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David Arnold has over 15 years of experience maintaining and operating UH-60 Black Hawk helicopters in the U.S. Army. He has extensive experience performing inspections, scheduled and unscheduled maintenance, troubleshooting aircraft parts, and ensuring safety. Arnold has also worked as a certified nursing assistant and home health aide, where he monitored patients and assisted with daily medical needs. He is trained in combat life saving techniques and maintains certifications for the UH-60 aircraft models.
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อ.สามพราน จ.นครปฐม
วันพฤหัสบดีที่ 20 ตุลาคม 2559
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Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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- 1. DAVID ARNOLD 4895 MARION RD CUNNINGHAM, TN 37052 931-624-7527 david.l.arnold00@gmail.com EXPERIENCE • Experienced in aircraft maintenance, troubleshooting, preventing maintenance, quality assurance inspections on aircraft parts and job safety. • Prior to each flight supervised passengers safety load on and off the helicopter. • Assessed landing zones for safety and security. • Perform personal and area security. • Experience in Automated Aviation Logistics Systems. • Maintain Environmental Safety Standers. • Experience in army supply program. • Train soldier on UH-60M Black hawk helicopter. • Perform 720 hour inspection. • Perform scheduled and unscheduled maintenance on the UH-60s Black hawk helicopter. • Performed inspections on the UH-60s Black hawk helicopter. • Perform duty as a crew chief managing loading of cargo, equipment and personnel to adverse location. • Perform numerous assault missions while deployed to Afghanistan. • In charger of shop supply net worth of $500,000 of parts vital to aircraft maintains. • Folded and unfolded UH-60 Black hawk helicopter for air transport. • Drove cross country in convoys of four vehicles to transport mail as well as travel to Israel for mail pick up. • Dealt with multinational customs regulation. • Did ground transport of six building from Israel to Egypt. • Squad leader for four months in charge of 10 soldiers monitoring attendance, performance and assigned job duties. • Maintained current inventory of shop tools and ground supports equipment valued at $750,000. • As a certified nursing assistant monitored 5-15 patients intakes and outputs of food and liquid, taking and recording vital signs, managing patients appointments, assisting patient with daily activities of living. • Managing patient’s daily health record and assisting doctors and nurses with patient treatment. • Monitored patient’s medication and health. • Gave report at change of shift to nurse and certified nursing assistant.
- 2. EMPLOYMENT HISTORY UH-60 Mechanic February 2005 - Present U.S. Army, Fort Campbell, KY El Gora, Egypt, Fort Hood, TX Home Health Aide October 2003 - February 2005 Dottie Steveson, Modesto, CA Certified Nursing Assistant November 2001 - October 2003 Modesto Rehabilitation Hospital EDUCATION Certification as Combat Life Saver (Advance First Aid), U.S. Army, Fort Campbell, KY, 2011 Certification, UH-60M, U.S. Army, Fort Campbell, KY, 2010 Certification, UH-60A-L, U.S. Army, Fort Eustis, VA, 2005 (33 credits) Criminal Justice, Clastop Community College, Astoria, OR 2004 Certification as Nursing Assistant, Clastop Community College / Tongue Point Job Corps, Astoria, OR 2003 Diploma, Gold Beach High School, Gold Beach OR, 2000