potential policy and regulatory changes anticipated in 2017, life sciences stakeholders large and small, public and private
are expected (and encouraged) to pay close attention to five sector trends that have the potential to help and/or hinder their clinical, financial,
and operational plans:
•• Managing cost pricing
•• Driving clinical innovation
•• Connecting with customers consumers
•• Transforming business operating models
•• Meeting regulatory compliance
Read on to learn about these trends and Deloitte’s considerations for sector participants seeking to manage clinical and business risks and
sustain growth in today’s dynamic life sciences marketplace.
Managing cost pricing
The pressure to reduce costs and prove value in life sciences is intense.43
Indeed, some assert that it will be the greatest challenge facing life
sciences companies in 2017. Uneven regional economic growth, reduced government health care spending in certain areas, and increasing
consumer out-of-pocket (OOP) costs for popular treatments are underpinning payer, provider, government, and patient demands for
lower-cost drugs and devices; greater use of generic medicines; value- and outcome-based payment models; and more stringent regulatory
processes. Increasingly, life sciences companies are expected to justify the cost of their products using improved targeting,44
comparative
effectiveness (CE) measures, and real-world evidence (RWE) in addition to hard clinical endpoints.
Adding to the pressure, the costs of bringing a new medicine to market have never been higher. Deloitte’s analysis of 12 leading
biopharmaceutical companies shows that the costs of the traditional, fully integrated pipeline process from idea to RD to commercialization
have increased from $1.188 billion in 2010 to $1.539 billion in 2016.45
Other cost estimates range both higher and lower, but the expense and
complexities of drug development have risen, particularly as researchers focus on challenging disease areas such as cancer. Companies big
and small are expending considerable time and effort to reduce the cost side of the equation by right-sizing their organizations, working more
cross-functionally, and increasing operational efficiency through digital supply networks (DNS) and other technology advancements (see
sidebar).
Global life sciences
sector trends in 2017
12. 2017 global life sciences outlook | Thriving in today’s uncertain market
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Virtually all countries have or are planning to institute drug price cost-containment measures or value-based pricing and reimbursement
models. Initiatives in several countries are posing significant challenges to research-based pharma companies:
•• In Japan, two new schemes were implemented in 2016 to strengthen pricing control–Health Technology Assessment (HTA) and “Huge
Seller” Re-Pricing. The former requires submission of HTA data for Japan’s National Health Insurance (NHI) price listing if a drug meets
certain criteria including sales forecast and level of premium requested by the manufacturer. The latter is designed to cut drug price by up
to 50 percent if annual drug sales exceed JPY 100 billion (approx. US $1 billion) and there is a certain gap between actual sales and the sales
forecast presented in NHI price application. As a result, several name-brand drugs got price cuts ranging from 10-31 percent.50
•• There is a new approach in the way cancer drugs are appraised and funded in the United Kingdom due to the old funding system being
financially unsustainable.51
The “new-look” Cancer Drug Fund (CDF) aims to enable faster patient access to drugs and be more sustainable,
while still giving patients access to drugs already supported by the fund, even if the National Institute for Health and Care Excellence (NICE)
reappraise the drug. The fund seems to be making a number of positive strides to being more sustainable. It also appears to be offsetting
a lot more work to NICE; depending on how many new drugs are being pushed through the pipeline there may be more work for NICE than
the agency can handle, potentially resulting in a treatment backlog.
The rise of life sciences digital supply networks
Forward-thinking life sciences companies are transforming their traditional, linear supply chain into a dynamic, interconnected system
that can more readily incorporate ecosystem partners and evolve to a more optimal state over time. This digital supply network (DSN)
integrates information from many different sources and locations to drive the physical act of production and distribution.46
By
leveraging both the traditional and the new, such as sensor-based data sets, DSNs enable integrated views of the supply network and
rapid, use-case-appropriate latency responses to changing situations.47
Historically, supply chain professionals managed the “four Vs” (volatility, volume, velocity, and visibility)48
as they attempted to optimize
results across a series of objectives that include total cost, service, quality, and support for innovation. These traditional priorities are
not likely to change, but going forward, supply chain decision-makers should be able to achieve higher levels of performance with
capabilities developed using new digital technologies. Already, life sciences companies are recognizing the many ways that DSNs can:
•• Enable end-to-end supply network visibility
•• Improve manufacturing operation efficiency and yield
•• Create new options for enabling clinical trial supply.
Many life sciences organizations already on the path to creating DSNs are shifting their focus away from managing and optimizing
discrete functions, such as procurement and manufacturing. Instead, they often use DSNs to focus more holistically on how the full
supply chain can better achieve business objectives, while informing corporate, business unit, and portfolio strategies. Indeed, DSNs
increasingly enable supply chain professional to become an integral part of strategic planning and decision-making, and to help create
new sources of revenue by providing faster access to markets and supporting the production of smart products. To this end,
organizations can develop and leverage multiple DSNs to complement different facets of their strategy and more effectively target
specific needs.49
Source: The rise of the digital supply network: Industry 4.0 enables the digital transformation of supply chains,
Deloitte University Press, 2016
13. 2017 global life sciences outlook | Thriving in today’s uncertain market
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End-to-end evidence strategies strengthen the product value proposition
To thrive in the “facts-beat-marketing-hype” future of value-based, personalized health care, life sciences companies are embracing
operating models that are based on end-to-end (E2E) evidence management strategies and capabilities throughout product
development, marketing and distribution.
Increasingly, empirical evidence around product efficacy, safety, and economic value as well as patient services “beyond the pill” are at
the heart of today’s value conversations between life sciences companies and their customers, replacing those based largely on
marketing value propositions and unit cost and rebate pricing strategies.
An insights-driven E2E evidence management model is becoming a necessary operating strategy in life sciences today. Advantages
include better data transparency; the design of less expensive, targeted clinical trials; the acceleration of product approvals; more
on-target market access channels; and the creation of comprehensive and real-world effectiveness analyses. Becoming a true insights-
driven company and executing E2E evidence management in daily practice requires alignment across the key components of strategy,
people, process, data, and technology.
Ultimately, evidence is at the core of customer decision-making and a strong evidence base will generate more productive
conversations with health care stakeholders.
Source: “Pharma’s Big Push for Value: A ‘How-To’ Primer Using End-to-End Evidence Strategies,” by R. Terry Hisey and Brett J. Davis,
Deloitte, Pharmaceutical Executive, May 2016
•• The United States has liberal drug pricing practices compared to countries like the United Kingdom (which uses ‘quality-adjusted life years’
to evaluate cost-effectiveness of treatments) and Germany (which uses ‘value dossiers’ to evaluate clinical, economic and therapeutic
value). However, U.S. drug pricing practices are changing, spurred by public interest and new government policies. The U.S. Department
of Health and Human Services (HHS) and U.S. Centers for Medicare and Medicaid Services (CMS) have set clear goals and a timeline for
shifting all traditional Medicare payments from volume to value–85 percent by 2016 and 90 percent by 201852
—and are testing new models
through various payment reform initiatives.53
Pressure is also coming from U.S. commercial/private health plans. Significant consolidation of
pharmacy benefits managers (PBMs) and payers is increasing their market power, and they are more aggressively utilizing access-restriction
tools (e.g., formulary tiering, formulary exclusions, step edits, prior authorizations) to extract higher discounts and rebates. The growing
use of price protection clauses is further limiting the viability of using price as a key lever for driving year-over-year (YoY) revenue growth.
Moreover, as specialty medicine budgets continue to grow and these TAs become more competitive, PBMs and payers are increasingly
turning their attention to high-priced specialty drugs.
•• In an effort to promote drug price reforms and encourage market competition, China’s National Development and Reform Commission
(NDRC) lifted price controls on most medicines starting June 1, 2016. Cheaper domestic brands should have an advantage under this
arrangement. Many provinces have also adjusted their tendering or purchasing process to either give preference to cheaper domestic
brands or to enact more complex processes for hospitals to purchase international brands.
•• Policies supporting the use of less expensive generic drugs (and, to a lesser extent, biosimilars) continue to be a popular and dependable
cost-savings practice in numerous countries. For example, Japan’s government aims to achieve an 80 percent generic substitution rate by
the end of FY2020, up from around 60 percent at the end of FY2015. To receive the benefit from the government-backed initiative, generic
manufacturers are investing in expanding their production capacity. Mexico plans to continue its cost-reduction strategy of using generic
drugs, which has produced an average reduction of 55 percent in medicine prices. In the United States, accountable care organizations
(ACOs) are being incentivized to increase utilization of generics and Integrated Delivery Networks (IDNs) are using electronic health records
(EHRs) to drive compliance with generic use protocols.
Some life sciences companies are making headway in addressing pricing controls, reimbursement model changes, reference pricing systems,
and generics by using end-to-end evidence management strategies to demonstrate the efficacy and cost-effectiveness of their products
(see sidebar). However, the broad challenge of managing cost and pricing is not expected to subside anytime soon; it should remain a front-
burner issue for 2017 and the foreseeable future.
14. 2017 global life sciences outlook | Thriving in today’s uncertain market
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Stakeholder considerations: Managing cost pricing
Even as an aging population and proliferating chronic diseases drive increased provider and patient demands for more and better therapies,
reform-driven drug price controls and government cost-containment measures continue to challenge the life sciences sector. With public and
private payers making increased use of value-based pricing and real-world evidence to provide clinical and commercial insights into the value
of products, life sciences companies should balance the pursuit of clinical innovation with improving operational and cost efficiencies via right-
sizing, DSN, and other initiatives. For example, to win in emerging markets, biosimilars players should adopt a long-term strategy to provide
affordable products and improved access to the large pockets of non-consumption. This will entail growing sales–though at a smaller margin
than in developed markets–among an increasingly affluent and health-conscious population. It will also require selecting TAs that offer the
largest potential impact for the local population.54
There may be an opportunity for improved cost-justification/rationalization via increased cooperation between life sciences companies and
payers based on the push-pull principle. On one hand, regulatory changes and reimbursement incentives will further push payers to reduce
health care costs. On the other hand, integrated care contracts may improve care and allow for revenue and profit-sharing between life
sciences companies and payers. Also, there is strength in numbers, so life sciences players should engage with other health care stakeholders
in markets transitioning to value-based care to make sure that the definition of “value” gives patients access to today’s and tomorrow’s life-
changing innovations55
while also enabling organizations to fund future RD, improve profitability, and meet shareholder expectations.
Driving clinical innovation
Driving and sustaining clinical innovation persists as a life sciences sector priority in 2017, as stiff competition and patent cliffs continue to
jeopardize revenue. Soaring RD costs, increasing pricing pressures, growing market share for generic pharmaceuticals and biosimilars, and
heightened scrutiny by regulators are having a dampening effect on clinical innovation. And even though health systems report substantial
improvements in outcomes for infectious diseases, heart disease, and stroke—the result of broad use of vaccines and antibiotics, and the
prescribing of “blockbuster” drugs such as statins56
—the demand for new, innovative treatments is unrelenting, driven by the proliferation
of age-related diseases such as cancer and dementia, and lifestyle-influenced or behavior-related chronic diseases, such as obesity and
diabetes.57
Unfortunately for many life sciences companies striving to innovate efficiently and cost-effectively, Deloitte analysis shows that
while the costs of taking a blockbuster drug from idea to market have somewhat stabilized after years of increases, forecast peak sales per
asset continue to decline (Figure 8).58
For the past two decades, the United States
was considered the world’s leading funder and
innovator—providing up to 70 to 80 percent
of global life sciences RD funding.59
Yet in
recent years, the country has had a major
decline in its RD competitiveness,60
with other
nations (especially those in Asia) more actively
competing and investing in various elements of
the value chain.61
Similarly, the UK life sciences
sector has lost some global prominence
relative to a number of other markets. Still,
there is positive news: The UK’s Minister for
Life Sciences in November 2014 announced
the Accelerated Access Review, with the aim
to consider how to speed-up patient access
to cost-effective and innovative medicines,
devices, and diagnostics. Two years later, the
U.S. Government approved the 21st Century
Cures Act, a package that includes bills on
mental health reform, FDA approval pathways,
Figure 8: Average RD costs vs. average forecasted sales
Source: Measuring the return from pharmaceutical innovation 2016: Balancing the RD
equation, Deloitte UK Centre for Health Solutions, 2016
15. 2017 global life sciences outlook | Thriving in today’s uncertain market
13
Blockchain technology could improve life sciences innovation, security,
and accountability
Blockchain technology has the potential to drive life sciences innovation, strengthen security efforts, and increase company and
industry accountability.i
Blockchain, the technology underlying the crypto currency bitcoin, is a distributed ledger where multiple
parties can see and add information transparently and securely.ii
Data is exchanged, verified, and stored in fixed structures called
blocks, and each copy of the blockchain independently validates new blocks before adding them to the chain.iii
Although blockchain was originally proposed to revolutionize the financial industry, experts have turned their attention to
pharmaceutical applications. As drugs are manufactured, patents filed, and clinical trials carried out, blockchain technology could be
used across the product lifecycle and provide visibility among pharmaceutical companies, CROs, regulators, distributors, and patients.
Blockchain could be used to validate user information, proof of work, and smart contracts (decentralized applications that
automatically execute actions based on blockchain activity),iv
thus changing how the industry manages and records data, and
improving stakeholder collaboration and transparency.
Blockchain also could provide enhanced visibility and data-tracking at various points along the pharmaceutical and medical device
supply chain, combatting the ongoing problem of counterfeit medications.v, vi
The idea is to track the medication by using an immutable
time stamp showing where and when it was produced. Blockchain also could supplement the pharma product serialization system by
monitoring the national drug code, the unique serial number or the active pharmaceutical ingredient.vii
Finally, blockchain applications
could help life sciences companies provide faster and more accurate reports to regulatory authorities by automating portions of the
compliance process that draw on immutable data sources.
and biomedical innovation funding. 62
The 21st Century Cures Act has broad industry, advocate, and stakeholder support, but concerns
remain. Some advocates say that the act does not go far enough in addressing prescription drug prices. Others say that the act’s funding is
not stable since it is not mandatory and would have to be re-appropriated every year.63
Companies and governments are expected to continue to increase funding into new product development:
•• Worldwide pharmaceutical RD spending totaled $149.8 billion in 2015, and is expected to grow by 2.8 percent annually to $182 billion in
2022 (compared with CAGR of 1.7 percent between 2008 and 2015).64
•• Overall medical device RD spending is expected to grow at a CAGR of 4.3 percent from 2015 to 2020. RD spend among leading medical
device manufacturers has grown by 38 percent YoY, from $1.6 billion in 2014 to $2.2 billion in 2015, driven by investments in less-invasive
devices, such as the innovative leadless pacemaker.65
•• Currently, more than 7,000 drugs and treatments are in development globally.66
i. http://dcebrief.com/applications-for-blockchain-pharmaceutical-industry/
ii. David Schatsky and Craig Muraskin, “Beyond bitcoin: Blockchain is coming to disrupt your industry,” Deloitte University Press, December 7, 2015,
http://dupress.deloitte.com/dup-us-en/focus/signals-for-strategists/trends-blockchain-bitcoin-security-transparency.html, accessed October 6, 2016
iii. Blockchain in insurance: Turning a buzzword into a breakthrough for health and life insurers, Deloitte Center for Health Solutions, 2016
iv. Ibid
v. http://www.ibtimes.com/blockchain-technology-could-help-solve-75-billion-counterfeit-drug-problem-2355984
vi. http://dcebrief.com/applications-for-blockchain-pharmaceutical-industry/
vii. Ibid
16. 2017 global life sciences outlook | Thriving in today’s uncertain market
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However, according to the Deloitte UK Centre for Health Solutions’ 2016 pharmaceutical innovation study,67
its seventh-annual review of 12
leading biopharma companies’ estimated returns, RD productivity remains hit-or-miss:
•• Annual projected pharma RD returns have continued to decline, from 10.1 percent in 2010 to 4.2 percent in 2015 to 3.7 percent in 2016.68
•• Peak sales per asset have fallen 11.4 percent year-on-year since 2010.69
•• Costs to bring a product to market have stabilized, from $1.57 billion in 2015 to $1.53 billion in 2016.70
•• Smaller pharma companies have seen a decline in overall performance, but on average they continue to outperform their larger
counterparts, generating returns up to three times higher.71
Even with less-than-stellar productivity gains, more treatments are moving swiftly through the RD pipeline:
•• Fifty-six products were approved in 2015, a record high—although 2016 may yield less stellar results.72
•• The number of orphan drugs (i.e., drugs that treat very rare diseases that are often life-limiting) approved in both the United States and
Europe has increased significantly over the last five years.73, 74
A number of vertical and horizontal clinical trends are expected to drive life sciences innovation; have significant, transformative impacts on
the products and services offered to patients; and improve how companies operate in terms of the efficiency and security of their product
supply (Figure 9):
Figure 9: Trends in clinical innovation
Genetics,
epigenomics, and
genomics
Biomechanical/
biomedical
engineering
Molecular
biology
Biotechnological/
biopharmaco logical
technologies
Breakthrough
drugs and
devices
By 2020, genetic testing
is expected to be part
of mainstream medical
practice, paving the
way for stratified or
personalized medicine
Pharma technologies of
the future will be better-
positioned to analyze
the molecular basis
of diseases, enabling
development of targeted
medicines
New clinical engineering
methods will drive
innovation around
regenerative medicine
(e.g., tissue-repair
products like skin grafts,
tissue-replacement
products using 3D
bioprinters to print living
tissue with ink derived
from human cells)
Advancements will
support continued
development of lower-cost
biosimilars, including
monoclonal antibiotics
and recombinant
products
Bone-rebuilding drug
Romosozumab (awaiting
FDA approval); 3D-printed
epilepsy drug, Spritam;
bioelectric implants;
and surgical robots are
anticipated to improve
health outcomes and
drive future life sciences
sector growth
Translational medicine. A translational approach to life sciences RD connects the traditionally discrete steps of discovery,
development, and delivery to facilitate a continuous process improvement cycle and accelerate time to market.3
Big pharma and other
life sciences companies are using translational medicine to develop novel therapies for cancer and chronic diseases, focusing on gene
sequencing, unlocking nanoparticles’ potential and evaluating biomarkers.
Health care digitalization. The collection and electronic exchange of vital biological and clinical data (e.g., disease statistics, patient
population statistics, electronic patient dossiers) among life sciences companies, providers, health plans, and patients can improve
drug and device RD, manufacturing, distribution, adoption, and use.
Artificial intelligence (AI). Technical advances by collaborating robotics and medtech companies are enabling semi-autonomous
patient care and robot-assisted surgeries.
Big data and analytics. Sophisticated data sharing, processing, and mining techniques can support the development of personalized
medicines, increase speed to market for new drugs and devices, and create a competitive advantage.
Sources: Deloitte’s path to 21st century cures: A call to action, Deloitte, 2014
http://www.delivering-tomorrow.de/wp-content/uploads/2015/08/dhl-white-paper-lsh.pdf;
http://whoswholegal.com/news/analysis/article/32977/trends-life-sciences-legal-market-2016.
17. 2017 global life sciences outlook | Thriving in today’s uncertain market
15
Stakeholder considerations: Driving clinical innovation
Aligning RD capabilities around a few, stable TAs may add to scientific, regulatory, and commercial value propositions. In addition,
reducing development complexity, through streamlining functions and addressing unproductive infrastructure, should materially
improve returns.75
Other suggestions to foster life sciences innovation include:
•• Using real-world data to identify unmet needs and/or populations that benefit from existing therapies (based on ethnicity,
genotype, comorbidities, etc.)
•• Using big data (i.e., “omics”) to develop new therapies targeting specific patient populations
•• Investing in companion diagnostics to guide research to the most likely targets, shorten RD lead times, and support higher
probabilities of success in subpopulations
•• “Institutionalizing” innovation by sponsoring academic research and providing local job opportunities in exchange for steady access
to a highly educated and well-trained workforce
•• Expanding collaboration with high-tech companies to develop/provide more patient-centric care solutions (e.g., wearable
technologies) that address unmet needs
•• Replacing traditional organizational structures and processes to improve collaboration among geographically dispersed employees
and partners
•• Moving “beyond the pill” to consider broad solutions around prevention rather than simply treatment.
Concurrent with driving clinical innovation, pharmaceutical and other life sciences companies need to minimize the accompanying
scientific, economic, and delivery risks that can diminish product value. Deloitte has identified seven options for “de-risking” and
creating value in the life sciences business model (Figure 10):76
Figure 10: Seven options for developing the pharma business model
Source: Facing the tidal wave: De-risking pharma and creating value for patients, Deloitte UK
Centre for Health Solutions, 2016
Value creation
De-risking
Digital platforms
Scientific risks
Continuous RD
innovation
Clinical
pathway delivery
Accelerated access
processes
Delivery risks
Launch
factories
Collaborative directed
research
Economic risks
Lifetime patient data
management
Core drivers
18. 2017 global life sciences outlook | Thriving in today’s uncertain market
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Continuous RD innovation. New innovation models can help improve the operational effectiveness of research organizations.
The continuous RD innovation model incorporates balancing skills, teamwork, a ‘manifesto’, partnerships, destructive creativity and
multidisciplinary staff.77
Lifetime patient data management. Lifetime patient datasets are used to develop an integrated understanding of patients and help de-
risk the process of discovery through a better focus on unmet needs; improve selection of biomarkers/sub-populations; and support earlier/
faster identification of trial patients.78
Clinical pathway delivery. Following a patient’s disease and treatments increases the probability of improved outcomes and increased
productivity. Also, joint development of clinical pathways offers the opportunity to reduce delivery risks by improving pathway design and
optimizing the division of work between pharma companies and the health care system.79
Digital platforms. Digital platforms can create a step change in the cost of engaging with patients and physicians, both delivering significant
new value and helping to lower costs.
Collaborative directed research. This approach shifts the balance of economic and scientific risk radically, and includes governments
or other funders directing the research. Collaborative directed research was used successfully in the development of vaccines for Zika and
Ebola.80
Accelerated access processes. Working with regulators to redesign access processes could accelerate the availability of new drugs,
increase adoption rates and redesign reimbursement and contacting models.81
Launch factories. Launch factories help improve launch efficiency, reliability and compliance. This makes them deliverable across different
countries and products over time. A launch factory industrializes tools, methodologies, data sources, people/talent and processes.82
Connecting with customers consumers
Increasingly engaged and empowered health care consumers are demanding services and solutions that are coordinated, convenient,
customized, and accessible. This trend is being driven by factors including patients’ ability to change their own outcomes based on behavior;
financial scrutiny due to cost-sharing models that push more costs onto the patient; the industry’s shift towards evaluating outcomes to
determine value delivered to the patient; and the availability of technology solutions providing patients with more information and the ability
to play an active role in managing their well-being.83
Large pharmaceutical companies focused on traditional markets have lagged in responding to the industry’s changing focus towards holistic
patient management—for example, many supply chain functions are struggling to wrap necessary services around their products to supply
the expanding home health care market. Companies have a small window of time to frame their engagement strategies for operating in a new,
customer-centered, digital ecosystem or risk being disintermediated by fast-moving entrants that are developing digitally enabled products
and programs to cater to changing patient expectations.84
According to findings from the Deloitte 2016 Survey of US Health Care Consumers, there is growing consumer appetite for using technology-
enabled care:
•• Seven in ten consumers are likely to use at least one of the technologies presented in the survey (e.g., telemedicine, remote patient
monitoring, drones).
•• Telemedicine, in which half of the respondents show interest, is the most popular technology. Respondents are most interested in using it
for post-surgical care and chronic disease monitoring.85
•• Particular subgroups are especially keen on these technologies, especially those with chronic diseases, Millennials using telemedicine, and
Seniors using remote monitoring.86
•• Caregivers are a key population. Consumers who are caregivers say they are most likely to use sensor technology when caring for others
rather than for themselves. Experienced caregivers are more likely to use telemedicine and remote monitoring technology than non-
caregivers.87
•• Consumers demand high-quality, personalized care. They also want assurance that their personal information will be safe.88
19. 2017 global life sciences outlook | Thriving in today’s uncertain market
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The increase in data and information access, mobile applications, and personal health devices is accelerating the pace of consumer
engagement in health care89
(Figure 11). Today’s consumers are posing pointed questions about the value of medicines, medical procedures,
treatment regimens, and claims of medical superiority. These actions are putting pressure on life sciences companies to shift their focus from
traditional product development and marketing models to more patient-centric ones.90
They can begin by leveraging their digital and analytics
capabilities to gather data and monitor
outcomes, improve treatment regimen
compliance, and increase product utilization.
Social networks have become powerful
customer engagement tools and offer a more
personal and open dialogue than traditional
marketing channels like commercials or
advertisements. These networks allow
patients and life sciences companies to
interact in new ways, including collecting
and sharing information on the efficacy of
treatments. Patients have been a driving force
for sharing and disseminating information
regarding treatments and patient experiences
through sites such as PatientsLikeMe,
DiabetesMine.com, and TheCancerForums.
Content is created within the blogs, online
support groups, and resource tools for
effective disease management. This allows
patients to connect and interact with other
patients to discuss treatment options and real
user experiences.91
Other online engagement efforts by life
sciences companies use web-based data
collection methods to capture the voice of
the consumer (i.e., patient) for longitudinal
medication safety data. Proper design of these instruments can help to increase the size of the population being monitored (thus increasing
the likelihood of identifying rare events) and for tailoring the populations being evaluated that were not well studied during the trials needed
for regulatory approval.92
One of the most interesting consumer engagement challenges facing life sciences companies is how to increase consumer trust and improve
the overall reputational perception of the sector. Historically, the pharmaceutical companies that manufacture prescribed medicines have
not been trusted go-to sources—for information, support, or counseling—compared to a physician, nurse, or community group. But these
companies are increasingly seeking to step in and answer questions and to help patients navigate the complexities involved in receiving a
diagnosis, deciding on treatment, securing financial assistance, connecting with other patients and community experts, and supplementing
clinical education.93
Although trust in life sciences companies has grown recently, it’s still lower than for other health care stakeholders and other industries. And
recent public and political outcries over price increases for several widely used older drugs have done little to improve the industry’s image.
Creating greater awareness of a drug or device’s role in the context of comprehensive treatment regimen costs is one way that companies
can continue to engender consumer confidence and gain permission to participate in customer engagement—which in turn can go a long way
towards building trust and impacting market opportunities.
Online tools: Online communities can empower patients and provide a
source of information and social/emotional support.
Social networks: These networks have become powerful customer
engagement tools and offer a more personal and open dialogue than
traditional marketing.
Telehealth: For patients with congestive heart failure, diabetes, depression,
and other chronic conditions, digital health technologies such as home
telemonitoring can reduce hospital readmissions and increase the ability of
individuals to live independently.
The Center for Medicare Medicaid Innovation, with $10 billion in funding for
10 years, is encouraging grant winners to use and test telemedicine and
home health services, among other offerings.
28%are very interested
in doing so in the future.
18%of surveyed consumers
consulted a provider using secure
messaging, texting, or email.
28%of surveyed consumers used
technologies to monitor and manage their
fitness/health, compared with 17% in 2013.
13%of surveyed consumers used video, a computer program, or
mobile app to learn about treatment options.
17%are very interested in doing so in the future.
Nearly 40% of surveyed
health care consumers looked
online for information related to
health and treatment.
23%used social media for
health related purposes.
Figure 11: Technology is powering consumer health care engagement
Source: Convergence of health care trends: Innovation strategies for emerging opportunities,
Deloitte US Center for Health Solutions, 2015
20. 2017 global life sciences outlook | Thriving in today’s uncertain market
18
Stakeholder considerations: Connecting with customers and consumers
The increasing number and diversity of customer segments calls for life sciences companies to shift from “one-size-fits-all” engagement
approaches to a more cross-functional, collaborative model that provides touchpoint opportunities throughout the product lifecycle.
Organizations that understand how consumers like to use online resources and health technologies may be better-positioned to develop
more effective engagement strategies. By doing so, companies can help to improve effectiveness, efficiency, and value in health care service
and product delivery; excel on quality measures that reflect the consumer experience; and outflank their competition by attracting and
retaining actively engaged customers.94
Life sciences companies should strengthen consumer connections by developing online information resources, mobile applications, and
personal health devices to help individuals in their patient populations and customer bases become more engaged.95
In addition, they will
need to streamline/harmonize all of their digital channels to provide a consistent customer experience and reduce costs. Using advanced
analytics may provide pharma companies with a view across all customer types (prescriber, patient, and payer) to better understand the
appropriate mix of messages and channels to help increase product utilization of products. However, solely offering technology tools may not
be enough to move the needle. Marketing, customer service, and technical support will be critical for raising consumers’ levels of awareness,
comfort, and trust.96
In addition, changing corporate culture is an important step in the evolution towards more customer- and patient-centric
business models. One leading pharmaceutical company, for example, appointed a Chief Patient Officer in 2014 who implemented a patient-
centric strategy into the organization.
Transforming business operating models
Many life sciences companies are looking at how they can transform their current business and operating models to counter rising cost
pressures and pursue excellence across their organizations–not only in RD and global operations, but also in areas such as finance, sales,
and distribution. According to Thriving in uncertainty, Deloitte’s fourth biennial cost survey: Cost improvement practices and trends in the
Fortune 1000, focus areas for life sciences and health care cost-management actions in the coming year include streamlining business
processes and improving policy compliance with a focus on reducing administration and operational costs (Figure 12).97
Because cost-management and transformation
opportunities vary across geographies,
customers and products, companies are taking
multiple paths to achieve their quality, cost, and
efficiency goals.
Collaborative product development—Life
sciences is joining other industries in which
companies have turned to open innovation
(OI) and other collaborative models as a way
to fill in-house capability gaps and overcome
RD and marketplace challenges by externally
sourcing innovative ideas, knowledge, skills, and
technologies.98
Indeed, collaborating throughout
the product development lifecycle is becoming
an increasingly common and effective way
for biopharma and medtech companies to
offset mounting RD costs, funding shortfalls,
increasing disease complexity, and rapid-fire
technology advances.99
Collaborations can span
the spectrum of openness (Figure 13, next page)
and potential partners may be found in government, academia, traditional biopharma, and new industry entrants. According to a Deloitte
analysis, there is a three-fold probability of success when drugs are sourced via OI.100
Likely cost action
Streamline
organization
structure
Streamline
business
processes
Strea
organ
stru
amline
siness
cesses
Improve
policy
compliance
amline
nization
ucture
a
n
u
Reduce
external
spend
duced
ernalt
pendp
Increase
centralization
rease
alizationa
Change
business
configuration
angeh
sinesss
gurationg
Outsource/
Off-shore
business
processes
Figure 12: Life sciences company likely cost-management actions
Source: Thriving in uncertainty: Deloitte’s fourth biennial cost survey: Cost improvement
practices and trends in the Fortune 1000, Deloitte, April 2016
21. 2017 global life sciences outlook | Thriving in today’s uncertain market
19
Figure 13: Mapping the major types of open innovation along the spectrum of openness
Source: Titles for Type 1, Pure Outsourcing, And Type 2, Licensing And Variants, from Waldron RF, “Open Innovation in Pharma:
Defining the Dialogue,” Pharmaceutical Executive, September 1, 2012. Titles for Type 3, Collaboration and Variants, and Type 4,
Open Source; the figure itself; and all definitions/details associated with all four types were developed by Deloitte Services LP.
Degree of alignment with open innovation
Low Medium High
Closed/traditional Open/emerging
Type 1
Pure outsourcing
RD activity
pursued by
external entity,
such as CROs and
universities
Type 2
Licensing and
variants
Licensing, mergers
and acquisitions,
technology trans-
fer, venture capital
funding
Type 3
Collaboration and
variants
Collaboration,
co-development,
joint ventures
Type 4
Open source
Sharing technology,
skills capabilities, to
better produce
products
Potential opportunity
for biopharma to
learn from other
industries
Adopted by other
industries like IT and
CIP, but not much by
biopharma companies
Among current examples of collaborative life sciences product development is the United States’ Accelerating Medicines Partnership (AMP), a
$230 million venture between the National Institutes of Health (NIH), 10 biopharmaceutical companies, and several non-profit organizations.
The initiative aims to transform diagnostic and treatment development by jointly identifying and comparing biological targets of disease.101
Japan’s top three pharmaceutical companies have announced that they will collaborate on building a biomarker database on healthy adults in
a bid to optimize and speed up the development of innovative medicines—the first deal of its kind among those drug companies. In addition,
22 pharmaceutical companies are offering a total of roughly 200,000 compounds to a project led by the Japan Agency for Medical Research
and Development (AMED) to match up drug makers’ compound libraries and academic institutions’ drug seeds.102
In the United States, the 21st Century Cures bill became law in December 2016, providing $4.8 billion in funding for the NIH and key initiatives
focused on precision medicine, cancer, and Alzheimer’s research. The regulation facilitates collaborative research and extends the National
Center for Advancing Translational Science (NCATS) ability to support clinical trials through Phase IIb (previously IIa). The regulation also calls
for innovation to the drug and development process—directing the FDA to establish a review pathway for biomarkers, provide guidance on
the use of patient-generated data in drug development, evaluate RWE for the approval of new indications, create a breakthrough pathway for
devices, and allow accelerated approval for regenerative medicine products.103
Universities are a willing partner in efforts by life sciences companies to decrease the risks associated with early-phase product development.
According to a Tufts Center study, many large life sciences companies have established collaborations with at least one academic medical
center (AMC). These arrangements enable the training of a steady pipeline of scientists who can take on the big challenges present in health
care. Regional innovation clusters, often found around major research universities, are also important to innovation.104
Collaboration opportunities also extend beyond early-stage RD. For instance, multination corporations (MNCs) may partner with local
enterprises to facilitate in-country product marketing and distribution. In addition, there is a growing trend of pharma MNCs teaming with
insurance companies and regulatory bodies to improve coverage of expensive therapies or provide patient payment-assistance programs.
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Portfolio and operational restructuring—Some biopharma and medtech companies are pursuing revenue and market growth by
expanding their product portfolios via investments in new technologies such as regenerative medicine. Others are transitioning from being
a short-term treatment provider to a long-term solutions provider offering products and services throughout a disease’s lifecycle, from
diagnosis to chronic-condition maintenance.
Numerous companies are streamlining offerings and/or operations by consolidating research centers or transferring non-core functions to
contract research or manufacturing organizations (CROs or CMOs); swapping products with other players to build critical mass in a specialty
area such as oncology or diabetes care; and divesting under-performing products or those in a certain lifecycle stage (i.e., off-patented drugs)
to concentrate on specific geographic and/or therapeutic areas (e.g., drugs or drug delivery mechanisms that target complex disease areas
with high unmet needs). It appears that medtech companies want to be seen as a master of a few products or therapies rather than a jack-of-
all trades, as evidenced by ongoing streamlining of their product portfolios. Most of the big life sciences sector players in the United Kingdom
continue to attempt to offload non-performing or uneconomic assets in their portfolios. It seems that many of these carve-outs are being
picked up by small, locally-based providers. In the medium to long term this may provide an opportunity for greater innovation in the UK life
sciences industry, provided these smaller operators can remain going concerns.
The Southeast Asia region is seeing changes in go-to-market models, where some MNCs partner or out-license their products to smaller
pharma companies to perform marketing, sales and distribution activities. The tendency to outsource certain operations is moving closer to
the core of supply chains, especially for mature products, for which filling and finishing is increasingly being shifted to contract manufacturers.
Third- and fourth- party logistics providers cover tactical and administrative logistical activities as well as specialist services; for example,
temperature management, emergency or courier shipments, recall management and patient assistance programs.
Growth through MA—Merger, acquisition, and divestiture activity plays a significant role in life sciences companies’ strategies to gain scale
and to add new markets, new drugs, and novel technologies. In 2015, 236 pharma mergers and acquisitions were closed worldwide, worth
over $403 billion combined. The medtech segment saw 51 deals worth over $1 billion.105
MA activity advanced in the first half of 2016,106
although through November, global life sciences deal volume and value were down from the previous year.107
Emerging markets performance
was mixed but remains important. 2016 was also notable for the deals that did not happen.108
The biggest transaction announced was
eventually called off after the United States implemented tax inversion rules.109
MNCs contemplating MA are also preparing for international tax reform now that the OECD G20 Base Erosion and Profit Shifting (BEPS)
initiative will fundamentally change the global tax landscape.110
BEPS is expected to alter the transfer pricing outcomes in many situations
and to require multinational enterprises to undertake additional analysis and documentation.111
BEPS and other tax changes may compel life
sciences organizations to alter supply chains, move IP, and restructure certain businesses.
The general consensus is for continued life sciences sector consolidation in 2017. However, in light of some failed deals, analysts anticipate
that big pharma will focus on acquiring smaller companies to strengthen businesses and portfolios. Medtech companies should also keep
active in MA, particularly with acquisitions of data analytics firms. As mentioned earlier, asset swaps in big pharma are likely as companies
become de-diversified by choosing to only focus on one or two key TAs. Also, life sciences companies are expected to continue to divest
assets and businesses in order to free-up cash and management attention to focus on core businesses and next-generation innovations.
Regional MA activity in 2017 could be variable: China expects to see increased outbound MA as domestic pharmaceutical companies
grow bigger and more eager to acquire advanced technologies and products overseas. Also, there are likely to be more attempts to form
joint ventures (JVs) between MNCs and local firms. This gives MNCs enhanced local capabilities and market access and local firms more
opportunities to learn advanced management skills. Conversely, disconcertion caused by BREXIT and continued political unrest in Ukraine
may slow MA activity in Europe.
23. 2017 global life sciences outlook | Thriving in today’s uncertain market
21
MA in emerging markets should continue to offer growth opportunities in 2017. Although results over the past few years have been mixed,
life sciences companies should still look for openings in markets with significant access constraints and unmet needs—within Latin America,
Southeast Asia and Africa, for example. Yet there are considerable barriers to acquiring, partnering, and operating in emerging markets.
Apart from political instability and regulatory inefficiencies, many underdeveloped nations have poor transport and logistics systems, and
the provision of intermediate goods to fuel production may become problematic. Even though cheaper labor may be available, the lack of
adequate skills embodied by the labor force may require manufacturers to expend considerable resources on training and development, or,
alternatively, to outsource labor. In addition to meeting good manufacturing practices as established by the World Health Organization (WHO),
the aforementioned bottlenecks would require ongoing risk management on time and cost overruns. Governments in emerging markets such
as China, Russia, and Southeast Asia also can make it difficult for MNCs to increase their global footprint by instituting policies that promote
locally produced drugs and encourage domestic companies to invest in pharmaceutical manufacturing.
Talent transformation—Achieving operational excellence, measurable cost savings, and sustained innovation requires that life sciences
companies leverage advancements in talent acquisition, management, and development as well as advances in technology because the two
are intrinsically linked.
A confluence of factors is changing the way that companies and their employees operate. Often, clinical and technical employees work on
global innovation teams that operate 24/7, aided by cloud-based computing, robotics, AI, and other technologies. More companies are
using part-time and contract employees and partnering arrangements. Some are considering employing a contingent workforce, even with
the legal and regulatory challenges that come with it, to temporarily fill skills gaps on demand and introduce more fluidity in recruitment.
Crowdsourcing platforms are also gaining steam. These developments and others call for new workforce management models that recognize
the advantages and challenges of an open talent economy and the need to develop and retain employees with critical clinical, business and
technology skill sets.
Persistent talent shortages will continue to challenge global life sciences companies, especially in developing markets. Government efforts to
boost domestic innovation and localized manufacturing in nations like Singapore and Russia are frequently stymied by a lack of qualified in-
country talent. Singapore, for example, is tightening the approval process for work visas and companies may need to revisit their operations in
Singapore if appropriate staff cannot be employed. Other Southeast Asian governments are working to ease restrictions on the movement of
labor but it remains to be seen if and how quickly those efforts will meet the region’s talent needs.112
Stakeholder considerations: Transforming business and operating models
Transforming customer needs and patient demands should compel pharma, biotech, and medtech companies to take a more holistic
approach to manage operational complexities and business risk and drive greater integration and collaboration across their RD,
manufacturing, and commercial functions–especially if they work with CROs, CMOs, or other external partners. For example, companies
can identify and analyze operational efficiencies as a way to develop innovative offerings while holding down RD costs. Such an all-
inclusive perspective could yield a different value model as opposed to the more traditional way of funding programs and controlling costs.
Consideration should also be given to alternative private funding sources, especially public–private partnerships (PPPs).113
Life sciences companies should examine their supply chain strategies and seek to eliminate inefficiencies along the value chain. Using
differentiated and specialized manufacturing and distribution systems–differentiating supply chains by product, for instance–could improve
overall operational efficiency. In this case, third- and fourth-party logistics providers could cover tactical and administrative logistical activities
as well as specialist services on behalf of pharmaceutical companies. Such activities could include temperature management, emergency or
courier shipments, recall management and patient assistance programs.
Finally, MA deal-making will continue in 2017 but transactions are likely to be smaller, especially compared with 2015’s impressive tally.
One area to watch is deals that combine life sciences with technology. While such transactions to date have been relatively small and more
focused on alliances, life sciences companies can benefit greatly from analytics and digital investments, especially as these capabilities are
not generally developed in-house. Also, if life sciences organizations don’t use MA and strategic partnering to join this community, they risk
being leapfrogged by the technology companies.
24. 2017 global life sciences outlook | Thriving in today’s uncertain market
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Meeting regulatory compliance
The life sciences sector operates in one of the world’s most regulated environments. Companies face particular compliance challenges as
they seek to push the boundaries of innovation, developing and launching new products which address unmet patient needs but for which
there is often little or no regulation.114
In 2017, organizations of all sizes will need to deal with a highly complex, changing set of global, regional,
country, and industry-specific laws and directives that span a drug or device’s developmental and commercial lifecycle. Primary regulatory
focus areas include cybersecurity, drug and device safety, counterfeit drugs, intellectual property (IP) protection, and corruption.
•• Cybersecurity—Cyber-theft and cyber-espionage continue to endanger sensitive RD and patient information and diminish life sciences
sector profits. Developed markets, including the United States and United Kingdom, have suffered economic losses of more than $279
billion due to cybercrime.115
Cyber security measures including implementing frameworks, integrated systems management programs,
and security patch applications to identify data breaches have strengthened companies’ ability to respond to threatened and actual cyber
incidents. However, the security infrastructure needs to be even more robust, as life sciences and health care companies experience 340
percent59
more security incidents than the average industry.116
•• Drug and device safety—In the past several decades there has been a rapid globalization in the manufacturing, distribution, and
marketing of medicine and medical devices. Gradually more and more biomedical companies are conducting research in emerging
countries that have nascent and expanding research regulations. Furthermore, pharmaceutical manufacturers are seeking to expand their
market and need to submit applications for products to be approved and enter countries with requirements discordant to that of their own;
this may result in additional costs, studies, and clinical trials and potentially slow down patient access to medicine. Global harmonization for
the evaluation of quality, safety, and efficacy of drugs and medical devices could substantially reduce cost, encourage sharing of knowledge
and resources, and result in fewer clinical trials. Identification of Medicinal Products (IDMP), for example, is a set of five data standards from
the International Organization for Standardization (ISO) that allow for the definition, characterization, and unique identification of regulated
pharmaceutical and biotech products across their lifecycle.117
The potential benefits of meeting evolving IDMP requirements extend far
beyond regulatory compliance. Through IDMP implementation, pharmaceutical companies can unlock the power of product data to
transform their business and improve patient health.118
•• Counterfeit drugs—According to the World Health Organization (WHO), 100,000 deaths annually are linked to the counterfeit drug
trade.119
These fake medicines threaten human safety, affect consumer perceptions of drugs and drug companies, infringe on IP rights,
and act as a barrier to pharmaceutical industry growth.120
Legitimate drug manufacturers and distributors should continuously invest
in countermeasures such as product traceability and authentication technologies. These efforts, however, can pose both financial and
strategic challenges for pharmaceutical manufacturers, as they need to continuously update technologies and security along their
distribution channels.
•• IP protection—Safeguarding valuable IP is a growing challenge, especially in Russia, Southeast Asia, and other emerging economies due
to increasing prices for innovative drugs and protectionist policies favoring national market players. Some emerging countries already
implement or have plans to implement compulsory licensing measures whereby patent-protected drugs are produced and sold without
any consent of patent holders. Another concern is leakage of sensitive commercial information121
amid the operational shift towards
collaborations with outside companies, suppliers, and scientists to spread RD costs and risks. The loss of information may damage
business prospects and help competitors. Furthermore, leakage of information surrounding clinical trials could introduce bias and
potentially halt the development of life-saving drugs. Pharmaceutical manufacturers will need to implement costly security measures to
protect their IP.
•• Corruption—Compliance failures such as payments to doctors/consultants and supply chain breaches carry the risk of fines and, more
importantly, reputational damage. The United States continues to aggressively pursue and prosecute pharmaceutical industry violations:
Over a 24-year period (1991 to 2015), U.S. federal and state governments made 373 settlements with pharmaceutical companies totaling
$36 billion.122
In addition, pharmaceutical companies are under significant scrutiny and have been receiving considerable negative press in
respect to perceived exorbitant drug pricing and what areas of RD and drug development they focus on and make available to patients.
China's anti-corruption campaign continues and compliance remains a critical focus for companies, especially how companies should put
appropriate controls on operations and how they should reorganize the sales force and optimize sales resources.
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23
The regulatory environment is becoming more demanding and detailed which, in turn, will require businesses to implement stricter
compliance policies, increase cross-functional collaboration, and improve data management and data integrity. For example, recent and
ongoing regulatory changes in the EU are anticipated to be among the most significant yet. Every pharmaceutical, biotechnology or medical
technology (medtech) company that currently sells or sponsors products in the EU will be impacted by IDMP, an enhanced EudraVigilance
System,123
the EU Medical Devices Regulation,124
a new Clinical Trials Regulation,125
the Falsified Medicines Directive,126
and other changes
At a country level, many of Germany’s legal and regulatory changes expected for 2017 are based on discussions identified at “Pharma
Dialog 2016” between the German health and research ministries, the German pharmaceuticals industry, the academic community, and
the respective trade union (IG BCE). Key discussion areas included continuously guaranteeing companies’ ability to supply drugs prone to
shortages, and protection against fortified medicines (suggesting the need for expanding the “securPharm” platform).
In China, regulatory complexities have a large impact on MNCs wanting to introduce innovative products there; companies may need to
make changes to global RD models to adapt to local policies. Mexico’s Ministry of Health, through COFEPRIS (Federal Commission for the
Protection against Sanitary Risk), is seeking to strengthen and align the country’s life sciences manufacturing best practices with international
standards including PICS (Pharmaceutical Inspection Cooperation Scheme). PICS includes 48 major health agencies that aim to exchange
information, streamline, standardize, and reduce the time and costs of procedures related to drugs and active ingredients. And while most
African countries do not have well-developed frameworks or bodies for regulating pharmaceutical and/or medical devices, South Africa is
developing the South African Health Products Regulatory Authority (SAHPRA) to replace the Medicines Control Council (MCC), to give the
government a wider mandate to regulate medical devices and complementary medicines. The entrance of SAHPRA, if it is approved in South
Africa by 2017, should ease entry of drugs and medical devices into the country.
Managing operating models along with evolving regulatory
requirements will test companies’ abilities to respond in a
coordinated, cost-efficient, and timely way. MNCs, regional,
and local life sciences companies in 2017 should consider
basing their efforts on a compliance risk framework
that identifies and addresses their overall risk architecture
(Figure 14).
Stakeholder considerations: Meeting regulatory
compliance
Compliance failures can be costly in terms of fines,
remediation costs, and reputational damage. Identifying,
analyzing, and mitigating compliance risks are, therefore,
essential in developing an effective compliance program.127
Based on Deloitte’s experience in helping companies
manage regulatory change, we estimate that each large
pharmaceutical company will need to invest in multi-million
dollar programs over the next few years to implement the
changes necessary for full compliance.128
In considering their
response, companies should look well beyond addressing
basic, functional-level compliance requirements. Ultimately,
the goal should be mitigating the most intrinsic industry
risks, such as safety concerns and drug supply interruptions.
By taking a proactive approach to tracking and monitoring
the regulatory developments and understanding their
independent and combined impacts to the business,
companies can be well-equipped to comply in a timely
manner, differentiate themselves in the marketplace, and be
part of defining tomorrow’s regulatory platform.129
Figure 14: Deloitte compliance risk framework
Source: The challenge of compliance in life sciences: Moving from cost to
value, Deloitte UK Centre for Health Solutions, 2015
Figure 1. Deloitte compliance risk tool
Culture of ethics
and compliance
Public relations,
patient advocacy and
government affairs
including anti-bribery
and corruption
Financial compliance
Clinical and research
development
Environmental,
health and
safety
Labour and
employment
Data, management,
integrity and
transparency
Cyber security and
privacy
Promotional activities
Market access,
pricing and
reimbursement
Supply chain
Product quality
Regulatory risk
Patient safety
Medical and scientific
exchange
Governance and
leadership
Continuous
improvement
Risk assessments and
due dilligence
Third-party
compliance
Testing and
monitoring
Case management and
investigations
Employee reporting
Training and
communications
Standards, policies
and procedures
Design
Assess
Implement
Technology
Process
People
Risk domains
Corporate IT compliance and quality Commercial Manufacturing and supply chain
Regulatory affairs Research and development
Source: Deloitte Enterprise Compliance and Life Sciences Compliance Advisory, 2015
26. 2017 global life sciences outlook | Thriving in today’s uncertain market
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Thriving amid uncertainty
“Sustainable growth” has evolved from catchphrase to mantra for companies operating in today’s increasingly competitive, regulated, and
cost-constrained life sciences sector. Incentivizing behaviors that will help enable organizations to tackle 2017’s challenges and opportunities
can pay off in increasing nimbleness, competitiveness, and growth. However, embedding the necessary corporate culture changes across
functions, business lines, and locations requires consistent, top-down efforts – especially in large, geographically dispersed organizations.
And although changes can be slow and uneven, they are taking place, as seen by expanding cultures of:
•• Partnering prowess—Functional networks of academic, industry, and regulatory partners with shared values and a collective commitment
to improve population health are becoming key competitive assets.
•• Shared accountability—Defining ownership of projects and processes instils a sense of personal and collective achievement and
responsibility.
•• Lifelong learning—Continuous learning and experimenting at all employee levels helps a company maintain the necessary plasticity and
enthusiasm to drive innovation.
•• Purposeful action—Fostering employee confidence to continually move forward and align actions to a common set of values and
objectives creates a purposeful work environment.
•• Nimble adaptability—Acknowledging the reality of “survival of the fittest” imparts a sense of urgency and willingness to embrace and
adapt to dynamic market conditions.
As mentioned at the beginning of this outlook, life sciences companies have always operated in a world of uncertainty, and they will continue
to do so in 2017. Issues around cost and pricing, clinical and operational innovation, customer and consumer engagement, and regulatory
compliance are not going away – in fact, these issues will continue to evolve and disrupt even the best strategic business models. Life
sciences leaders who understand this reality, plan accordingly, and embrace change should be well-positioned to thrive amid uncertainty.
27. 2017 global life sciences outlook | Thriving in today’s uncertain market
25
Explore additional Deloitte life sciences insights
Explore the latest life sciences sector research from Deloitte member firms or visit:
www.deloitte.com/us/healthsolutions
www.deloitte.co.uk/centreforhealthsolutions
www.deloitte.com/lifesciences
Are physicians ready for MACRA and its changes? Perspectives from the Deloitte Center for Health Solutions 2016 Survey of US Physicians
The Deloitte Center for Health Solutions 2016 Survey of US Physicians sheds light on physicians’ awareness of MACRA, their perspectives on
its implications, and their readiness for change. The survey is a nationally representative sample of 600 primary care and specialty physicians
who were asked about a range of topics on value-based payment models, consolidation, and health information technology (HIT).
Measuring the return from pharmaceutical innovation 2016: Balancing the RD equation
The pharmaceutical industry continues to face regulatory and reimbursement hurdles weighing on the research and development returns of
pharmaceutical firms this year. The seventh annual pharmaceutical innovation study by the Deloitte UK Centre for Health Solutions looks at
the challenges the industry faces in generating returns from its RD investments while highlighting the key strategies to help increase pipeline
value while reduce RD costs to generate sustainable RD returns.
Blockchain in insurance: Turning a buzzword into a breakthrough for health and life insurers
Health and life insurers are among the many players scrambling to determine how blockchain could be adapted to improve the way they
maintain records, execute transactions, and interact with stakeholders. Key questions center on whether blockchain’s unique attributes
could help insurers cut costs, manage risk, improve customer service, grow their business, and, ultimately, bolster the bottom line. How can a
cryptocurrency technology like blockchain potentially solve these problems and more?
Convergence of health care trends: Innovation strategies for emerging opportunities
The convergence of powerful trends—new technologies, the demand for value, a growing health economy, and the government as an
influencer—is transforming the traditional US health care market. While this convergence is creating substantial challenges for health care
stakeholders, it is also creating opportunities for innovation in four major areas.
Delivering medical innovation in a value-based world: Summary of the meeting between the Deloitte Center for Health Solutions and the
Network for Excellence in Health Education
Discover the implications for medical innovation as the health care industry transitions to value-based care. Biopharma, medtech, health
plans, and provider executives suggest four changes that could encourage innovation as value-based care takes root and evolves.
Appendix
28. 2017 global life sciences outlook | Thriving in today’s uncertain market
26
Deloitte’s path to 21st century cures: A call to action
The United States has had a strong commitment to life sciences research and development (RD) for new treatments and cures. A
translational approach to the RD value chain removes discrete steps and connects the discovery, development, and delivery processes. New
learnings inform this value chain, and additional discoveries and developments lead to a continuous process improvement cycle. This could
accelerate U.S. life sciences RD and bolster global competitiveness.
Executing an open innovation model: Cooperation is key to competition for biopharmaceutical companies
Biopharma companies’ reliance on a traditional, closed RD model might stifle true innovation. However, companies that adopt a cooperative,
open innovation framework are likely to spur product development, speed time to market, reduce costs, and increase competitiveness.
Facing the tidal wave: De-risking pharma and creating value for patients
The pharmaceutical industry is facing a ‘tidal wave’ of complex age and behavior related diseases creating increased economic, scientific and
delivery risks. How can pharma companies evolve to overcome these obstacles? Report looks at the changing pattern of diseases and its
implications for the industry whilst highlighting a series of bold choices on de-risking and delivering greater value to healthcare systems
Health care consumer engagement: No “one-size-fits-all” approach: Trends in consumers’ use of online resources and health technologies
from the Deloitte Center for Health Solutions 2015 Survey of US Health Care Consumers
Findings from the Deloitte Center for Health Solutions 2015 Survey of US Health Care Consumers provide evidence that consumer
engagement is trending upward in three important areas — partnering with providers, tapping online resources, and relying on technology.
Measuring the return from pharmaceutical innovation 2015: Transforming RD returns in uncertain times
Deloitte UK’s Centre for Health Solutions sixth annual pharmaceutical innovation study looks at the challenges the industry faces in
generating returns from its RD investments.
No regulation is an island: EU regulatory changes and their impact on the global life sciences industry
The life sciences industry operates in one of the world’s most regulated environments. Recent and ongoing European regulatory changes are
anticipated to be among the most significant yet for the global life sciences industry. The new and updated EU legislation is expected to drive
enterprise-wide changes for life sciences companies, impacting current organisational structures, governance, processes, and technology.
Patient engagement strategies in a digital environment: Life sciences companies respond to changing patient expectations
In a shifting health care landscape, patients are demanding care and solutions that are coordinated, convenient, customized, and accessible.
In response, nontraditional players – pharma companies in particular – are coming forward to address these emerging expectations and
establish their brands for patient engagement services.
The building blocks of IDMP implementation: Unlock the power of data to transform business and improve patient health
The potential benefits of meeting evolving Identification of Medicinal Product (IDMP) requirements extend far beyond regulatory compliance.
Through IDMP implementation, pharmaceutical companies can unlock the power of product data to transform their business and improve
patient health.
29. 2017 global life sciences outlook | Thriving in today’s uncertain market
27
The challenge of compliance in life sciences: Moving from cost to value
How well does the life sciences industry understand the totality of its compliance risks? How is compliance managed and implemented?
What does the future hold for compliance functions? The Deloitte UK Centre for Health Solutions’ research provides a unique view of the
enterprise-wide compliance functions of major life sciences companies.
The new transfer pricing landscape: A practical guide to the BEPS changes,
The new BEPS guidance has been hailed as a game changer intended to alter the transfer pricing outcomes in many situations and require
multinational enterprises to undertake additional analysis and documentation. But how will the new BEPS guidance impact your company?
The rise of the digital supply network: Industry 4.0 enables the digital transformation of supply chains
SUPPLY chains traditionally are linear in nature, with a discrete progression of design, plan, source, make, and deliver. Today, however, many
supply chains are transforming from a staid sequence to a dynamic, interconnected system that can more readily incorporate ecosystem
partners and evolve to a more optimal state over time. This shift from linear, sequential supply chain operations to an interconnected, open
system of supply operations could lay the foundation for how companies compete in the future.
Thriving in uncertainty: Deloitte’s fourth biennial cost survey: Cost improvement practices and trends in the Fortune 1000
Global macroeconomic factors are having a major impact on cost management efforts at large US companies. Deloitte’s fourth biennial
survey of cost management and cost improvement trends explores how companies are managing costs in this challenging environment.
Unlocking the potential of value-based care in Medicare Advantage
Are health plans effectively engaging providers in testing value-based care (VBC) arrangements in Medicare Advantage (MA)? Results from
Deloitte’s 2015 Study of MA Health Plans and Providers suggest that there is great – and unrealized – potential. As yet, the business case for
VBC in MA is not evident to all stakeholders.
Will patients and caregivers embrace technology-enabled health care? Findings from the Deloitte 2016 Survey of US Health Care Consumers
MOST everyone who has set foot in a hospital or clinic in recent years has seen changes in everything from ICU equipment to billing practices,
primarily based on technology advances. And now technology is actually making care outside of traditional settings both possible and
desirable.. But it turns out that consumers—both patients and caregivers—can also be amenable to technology-enabled care.
Winning with biosimilars: Opportunities in global markets
Biosimilars are gaining traction across the globe. While developed markets will remain important for biosimilars manufacturers, Deloitte
analysis indicates that long-term growth may be fueled by emerging markets. To win in these markets, biosimilars players will need to adopt a
long-term strategy to provide affordable products and improved access to the large pockets of non-consumption.
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Endnotes
1. World Industry Outlook, Healthcare and Pharmaceuticals, Economist Intelligence
Unit, June 2016
2. Ibid
3. Global Healthcare Risks, WHO
4. National Institute of Aging, 2016
5. Global Life Expectancy reaches new heights, WHO, National Institute of Aging,
2016
6. World Industry Outlook, Healthcare and Pharmaceuticals, Economist Intelligence
Unit, June 2016
7. Top 10 causes of death, WHO
8. World Industry Outlook, Healthcare and Pharmaceuticals, Economist Intelligence
Unit, June 2016, citing the International Diabetes Federation.
9. Facing the tidal wave: De-risking pharma and creating value for patients, Deloitte
UK Centre for Health Solutions, 2016
10. Ibid
11. World Industry Outlook, Healthcare and Pharmaceuticals, Economist Intelligence
Unit, June 2016
12. Annual reports; Form 10K; EP Vantage 2016 Preview, December 2015
13. World Industry Outlook, Healthcare and Pharmaceuticals, Economist Intelligence
Unit, June 2016
14. Ibid
15. Ibid
16. Ibid
17. EIU data tool accessed on 19 July 2016
18. Ibid
19. Ibid
20. IBISWorld Industry Report, Global Biotechnology, October 2016
21. “Top drugs by sales revenue in 2015: Who sold the biggest blockbuster drugs?”,
Pharmacompass
22. IBISWorld Industry Report, Global Biotechnology, October 2016
23. Ibid
24. Obesity Therapy Market to Reach $8.4 billion by 2022, GlobalData
25. World Industry Outlook, Healthcare and Pharmaceuticals, Economist Intelligence
Unit, June 2016
26. EvaluatePharma: World Preview 2015, Outlook to 2020
27. World Industry Outlook, Healthcare and Pharmaceuticals, Economist Intelligence
Unit, June 2016
28. Ibid
29. Winning with biosimilars: Opportunities in global markets, Deloitte, 2015, citing
BioTrends Research Group, Global Biosimilars Pathway and Clinical Development
Activity: Where are the Biosimilar Hotspots?, 2014
30. Winning with biosimilars: Opportunities in global markets, Deloitte, 2015, citing
Allied Market Research, Global Biosimilars/Follow-on- Biologics Market, July 2014
31. Winning with biosimilars: Opportunities in global markets, Deloitte, 2015
32. World Preview 2015, Outlook to 2020, Evaluate MedTech
33. Ibid
34. Are physicians ready for MACRA and its changes? Perspectives from the Deloitte
Center for Health Solutions 2016 Survey of US Physicians, Deloitte Center for Health
Solutions, 2016
35. World Preview 2015, Outlook to 2020, Evaluate MedTech, World bank statistics-
Elderly population
36. 2016 Global Life Sciences Outlook: Moving forward with cautious optimism, Deloitte
Touche Tohmatsu Limited, 2015
37. Global Pharmaceuticals Wholesale and Distribution Market 2015-2019, Technavio,
2014, www.technavio.com
38. Ibid
39. Ibid
40. Ibid
41. http://www.iracm.com/en/thematic-observatory/parallel-imports/
42. http://www.tilleke.com/resources/pharmaceutical-parallel-imports-solution-or-
problem
43. World Industry Outlook: Healthcare and Pharmaceuticals, Economist Intelligence
Unit, June 2016
44. Ibid
45. Measuring the return from pharmaceutical innovation 2016: Balancing the RD
equation, Deloitte UK Centre for Health Solutions, 2016
46. Brenna Sniderman, Monica Mahto, and Mark Cotteleer, Industry 4.0 and
manufacturing ecosystems: Exploring the world of connected enterprises, Deloitte
University Press, February 22, 2016, http://dupress.com/articles/industry-4-0-
manufacturing-ecosystems-exploring-world-connected-enterprises/
47. The rise of the digital supply network: Industry 4.0 enables the digital transformation
of supply chains, Deloitte University Press, 2016
48. Tony Hines, Supply Chain Strategies: Demand Driven and Customer Focused
(Routledge, 2014).