This document provides an overview and leader's manual for a 16-session cognitive-behavioral group therapy program for treating adolescent depression. The treatment was developed by researchers at Kaiser Permanente and teaches adolescents skills for overcoming depression, including relaxation, changing irrational thoughts, social skills, communication, and problem-solving. Research has found the program significantly improves over 70% of adolescents and the effects are maintained for up to 12 months after treatment. The manual provides background on the treatment approach, instructions for conducting each therapy session, and adapting the program for parent-adolescent sessions.